Compounds > 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and zstk474

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with zstk474 in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cushing, TD; McGee, LR; Metz, DP; Whittington, DA1
Andrs, M; Bartek, J; Hodny, Z; Jun, D; Korabecny, J; Kuca, K1
Hamilton, JR; Jennings, IG; Mountford, SJ; Sundaram, K; Thompson, PE; Zheng, Z1
Hamilton, JR; Jackson, SP; Jennings, IG; Mountford, SJ; Nelson, EM; Orive, S; Pinson, JA; Powell, A; Schoenwaelder, SM; Shackleford, D; Thompson, PE; Zheng, Z1
Duan, HQ; Gan, CC; Jia, M; Jin, MN; Liu, Q; Qin, N; Shou, XA; Wu, XR; Yu, Y1
Fukui, Y; Gouda, H; Hirono, S; Koshimizu, I; Matsuno, T; Yaguchi, S; Yamazaki, K; Yamori, T; Yoshimi, H1
Kong, D; Yamori, T1
Kong, D; Yaguchi, S; Yamori, T1
Dan, S; Kong, D; Yamazaki, K; Yamori, T1

Reviews

1 review(s) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and zstk474

ArticleYear
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
    Journal of medicinal chemistry, 2012, Oct-25, Volume: 55, Issue:20

    Topics: Animals; Autoimmune Diseases; B-Lymphocytes; Class Ia Phosphatidylinositol 3-Kinase; Class Ib Phosphatidylinositol 3-Kinase; Humans; Inflammation; Isoenzymes; Molecular Targeted Therapy; Neutrophils; Phosphoinositide-3 Kinase Inhibitors; Protein Conformation; T-Lymphocytes

2012

Other Studies

8 other study(ies) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and zstk474

ArticleYear
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
    Journal of medicinal chemistry, 2015, Jan-08, Volume: 58, Issue:1

    Topics: Drug Design; Humans; Hydrogen Bonding; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Signal Transduction

2015
Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.
    ACS medicinal chemistry letters, 2015, Jan-08, Volume: 6, Issue:1

    Topics:

2015
Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).
    European journal of medicinal chemistry, 2016, Oct-21, Volume: 122

    Topics: Animals; Drug Discovery; Enzyme Inhibitors; Humans; Male; Mice; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Triazines

2016
Synthesis and anti-metastatic effects of pregn-17(20)-en-3-amine derivatives.
    European journal of medicinal chemistry, 2016, Nov-29, Volume: 124

    Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Humans; Inhibitory Concentration 50; Integrin beta1; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship

2016
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor.
    Journal of the National Cancer Institute, 2006, Apr-19, Volume: 98, Issue:8

    Topics: Androstadienes; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromones; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Immunohistochemistry; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Transplantation, Heterologous; Triazines; Wortmannin

2006
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.
    Cancer science, 2007, Volume: 98, Issue:10

    Topics: Adenosine Triphosphate; Binding, Competitive; Chromones; Enzyme Inhibitors; Fluoroimmunoassay; Humans; Isoenzymes; Kinetics; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Triazines

2007
Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:2

    Topics: Chromones; DNA-Activated Protein Kinase; Enzyme Inhibitors; Furans; Imidazoles; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Pyrimidines; Quinolines; Structure-Activity Relationship; Substrate Specificity; Triazines

2009
Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39.
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:6

    Topics: Algorithms; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Humans; Imidazoles; Indazoles; Morpholines; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinolines; Substrate Specificity; Sulfonamides; Triazines

2010