Page last updated: 2024-09-03

2-(n,n-dipropyl)amino-5,6-dihydroxytetralin and yohimbine

2-(n,n-dipropyl)amino-5,6-dihydroxytetralin has been researched along with yohimbine in 5 studies

Compound Research Comparison

Studies
(2-(n,n-dipropyl)amino-5,6-dihydroxytetralin)
Trials
(2-(n,n-dipropyl)amino-5,6-dihydroxytetralin)
Recent Studies (post-2010)
(2-(n,n-dipropyl)amino-5,6-dihydroxytetralin)
Studies
(yohimbine)
Trials
(yohimbine)
Recent Studies (post-2010) (yohimbine)
37005,893253532

Protein Interaction Comparison

ProteinTaxonomy2-(n,n-dipropyl)amino-5,6-dihydroxytetralin (IC50)yohimbine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.0353
Cytochrome P450 2D6Homo sapiens (human)1.02
D(2) dopamine receptorHomo sapiens (human)2.06
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-2B adrenergic receptorHomo sapiens (human)0.0428
Alpha-2C adrenergic receptorHomo sapiens (human)0.0466
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.126
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-1D adrenergic receptorHomo sapiens (human)1.013
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.126
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.074
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)1.3
5-hydroxytryptamine receptor 6Homo sapiens (human)1.689

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Batink, H; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B1
Costall, B; Naylor, RJ; Tan, CC1
Bradbury, AJ; Costall, B; Kelly, ME; Naylor, RJ; Smith, JA1
Costall, B; Lim, SK; Naylor, RJ1
Westerink, BH1

Other Studies

5 other study(ies) available for 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin and yohimbine

ArticleYear
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cell Membrane; Clonidine; Kinetics; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vasoconstriction

1984
The sites and mechanisms of action of 2-di-n-propylamino-5, 6-dihydroxytetralin in the hypothalamus of the rat to modify gastric secretion.
    Neuropharmacology, 1986, Volume: 25, Issue:7

    Topics: Animals; Antipsychotic Agents; Brain Mapping; Gastric Juice; Gastric Mucosa; Hypothalamus; Hypothalamus, Posterior; Male; Naphthalenes; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Tetrahydronaphthalenes; Ventromedial Hypothalamic Nucleus; Yohimbine

1986
Biochemical correlates of motor changes caused by the manipulation of dopamine function in the substantia nigra of the mouse.
    Neuropharmacology, 1985, Volume: 24, Issue:12

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Dopamine; Injections, Intraventricular; Male; Mesencephalon; Mice; Motor Activity; Norepinephrine; Serotonin; Substantia Nigra; Tetrahydronaphthalenes; Yohimbine

1985
Characterisation of the mechanisms by which purported dopamine agonists reduce spontaneous locomotor activity of mice.
    European journal of pharmacology, 1981, Jul-17, Volume: 73, Issue:2-3

    Topics: Animals; Antipsychotic Agents; Apomorphine; Bromocriptine; Catecholamines; Dopamine; Dose-Response Relationship, Drug; Imidazolines; Male; Mice; Motor Activity; Prazosin; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes; Yohimbine

1981
Determination of normetanephrine, 3,4-dihydroxyphenylethyleneglycol (free and total), and 3-methoxy-4-hydroxyphenylethyleneglycol (free and total) in rat brain by high-performance liquid chromatography with electrochemical detection and effects of drugs o
    Journal of neurochemistry, 1984, Volume: 42, Issue:4

    Topics: Animals; Brain Chemistry; Chlorpromazine; Chromatography, High Pressure Liquid; Clonidine; Glycols; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes; Yohimbine

1984