Page last updated: 2024-09-03

2-(4-morpholinyl)-4h-1-benzopyran-4-one and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

2-(4-morpholinyl)-4h-1-benzopyran-4-one has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 4 studies

*2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source [MeSH]

*2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source [MeSH]

Compound Research Comparison

Studies
(2-(4-morpholinyl)-4h-1-benzopyran-4-one)
Trials
(2-(4-morpholinyl)-4h-1-benzopyran-4-one)
Recent Studies (post-2010)
(2-(4-morpholinyl)-4h-1-benzopyran-4-one)
Studies
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
Trials
(2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
Recent Studies (post-2010) (2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one)
6004,82351,810

Protein Interaction Comparison

ProteinTaxonomy2-(4-morpholinyl)-4h-1-benzopyran-4-one (IC50)2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one (IC50)
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)4
Chain A, Methyltransferase WbddEscherichia coli68
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)1.6413
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaHomo sapiens (human)1.4218
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.002
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)9.614
Cytochrome P450 1A2Homo sapiens (human)1
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)1.6
Serine/threonine-protein kinase pim-1Homo sapiens (human)3.364
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)1.6
Casein kinase II subunit alpha'Homo sapiens (human)6.9
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.1638
5-hydroxytryptamine receptor 2AHomo sapiens (human)2.796
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.002
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)2.3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformBos taurus (cattle)3.7533
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)1.4593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Mus musculus (house mouse)0.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)1.2922
Serine/threonine-protein kinase mTORHomo sapiens (human)4.1638
Serine/threonine-protein kinase mTORRattus norvegicus (Norway rat)2.5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)2.4845
Glycogen synthase kinase-3 betaHomo sapiens (human)8.1
Serine/threonine-protein kinase PLK1Homo sapiens (human)2.05
Casein kinase II subunit betaHomo sapiens (human)6.9
Casein kinase II subunit alphaHomo sapiens (human)6.9
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.32
Mu-type opioid receptorCavia porcellus (domestic guinea pig)1.6
Serine/threonine-protein kinase pim-3Homo sapiens (human)1.4
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)1.72
Serine/threonine-protein kinase PLK3Homo sapiens (human)3

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chiosis, G; Rosen, N; Sepp-Lorenzino, L1
Golding, BT; Griffin, RJ; Hardcastle, IR; Leahy, JJ; Richardson, C; Rigoreau, L; Smith, GC1
Fontana, G; Golding, BT; Griffin, RJ; Guiard, S; Hardcastle, IR; Leahy, JJ; Martin, N; Richardson, C; Rigoreau, L; Smith, GC; Stockley, M1
Bardos, J; Cano, C; Golding, BT; Griffin, RJ; Hardcastle, IR; Parveen, N; Payne, SL; Peacock, M; Rodriguez-Aristegui, S1

Other Studies

4 other study(ies) available for 2-(4-morpholinyl)-4h-1-benzopyran-4-one and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

ArticleYear
LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
    Bioorganic & medicinal chemistry letters, 2001, Apr-09, Volume: 11, Issue:7

    Topics: Ataxia Telangiectasia Mutated Proteins; Benzoquinones; Cell Cycle Proteins; Chromones; Dimerization; DNA-Activated Protein Kinase; DNA-Binding Proteins; HSP90 Heat-Shock Proteins; Inhibitory Concentration 50; Lactams, Macrocyclic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinones; Tumor Suppressor Proteins

2001
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries.
    Bioorganic & medicinal chemistry letters, 2004, Dec-20, Volume: 14, Issue:24

    Topics: Chromones; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Molecular Structure; Morpholines; Protein Serine-Threonine Kinases; Structure-Activity Relationship

2004
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
    Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2

    Topics: Benzopyrans; Chromones; DNA-Activated Protein Kinase; DNA-Binding Proteins; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Isoquinolines; Morpholines; Nuclear Proteins; Protein Serine-Threonine Kinases; Pyrimidines; Radiation-Sensitizing Agents; Radiation, Ionizing; Stereoisomerism; Structure-Activity Relationship

2005
Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors.
    Bioorganic & medicinal chemistry letters, 2010, Jun-15, Volume: 20, Issue:12

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Chromones; Coumarins; DNA-Activated Protein Kinase; Humans; Inhibitory Concentration 50; Isocoumarins; Structure-Activity Relationship

2010