2-(2,3-dicarboxycyclopropyl)glycine has been researched along with ly 341495 in 22 studies
| Studies (2-(2,3-dicarboxycyclopropyl)glycine) | Trials (2-(2,3-dicarboxycyclopropyl)glycine) | Recent Studies (post-2010) (2-(2,3-dicarboxycyclopropyl)glycine) | Studies (ly 341495) | Trials (ly 341495) | Recent Studies (post-2010) (ly 341495) |
|---|---|---|---|---|---|
| 14 | 0 | 1 | 17 | 0 | 5 |
| 166 | 0 | 27 | 247 | 0 | 106 |
| Protein | Taxonomy | 2-(2,3-dicarboxycyclopropyl)glycine (IC50) | ly 341495 (IC50) |
|---|---|---|---|
| Metabotropic glutamate receptor 8 | Homo sapiens (human) | 0.17 | |
| NADH-cytochrome b5 reductase 3 | Homo sapiens (human) | 8.2 | |
| Metabotropic glutamate receptor 1 | Rattus norvegicus (Norway rat) | 8.99 | |
| Metabotropic glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.1116 | |
| Metabotropic glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.0168 | |
| Metabotropic glutamate receptor 4 | Rattus norvegicus (Norway rat) | 2.65 | |
| Metabotropic glutamate receptor 6 | Rattus norvegicus (Norway rat) | 1.14 | |
| Metabotropic glutamate receptor 5 | Homo sapiens (human) | 8.2 | |
| Metabotropic glutamate receptor 1 | Homo sapiens (human) | 7.8 | |
| Metabotropic glutamate receptor 2 | Homo sapiens (human) | 0.0469 | |
| Metabotropic glutamate receptor 7 | Homo sapiens (human) | 0.99 | |
| Metabotropic glutamate receptor 3 | Homo sapiens (human) | 0.0086 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 13 (59.09) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adam, G; Cartmell, J; Chaboz, S; Henningsen, R; Kemp, JA; Klingelschmidt, A; Metzler, V; Monsma, F; Mutel, V; Schaffhauser, H; Wichmann, J | 1 |
| Arnold, MB; Johnson, BG; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA | 1 |
| Adam, G; Kratzeisen, C; Lundstrom, K; Malherbe, P; Mutel, V; Ohresser, S; Schweitzer, C; Stadler, H; Wichmann, J; Woltering, T | 1 |
| Arnold, MB; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA | 1 |
| Losonczy, A; Nusser, Z; Somogyi, P | 1 |
| Bain, G; Bristow, LJ; Chavez-Noriega, LE; Daggett, LP; Jachec, C; Morales, S; Pinkerton, AB; Rao, SP; Rowe, BA; Schaffhauser, H; Varney, MA; Vernier, JM; Yin, R | 1 |
| Johnson, SW; Shen, KZ | 1 |
| Anwyl, R; Rowan, MJ; Wu, J | 1 |
| Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K; Teramoto, T | 1 |
| Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K | 1 |
| Alexander, GM; Godwin, DW | 1 |
| Abeniyi, OA; Conn, PJ; Poisik, O; Raju, DV; Rodriguez, A; Smith, Y; Verreault, M | 1 |
| Mateo, Z; Porter, JT | 1 |
| Kinouchi, H; Sugita, M; Yoshioka, H | 1 |
| Dietrich, D; Wostrack, M | 1 |
| Coiret, G; Corsi, M; Corti, C; Gerber, U; Grewe, BF; Helmchen, F; Mateos, JM; Ster, J | 1 |
| Bortolotto, ZA; Collingridge, GL; Lodge, D; Lucas, SJ | 1 |
| Breustedt, J; Kintscher, M; Miceli, S; Schmitz, D; Wozny, C | 1 |
| Kaba, H; Murata, Y; Nakanishi, S; Okutani, F; Shinohara, Y; Taniguchi, M; Yokoi, M | 1 |
| Ahnaou, A; Andrés, JI; Atack, JR; Biesmans, I; Cid, JM; Dautzenberg, FM; Drinkenburg, W; Langlois, X; Lavreysen, H; Lütjens, R; Macdonald, G; Megens, A; Peeters, L; te Riele, P; Trabanco, AA; Van der Linden, I; Wintmolders, C | 1 |
| Curry, RJ; Dinh, EH; Hamlet, WR; Liu, YW; Lu, Y; Shi, W; Tang, ZQ | 1 |
| Blaabjerg, M; Bogetofte, H; Dindler, A; Kamand, M; Meyer, M | 1 |
22 other study(ies) available for 2-(2,3-dicarboxycyclopropyl)glycine and ly 341495
| Article | Year |
|---|---|
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
Topics: Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclopropanes; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Protein Binding; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sulfur Radioisotopes; Transfection; Tritium | 1998 |
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
Topics: Amino Acids; Animals; Binding, Competitive; Calcium; Cell Membrane; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Transfection; Tritium; Xanthenes | 1999 |
Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors.
Topics: Amino Acids; Animals; Binding, Competitive; Bridged Bicyclo Compounds; Cell Membrane; Chlorides; CHO Cells; Cricetinae; DNA, Recombinant; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Genetic Vectors; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Rats; Receptors, Metabotropic Glutamate; Semliki forest virus; Tritium; Xanthenes; Zinc Compounds | 2000 |
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
Topics: Amino Acids; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Substrate Specificity; Tritium; Xanthenes | 2000 |
Reduction of excitatory postsynaptic responses by persistently active metabotropic glutamate receptors in the hippocampus.
Topics: Amino Acids; Animals; Anticonvulsants; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Presynaptic Terminals; Propionates; Receptors, Metabotropic Glutamate; Xanthenes | 2003 |
Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.
Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Calcium; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Cyclopropanes; Dentate Gyrus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Molecular Sequence Data; Perforant Pathway; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Metabotropic Glutamate; Sequence Homology, Amino Acid; Sulfonamides; Tritium; Xanthenes | 2003 |
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes | 2003 |
An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro.
Topics: Amino Acids; Animals; Cyclopropanes; Dentate Gyrus; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Long-Term Potentiation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Xanthenes | 2004 |
Inhibitory effects of group II mGluR-related drugs on memory performance in mice.
Topics: Amino Acids; Animals; Anticonvulsants; Avoidance Learning; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Isoquinolines; Male; Memory; Mice; Reaction Time; Receptors, Metabotropic Glutamate; Rolipram; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Xanthenes | 2004 |
Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice.
Topics: Amino Acids; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cyclopropanes; Donepezil; Excitatory Amino Acid Antagonists; Glycine; Indans; Male; Memory; Mice; Nootropic Agents; Piperidines; Receptors, Metabotropic Glutamate; Xanthenes | 2003 |
Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors.
Topics: Amino Acids; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; Ferrets; Geniculate Bodies; Glycine; In Vitro Techniques; Male; Neural Inhibition; Neural Pathways; Neurons; Presynaptic Terminals; Receptors, Metabotropic Glutamate; Synaptic Transmission; Time Factors; Xanthenes | 2005 |
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Aminobutyrates; Anesthetics, Local; Animals; Animals, Newborn; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Glycine; In Vitro Techniques; Lidocaine; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Patch-Clamp Techniques; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides; Synaptic Transmission; Xanthenes | 2005 |
Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.
Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Immunohistochemistry; In Vitro Techniques; Mice; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Somatosensory Cortex; Synapses; Thalamus; Xanthenes | 2007 |
Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia.
Topics: Amino Acids; Animals; Carotid Stenosis; Cerebrovascular Circulation; Cyclopropanes; Extracellular Space; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Male; Microdialysis; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Xanthenes | 2009 |
Involvement of Group II mGluRs in mossy fiber LTD.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2009 |
Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Topics: Action Potentials; Amino Acids; Animals; CA3 Region, Hippocampal; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Interneurons; Mice; Mice, Knockout; Microscopy, Electron; Nerve Net; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Theta Rhythm; Xanthenes | 2011 |
Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Amygdala; Animals; Bridged Bicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Long-Term Synaptic Depression; Mice; Mice, Knockout; Rats; Rats, Mutant Strains; Rats, Wistar; Receptors, Metabotropic Glutamate; Xanthenes | 2013 |
Group II metabotropic glutamate receptors depress synaptic transmission onto subicular burst firing neurons.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2012 |
Regulation of synaptic currents by mGluR2 at reciprocal synapses in the mouse accessory olfactory bulb.
Topics: Action Potentials; Amino Acids; Animals; Anticonvulsants; Calcium Channels; Cyclopropanes; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Mice; Mice, Inbred BALB C; Mutation; Olfactory Bulb; Receptors, Metabotropic Glutamate; Synapses; Xanthenes | 2013 |
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
Topics: Amino Acids; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Calcium; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isotope Labeling; Ligands; Male; Mice; Motor Activity; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sleep; Tritium; Xanthenes | 2013 |
Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.
Topics: Amino Acids; Animals; Chick Embryo; Cochlear Nucleus; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABAergic Neurons; Glycine; Inhibitory Postsynaptic Potentials; Long-Term Synaptic Depression; Neural Inhibition; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Xanthenes | 2013 |
Activation of Group II Metabotropic Glutamate Receptors Increases Proliferation but does not Influence Neuronal Differentiation of a Human Neural Stem Cell Line.
Topics: Amino Acids; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cyclopropanes; Glutamic Acid; Glycine; Humans; Neural Stem Cells; Neurons; Receptors, Metabotropic Glutamate; Xanthenes | 2018 |