Page last updated: 2024-09-03

2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide and u-50488

2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide has been researched along with u-50488 in 3 studies

Compound Research Comparison

Studies
(2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide)
Trials
(2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide)
Recent Studies (post-2010)
(2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide)
Studies
(u-50488)
Trials
(u-50488)
Recent Studies (post-2010) (u-50488)
8021,6643209

Protein Interaction Comparison

ProteinTaxonomy2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide (IC50)u-50488 (IC50)
Delta-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorMus musculus (house mouse)0.0027
Mu-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.7171
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0958
Kappa-type opioid receptorHomo sapiens (human)0.0537

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, AC; Gleason, WB; Ojala, WH; Portoghese, PS; Takemori, AE1
Kuzmin, A; Ogren, SO; Sandin, J; Terenius, L1
Husbands, SM; Lewis, JW; Lomas, LM; Picker, MJ; Terner, JM1

Other Studies

3 other study(ies) available for 2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide and u-50488

ArticleYear
kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists.
    Journal of medicinal chemistry, 1994, Dec-23, Volume: 37, Issue:26

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Affinity Labels; Analgesics; Animals; Crystallography, X-Ray; Guinea Pigs; In Vitro Techniques; Isothiocyanates; Male; Mice; Models, Molecular; Molecular Conformation; Muscle Contraction; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship

1994
Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Animals; Benzomorphans; Dose-Response Relationship, Drug; Isothiocyanates; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, kappa; Time Factors

2000
Effects of the long-lasting kappa opioid 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl) ethyl] acetamide in a drug discrimination and warm water tail-withdrawal procedure.
    Behavioural pharmacology, 2005, Volume: 16, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesics; Analgesics, Non-Narcotic; Animals; Columbidae; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Isothiocyanates; Mice; Narcotics; Pain Measurement; Pyrrolidines; Rats; Rats, Long-Evans; Reaction Time; Receptors, Opioid, kappa

2005