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2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one and zopiclone

2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one has been researched along with zopiclone in 6 studies

Compound Research Comparison

Studies
(2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one)
Trials
(2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one)
Recent Studies (post-2010)
(2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one)
Studies
(zopiclone)
Trials
(zopiclone)
Recent Studies (post-2010) (zopiclone)
5602747204184

Protein Interaction Comparison

ProteinTaxonomy2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one (IC50)zopiclone (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.029
GABA theta subunitRattus norvegicus (Norway rat)0.029
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.029

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Joly, D; Sanger, DJ; Zivkovic, B1
Joly, D; Sanger, DJ1
Ator, NA; Griffiths, RR1
Spealman, RD; Wettstein, JG1
Williams, M1
Goldberg, ME; Malick, JB; Patel, JB; Salama, AI1

Reviews

2 review(s) available for 2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one and zopiclone

ArticleYear
Anxioselective anxiolytics.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:5

    Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Benzodiazepines; Brain Chemistry; Drug Interactions; Etazolate; gamma-Aminobutyric Acid; Humans; Molecular Weight; Piperazines; Pyrazoles; Pyridazines; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Structure-Activity Relationship

1983
Novel non-benzodiazepine anxiolytics.
    Neuropharmacology, 1983, Volume: 22, Issue:12B

    Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Conflict, Psychological; Flumazenil; Flunitrazepam; Hypnotics and Sedatives; Mice; Piperazines; Pyrazoles; Pyridazines; Rats; Receptors, Cell Surface; Receptors, GABA-A

1983

Other Studies

4 other study(ies) available for 2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one and zopiclone

ArticleYear
Behavioral effects of nonbenzodiazepine anxiolytic drugs: a comparison of CGS 9896 and zopiclone with chlordiazepoxide.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Male; Piperazines; Punishment; Pyrazoles; Rats; Rats, Inbred Strains; Reinforcement Schedule; Reinforcement, Psychology

1985
Anxiolytic drugs and the acquisition of conditioned fear in mice.
    Psychopharmacology, 1985, Volume: 85, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Chlordiazepoxide; Conditioning, Psychological; Diazepam; Fear; Male; Mice; Motor Activity; Piperazines; Pyrazoles

1985
Discriminative stimulus effects of atypical anxiolytics in baboons and rats.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Benzodiazepinones; Buspirone; Discrimination Learning; Flumazenil; Isoxazoles; Lorazepam; Male; Papio; Piperazines; Pyrazoles; Pyridazines; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
Behavioral effects of the pyrazoloquinoline CGS 9896: agonist and antagonist actions in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1

    Topics: Animals; Azabicyclo Compounds; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Lorazepam; Male; Piperazines; Pyrazoles; Saimiri

1987