2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and resveratrol

2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with resveratrol in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (29.63)29.6817
2010's16 (59.26)24.3611
2020's3 (11.11)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Eräsalo, H; Haavikko, R; Hämäläinen, M; Laavola, M; Leppänen, T; Mäki-Opas, I; Moilanen, E; Yli-Kauhaluoma, J1
Arora, S; Chaturvedi, A; Heuser, M; Joshi, G; Kumar, R; Patil, S1
Alvarez-Barrientos, A; Centeno, F; Fernandez-Salguero, PM; Lorenzo-Benayas, MJ; Merino, JM; Mulero-Navarro, S; Pozo-Guisado, E; Salguero, PM1
Blair, D; Chiles, TC; Dufort, FJ; Faber, AC; Roberts, MF; Wagner, D1
Chen, WP; Cheng, JT; Chi, TC; Chi, TL; Kuo, TF; Lee, SS; Su, MJ1
Brown, J; Le, AD; Nishitani, J; Shi, S; Tang, X; Zhang, Q1
Cahill, PA; Cullen, JP; Jin, Y; Morrow, D; Redmond, EM; Sitzmann, JV; von Offenberg Sweeney, N1
Fitzpatrick, JM; Gill, C; Morrissey, C; Walsh, SE; Watson, RW1
Hei, TK; Ivanov, VN; Johnson, GE1
Chen, Q; Ganapathy, S; Shankar, S; Singh, KP; Srivastava, RK1
Matté, A; Netto, CA; Pagnussat, AS; Salbego, CG; Simão, F1
Cho, MK; Choi, YJ; Im, JH; Kim, YB; Lee, SH; Lee, YJ; Nam, HS; Won, SY1
Chong, ZZ; Maiese, K; Shang, YC; Wang, S1
Jajoo, S; Kaur, T; Mukherjea, D; Ramkumar, V; Rybak, LP; Sheehan, K; Sheth, S1
Duan, W; Han, L; Li, B; Li, W; Liu, J; Ma, J; Ma, Q; Wang, F; Wu, E; Xu, Q; Yu, S1
Li, X; Liao, D; Lin, L; Zhang, R; Zuo, H1
Chen, YD; Fu, HY; He, J; Hu, HJ; Le, QF; Lin, XL; Liu, J; Liu, MH; Tan, TP; Tian, W; Wu, SJ; Yu, S; Yuan, C; Zhang, Y1
Go, KC; Hyun, MY; Kim, BJ; Kim, SY; Zouboulis, CC1
Chu, L; Ding, M; Huang, W; Li, H; Liu, XY; Xiao, J; Xu, H; Yang, D; Yang, Y1
Chung, HY; Jung, JH; Kim, DH; Kim, MJ; Kim, ND; Suh, H; Sung, B1
Guan, Z; Hei, B; Liang, H; Meng, X; Shen, L; Yang, L; Yu, H1
Chen, Q; Hu, J; Liu, J; Meng, Z; Ni, Z; Sun, L; Tang, L; Wang, X; Zhu, L1
Li, BH; Lu, YZ; Meng, DC; Song, J; Wang, D; Wang, J1
Chen, K; Lin, K; Shang, X; Wang, L; Xu, J; Yu, R; Zhang, Y; Zhu, P1
Fu, Y; He, Y; Liu, Y; Xi, J; Xi, M; Zhang, Y; Zhao, Y; Zheng, H1
Chen, Z; Li, H; Li, L; Li, T; Xie, J; Zhou, Y1

Other Studies

27 other study(ies) available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and resveratrol

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner.
    Journal of natural products, 2018, 05-25, Volume: 81, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Biological Products; Cell Line; Chemokine CCL2; Down-Regulation; Inflammation; Inflammation Mediators; Interleukin-6; Macrophages; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction

2018
A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Allosteric Regulation; Allosteric Site; Carrier Proteins; Chemistry, Pharmaceutical; Glycolysis; Humans; Membrane Proteins; Protein Kinase Inhibitors; Thyroid Hormone-Binding Proteins; Thyroid Hormones

2022
Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB.
    International journal of cancer, 2005, May-20, Volume: 115, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Calpain; Caspase 3; Caspase 8; Caspases; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Nucleus; Chromones; Collagen; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Estrogens; Flow Cytometry; Humans; Immunoblotting; Immunoprecipitation; Matrix Metalloproteinase 9; Membrane Potentials; Mitochondria; Models, Biological; Morpholines; NF-kappa B; Nitrites; Oxygen; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stilbenes; Time Factors

2005
Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas.
    Biochemical pharmacology, 2006, Nov-15, Volume: 72, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Glucose; Glycolysis; Humans; Lymphoma, Large B-Cell, Diffuse; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Resveratrol; Stilbenes

2006
Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats.
    Life sciences, 2007, Apr-10, Volume: 80, Issue:18

    Topics: Androstadienes; Animals; Antioxidants; Blood Glucose; Carboxy-Lyases; Chromones; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Hypoglycemic Agents; Liver; Male; Morpholines; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Resveratrol; Signal Transduction; Stilbenes; Vitis; Wortmannin

2007
Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9

    Topics: Anticarcinogenic Agents; Carcinoma; Chromones; Female; Flavonoids; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neovascularization, Pathologic; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Phosphoinositide-3 Kinase Inhibitors; Repressor Proteins; Resveratrol; RNA, Small Interfering; Stilbenes; Transcriptional Activation; Transfection; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A

2007
Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.
    Atherosclerosis, 2007, Volume: 195, Issue:1

    Topics: Cell Line; Cell Separation; Cell Survival; Chromones; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Kinetics; Monocytes; Morpholines; NG-Nitroarginine Methyl Ester; Reactive Oxygen Species; Receptors, CCR2; Resveratrol; RNA, Messenger; Stilbenes

2007
Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms.
    The Prostate, 2007, Nov-01, Volume: 67, Issue:15

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Gene Silencing; Humans; Inhibitor of Apoptosis Proteins; Male; Morpholines; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Death Domain; Resveratrol; RNA, Small Interfering; Signal Transduction; Stilbenes; Ubiquitin-Protein Ligases

2007
Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival.
    Apoptosis : an international journal on programmed cell death, 2008, Volume: 13, Issue:6

    Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Chromones; Combined Modality Therapy; Cyclooxygenase 2 Inhibitors; Gamma Rays; Humans; MAP Kinase Signaling System; Melanoma; Mice; Morpholines; Nitrobenzenes; Phosphoinositide-3 Kinase Inhibitors; Radiation-Sensitizing Agents; Resveratrol; RNA Interference; Signal Transduction; Stilbenes; Sulfonamides; TNF-Related Apoptosis-Inducing Ligand

2008
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.
    PloS one, 2010, Dec-14, Volume: 5, Issue:12

    Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromones; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Male; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Resveratrol; Stilbenes; Wortmannin

2010
Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways.
    The European journal of neuroscience, 2012, Volume: 36, Issue:7

    Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Chromones; Cyclic AMP Response Element-Binding Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Morpholines; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reperfusion Injury; Resveratrol; Signal Transduction; Stilbenes

2012
Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 52

    Topics: Adenine Nucleotides; Antineoplastic Combined Chemotherapy Protocols; Arabinonucleosides; Cell Line, Tumor; Cell Proliferation; Chromones; Clofarabine; Cyclin D1; Enzyme Inhibitors; Epithelial Cells; Humans; Mesothelioma; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Resveratrol; Sp1 Transcription Factor; Stilbenes

2013
WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1.
    Current neurovascular research, 2013, Volume: 10, Issue:1

    Topics: Androstadienes; Caspase 3; CCN Intercellular Signaling Proteins; Cell Hypoxia; Cell Survival; Chromones; Enzyme Inhibitors; Forkhead Box Protein O3; Forkhead Transcription Factors; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Homeostasis; Humans; Morpholines; Neurons; Oxidative Stress; Phosphorylation; Proto-Oncogene Proteins; Resveratrol; Signal Transduction; Sirtuin 1; Stilbenes; Wortmannin

2013
Resveratrol reduces prostate cancer growth and metastasis by inhibiting the Akt/MicroRNA-21 pathway.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Enzyme Inhibitors; Estrogens; Flow Cytometry; Genes, Tumor Suppressor; Humans; Male; Mice; Mice, SCID; MicroRNAs; Morpholines; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Oligonucleotides; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Resveratrol; RNA, Small Interfering; Stilbenes; Wound Healing

2012
Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway.
    Current medicinal chemistry, 2013, Volume: 20, Issue:33

    Topics: Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Chromones; Epithelial-Mesenchymal Transition; Humans; Matrix Metalloproteinases; Morpholines; NF-kappa B; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Stilbenes; Transforming Growth Factor beta; Vimentin

2013
[Resveratrol attenuates hypoxia-reperfusion injury induced rat myocardium microvascular endothelial cell dysfunction through upregulating PI3K/Akt/SVV pathways].
    Zhonghua xin xue guan bing za zhi, 2014, Volume: 42, Issue:8

    Topics: Animals; Apoptosis; Cell Proliferation; Chromones; Endothelial Cells; Enzyme Inhibitors; Heart; Hypoxia; Morpholines; Myocardium; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Resveratrol; Stilbenes; Up-Regulation

2014
Resveratrol protects PC12 cells from high glucose-induced neurotoxicity via PI3K/Akt/FoxO3a pathway.
    Cellular and molecular neurobiology, 2015, Volume: 35, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Nucleus; Chromones; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Glucose; Membrane Proteins; Morpholines; Neuroprotection; Neuroprotective Agents; Neurotoxins; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Resveratrol; Signal Transduction; Stilbenes

2015
Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway.
    International journal of molecular medicine, 2015, Volume: 35, Issue:4

    Topics: Cell Line, Transformed; Cell Proliferation; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Lipogenesis; Morpholines; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Resveratrol; Sebaceous Glands; Signal Transduction; Stilbenes

2015
Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus.
    Journal of cellular and molecular medicine, 2015, Volume: 19, Issue:5

    Topics: Adenoviridae; Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Survival; Chromones; Enzyme Inhibitors; Female; Genetic Therapy; Genetic Vectors; Green Fluorescent Proteins; Humans; Lung Neoplasms; Mice, Inbred BALB C; Microscopy, Fluorescence; Morpholines; Neoplastic Stem Cells; Oncolytic Virotherapy; Oncolytic Viruses; Resveratrol; Stilbenes; TNF-Related Apoptosis-Inducing Ligand; Tumor Burden; Xenograft Model Antitumor Assays

2015
Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells.
    Oncology reports, 2017, Volume: 37, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Chromones; Colonic Neoplasms; Cytochromes c; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; HCT116 Cells; Humans; Morpholines; Naphthols; Phosphorylation; Proto-Oncogene Proteins c-akt; Resorcinols; Resveratrol; Stilbenes

2017
Resveratrol inhibits hypoxia-induced proliferation and migration of pulmonary artery vascular smooth muscle cells by inhibiting the phosphoinositide 3-kinase/protein kinase B signaling pathway.
    Molecular medicine reports, 2017, Volume: 16, Issue:2

    Topics: Animals; Cell Hypoxia; Cell Movement; Cell Proliferation; Chromones; Drug Synergism; Morpholines; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats; Resveratrol; Signal Transduction; Stilbenes

2017
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:5

    Topics: Animals; Asthma; Blotting, Western; Cell Line; Chromones; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Humans; Immunohistochemistry; Interleukin-6; Lung; Morpholines; Naphthols; Phenylpropionates; Proto-Oncogene Proteins c-akt; Resveratrol; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Stilbenes

2017
[A study on anti-arrhythmia mechanisms of resveratrol on ischemia/reperfusion in rats by regulating PI3K/Akt signaling pathway].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2017, Mar-08, Volume: 33, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Chromones; Male; Morpholines; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Resveratrol; Signal Transduction; Stilbenes; Ventricular Function, Left

2017
Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Dec-06, Volume: 25

    Topics: Animals; Apoptosis; Cardiomyopathies; China; Chromones; Disease Models, Animal; Heart; Male; Morpholines; Myocardium; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resveratrol; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2019
Zn
    Metallomics : integrated biometal science, 2020, 02-26, Volume: 12, Issue:2

    Topics: Animals; Cardiotonic Agents; Cell Line; Chromones; Endoplasmic Reticulum Stress; Glycogen Synthase Kinase 3 beta; Mitochondrial Permeability Transition Pore; Morpholines; Myocytes, Cardiac; Rats; Resveratrol; Signal Transduction; Zinc

2020
Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Animals; Apoptosis; Chromones; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Male; Morpholines; Myocardial Infarction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Resveratrol; Signal Transduction

2021