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2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile and alpha-(3-aminopropyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile

2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile has been researched along with alpha-(3-aminopropyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19903 (37.50)18.7374
1990's4 (50.00)18.2507
2000's1 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balderston, SM; Johnson, KE; Mann, DE; Pieper, JA; Reiter, MJ1
Husum, D; Jensen, G; Johnsen, A1
Metelitsa, VI; Nikolenko, SA; Piotrovskii, VK; Riabokon, OS; Rumiantsev, DO1
Barbieri, E; Cargnelli, G; Ferrari, M; Padrini, R; Piovan, D; Toffoli, M; Trevi, G1
Barbieri, E; Ferrari, M; Motta, A; Padrini, R; Piovan, D; Toffoli, M; Trevi, GP1
Akers, WS; Johnson, JA1
Gonzalez, FJ; Korzekwa, KR; Tracy, TS; Wainer, IW1
Borlak, J; Levsen, K; Thum, T; Walles, M1

Other Studies

8 other study(ies) available for 2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile and alpha-(3-aminopropyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile

ArticleYear
Electrophysiologic effects of verapamil metabolites in the isolated heart.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:5

    Topics: Animals; Atrioventricular Node; Electrophysiology; Female; Heart; Heart Conduction System; Male; Nitriles; Rabbits; Random Allocation; Verapamil

1991
Requirements for drug monitoring of verapamil: experience from an unselected group of patients with cardiovascular disease.
    Pharmacology & toxicology, 1990, Volume: 66, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Biotransformation; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Nitriles; Regression Analysis; Verapamil

1990
Disposition kinetics and urinary excretion of verapamil and some of its primary metabolites after oral administration in patients with angina pectoris.
    International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:1

    Topics: Administration, Oral; Angina Pectoris; Biological Availability; Half-Life; Humans; Kinetics; Male; Middle Aged; Nitriles; Regression Analysis; Verapamil

1986
Plasma levels and urinary excretion of verapamil, norverapamil, N-dealkylverapamil (D617), N-dealkylnorverapamil (D620) following oral administration of a slow-release preparation.
    International journal of clinical pharmacology research, 1985, Volume: 5, Issue:2

    Topics: Adult; Cardiac Catheterization; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middle Aged; Nitriles; Plasma; Verapamil

1985
Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:6

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Coronary Disease; Female; Heart Valve Diseases; Humans; Male; Mathematics; Middle Aged; Models, Biological; Myocardium; Nitriles; Verapamil

1985
Influence of metabolites on protein binding of verapamil enantiomers.
    British journal of clinical pharmacology, 1995, Volume: 39, Issue:5

    Topics: Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; In Vitro Techniques; Male; Nitriles; Protein Binding; Stereoisomerism; Verapamil

1995
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:5

    Topics: Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mixed Function Oxygenases; Nitriles; Stereoisomerism; Substrate Specificity; Tumor Cells, Cultured; Verapamil

1999
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7

    Topics: Aryl Hydrocarbon Hydroxylases; Cell Culture Techniques; Coronary Vessels; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2E1; Endothelium, Vascular; Gene Expression; Humans; Nitriles; Oxidoreductases, N-Demethylating; Recombinant Proteins; Verapamil

2003