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2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide and ici 199441

2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide has been researched along with ici 199441 in 3 studies

Compound Research Comparison

Studies
(2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide)
Trials
(2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide)
Recent Studies (post-2010)
(2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide)
Studies
(ici 199441)
Trials
(ici 199441)
Recent Studies (post-2010) (ici 199441)
8021603
8021603

Protein Interaction Comparison

ProteinTaxonomy2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide (IC50)ici 199441 (IC50)
Cytochrome P450 2D6Homo sapiens (human)0.026
Kappa-type opioid receptorMus musculus (house mouse)0.0025
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0036

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Husbands, SM; Lewis, JW; Lomas, LM; Picker, MJ; Terner, JM1
Chang, AC; Gleason, WB; Ojala, WH; Portoghese, PS; Takemori, AE1
Chang, AC; Portoghese, PS; Takemori, AE1

Other Studies

3 other study(ies) available for 2-(3,4-dichlorophenyl)-n-methyl-n-(1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl)acetamide and ici 199441

ArticleYear
Effects of the long-lasting kappa opioid 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl) ethyl] acetamide in a drug discrimination and warm water tail-withdrawal procedure.
    Behavioural pharmacology, 2005, Volume: 16, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Analgesics; Analgesics, Non-Narcotic; Animals; Columbidae; Conditioning, Operant; Dextroamphetamine; Discrimination Learning; Discrimination, Psychological; Dopamine Uptake Inhibitors; Isothiocyanates; Mice; Narcotics; Pain Measurement; Pyrrolidines; Rats; Rats, Long-Evans; Reaction Time; Receptors, Opioid, kappa

2005
kappa Opioid receptor selective affinity labels: electrophilic benzeneacetamides as kappa-selective opioid antagonists.
    Journal of medicinal chemistry, 1994, Dec-23, Volume: 37, Issue:26

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetamides; Affinity Labels; Analgesics; Animals; Crystallography, X-Ray; Guinea Pigs; In Vitro Techniques; Isothiocyanates; Male; Mice; Models, Molecular; Molecular Conformation; Muscle Contraction; Pyrrolidines; Receptors, Opioid, kappa; Structure-Activity Relationship

1994
2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice.
    Journal of medicinal chemistry, 1994, May-27, Volume: 37, Issue:11

    Topics: Acetamides; Affinity Labels; Animals; Binding Sites; Guinea Pigs; Isothiocyanates; Mice; Molecular Structure; Muscle, Smooth; Nociceptors; Pain Measurement; Receptors, Opioid, kappa

1994