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2-(n,n-dimethylamino)-6,7-dihydroxytetralin and prazosin

2-(n,n-dimethylamino)-6,7-dihydroxytetralin has been researched along with prazosin in 4 studies

Compound Research Comparison

Studies
(2-(n,n-dimethylamino)-6,7-dihydroxytetralin)
Trials
(2-(n,n-dimethylamino)-6,7-dihydroxytetralin)
Recent Studies (post-2010)
(2-(n,n-dimethylamino)-6,7-dihydroxytetralin)
Studies
(prazosin)
Trials
(prazosin)
Recent Studies (post-2010) (prazosin)
46007,914713682

Protein Interaction Comparison

ProteinTaxonomy2-(n,n-dimethylamino)-6,7-dihydroxytetralin (IC50)prazosin (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)5.87
Interstitial collagenaseHomo sapiens (human)4.036
Alpha-2A adrenergic receptorHomo sapiens (human)2.638
Matrix metalloproteinase-9Homo sapiens (human)6.963
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0008
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)0.0078
Alpha-2B adrenergic receptorHomo sapiens (human)0.29
Alpha-2C adrenergic receptorHomo sapiens (human)0.647
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0008
Alpha-1D adrenergic receptorHomo sapiens (human)0.0007
Bromodomain-containing protein 2Homo sapiens (human)0.0009
Alpha-1A adrenergic receptorHomo sapiens (human)0.0006
Alpha-1B adrenergic receptorHomo sapiens (human)0.0006
5-hydroxytryptamine receptor 2BHomo sapiens (human)4.118
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0008
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)9.9
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.5849
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.6

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Moulds, RF; Stevens, MJ1
Cannon, JG; Hicks, PE1
Hicks, PE1
De Jonge, A; Thoolen, MJ; Timmermans, PB; Van Zwieten, PA; Wilffert, B1

Other Studies

4 other study(ies) available for 2-(n,n-dimethylamino)-6,7-dihydroxytetralin and prazosin

ArticleYear
Antagonism by nifedipine of alpha-1 and alpha-2 adrenoceptor-mediated responses of human digital arteries.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3

    Topics: Electric Stimulation; Fingers; Humans; In Vitro Techniques; Methoxamine; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Tetrahydronaphthalenes; Tritium; Vasoconstriction; Yohimbine

1986
Cardiovascular effects of 2-(NN-dimethyl)amino-6,7-dihydroxy-1,2,3,4 tetrahydronaphthalene in pithed rats: differential antagonism by yohimbine and prazosin.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:11

    Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Male; Naphthols; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Tetrahydronaphthalenes; Yohimbine

1980
Antagonism of pre and postsynaptic alpha-adrenoreceptors by BE 2254 (HEAT) and prazosin.
    Journal of autonomic pharmacology, 1981, Volume: 1, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Phenethylamines; Prazosin; Quinazolines; Rats; Rats, Inbred Strains; Synapses; Tetrahydronaphthalenes; Tetralones

1981
Heterogeneity of the interaction between alpha 1- and alpha 2-adrenoceptor agonists with their respective receptors in the vascular system of the pithed rat.
    European journal of pharmacology, 1984, Oct-01, Volume: 105, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Cocaine; Dopamine; Electric Stimulation; Emetics; Ethanolamines; Hemodynamics; Male; Naphthols; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetrahydronaphthalenes; Yohimbine

1984