2-(2,6-dioxopiperidin-3-yl)phthalimidine has been researched along with thalidomide in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Che, J; Jones, LH; Kong, NR; Liu, H | 1 |
| Gershbein, LL | 1 |
| Heger, W; Nau, H; Schmahl, HJ | 1 |
| Klinkmüller, KD; Schmahl, HJ; Winckler, K | 1 |
| Nau, H; Neubert, D; Schmahl, HJ | 1 |
| Heger, W; Klug, S; Merker, HJ; Nau, H; Neubert, D; Schmahl, HJ | 1 |
| Heger, W; Merker, HJ; Neubert, D; Sames, K; Stürje, H | 1 |
| Jordan, RL; Schumacher, HJ; Terapane, J; Wilson, JG | 1 |
| Krowke, R; Neubert, D | 1 |
| Dumpert, K; Zietz, E | 1 |
| Felies, A; Heger, W; Klug, S; Merker, HJ; Nau, H; Neubert, D; Schmahl, HJ | 1 |
| Hinz, N; Neubert, D; Neubert, R; Thiel, R | 1 |
| Chahoud, I; Dencker, L; Nau, H; Plum, C; Schmahl, HJ | 1 |
| Nicolai, S; Sies, H; Stahl, W | 1 |
| Browne, F; D'Amato, RJ; Kenyon, BM | 1 |
| Banquerigo, ML; Brahn, E; Cheng, TP; Oliver, SJ | 1 |
| Kastner, U; Neubert, R; Thiel, R | 1 |
| Onat, D; Sies, H; Stahl, W | 1 |
| Figg, WD; Kruger, EA; Luzzio, FA; Mayorov, AV; Ng, SS | 1 |
| Funke, L; Hiller, M; Lehmann, T; Sharma, V; Stuckas, H | 1 |
20 other study(ies) available for 2-(2,6-dioxopiperidin-3-yl)phthalimidine and thalidomide
| Article | Year |
|---|---|
Physicochemistry of Cereblon Modulating Drugs Determines Pharmacokinetics and Disposition.
Topics: | 2021 |
The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Dimethylhydrazines; Drug Synergism; Intestinal Neoplasms; Intestine, Small; Male; Rats; Rats, Inbred Strains; Thalidomide | 1991 |
The enantiomers of the teratogenic thalidomide analogue EM 12. 2. Chemical stability, stereoselectivity of metabolism and renal excretion in the marmoset monkey.
Topics: Animals; Callitrichinae; Chromatography, High Pressure Liquid; Half-Life; Hydrolysis; In Vitro Techniques; Kidney; Stereoisomerism; Thalidomide | 1989 |
Determination of the thalidomide analogues 2-(2,6-dioxopiperidine-3-yl)phthalimidine (EM 12), 2-(2,6-dioxopiperidine-4-yl)phthalimidine (EM 16) and their metabolites in biological samples.
Topics: Animals; Callitrichinae; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Thalidomide | 1989 |
The enantiomers of the teratogenic thalidomide analogue EM 12: 1. Chiral inversion and plasma pharmacokinetics in the marmoset monkey.
Topics: Animals; Callitrichinae; Stereoisomerism; Thalidomide | 1988 |
Embryotoxic effects of thalidomide derivatives on the non-human primate Callithrix jacchus; 3. Teratogenic potency of the EM 12 enantiomers.
Topics: Abnormalities, Drug-Induced; Animals; Callithrix; Female; Pregnancy; Stereoisomerism; Thalidomide | 1988 |
Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Callithrix; Dose-Response Relationship, Drug; Facial Bones; Female; Gestational Age; Limb Deformities, Congenital; Male; Pregnancy; Skull; Species Specificity; Thalidomide | 1988 |
The teratogenic activity of a thalidomide analogue, EM 12 in rabbits, rats, and monkeys.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Bone Diseases, Developmental; Female; Fetal Death; Fetal Diseases; Forelimb; Gestational Age; Haplorhini; Hindlimb; Injections, Intravenous; Macaca; Piperidines; Pregnancy; Pyrrolidinones; Rabbits; Rats; Species Specificity; Spine; Thalidomide; Time Factors; Wrist | 1972 |
Effect of thalidomide-derivatives on limb development in culture.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Extremities; Female; Limb Deformities, Congenital; Mice; Mice, Inbred Strains; Microsomes, Liver; Organ Culture Techniques; Pregnancy; Procollagen-Proline Dioxygenase; Thalidomide | 1983 |
Platanna (Xenopus laevis) as a test organism for determining the embryotoxic effects of environmental chemicals.
Topics: Abnormalities, Drug-Induced; Animals; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Environmental Pollutants; Female; Male; Methylmercury Compounds; Thalidomide; Xenopus laevis | 1984 |
Embryotoxic effects of thalidomide derivatives in the non-human primate callithrix jacchus. IV. Teratogenicity of micrograms/kg doses of the EM12 enantiomers.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Callithrix; Dose-Response Relationship, Drug; Female; Male; Stereoisomerism; Thalidomide | 1994 |
Down-regulation of adhesion receptors on cells of primate embryos as a probable mechanism of the teratogenic action of thalidomide.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Callithrix; Cells, Cultured; Down-Regulation; Embryo, Mammalian; Embryonic and Fetal Development; Female; Flow Cytometry; Forelimb; Integrins; L-Selectin; Male; Membrane Glycoproteins; Membrane Proteins; Platelet Glycoprotein GPIb-IX Complex; Pregnancy; Teratogens; Thalidomide | 1996 |
Stereoselective distribution of the teratogenic thalidomide analogue EM12 in the early embryo of marmoset monkey, Wistar rat and NMRI mouse.
Topics: Animals; Autoradiography; Callithrix; Embryonic and Fetal Development; Female; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Pregnancy; Rats; Rats, Wistar; Teratogens; Thalidomide | 1996 |
Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human skin fibroblasts.
Topics: Cell Communication; Cell Line; Fibroblasts; Gap Junctions; Humans; Skin; Stereoisomerism; Thalidomide | 1997 |
Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization.
Topics: Administration, Oral; Animals; Cornea; Corneal Neovascularization; Endothelial Growth Factors; Female; Fibroblast Growth Factor 2; Glutamates; Injections, Intraperitoneal; Lymphokines; Mice; Mice, Inbred C57BL; Structure-Activity Relationship; Teratogens; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
The effect of thalidomide and 2 analogs on collagen induced arthritis.
Topics: Animals; Arthritis, Rheumatoid; Collagen; Disease Models, Animal; Endothelial Growth Factors; Female; Immunosuppressive Agents; Lymphokines; Radiography; Rats; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Expression of adhesion receptors on rat limb bud cells and results of treatment with a thalidomide derivative.
Topics: Animals; Cell Adhesion Molecules; Female; Integrins; Limb Buds; Rats; Rats, Wistar; Species Specificity; Teratogens; Thalidomide | 2000 |
Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human fetal skin fibroblasts (HFFF2) and in rat liver epithelial cells (WB-F344).
Topics: Angiogenesis Inhibitors; Animals; Biotransformation; Cell Communication; Cell Survival; Coenzymes; Epithelial Cells; Fetus; Fibroblasts; Gap Junctions; Humans; Liver; Rats; Rats, Inbred F344; Skin; Thalidomide; Time Factors | 2001 |
Thalidomide metabolites and analogues. 3. Synthesis and antiangiogenic activity of the teratogenic and TNFalpha-modulatory thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine.
Topics: Angiogenesis Inhibitors; Animals; Aorta; Culture Techniques; Female; Microcirculation; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thalidomide; Tumor Necrosis Factor-alpha | 2003 |
Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA; Eutheria; Evolution, Molecular; Gubernaculum; Insulin; Male; Mutation; Phylogeny; Proteins; Receptors, G-Protein-Coupled; Testis; Thalidomide | 2018 |