Compounds > 2-(2,3-dicarboxycyclopropyl)glycine
Page last updated: 2024-09-03

2-(2,3-dicarboxycyclopropyl)glycine and kainic acid

2-(2,3-dicarboxycyclopropyl)glycine has been researched along with kainic acid in 9 studies

Compound Research Comparison

Studies
(2-(2,3-dicarboxycyclopropyl)glycine)		Trials
(2-(2,3-dicarboxycyclopropyl)glycine)		Recent Studies (post-2010)
(2-(2,3-dicarboxycyclopropyl)glycine)		Studies
(kainic acid)		Trials
(kainic acid)		Recent Studies (post-2010) (kainic acid)
1660279,54031,775

Protein Interaction Comparison

ProteinTaxonomy2-(2,3-dicarboxycyclopropyl)glycine (IC50)kainic acid (IC50)
Glutamate receptor 1Rattus norvegicus (Norway rat)4.2857
Glutamate receptor 2Rattus norvegicus (Norway rat)4.2857
Glutamate receptor 3Rattus norvegicus (Norway rat)4.2857
Glutamate receptor 4Rattus norvegicus (Norway rat)4.2857
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)0.0126
Glutamate receptor ionotropic, kainate 1Homo sapiens (human)0.077
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)0.0126
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)0.0126
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)0.0126
Glutamate receptor ionotropic, kainate 2Homo sapiens (human)0.077
Glutamate receptor ionotropic, kainate 3Homo sapiens (human)0.077
Glutamate receptor ionotropic, kainate 4Homo sapiens (human)0.077
Glutamate receptor ionotropic, kainate 5Homo sapiens (human)0.077
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)0.0126

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Battaglia, G; Bruno, V; Copani, A; Nicoletti, F; Raffaele, R; Shinozaki, H1
Opitz, T; Pidoplichko, VI; Reymann, KG; Shinozaki, H; Wilsch, VW1
Shinozaki, H1
Buisson, A; Choi, DW; Yu, SP1
Ishida, M; Miyamoto, M; Shinozaki, H1
Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F1
O'Neill, MJ1
Breustedt, J; Schmitz, D1
Castillo, PE; Kwon, HB1

Other Studies

9 other study(ies) available for 2-(2,3-dicarboxycyclopropyl)glycine and kainic acid

ArticleYear
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
    European journal of pharmacology, 1994, Apr-11, Volume: 256, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Amino Acids, Dicarboxylic; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cyclopropanes; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate

1994
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons.
    European journal of pharmacology, 1994, Sep-12, Volume: 262, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Glycine; Hippocampus; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism

1994
Neuron damage induced by some potent kainoids and neuroprotective action of new agonists for metabotropic glutamate receptors.
    European neurology, 1994, Volume: 34 Suppl 3

    Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Brain; Culture Techniques; Cyclopropanes; Dose-Response Relationship, Drug; Ganglia, Spinal; Glycine; Kainic Acid; Motor Neurons; Nerve Degeneration; Neuromuscular Diseases; Neurons; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Transmission

1994
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
    The European journal of neuroscience, 1996, Volume: 8, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Glycine; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella

1996
Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat.
    Neuroscience, 1997, Volume: 77, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures

1997
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
    Neurochemistry international, 2001, Volume: 38, Issue:1

    Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles

2001
Pharmacology and neuroprotective actions of mGlu receptor ligands.
    Developmental medicine and child neurology. Supplement, 2001, Volume: 86

    Topics: Amino Acids; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Glycine; Hippocampus; Humans; Kainic Acid; Ligands; Nerve Degeneration; Neuroprotective Agents; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2001
Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids, Dicarboxylic; Animals; Benzodiazepines; Cyclopropanes; Excitatory Postsynaptic Potentials; Gene Deletion; GluK2 Kainate Receptor; Glycine; Isoquinolines; Isoxazoles; Kainic Acid; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Patch-Clamp Techniques; Potassium; Propionates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission

2004
Role of glutamate autoreceptors at hippocampal mossy fiber synapses.
    Neuron, 2008, Dec-26, Volume: 60, Issue:6

    Topics: Animals; Animals, Newborn; Autoreceptors; Biophysics; Calcium; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, Glutamate; Sodium Channel Blockers; Synapses; Tetrodotoxin

2008