Compounds > 2-(4-hydroxyphenyl)-5-6-7-trimethoxy-4H-1-benzopyran-4-one

2-(4-hydroxyphenyl)-5-6-7-trimethoxy-4H-1-benzopyran-4-one and centaureidin

2-(4-hydroxyphenyl)-5-6-7-trimethoxy-4H-1-benzopyran-4-one has been researched along with centaureidin* in 1 studies

Other Studies

1 other study(ies) available for 2-(4-hydroxyphenyl)-5-6-7-trimethoxy-4H-1-benzopyran-4-one and centaureidin

Article	Year
Structure-activity requirements for flavone cytotoxicity and binding to tubulin. Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13 A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy-5, 7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resulting cytotoxicity profiles of these flavones were compared for degree of similarity to the profile of 1. Selected compounds were further evaluated with in vitro assays of tubulin polymerization and [3H]colchicine binding to tubulin. Maximum potencies for tubulin interaction and production of differential cytotoxicity profiles characteristic of 1 were observed only with compounds containing hydroxyl substituents at C-3' and C-5 and methoxyl groups at C-3 and C-4'. Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured	1998

Article

Year

Structure-activity requirements for flavone cytotoxicity and binding to tubulin.

Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13

A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy-5, 7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resulting cytotoxicity profiles of these flavones were compared for degree of similarity to the profile of 1. Selected compounds were further evaluated with in vitro assays of tubulin polymerization and [3H]colchicine binding to tubulin. Maximum potencies for tubulin interaction and production of differential cytotoxicity profiles characteristic of 1 were observed only with compounds containing hydroxyl substituents at C-3' and C-5 and methoxyl groups at C-3 and C-4'.

Topics: Antineoplastic Agents, Phytogenic; Biopolymers; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Flavonoids; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tumor Cells, Cultured

1998