Compounds > 2-(2-benzofuranyl)-2-imidazoline

2-(2-benzofuranyl)-2-imidazoline and rasagiline

2-(2-benzofuranyl)-2-imidazoline has been researched along with rasagiline* in 1 studies

Other Studies

1 other study(ies) available for 2-(2-benzofuranyl)-2-imidazoline and rasagiline

Article	Year
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline. European journal of medicinal chemistry, 2018, Feb-10, Volume: 145 Parkinson's disease (PD) is associated with elevated levels of hMAO-B in the brain, and MAO-B has been recognized a successful target for developing anti-PD drugs. Herein we report rasagiline derivatives as novel potent and selective hMAO-B inhibitors. They were designed by employing fragment-based drug design strategy to link rasagiline and hydrophobic fragments, which may target a hydrophobic pocket in the entrance cavity of hMAO-B. Different linkers such as -OCH Topics: Amines; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Indenes; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship	2018

Article

Year

Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline.

European journal of medicinal chemistry, 2018, Feb-10, Volume: 145

Parkinson's disease (PD) is associated with elevated levels of hMAO-B in the brain, and MAO-B has been recognized a successful target for developing anti-PD drugs. Herein we report rasagiline derivatives as novel potent and selective hMAO-B inhibitors. They were designed by employing fragment-based drug design strategy to link rasagiline and hydrophobic fragments, which may target a hydrophobic pocket in the entrance cavity of hMAO-B. Different linkers such as -OCH

Topics: Amines; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Indenes; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2018