2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one and cyclic gmp

2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one has been researched along with cyclic gmp in 2 studies

Compound Research Comparison

Studies (2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one)	Trials (2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one)	Recent Studies (post-2010) (2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one)	Studies (cyclic gmp)	Trials (cyclic gmp)	Recent Studies (post-2010) (cyclic gmp)
56	0	2	22,346	333	4,062

Protein Interaction Comparison

Protein	Taxonomy	cyclic gmp (IC50)
Phosphodiesterase	Bos taurus (cattle)	0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	2.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	2.4

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (50.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ambrose, F; Barbaz, B; Bittiger, H; Iyengar, S; Neale, RF; Petrack, B; Rinehart, RK; Steel, DJ; Williams, M; Wood, PL	1
Bardone, MC; Boireau, A; Canton, T; Doble, A; Dreisler, S; Piot, O; Rataud, J; Roussel, G; Roux, M; Stutzmann, JM	1

Other Studies

2 other study(ies) available for 2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3h)-one and cyclic gmp

Article	Year
Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Amygdala; Animals; Benzodiazepines; Brain; Cerebral Cortex; Chlordiazepoxide; Corpus Striatum; Cyclic GMP; Flunitrazepam; Kinetics; Male; Membranes; Midazolam; Pentobarbital; Pyrazoles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Sleep; Thiazolidines; Thyrotropin; Thyrotropin-Releasing Hormone	1986
RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding, Competitive; Cerebellum; Conflict, Psychological; Cyclic GMP; Electrocardiography; Guinea Pigs; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Mice; Mice, Inbred Strains; Muscle Relaxation; Naphthyridines; Pentylenetetrazole; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Tritium	1993

Article

Year

Benzodiazepine interactions with central thyroid-releasing hormone binding sites: characterization and physiological significance.

The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1

Topics: Amygdala; Animals; Benzodiazepines; Brain; Cerebral Cortex; Chlordiazepoxide; Corpus Striatum; Cyclic GMP; Flunitrazepam; Kinetics; Male; Membranes; Midazolam; Pentobarbital; Pyrazoles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Thyrotropin-Releasing Hormone; Sleep; Thiazolidines; Thyrotropin; Thyrotropin-Releasing Hormone

1986

RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent.

The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding, Competitive; Cerebellum; Conflict, Psychological; Cyclic GMP; Electrocardiography; Guinea Pigs; Hypnotics and Sedatives; Indoles; Isoindoles; Male; Mice; Mice, Inbred Strains; Muscle Relaxation; Naphthyridines; Pentylenetetrazole; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Tritium

1993