2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with rtki cpd in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.00) | 18.2507 |
| 2000's | 21 (52.50) | 29.6817 |
| 2010's | 16 (40.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C | 1 |
| Gillham, H; Golding, MC; Gullick, WJ; Pepperkok, R | 1 |
| Brattain, MG; Jackson, JG; Koterba, AP; Kreisberg, JI; Yee, D | 1 |
| Conway, A; Pyne, NJ; Pyne, S | 1 |
| Huggett, TM; Jost, M; Kari, C; Rodeck, U | 1 |
| Pouysségur, J; Viñals, F | 1 |
| Chen, K; Keaney, JF; Thomas, SR | 1 |
| Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M | 1 |
| Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Knies, Y; Loitsch, S; Müller, J | 1 |
| Chen, L; Gao, P; Ma, D; Oppenheim, JJ; Sun, R; Wang, J; Zhang, N | 1 |
| Chan, CT; Kane, SE; Metz, MZ | 1 |
| Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T | 1 |
| Birukov, KG; Garcia, JG; Hassoun, PM; Papaiahgari, S; Reddy, SP; Yerrapureddy, A | 1 |
| Chopp, M; Hong, X; Jiang, F; Kalkanis, SN; Katakowski, M; Yang, H; Zhang, X; Zhang, ZG; Zheng, X | 1 |
| Daubert, RA; Schnellmann, RG; Yan, Y; Zhuang, S | 1 |
| Abad, PC; Chandramouly, G; Knowles, DW; Lelièvre, SA | 1 |
| Carmona-Cuenca, I; Del Castillo, G; Fabregat, I; Fernández, M; Murillo, MM; Ortiz, C; Roncero, C; Sánchez, A | 1 |
| Bae, YS; Catt, KJ; Choi, H; Hunyady, L; Leto, TL; Rhee, SG | 1 |
| Chen, DY; Hou, Y; Li, M; Liang, CG; Lin, SL; Schatten, H; Sun, QY; Xiong, B; Xu, BZ | 1 |
| Lin, CC; Lin, WN; Luo, SF; Wu, CB; Yang, CM | 1 |
| Jeong, M; Jin, YW; Kim, CS; Kim, HS; Kim, J; Kim, JK; Nam, SY; Yang, KH | 1 |
| Aird, WC; Hwang, TL; Lee, CW; Lee, HC; Lee, IT; Lin, CC; Luo, SF; Yang, CM | 1 |
| Feng, R; Hu, Q; Li, L; Li, M; Wang, S; Wen, J; Yang, X; Zhang, L | 1 |
| Chuu, CP; Kuo, LK; Lin, HP | 1 |
| Grandal, MV; Grøvdal, LM; Holst, MR; Kim, J; Knudsen, SL; van Deurs, B | 1 |
| Groves, AK; Segil, N; Stone, JS; White, PM | 1 |
| Pick, A; Wiese, M | 1 |
| Fu, S; Li, P; Li, ZB; Lu, B; Torossian, A; Xu, WC; Zhang, Q | 1 |
| Fu, S; Li, P; Torossian, A; Xu, WC; Zhang, Q | 1 |
| Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ | 1 |
| Inase, N; Miyazaki, Y; Okayasu, K; Sumi, Y; Takayama, S; Tamaoka, M; Yoshizawa, Y | 1 |
| Han, D; Sun, J; Wang, F; Xiao, W; Zhu, Y | 1 |
| Fujiki, K; Inamura, H; Matsuoka, M | 1 |
| Kimura, M; Moteki, H; Ogihara, M | 1 |
| Sui, JQ; Xie, KP; Xie, MJ | 1 |
| Chen, G; Hossain, MM; Hu, B; Meng, X; Sun, Y; Zhang, X | 1 |
| Cai, L; Chen, X; He, J; Lan, P; Li, L; Li, X; Zhang, X | 1 |
1 review(s) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and rtki cpd
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
39 other study(ies) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and rtki cpd
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromones; Cytochalasin D; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrphostins | 1999 |
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
Topics: Alkaline Phosphatase; Biological Transport; Breast Neoplasms; Cell Nucleus; Chromones; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Macromolecular Substances; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrphostins; Ubiquitin-Protein Ligases | 2000 |
Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.
Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Ceramides; Chromones; Enzyme Activation; Guinea Pigs; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; Respiratory System; Signal Transduction; Sphingosine; Tyrphostins | 2000 |
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins | 2001 |
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin | 2001 |
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.
Topics: Animals; Aorta; Arginine; Calcium Signaling; Cells, Cultured; Chromones; Citrulline; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Quinazolines; Signal Transduction; Swine; Tyrphostins | 2002 |
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins | 2004 |
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Membrane; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epithelial Cells; ErbB Receptors; Genes, Dominant; Humans; Immunoblotting; Microscopy, Confocal; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; Threonine; Time Factors; Tyrphostins; Wortmannin | 2005 |
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Topics: Alkaloids; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Morpholines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2005 |
Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromones; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab; Tumor Cells, Cultured; Tyrphostins | 2005 |
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins | 2006 |
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.
Topics: Actins; Animals; Antioxidants; Chromones; Endothelial Cells; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Lung; Mice; Morpholines; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Response Elements; RNA, Messenger; Signal Transduction; Stress, Mechanical; Transcription, Genetic; Tyrphostins | 2007 |
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Inhibitors; Gene Expression; Glioma; Gliosarcoma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection; Tyrphostins | 2007 |
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing | 2007 |
The control of tissue architecture over nuclear organization is crucial for epithelial cell fate.
Topics: Antigens, Neoplasm; Antigens, Nuclear; Apoptosis; beta Catenin; Cell Culture Techniques; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Polarity; Chromones; Collagen Type IV; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; ErbB Receptors; Histones; Humans; Integrin alpha6; Ki-67 Antigen; Membrane Proteins; Morpholines; Mucin-1; Mucins; Neoplasm Proteins; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Phosphoproteins; Promyelocytic Leukemia Protein; Quinazolines; RNA, Small Interfering; Transcription Factors; Tumor Suppressor Proteins; Tyrphostins; Zonula Occludens-1 Protein | 2007 |
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation | 2007 |
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Angiotensin II; Animals; Cell Line; CHO Cells; Chromones; Cricetinae; Cricetulus; Gene Expression; Humans; Indoles; Maleimides; Membrane Glycoproteins; Morpholines; Mutation; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Pyrazoles; Pyrimidines; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Tyrphostins; Wortmannin | 2008 |
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins | 2008 |
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
Topics: Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Chromones; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; ErbB Receptors; Humans; Lipopolysaccharides; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Trachea; Transfection; Tyrphostins; Vascular Cell Adhesion Molecule-1; Wortmannin | 2008 |
Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt.
Topics: Cell Proliferation; Chromones; Enzyme Activation; Fibroblasts; Gamma Rays; Humans; Lung; Morpholines; p21-Activated Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins | 2007 |
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
Topics: Active Transport, Cell Nucleus; Antibodies; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cell Adhesion; Cell Nucleus; Chromones; E1A-Associated p300 Protein; Enzyme Activation; Gene Expression Regulation; Histone Acetyltransferases; Histone Deacetylases; Humans; Isoenzymes; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Repressor Proteins; Trachea; Tumor Necrosis Factor-alpha; Tyrphostins; Vascular Cell Adhesion Molecule-1 | 2008 |
The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Chromones; Enzyme Inhibitors; ErbB Receptors; Immunohistochemistry; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; SOXB1 Transcription Factors; Tyrphostins | 2010 |
Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
Topics: Antineoplastic Agents; Biological Availability; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Curcuma; Curcumin; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Humans; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Pyrimidines; Quinazolines; Receptors, Fibroblast Growth Factor; Signal Transduction; Somatomedins; Tyrphostins | 2012 |
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; MAP Kinase Kinase 1; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2012 |
EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Chromones; Cochlea; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Gene Expression Profiling; Green Fluorescent Proteins; Hair Cells, Auditory; Labyrinth Supporting Cells; Mice; Mice, 129 Strain; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Morpholines; Organ Culture Techniques; Organ of Corti; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Nerve Growth Factor; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2012 |
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chromones; ErbB Receptors; Female; G1 Phase; Humans; Mice; Mice, Nude; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Resting Phase, Cell Cycle; Tyrphostins | 2012 |
Inhibition of phosphoinositide 3-kinase enhances the cytotoxicity of AG1478, an epidermal growth factor receptor inhibitor, in breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Flow Cytometry; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Tyrphostins | 2012 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins | 2013 |
RANTES expression induced by Toll-like receptor 4 ligand in rat airway smooth muscle cells.
Topics: Animals; Asthma; Cell Culture Techniques; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chromones; Dipeptides; ErbB Receptors; Lipopolysaccharides; Male; Matrix Metalloproteinase Inhibitors; Morpholines; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Rats, Inbred BN; Signal Transduction; Toll-Like Receptor 4; Trachea; Transcriptional Activation; Tyrphostins | 2010 |
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; MicroRNAs; Models, Genetic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2014 |
Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.
Topics: Cadmium Chloride; Calcium-Binding Proteins; Cell Line; Chromones; Down-Regulation; Epithelial Cells; ErbB Receptors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Jagged-2 Protein; Kidney Tubules, Proximal; Maleimides; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Receptor, Notch1; RNA Interference; RNA, Small Interfering; Serrate-Jagged Proteins; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins | 2014 |
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins | 2014 |
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Luteolin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Quinazolines; Tyrphostins | 2016 |
ADAM17-siRNA inhibits MCF-7 breast cancer through EGFR-PI3K-AKT activation.
Topics: ADAM17 Protein; Animals; Benzamides; Breast Neoplasms; Chromones; Diphenylamine; ErbB Receptors; Female; Humans; MCF-7 Cells; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Tyrphostins; Xenograft Model Antitumor Assays | 2016 |
Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Down-Regulation; Drug Therapy, Combination; Esophageal Neoplasms; Female; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Photochemotherapy; Photosensitizing Agents; Protein Kinases; Quinazolines; Signal Transduction; Tyrphostins | 2017 |