2-(2,3-dicarboxycyclopropyl)glycine has been researched along with glycine in 163 studies
| Studies (2-(2,3-dicarboxycyclopropyl)glycine) | Trials (2-(2,3-dicarboxycyclopropyl)glycine) | Recent Studies (post-2010) (2-(2,3-dicarboxycyclopropyl)glycine) | Studies (glycine) | Trials (glycine) | Recent Studies (post-2010) (glycine) |
|---|---|---|---|---|---|
| 166 | 0 | 27 | 35,163 | 756 | 8,415 |
| Protein | Taxonomy | 2-(2,3-dicarboxycyclopropyl)glycine (IC50) | glycine (IC50) |
|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 1.4852 | |
| Sodium- and chloride-dependent glycine transporter 1 | Homo sapiens (human) | 106 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.3253 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.3253 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.3253 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.3253 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.3253 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.3253 | |
| Sodium- and chloride-dependent glycine transporter 2 | Homo sapiens (human) | 128 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 56 (34.36) | 18.2507 |
| 2000's | 75 (46.01) | 29.6817 |
| 2010's | 31 (19.02) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Battaglia, G; Bruno, V; Copani, A; Nicoletti, F; Raffaele, R; Shinozaki, H | 1 |
| Casabona, G; Genazzani, AA; L'Episcopo, MR; Nicoletti, F; Shinozaki, H | 2 |
| Shinozaki, H | 2 |
| Conn, PJ; Gereau, RW; Winder, DG | 1 |
| Opitz, T; Pidoplichko, VI; Reymann, KG; Shinozaki, H; Wilsch, VW | 1 |
| Hayashi, Y; Mizuno, N; Momiyama, A; Nakanishi, S; Ogawa-Meguro, R; Ohishi, H; Shigemoto, R; Takahashi, T | 1 |
| Ishida, M; Kwak, S; Miyamoto, M; Shinozaki, H | 2 |
| Hayashi, Y; Higuchi, T; Kaba, H; Nakanishi, S | 1 |
| Caciagli, F; Casabona, G; Ciccarelli, R; De Bernardis, E; Di Iorio, P; L'Episcopo, MR; Nicoletti, F; Shinozaki, H | 1 |
| Ishida, M; Saitoh, T; Shinozaki, H | 1 |
| Ishida, M; Ohfune, Y; Saitoh, T; Shimamoto, K; Shinozaki, H | 1 |
| Clarke, VR; Collingridge, GL; Davies, CH; Jane, DE | 1 |
| Kamiya, H; Yoshino, M | 1 |
| Choi, S; Lovinger, DM | 1 |
| Katsuki, M; Katsuura, G; Kobayashi, K; Manabe, T; Nakamura, K; Nakanishi, S; Nakao, K; Nomura, S; Ohishi, H; Sakaguchi, I; Shigemoto, R; Takahashi, T; Yokoi, M | 1 |
| Ballerini, P; Battaglia, G; Caciagli, F; Ciccarelli, R; Di Iorio, P; Giuliani, P; Nicoletti, F; Poli, A | 1 |
| Kamiya, H; Sawada, S; Yamamoto, C; Yoshino, M | 1 |
| Buisson, A; Choi, DW; Yu, SP | 1 |
| Kamiya, H; Shinozaki, H; Yamamoto, C | 1 |
| Bischofberger, J; Schild, D | 1 |
| Glitsch, M; Llano, I; Marty, A | 1 |
| Ishida, M; Miyamoto, M; Shinozaki, H | 1 |
| Bruno, V; Caruso, A; Casabona, G; Knopfel, T; Kuhn, R; Nicoletti, F; Storto, M; Sureda, FX | 1 |
| Anwyl, R; Breakwell, NA; Huang, L; Rowan, MJ | 1 |
| Ishida, M; Shinozaki, H; Uyama, Y | 1 |
| Anwyl, R; Huang, LQ; Rowan, MJ | 1 |
| Coderre, TJ; Fisher, K | 1 |
| Abbott, A; Lacey, MG; Wigmore, MA | 1 |
| Caciagli, F; Caruso, A; Casabona, G; Ciccarelli, R; Condorelli, DF; Di Iorio, P; Nicoletti, F; Spinella, F; Sureda, FX | 1 |
| Maccaferri, G; McBain, CJ; Tóth, K | 1 |
| Adam, G; Cartmell, J; Chaboz, S; Henningsen, R; Kemp, JA; Klingelschmidt, A; Metzler, V; Monsma, F; Mutel, V; Schaffhauser, H; Wichmann, J | 1 |
| Cassidy, EM; O'Connor, JJ; O'Leary, DM | 1 |
| Kemp, JA; Knoflach, F | 1 |
| Alger, BE; Kirov, SA; Morishita, W | 1 |
| Bruno, V; Fiore, L; Nicoletti, F; Wroblewska, B; Wroblewski, JT | 1 |
| Narita, S | 1 |
| Attwell, PJ; Bradford, HF; Croucher, MJ; Jane, DE; Singh Kent, N | 1 |
| Anwyl, R; Huang, LQ; Kilbride, J; Rowan, MJ | 1 |
| Balschun, D; Behnisch, T; Reymann, KG; Wilsch, VW | 1 |
| Adam, G; Chaboz, S; Kemp, JA; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Wichmann, J; Woltering, T | 1 |
| Acher, F; Bockaert, J; Brabet, I; De Colle, C; Parmentier, ML; Pin, JP | 1 |
| Manahan-Vaughan, D | 1 |
| Anwyl, R; Huang, L; Rowan, MJ | 1 |
| Kobayashi, K; Manabe, T; Takahashi, T | 1 |
| Oja, SS; Saransaari, P | 2 |
| Kamiya, H; Ozawa, S | 1 |
| Kalda, A; Zharkovsky, A | 1 |
| Casabona, G; De Paolis, P; Lucchi, R; Nicoletti, F; Notari, S; Poli, A; Storto, M | 1 |
| Battaglia, G; Bruno, V; Caciagli, F; Ciccarelli, R; D'Alimonte, I; D'Onofrio, M; Di Iorio, P; Nicoletti, F | 1 |
| Mao, L; Wang, JQ | 1 |
| Aggleton, JP; Bashir, ZI; Bortolotto, ZA; Brown, MW; Cho, K; Collingridge, GL; Conquet, F; McCaffery, B | 1 |
| Nishi, N | 1 |
| Schmidt, JT; Zhang, C | 1 |
| Kalivas, PW; Swanson, CJ | 1 |
| Hülsmann, S; Oku, Y; Richter, DW; Zhang, W | 1 |
| Chadha, A; Dawson, L; Duty, S; Megalou, M | 1 |
| Crawford, JH; Heavens, R; Martin, DJ; Pollock, J; Scott, RH; Seabrook, GR; Wainwright, A | 1 |
| Clarke, G; Collingridge, GL; Fitzjohn, SM; Tolchard, S | 1 |
| Casabona, G; Copani, A; Di Giorgi Gerevini, V; Mutel, V; Nicoletti, F; Nicosia, A; Romano, C; Storto, M | 1 |
| Alger, BE; Morishita, W | 1 |
| Cai, Z; Conn, PJ; Hubalek, F; Macek, TA; Murphy, TJ; Pohl, J; Schaffhauser, H | 1 |
| Balcar, VJ; FitzGibbon, T; Lawrance, ML; Pliss, L; Shave, E; Stastny, F | 1 |
| Gerber, G; Randic, M; Youn, D; Zhong, J | 1 |
| Cassidy, J; Davies, SN; Ross, FM; Wilson, M | 1 |
| Gahwiler, BH; McKinney, RA; Poncer, JC; Thompson, SM | 1 |
| Hardison, JL; Nadler, JV; Okazaki, MM | 1 |
| Ichikawa, T; Kumanishi, T; Murata, M; Takahashi, Y; Tomita, N; Washiyama, K; Watanabe, H | 1 |
| Cano, J; Machado, A; Matarredona, ER; Santiago, M; Venero, JL | 1 |
| O'Neill, MJ | 1 |
| Berman, RF; Gong, QZ; Lyeth, BG; Muizelaar, JP; Zwienenberg, M | 1 |
| Savić, N; Sciancalepore, M | 1 |
| Anwyl, R; Kilbride, J; Rowan, MJ; Rush, AM | 1 |
| Darby-King, A; Harley, CW; McLean, JH; Rumsey, JD | 1 |
| Batchelor, AM; Garthwaite, J; Neale, SA | 1 |
| Folbergrová, J; Haugvicová, R; Mares, P | 1 |
| Konishi, S; Murakoshi, T; Song, SY; Tanabe, T | 1 |
| Abraham, WC; Mellentin, C | 1 |
| Bernardi, G; Bonsi, P; Calabresi, P; Centonze, D; Conquet, F; Gubellini, P; Picconi, B; Pisani, A | 1 |
| Lei, S; McBain, CJ | 1 |
| Crépel, F; Daniel, H; Otani, S; Takita, M | 1 |
| Meeker, RB | 1 |
| Cano, J; Machado, A; Matarredona, ER; Santiago, M; Tomás-Camardiel, M; Venero, JL | 1 |
| Chen, YL; Hsu, KS; Huang, CC; Liang, YC | 1 |
| Chen, WP; Kirchgessner, AL | 1 |
| Maeda, J; Okauchi, T; Semba, J; Suhara, T | 1 |
| Auclair, N; Barbara, JG; Caboche, J; Crepel, F; Otani, S; Roisin, MP; Soubrie, P; Valjent, E | 1 |
| Losonczy, A; Nusser, Z; Somogyi, P | 1 |
| Lea, PM; Sarvey, JM | 1 |
| Berretta, N; Cherubini, E; Gasparini, S; M Kasyanov, A; Rossokhin, AV; Sokolov, MV; Voronin, LL | 1 |
| Hsu, KS; Huang, CC | 2 |
| Bain, G; Bristow, LJ; Chavez-Noriega, LE; Daggett, LP; Jachec, C; Morales, S; Pinkerton, AB; Rao, SP; Rowe, BA; Schaffhauser, H; Varney, MA; Vernier, JM; Yin, R | 1 |
| Johnson, SW; Shen, KZ | 1 |
| Anwyl, R; Gisabella, B; Rowan, MJ | 1 |
| Johnston, D; Wang, J; Yeckel, MF; Zucker, RS | 1 |
| Grinspan, ZM; Lawrence, JJ; McBain, CJ | 1 |
| Anwyl, R; Rowan, MJ; Wu, J | 1 |
| Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K; Teramoto, T | 1 |
| Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I | 1 |
| Inoue, M; Kawamura, Y; Kudo, Y; Manita, S; Miyakawa, H; Nakamura, T | 1 |
| Konishi, S; Rusakov, D; Saitow, F; Satake, S | 1 |
| Irifune, M; Nishikawa, T; Ohnishi, Y; Sato, T; Tanaka, K | 1 |
| Beck, H; Dietrich, D; Kirschstein, T; Steinhäuser, M; Vinçon, A; von der Brelie, C | 1 |
| Arif, M; Dionísio, JC; Matias, CM; Quinta-Ferreira, ME | 1 |
| Breustedt, J; Schmitz, D | 1 |
| Cano, J; Machado, A; Rite, I; Venero, JL | 1 |
| Barda, D; Britton, TC; Emkey, R; Hornback, WJ; Jagdmann, GE; Johnson, MP; McKinzie, DL; Nisenbaum, ES; Schoepp, DD; Tizzano, JP | 1 |
| Alexander, GM; Godwin, DW | 1 |
| Dietrich, D; Fredholm, BB; Kukley, M; Schwan, M | 1 |
| Abeniyi, OA; Conn, PJ; Poisik, O; Raju, DV; Rodriguez, A; Smith, Y; Verreault, M | 1 |
| Brose, N; Gibson, HE; Jones, S; Morton, AJ; Reim, K | 1 |
| Glitsch, M | 1 |
| Ding, JH; Hu, G; Wu, JY; Yang, YJ; Yao, HH; Zhang, J; Zhou, F | 1 |
| Lacaille, JC; McBain, CJ; Pelkey, KA; Topolnik, L | 1 |
| Bai, HM; Fei, Z; Jiang, XF; Wang, XL; Zhang, X | 1 |
| Kanumilli, S; Roberts, PJ | 1 |
| Manabe, T; Nakamura, M; Sekino, Y | 1 |
| Mateo, Z; Porter, JT | 1 |
| Klausnitzer, J; Manahan-Vaughan, D | 1 |
| Chittajallu, R; Gallo, V; Kunze, A; Mangin, JM | 1 |
| Arshadmansab, MF; Ermolinsky, BS; Francisco, S; Garrido-Sanabria, ER; Herrera, B; Otalora, LF | 1 |
| Barrionuevo, G; Calixto, E; Galván, EJ | 1 |
| Castillo, PE; Kwon, HB | 1 |
| Ando, M; Kanno, S; Oku, N; Takeda, A | 1 |
| Kinouchi, H; Sugita, M; Yoshioka, H | 1 |
| Dietrich, D; Wostrack, M | 1 |
| Ceccom, J; Daumas, S; Francés, B; Halley, H; Lassalle, JM | 1 |
| Breustedt, J; Brose, N; Gundlfinger, A; Reim, K; Schmitz, D; Varoqueaux, F | 1 |
| Deng, PY; Lei, S; Xiao, Z | 1 |
| Hagena, H; Manahan-Vaughan, D | 1 |
| Aas, P; Enger, S; Myhrer, T | 2 |
| Barrionuevo, G; Cosgrove, KE; Meriney, SD | 1 |
| Machado, A; Mauriño, R; Santiago, M; Venero, JL | 1 |
| Barker, GR; Bortolotto, ZA; Ceolin, L; Collingridge, GL; Fitzjohn, SM; Hanna, L; Kantamneni, S; Lodge, D; Monn, JA; Murray, L; Robinson, ES; Warburton, EC | 1 |
| Coiret, G; Corsi, M; Corti, C; Gerber, U; Grewe, BF; Helmchen, F; Mateos, JM; Ster, J | 1 |
| Bortolotto, Z; Ceolin, L; Collingridge, G; Hanna, L; Johnson, B; Lodge, D; Lucas, S; Monn, J | 1 |
| Brennan, PA; Khan, S; Leszkowicz, E; Ng, S; Swallow, DL; Ved, N | 1 |
| Alzheimer, C; Wess, J; Zheng, F | 1 |
| Bortolotto, ZA; Collingridge, GL; Lodge, D; Lucas, SJ | 1 |
| Kammermeier, PJ | 1 |
| Broad, LM; Colvin, EM; Findlay, JD; Grubisha, O; Hanna, L; Heinz, BA; Lodge, D; Monn, JA; Sanger, H; Sher, E; Ursu, D; Vivier, RG | 1 |
| Mitchell, VA; Vaughan, CW; Wilson-Poe, AR | 1 |
| Breustedt, J; Kintscher, M; Miceli, S; Schmitz, D; Wozny, C | 1 |
| Kaba, H; Murata, Y; Nakanishi, S; Okutani, F; Shinohara, Y; Taniguchi, M; Yokoi, M | 1 |
| Lam, YW; Sherman, SM | 1 |
| Li, DP; Pan, HL; Ye, ZY | 1 |
| Ahnaou, A; Andrés, JI; Atack, JR; Biesmans, I; Cid, JM; Dautzenberg, FM; Drinkenburg, W; Langlois, X; Lavreysen, H; Lütjens, R; Macdonald, G; Megens, A; Peeters, L; te Riele, P; Trabanco, AA; Van der Linden, I; Wintmolders, C | 1 |
| Ardiles, AO; Gallagher, M; Kirkwood, A; Koh, MT; Lee, HK; Megill, A; Ransom, S; Tran, T; Yang, S | 1 |
| Aas, P; Enger, S; Mariussen, E; Myhrer, T | 1 |
| Curry, RJ; Dinh, EH; Hamlet, WR; Liu, YW; Lu, Y; Shi, W; Tang, ZQ | 1 |
| Dionísio, JC; Matias, CM; Quinta-Ferreira, ME; Saggau, P | 1 |
| Georgopoulos, P; Papatheodoropoulos, C; Petrides, T; Pofantis, H | 1 |
| Aksoy-Aksel, A; Manahan-Vaughan, D | 1 |
| Garcia-Bereguiain, MA; Gonzalez-Islas, C; Lindsly, C; Wenner, P | 1 |
| Blaabjerg, M; Bogetofte, H; Dindler, A; Kamand, M; Meyer, M | 1 |
| Baty, D; Blanc, E; Bossi, S; Chames, P; Daniel, H; de Bundel, D; Dupuis, E; El Moustaine, D; Mathieu, M; Mathis, G; McLean, H; Moreno-Delgado, D; Møller, TC; Nevoltris, D; Pin, JP; Rondard, P; Rovira, X; Scholler, P; Trinquet, E; Valjent, E | 1 |
| Bills, KB; Chang, S; Fan, Y; Gwak, YS; Jang, EY; Kim, HY; Kim, NJ; Koo, JS; Lee, BH; Ryu, Y; Steffensen, SC; Yang, CH | 1 |
| Afsari, HS; Liauw, BW; Vafabakhsh, R | 1 |
1 review(s) available for 2-(2,3-dicarboxycyclopropyl)glycine and glycine
| Article | Year |
|---|---|
[Excitatory amino acids and neuronal death].
Topics: Animals; Cell Death; Central Nervous System; Cyclopropanes; Excitatory Amino Acids; Glycine; Neurons; Rats; Receptors, Glutamate | 1995 |
162 other study(ies) available for 2-(2,3-dicarboxycyclopropyl)glycine and glycine
| Article | Year |
|---|---|
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids, Dicarboxylic; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Cyclopropanes; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate | 1994 |
(2s,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carbachol; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus.
Topics: Adrenergic beta-Agonists; Animals; Cyclopropanes; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Metabotropic Glutamate; Resorcinols; Synapses; Synaptic Transmission | 1995 |
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Glycine; Hippocampus; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
(2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl) glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices.
Topics: Animals; Cyclopropanes; Glycine; Hippocampus; Hydrolysis; In Vitro Techniques; Phosphatidylinositol Phosphates; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1994 |
Neuron damage induced by some potent kainoids and neuroprotective action of new agonists for metabotropic glutamate receptors.
Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Brain; Culture Techniques; Cyclopropanes; Dose-Response Relationship, Drug; Ganglia, Spinal; Glycine; Kainic Acid; Motor Neurons; Nerve Degeneration; Neuromuscular Diseases; Neurons; Rats; Receptors, Metabotropic Glutamate; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Synaptic Transmission | 1994 |
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb.
Topics: Animals; CHO Cells; Cricetinae; Cyclopropanes; Dendrites; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Interneurons; Olfactory Bulb; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1993 |
Agonists for metabotropic glutamate receptors in the rat delay recovery from halothane anesthesia.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Anesthesia; Animals; Cycloleucine; Cyclopropanes; Glycine; Halothane; Injections, Intraventricular; Male; Neurotoxins; Postural Balance; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Induction of an olfactory memory by the activation of a metabotropic glutamate receptor.
Topics: Animals; Cycloleucine; Cyclopropanes; Estrus; Female; gamma-Aminobutyric Acid; Glycine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Neuronal Plasticity; Olfactory Bulb; Phentolamine; Pheromones; Pregnancy; Pregnancy, Animal; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Sexual Behavior, Animal | 1994 |
Interaction between metabotropic receptors and purinergic transmission in rat hippocampal slices.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Colforsin; Cycloleucine; Cyclopropanes; Glycine; Hippocampus; In Vitro Techniques; Male; Neurotoxins; Purines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1994 |
A new metabotropic glutamate receptor agonist: developmental change of its sensitivity to receptors in the newborn rat spinal cord.
Topics: Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Baclofen; Cycloleucine; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; In Vitro Techniques; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Spinal Cord; Synapses | 1993 |
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Cycloleucine; Cyclopropanes; Electric Stimulation; Electrophysiology; Glycine; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Reflex, Monosynaptic; Spinal Cord | 1993 |
Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones.
Topics: Animals; Cyclopropanes; Dicarboxylic Acids; Female; Glycine; Hippocampus; Membrane Potentials; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1995 |
Suppression of presynaptic calcium influx by metabotropic glutamate receptor agonists in neonatal rat hippocampus.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels; Cyclopropanes; Depression, Chemical; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glycine; Heterocyclic Compounds, 3-Ring; Hippocampus; In Vitro Techniques; Presynaptic Terminals; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1995 |
Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons.
Topics: Animals; Benzoates; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Cycloleucine; Cyclopropanes; Electrophysiology; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Ion Channel Gating; Neurons; Neurotoxins; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spider Venoms | 1996 |
Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.
Topics: Animals; Axons; Cyclopropanes; Electric Stimulation; Gene Targeting; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Maze Learning; Mice; Mice, Knockout; Neuronal Plasticity; Pyramidal Cells; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1996 |
Interaction between A1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices.
Topics: Adenosine; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acids; Glutamic Acid; Glycine; Hippocampus; Male; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Xanthines | 1996 |
A metabotropic glutamate receptor agonist DCG-IV suppresses synaptic transmission at mossy fiber pathway of the guinea pig hippocampus.
Topics: Aminobutyrates; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Receptors, Metabotropic Glutamate | 1996 |
DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bucladesine; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Glycine; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; Virulence Factors, Bordetella | 1996 |
Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses.
Topics: Animals; Cyclopropanes; Depression, Chemical; Electric Stimulation; Electrophysiology; Extracellular Space; Glycine; Hippocampus; In Vitro Techniques; Membrane Potentials; Nerve Fibers; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 1996 |
Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine, a potent agonist for class II metabotropic glutamate receptors, in the rat.
Topics: Animals; Behavior, Animal; Brain; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; Hippocampus; Male; Nerve Degeneration; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1996 |
Glutamate and N-acetylaspartylglutamate block HVA calcium currents in frog olfactory bulb interneurons via an mGluR2/3-like receptor.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Cyclopropanes; Dipeptides; Glutamic Acid; Glycine; Homovanillic Acid; Interneurons; Ion Channel Gating; Olfactory Bulb; Receptors, Metabotropic Glutamate; Synapses; Xenopus | 1996 |
Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Benzoates; Colforsin; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Interneurons; Kinetics; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin | 1996 |
Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 1997 |
The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling.
Topics: Animals; Astrocytes; Cells, Cultured; Cyclopropanes; Glycine; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Receptors, Metabotropic Glutamate | 1997 |
DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclopropanes; Evoked Potentials; Glycine; Purinergic P1 Receptor Antagonists; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Xanthines | 1997 |
DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice.
Topics: Animals; Cyclopropanes; Differential Threshold; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Frontal Lobe; Glycine; Male; N-Methylaspartate; Osmolar Concentration; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1997 |
mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD induction, in the dentate gyrus in vitro.
Topics: Amino Acids, Dicarboxylic; Animals; Cyclopropanes; Dentate Gyrus; Evoked Potentials; Glycine; In Vitro Techniques; Long-Term Potentiation; Male; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Time Factors | 1997 |
The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception.
Topics: Aminobutyrates; Analysis of Variance; Animals; Benzoates; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Male; Pain; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 1996 |
Excitation of rat subthalamic nucleus neurones in vitro by activation of a group I metabotropic glutamate receptor.
Topics: Adenine Nucleotides; Affinity Labels; Animals; Benzoates; Cycloleucine; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Male; Neurons; Neuroprotective Agents; Pyridoxal; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Thalamic Nuclei | 1997 |
Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture.
Topics: Animals; Astrocytes; Blotting, Western; Calcium; Cell Division; Cells, Cultured; Cyclopropanes; DNA; Excitatory Amino Acid Antagonists; Glycine; Polymerase Chain Reaction; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 1997 |
Target-specific expression of presynaptic mossy fiber plasticity.
Topics: Afferent Pathways; Animals; Colforsin; Cyclic AMP; Cycloleucine; Cyclopropanes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Long-Term Potentiation; Mossy Fibers, Hippocampal; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1998 |
Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes.
Topics: Animals; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclopropanes; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Protein Binding; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sulfur Radioisotopes; Transfection; Tritium | 1998 |
Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Cycloleucine; Cyclopropanes; Dentate Gyrus; Evoked Potentials, Somatosensory; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Resorcinols | 1997 |
Metabotropic glutamate group II receptors activate a G protein-coupled inwardly rectifying K+ current in neurones of the rat cerebellum.
Topics: Animals; Barium; Bridged Bicyclo Compounds; Calcium; Calcium Channels; Cerebellum; Cyclopropanes; Excitatory Amino Acid Agonists; Glycine; GTP-Binding Proteins; In Vitro Techniques; Interneurons; Membrane Potentials; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.
Topics: 4-Aminopyridine; Amino Acids, Dicarboxylic; Animals; Benzoates; Calcium Channels; Cycloleucine; Cyclopropanes; Enzyme Inhibitors; Ethylmaleimide; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Male; Membrane Potentials; Neural Inhibition; Neuroprotective Agents; Patch-Clamp Techniques; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Signal Transduction; Synapses | 1998 |
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Dipeptides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate | 1998 |
[Pharmacological study on metabotropic glutamate receptors on trigeminal neurons].
Topics: Action Potentials; Animals; Cyclopropanes; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Motor Neurons; Neurons, Afferent; Propionates; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Trigeminal Nerve | 1998 |
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cyclopropanes; Glutamic Acid; Glycine; Kindling, Neurologic; Lamotrigine; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Synaptosomes; Triazines | 1998 |
Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV.
Topics: Animals; Bridged Bicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1998 |
The role of group II metabotropic glutamate receptors in hippocampal CA1 long-term potentiation in vitro.
Topics: Amino Acids, Dicarboxylic; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Long-Term Potentiation; Male; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1998 |
Characterization of (2S,2'R,3'R)-2-(2',3'-[3H]-dicarboxycyclopropyl)glycine binding in rat brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cerebral Cortex; Cyclopropanes; Glycine; Image Processing, Computer-Assisted; Ligands; Male; Rats; Receptors, Metabotropic Glutamate; Tissue Distribution | 1998 |
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.
Topics: 1-Carboxyglutamic Acid; Amino Acids, Dicarboxylic; Cell Line; Cloning, Molecular; Cyclopropanes; Excitatory Amino Acid Agonists; Glycine; Humans; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1998 |
Priming of group 2 metabotropic glutamate receptors facilitates induction of long-term depression in the dentate gyrus of freely moving rats.
Topics: Animals; Benzoates; Cerebral Ventricles; Cyclopropanes; Dentate Gyrus; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamates; Glycine; Male; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1998 |
Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro.
Topics: Animals; Anticonvulsants; Benzoates; Cyclopropanes; Dentate Gyrus; Dipeptides; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Ligands; Long-Term Potentiation; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1999 |
Calcium-dependent mechanisms involved in presynaptic long-term depression at the hippocampal mossy fibre-CA3 synapse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Chelating Agents; Cyclopropanes; Egtazic Acid; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Magnesium; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Neural Inhibition; Neuronal Plasticity; Phosphorylation; Presynaptic Terminals; Receptors, Metabotropic Glutamate | 1999 |
Involvement of metabotropic glutamate receptors in taurine release in the adult and developing mouse hippocampus.
Topics: Age Factors; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Mice; Quisqualic Acid; Receptors, Metabotropic Glutamate; Taurine; Time Factors | 1999 |
Dual mechanism for presynaptic modulation by axonal metabotropic glutamate receptor at the mouse mossy fibre-CA3 synapse.
Topics: Algorithms; Animals; Axons; Coloring Agents; Cyclopropanes; Excitatory Postsynaptic Potentials; Fluorescent Dyes; GABA Agonists; Glycine; Heterocyclic Compounds, 3-Ring; In Vitro Techniques; Mice; Mossy Fibers, Hippocampal; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synapses | 1999 |
Metabotropic glutamate receptor agonists protect from oxygen-glucose deprivation- and colchicine-induced apoptosis in primary cultures of cerebellar granule cells.
Topics: Animals; Apoptosis; Cell Hypoxia; Cells, Cultured; Cerebellum; Colchicine; Cycloleucine; Cyclopropanes; Glucose; Glycine; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1999 |
Predominant expression of group-II metabotropic glutamate receptors in the goldfish brain.
Topics: Animals; Brain; Cyclopropanes; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Goldfish; Male; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tissue Distribution | 1999 |
Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes.
Topics: Adenosine; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glycine; Kinetics; Nerve Growth Factors; Neuroglia; Proline; Rats; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Transcription, Genetic | 1999 |
Protection against acute amphetamine-induced behavior by microinjection of a group II metabotropic glutamate receptor agonist into the dorsal striatum of rats.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Cyclopropanes; Dopamine Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Male; Microinjections; Motor Activity; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro.
Topics: Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; Neocortex; Neuronal Plasticity; Organ Culture Techniques; Propionates; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Temporal Lobe | 1999 |
[Functional coupling between metabotropic glutamate receptors and G proteins in rat cerebral cortex].
Topics: Animals; Cerebral Cortex; Cyclopropanes; Glycine; GTP Phosphohydrolases; GTP-Binding Proteins; Male; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Signal Transduction | 1999 |
Adenosine A1 and class II metabotropic glutamate receptors mediate shared presynaptic inhibition of retinotectal transmission.
Topics: Adenosine; Animals; Calcium Channels; Cells, Cultured; Cyclopropanes; Enzyme Activation; Glycine; Goldfish; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Potentials; Pertussis Toxin; Protein Kinase C; Purinergic P1 Receptor Agonists; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Receptors, Purinergic P1; Retina; Retinal Ganglion Cells; Superior Colliculi; Synapses; Synaptic Transmission; Virulence Factors, Bordetella | 1999 |
Regulation of locomotor activity by metabotropic glutamate receptors in the nucleus accumbens and ventral tegmental area.
Topics: Animals; Behavior, Animal; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Male; Methoxyhydroxyphenylglycol; Microinjections; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereotaxic Techniques; Time Factors; Ventral Tegmental Area; Video Recording | 2000 |
Metabotropic glutamate receptors and blockade of glial Krebs cycle depress glycinergic synaptic currents of mouse hypoglossal motoneurons.
Topics: Animals; Animals, Newborn; Aspartic Acid; Citric Acid Cycle; Cycloleucine; Cyclopropanes; Excitatory Postsynaptic Potentials; Female; Glycine; Hypoglossal Nerve; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Motor Neurons; Neuroglia; Neuroprotective Agents; Patch-Clamp Techniques; Propionates; Receptors, Metabotropic Glutamate; Synapses | 2000 |
The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Cyclopropanes; Dyskinesia, Drug-Induced; Glycine; Injections; Injections, Intraventricular; Male; Motor Activity; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reserpine; Substantia Nigra | 2000 |
Mobilisation of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cells, Cultured; Cycloleucine; Cyclopropanes; Dantrolene; Fluorescence; Ganglia, Spinal; Glutamic Acid; Glycine; Indans; Phenylacetates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Stereoisomerism | 2000 |
Modulation of synaptic transmission in the rat ventral septal area by the pharmacological activation of metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclopropanes; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Methoxyhydroxyphenylglycol; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Septum of Brain; Synaptic Transmission | 2000 |
Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Carbachol; Cell Membrane; Cerebellum; CHO Cells; Cholinergic Agonists; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Dimerization; Dithiothreitol; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Humans; Kidney; Neurons; Neuroprotective Agents; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 2000 |
Differential effects of the group II mGluR agonist, DCG-IV, on depolarization-induced suppression of inhibition in hippocampal CA1 and CA3 neurons.
Topics: Animals; Anticonvulsants; Carbachol; Cyclopropanes; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses | 2000 |
cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Amino Acid Sequence; Animals; Anticonvulsants; CHO Cells; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Dentate Gyrus; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Isoquinolines; Molecular Sequence Data; Mutagenesis; Neurons; Perforant Pathway; Phosphorylation; Protein Binding; Rats; Receptors, Metabotropic Glutamate; Serine; Sulfonamides; Transfection | 2000 |
Regional distribution and pharmacological characteristics of [3H]N-acetyl-aspartyl-glutamate (NAAG) binding sites in rat brain.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain; Brain Chemistry; Carboxypeptidases; Cold Temperature; Cycloleucine; Cyclopropanes; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamate Carboxypeptidase II; Glycine; Kainic Acid; Male; Nerve Tissue Proteins; Phosphoserine; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2001 |
Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cyclopropanes; Excitatory Postsynaptic Potentials; Glycine; Posterior Horn Cells; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission | 2000 |
Developmental regulation of hippocampal excitatory synaptic transmission by metabotropic glutamate receptors.
Topics: Animals; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glycine; Hippocampus; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Resorcinols; Synaptic Transmission | 2000 |
Differential control of GABA release at synapses from distinct interneurons in rat hippocampus.
Topics: Animals; Calcium Channel Blockers; Cyclopropanes; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Presynaptic Terminals; Pyramidal Cells; Rats; Reaction Time; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synapses | 2000 |
Involvement of metabotropic glutamate receptors in ischemia-induced taurine release in the developing and adult hippocampus.
Topics: Aging; Animals; Brain Ischemia; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamates; Glycine; Hippocampus; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Neurons; Receptors, Metabotropic Glutamate; Taurine | 2000 |
Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Cyclopropanes; Extracellular Space; GABA Antagonists; Glycine; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Neuronal Plasticity; Pilocarpine; Potassium; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2000 |
The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Behavior, Animal; Blotting, Northern; Cyclopropanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutamate Decarboxylase; Glycine; Male; Mice; Mice, Inbred ICR; Motor Activity; Polycyclic Compounds; Prefrontal Cortex | 2000 |
Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzoates; Brain-Derived Neurotrophic Factor; Corpus Striatum; Cyclopropanes; Disease Models, Animal; Dopamine; Dopamine Agents; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; In Situ Hybridization; Male; Microdialysis; Microglia; MPTP Poisoning; Neurons; Presynaptic Terminals; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger | 2001 |
Pharmacology and neuroprotective actions of mGlu receptor ligands.
Topics: Amino Acids; Brain; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Glycine; Hippocampus; Humans; Kainic Acid; Ligands; Nerve Degeneration; Neuroprotective Agents; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate | 2001 |
The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury.
Topics: Animals; Brain Injuries; Cyclopropanes; Dose-Response Relationship, Drug; Fluorescent Dyes; Glycine; Male; Microscopy, Fluorescence; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Trauma Severity Indices | 2001 |
Electrophysiological characterization of "giant" cells in stratum radiatum of the CA3 hippocampal region.
Topics: 2-Amino-5-phosphonovalerate; 3,3'-Diaminobenzidine; Action Potentials; Animals; Axons; Bicuculline; Calcium; Cesium; Chlorides; Choline; Cyclopropanes; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Immunoenzyme Techniques; Microscopy, Video; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2001 |
Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Cyclopropanes; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Male; Neural Inhibition; Perforant Pathway; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2001 |
Infusion of the metabotropic receptor agonist, DCG-IV, into the main olfactory bulb induces olfactory preference learning in rat pups.
Topics: Animals; Animals, Newborn; Anticonvulsants; Conditioning, Psychological; Cyclopropanes; Discrimination Learning; gamma-Aminobutyric Acid; Glycine; Memory; Mentha piperita; Microinjections; Neural Inhibition; Odorants; Olfactory Bulb; Olfactory Receptor Neurons; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Smell | 2001 |
Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum.
Topics: Aminobutyrates; Animals; Anticonvulsants; Cerebellum; Cyclopropanes; Glycine; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Purkinje Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 2001 |
Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Cyclobutanes; Cyclopropanes; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Glycine; Homocysteine; Male; Neuroprotective Agents; Organophosphorus Compounds; Proline; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2001 |
Multiple G-protein-coupled receptors mediate presynaptic inhibition at single excitatory synapses in the rat visual cortex.
Topics: Adenosine; Animals; Anticonvulsants; Baclofen; Carbachol; Cholinergic Agents; Cyclopropanes; Excitatory Postsynaptic Potentials; GABA Agonists; Glycine; GTP-Binding Proteins; Neural Inhibition; Pyramidal Cells; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Presynaptic; Serotonin; Visual Cortex | 2001 |
Priming stimulation of group II metabotropic glutamate receptors inhibits the subsequent induction of rat hippocampal long-term depression in vitro.
Topics: Animals; Anticonvulsants; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Male; Methoxyhydroxyphenylglycol; Neural Inhibition; Neuronal Plasticity; Neurons; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2001 |
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission | 2001 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 2002 |
Long-term depression induced by postsynaptic group II metabotropic glutamate receptors linked to phospholipase C and intracellular calcium rises in rat prefrontal cortex.
Topics: Animals; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Glycine; Heparin; In Vitro Techniques; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Fluid; Male; Neural Inhibition; Neuronal Plasticity; Phospholipase D; Prefrontal Cortex; Protein Kinase C; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Time; Type C Phospholipases | 2002 |
Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons.
Topics: Animals; Calcium Signaling; Cells, Cultured; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Female; Glycine; Image Processing, Computer-Assisted; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Neurosecretory Systems; Osmolar Concentration; Pregnancy; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus | 2002 |
DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Cyclopropanes; DNA Fragmentation; Dose-Response Relationship, Drug; Glycine; Male; Microglia; Nerve Degeneration; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger | 2002 |
Role for cAMP and protein phosphatase in the presynaptic expression of mouse hippocampal mossy fibre depotentiation.
Topics: Animals; Anticonvulsants; Cyclic AMP; Cyclopropanes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Organ Culture Techniques; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Presynaptic Terminals; Receptors, Metabotropic Glutamate | 2002 |
Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons.
Topics: Animals; Barium; Cadmium; Calcium; Calcium Channel Blockers; Calcium Channels; Cyclopropanes; Electric Conductivity; Glutamic Acid; Glycine; GTP-Binding Proteins; Guinea Pigs; Ion Channel Gating; Male; Myenteric Plexus; Neurons; Nifedipine; omega-Conotoxin GVIA; Pertussis Toxin; Proline; Receptors, Metabotropic Glutamate | 2002 |
Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex.
Topics: Animals; Anticonvulsants; Cycloleucine; Cyclopropanes; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Hallucinogens; Male; Microdialysis; Neuroprotective Agents; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Time Factors | 2003 |
Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signalling in layer V pyramidal neurons from the rat prefrontal cortex.
Topics: Animals; Anticonvulsants; Benzoxazines; Calcium Channel Blockers; Cyclopropanes; Excitatory Postsynaptic Potentials; Glycine; Immunohistochemistry; Long-Term Potentiation; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Neuronal Plasticity; Organ Culture Techniques; Phosphorylation; Phosphoserine; Piperidines; Prefrontal Cortex; Pyramidal Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Metabotropic Glutamate; Rimonabant; Signal Transduction | 2003 |
Reduction of excitatory postsynaptic responses by persistently active metabotropic glutamate receptors in the hippocampus.
Topics: Amino Acids; Animals; Anticonvulsants; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Presynaptic Terminals; Propionates; Receptors, Metabotropic Glutamate; Xanthenes | 2003 |
Modulation of epileptiform burst frequency by the metabotropic glutamate receptor subtype mGluR3.
Topics: Animals; Anticonvulsants; Calcium; Cerebrospinal Fluid; Cyclopropanes; Dentate Gyrus; Dipeptides; Electrophysiology; Epilepsy; Glutamates; Glycine; In Vitro Techniques; Male; Osmolar Concentration; Perfusion; Potassium; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2003 |
Associative mossy fibre LTP induced by pairing presynaptic stimulation with postsynaptic hyperpolarization of CA3 neurons in rat hippocampal slice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzoates; Chelating Agents; Cyclopropanes; Dialysis; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fibrinolytic Agents; Glycine; Heparin; In Vitro Techniques; Long-Term Potentiation; Membrane Potentials; Mossy Fibers, Hippocampal; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Tetanus | 2003 |
Reexamination of the role of hyperpolarization-activated cation channels in short- and long-term plasticity at hippocampal mossy fiber synapses.
Topics: Animals; Carbazoles; Cesium; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide-Gated Cation Channels; Cyclopropanes; Dizocilpine Maleate; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Glycine; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Indoles; Ion Channels; Long-Term Potentiation; Membrane Potentials; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Potassium Channels; Pyrimidines; Pyrroles; Synapses | 2003 |
Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.
Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Calcium; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Cyclopropanes; Dentate Gyrus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Molecular Sequence Data; Perforant Pathway; Protein Structure, Tertiary; Pyridines; Rats; Receptors, Metabotropic Glutamate; Sequence Homology, Amino Acid; Sulfonamides; Tritium; Xanthenes | 2003 |
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes | 2003 |
Mechanisms underlying the inhibition of long-term potentiation by preconditioning stimulation in the hippocampus in vitro.
Topics: Animals; Anticonvulsants; Cyclopropanes; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Flavonoids; Glycine; Hippocampus; Imidazoles; In Vitro Techniques; Long-Term Potentiation; Male; Methoxyhydroxyphenylglycol; Neural Inhibition; Pyridines; Rats; Rats, Wistar; Synapses; Time Factors | 2003 |
Photolysis of postsynaptic caged Ca2+ can potentiate and depress mossy fiber synaptic responses in rat hippocampal CA3 pyramidal neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzothiazoles; Calcium; Coumarins; Cyclopropanes; Cyclosporine; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Marine Toxins; Mossy Fibers, Hippocampal; Oxazoles; Patch-Clamp Techniques; Photolysis; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2004 |
Quantal transmission at mossy fibre targets in the CA3 region of the rat hippocampus.
Topics: Action Potentials; Animals; Anticonvulsants; Cyclopropanes; Excitatory Postsynaptic Potentials; Glycine; Interneurons; Mossy Fibers, Hippocampal; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Strontium; Synapses; Synaptic Transmission | 2004 |
An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro.
Topics: Amino Acids; Animals; Cyclopropanes; Dentate Gyrus; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Long-Term Potentiation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Xanthenes | 2004 |
Inhibitory effects of group II mGluR-related drugs on memory performance in mice.
Topics: Amino Acids; Animals; Anticonvulsants; Avoidance Learning; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Isoquinolines; Male; Memory; Mice; Reaction Time; Receptors, Metabotropic Glutamate; Rolipram; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Xanthenes | 2004 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Ligands; Limbic System; Male; Microdialysis; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures | 2004 |
Glutamate release increases during mossy-CA3 LTP but not during Schaffer-CA1 LTP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Colforsin; Coloring Agents; Cyclopropanes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Magnesium; Male; Mossy Fibers, Hippocampal; Neuroglia; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
AMPA receptor-mediated presynaptic inhibition at cerebellar GABAergic synapses: a characterization of molecular mechanisms.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Benzoxazines; Calcium; Calcium Channel Blockers; Cerebellum; Chelating Agents; Colforsin; Cyclopropanes; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Piperidines; Presynaptic Terminals; Pyrazoles; Rats; Rats, Wistar; Receptors, AMPA; Ryanodine; Synapses; Triazines; Triazoles | 2004 |
Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice.
Topics: Amino Acids; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cyclopropanes; Donepezil; Excitatory Amino Acid Antagonists; Glycine; Indans; Male; Memory; Mice; Nootropic Agents; Piperidines; Receptors, Metabotropic Glutamate; Xanthenes | 2003 |
L-CCG-I activates group III metabotropic glutamate receptors in the hippocampal CA3 region.
Topics: Amino Acids, Dicarboxylic; Animals; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Glycine; Hippocampus; Ligands; Male; Mossy Fibers, Hippocampal; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Phosphoserine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2004 |
Measurement of presynaptic zinc changes in hippocampal mossy fibers.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminoquinolines; Animals; Anticonvulsants; Cholinesterase Inhibitors; Cyclopropanes; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Ethylenediamines; Excitatory Amino Acid Antagonists; Fluorescent Dyes; GABA Antagonists; Glycine; In Vitro Techniques; Long-Term Potentiation; Mossy Fibers, Hippocampal; Picrotoxin; Rats; Rats, Inbred WF; Synapses; Time Factors; Tosyl Compounds; Zinc | 2004 |
Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids, Dicarboxylic; Animals; Benzodiazepines; Cyclopropanes; Excitatory Postsynaptic Potentials; Gene Deletion; GluK2 Kainate Receptor; Glycine; Isoquinolines; Isoxazoles; Kainic Acid; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Patch-Clamp Techniques; Potassium; Propionates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission | 2004 |
Divergent regulatory mechanisms governing BDNF mRNA expression in cerebral cortex and substantia nigra in response to striatal target ablation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Corpus Striatum; Cyclopropanes; Denervation; Disease Models, Animal; Down-Regulation; Female; Glutamate Decarboxylase; Glycine; Huntington Disease; N-Methylaspartate; Neural Pathways; Neurons; Neurotoxins; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Wistar; Receptor, trkB; RNA, Messenger; Substantia Nigra; Subthalamic Nucleus; Tyrosine 3-Monooxygenase | 2005 |
Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).
Topics: Animals; Anxiety; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Humans; Male; Mice; Mice, Inbred DBA; Mice, Inbred ICR; Motor Activity; Phencyclidine; Psychotic Disorders; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2005 |
Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors.
Topics: Amino Acids; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; Ferrets; Geniculate Bodies; Glycine; In Vitro Techniques; Male; Neural Inhibition; Neural Pathways; Neurons; Presynaptic Terminals; Receptors, Metabotropic Glutamate; Synaptic Transmission; Time Factors; Xanthenes | 2005 |
The role of extracellular adenosine in regulating mossy fiber synaptic plasticity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Animals, Newborn; Bicuculline; Cyclopentanes; Cyclopropanes; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptor, Adenosine A1; Synapses; Synaptic Transmission; Xanthines | 2005 |
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Aminobutyrates; Anesthetics, Local; Animals; Animals, Newborn; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Glycine; In Vitro Techniques; Lidocaine; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Patch-Clamp Techniques; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides; Synaptic Transmission; Xanthenes | 2005 |
A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.
Topics: 2-Amino-5-phosphonovalerate; Adaptor Proteins, Vesicular Transport; Age Factors; Animals; Anticonvulsants; Colforsin; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Huntington Disease; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Patch-Clamp Techniques; Time Factors | 2005 |
Selective inhibition of spontaneous but not Ca2+ -dependent release machinery by presynaptic group II mGluRs in rat cerebellar slices.
Topics: Action Potentials; Animals; Cadmium; Calcium; Calcium Channels; Cerebellum; Colforsin; Cyclopropanes; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Interneurons; N-Methylaspartate; Nickel; Patch-Clamp Techniques; Presynaptic Terminals; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Vesicles | 2006 |
Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake.
Topics: Animals; Apoptosis; Astrocytes; Brain; Cells, Cultured; Cyclopropanes; Excitatory Amino Acid Agonists; Glutamic Acid; Glutathione; Glycine; Immunohistochemistry; Lipopolysaccharides; Neurons; Neuroprotective Agents; Phosphoserine; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2006 |
Compartmentalized Ca(2+) channel regulation at divergent mossy-fiber release sites underlies target cell-dependent plasticity.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cyclopropanes; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Neural Inhibition; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Propionates; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2006 |
Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury.
Topics: Animals; Body Water; Brain; Brain Edema; Cell Death; Cyclopropanes; Diffuse Axonal Injury; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Injections, Intraventricular; Male; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Treatment Outcome | 2006 |
Mechanisms of glutamate receptor induced proliferation of astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Count; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Cycloleucine; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycerophospholipids; Glycine; Indoles; Maleimides; Methoxyhydroxyphenylglycol; Phospholipase D; Pyridines; Rats; Rats, Wistar; Receptors, Glutamate; Tritium | 2006 |
GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Bicuculline; Cyclopropanes; Enkephalin, Methionine; Excitatory Postsynaptic Potentials; Fluorescent Dyes; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; Interneurons; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Muscimol; Patch-Clamp Techniques; Picrotoxin; Presynaptic Terminals; Pyridazines; Pyridinium Compounds; Receptors, GABA-A; Synaptic Transmission; Tetrodotoxin | 2007 |
Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.
Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Immunohistochemistry; In Vitro Techniques; Mice; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Somatosensory Cortex; Synapses; Thalamus; Xanthenes | 2007 |
The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex.
Topics: Amino Acids; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Male; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Valine | 2008 |
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats is regulated by adenosine A1 receptors.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Behavior, Animal; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Male; Mossy Fibers, Hippocampal; Rats; Rats, Wistar; Receptor, Adenosine A1; Synapses; Wakefulness; Xanthines | 2008 |
Satellite NG2 progenitor cells share common glutamatergic inputs with associated interneurons in the mouse dentate gyrus.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Animals, Newborn; Antigens; Benzothiadiazines; Cyclopropanes; Dentate Gyrus; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Glycine; Green Fluorescent Proteins; In Vitro Techniques; Interneurons; Mice; Mice, Transgenic; Patch-Clamp Techniques; Phosphopyruvate Hydratase; Phosphoric Diester Hydrolases; Picrotoxin; Proteoglycans; Satellite Cells, Perineuronal; Sodium Channel Blockers; Stem Cells; Tetrodotoxin | 2008 |
Impaired expression and function of group II metabotropic glutamate receptors in pilocarpine-treated chronically epileptic rats.
Topics: Animals; Anticonvulsants; Blotting, Western; Brain; Chronic Disease; Convulsants; Cyclopropanes; Epilepsy; Excitatory Postsynaptic Potentials; Glycine; Immunohistochemistry; Neuronal Plasticity; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Bidirectional Hebbian plasticity at hippocampal mossy fiber synapses on CA3 interneurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Calcium Channel Blockers; Chelating Agents; Cyclopropanes; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Long-Term Potentiation; Lysine; Male; Membrane Potentials; Mossy Fibers, Hippocampal; Neuronal Plasticity; Nicotinic Antagonists; Nimodipine; Patch-Clamp Techniques; Polyamines; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Role of glutamate autoreceptors at hippocampal mossy fiber synapses.
Topics: Animals; Animals, Newborn; Autoreceptors; Biophysics; Calcium; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Kainic Acid; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Receptors, Glutamate; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2008 |
Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation.
Topics: Animals; Anticonvulsants; Biophysics; Clioquinol; Cyclopropanes; Electric Stimulation; Excitatory Postsynaptic Potentials; Extracellular Fluid; Glycine; Hindlimb Suspension; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Mossy Fibers, Hippocampal; Patch-Clamp Techniques; Rats; Rats, Wistar; Stress, Psychological; Time Factors; Trace Elements; Zinc | 2009 |
Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia.
Topics: Amino Acids; Animals; Carotid Stenosis; Cerebrovascular Circulation; Cyclopropanes; Extracellular Space; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Male; Microdialysis; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Xanthenes | 2009 |
Involvement of Group II mGluRs in mossy fiber LTD.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2009 |
Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.
Topics: Animals; Anticonvulsants; Cyclopropanes; Dentate Gyrus; Fear; Freezing Reaction, Cataleptic; Glycine; Memory; Mice; Mossy Fibers, Hippocampal; Neural Pathways; Perforant Pathway; Receptors, Metabotropic Glutamate | 2009 |
Munc13-2 differentially affects hippocampal synaptic transmission and plasticity.
Topics: Animals; Animals, Newborn; Calcium; Cyclopropanes; Dipeptides; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Synapses | 2010 |
Distinct modes of modulation of GABAergic transmission by Group I metabotropic glutamate receptors in rat entorhinal cortex.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzoates; Cardiotonic Agents; Cyclopropanes; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phenylacetates; Potassium Channel Blockers; Pyrimidines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission; Tetraethylammonium | 2010 |
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Biophysics; CA3 Region, Hippocampal; Cyclopropanes; Dihydropyridines; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Long-Term Synaptic Depression; Male; Mossy Fibers, Hippocampal; Rats; Rats, Wistar; Receptor, Adenosine A1; Statistics as Topic; Time Factors; Valine; Wakefulness; Xanthines; Xylenes | 2010 |
Modulators of metabotropic glutamate receptors microinfused into perirhinal cortex: anticonvulsant effects in rats challenged with soman.
Topics: Animals; Anticonvulsants; Benzoates; Cyclopropanes; Dose-Response Relationship, Drug; Glycine; Infusion Pumps; Male; Microinjections; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures; Soman; Temporal Lobe; Time Factors | 2010 |
High affinity group III mGluRs regulate mossy fiber input to CA3 interneurons.
Topics: Action Potentials; Aminobutyrates; Animals; CA3 Region, Hippocampal; Cyclopropanes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Interneurons; Male; Mossy Fibers, Hippocampal; Patch-Clamp Techniques; Phosphoserine; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Presynaptic | 2011 |
Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals.
Topics: Animals; Corpus Striatum; Cyclopropanes; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glycine; Male; Neuroprotective Agents; Parkinsonian Disorders; Presynaptic Terminals; Rats; Rats, Wistar | 2010 |
Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype.
Topics: Animals; Anxiety; Behavior, Animal; Blotting, Western; CA1 Region, Hippocampal; Cyclopropanes; Electrophysiology; Excitatory Postsynaptic Potentials; Glycine; Male; Mice; Mice, Knockout; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2011 |
Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Topics: Action Potentials; Amino Acids; Animals; CA3 Region, Hippocampal; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Interneurons; Mice; Mice, Knockout; Microscopy, Electron; Nerve Net; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Theta Rhythm; Xanthenes | 2011 |
Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.
Topics: Amino Acids, Dicarboxylic; Amphetamine; Animals; Bridged Bicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Mice; Mice, Inbred ICR; Mice, Knockout; Motor Activity; Phencyclidine; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2013 |
Noradrenaline-induced enhancement of oscillatory local field potentials in the mouse accessory olfactory bulb does not depend on disinhibition of mitral cells.
Topics: Anesthetics, Intravenous; Animals; Brain Waves; Cyclopropanes; Excitatory Amino Acid Agonists; Female; GABA Agonists; Glycine; Isonicotinic Acids; Mice; Mice, Inbred BALB C; Microdialysis; Neurons; Norepinephrine; Olfactory Bulb; Urethane; Wakefulness | 2012 |
M2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion.
Topics: Animals; Anthracenes; Anticonvulsants; Biophysical Phenomena; Bungarotoxins; CA3 Region, Hippocampal; Colforsin; Cyclopropanes; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; Gallamine Triethiodide; Glycine; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Knockout; Nerve Net; Nicotinic Antagonists; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyramidal Cells; Receptor, Muscarinic M2; Synapses; Time Factors | 2012 |
Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Amygdala; Animals; Bridged Bicyclo Compounds; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Long-Term Synaptic Depression; Mice; Mice, Knockout; Rats; Rats, Mutant Strains; Rats, Wistar; Receptors, Metabotropic Glutamate; Xanthenes | 2013 |
Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclopropanes; Glycine; Ligands; Neurons; Propionates; Protein Multimerization; Protein Subunits; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Superior Cervical Ganglion | 2012 |
Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR.
Topics: Allosteric Regulation; Amino Acids; Amino Acids, Dicarboxylic; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium Signaling; Cerebral Cortex; Cyclic AMP; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Indans; Ligands; Mice; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Neurons; Optical Imaging; Primary Cell Culture; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sulfonamides | 2013 |
Postsynaptic mGluR mediated excitation of neurons in midbrain periaqueductal grey.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Aspartic Acid; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glycine; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Periaqueductal Gray; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2013 |
Group II metabotropic glutamate receptors depress synaptic transmission onto subicular burst firing neurons.
Topics: Amino Acids; Amino Acids, Dicarboxylic; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cyclopropanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptic Transmission; Xanthenes | 2012 |
The perirhinal cortex of rats: an intricate area for microinfusion of anticonvulsants against soman-induced seizures.
Topics: Animals; Anticonvulsants; Brain Waves; Catheters, Indwelling; Cerebral Cortex; Cyclopentanes; Cyclopropanes; Disease Models, Animal; Drug Delivery Systems; Electroencephalography; Glycine; Infusions, Parenteral; Male; Micromanipulation; Procyclidine; Pyridines; Rats; Rats, Wistar; Reaction Time; Seizures; Soman; Time Factors | 2013 |
Regulation of synaptic currents by mGluR2 at reciprocal synapses in the mouse accessory olfactory bulb.
Topics: Action Potentials; Amino Acids; Animals; Anticonvulsants; Calcium Channels; Cyclopropanes; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Mice; Mice, Inbred BALB C; Mutation; Olfactory Bulb; Receptors, Metabotropic Glutamate; Synapses; Xanthenes | 2013 |
Activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission.
Topics: Animals; Cerebral Cortex; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Geniculate Bodies; Glycine; Mice; Neural Inhibition; Neural Pathways; Photic Stimulation; Receptors, Metabotropic Glutamate; Resorcinols; Retina; Synaptic Transmission; Thalamus; Visual Pathways | 2013 |
Regulation of Hypothalamic Presympathetic Neurons and Sympathetic Outflow by Group II Metabotropic Glutamate Receptors in Spontaneously Hypertensive Rats.
Topics: Adaptation, Physiological; Animals; Cyclopropanes; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hypertension; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Sympathetic Nervous System | 2013 |
Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.
Topics: Amino Acids; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Calcium; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Cricetulus; Cyclopropanes; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Glycine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isotope Labeling; Ligands; Male; Mice; Motor Activity; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sleep; Tritium; Xanthenes | 2013 |
Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats.
Topics: Age Factors; Aging; Animals; Biophysics; CA3 Region, Hippocampal; Cyclopropanes; Electric Stimulation; Excitatory Amino Acid Agents; Glycine; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Maze Learning; Nerve Net; Neural Inhibition; Pyramidal Cells; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Swimming; Synapses | 2013 |
Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Butyrylcholinesterase; Cyclopropanes; Drug Interactions; Glycine; Levetiracetam; Male; Oximes; Piracetam; Procyclidine; Pyridines; Pyridinium Compounds; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Seizures; Soman | 2013 |
Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.
Topics: Amino Acids; Animals; Chick Embryo; Cochlear Nucleus; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABAergic Neurons; Glycine; Inhibitory Postsynaptic Potentials; Long-Term Synaptic Depression; Neural Inhibition; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Xanthenes | 2013 |
Activation of group II metabotropic glutamate receptors blocks zinc release from hippocampal mossy fibers.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Cyclopropanes; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Mossy Fibers, Hippocampal; Presynaptic Terminals; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Statistics, Nonparametric; Synaptic Transmission; Synaptic Vesicles; Zinc | 2014 |
Differences in paired-pulse inhibition and facilitation in the dentate gyrus and CA3 field between dorsal and ventral rat hippocampus.
Topics: Animals; Benzylamines; Biophysics; CA3 Region, Hippocampal; Cyclopropanes; Dentate Gyrus; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; In Vitro Techniques; Male; Nerve Net; Organophosphorus Compounds; Phosphinic Acids; Piperazines; Rats; Rats, Wistar; Statistics, Nonparametric | 2015 |
Synaptic strength at the temporoammonic input to the hippocampal CA1 region in vivo is regulated by NMDA receptors, metabotropic glutamate receptors and voltage-gated calcium channels.
Topics: Animals; CA1 Region, Hippocampal; Calcium Channels, L-Type; Cyclopropanes; Dentate Gyrus; Dose-Response Relationship, Drug; Electric Stimulation; Electrocorticography; Electrodes, Implanted; Excitatory Postsynaptic Potentials; Gallopamil; Glycine; Long-Term Potentiation; Male; Neurotransmitter Agents; Perforant Pathway; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Valine | 2015 |
Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo.
Topics: Action Potentials; Age Factors; Anesthetics, Local; Animals; Anticonvulsants; Chick Embryo; Chlorides; Cyclopropanes; Female; gamma-Aminobutyric Acid; Glycine; Homeostasis; Lidocaine; Male; Motor Neurons; Movement; Nerve Net; Neurotransmitter Agents; Receptors, GABA-A; Spinal Cord; Synapses; Synaptic Potentials | 2016 |
Activation of Group II Metabotropic Glutamate Receptors Increases Proliferation but does not Influence Neuronal Differentiation of a Human Neural Stem Cell Line.
Topics: Amino Acids; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cyclopropanes; Glutamic Acid; Glycine; Humans; Neural Stem Cells; Neurons; Receptors, Metabotropic Glutamate; Xanthenes | 2018 |
Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.
Topics: Allosteric Regulation; Animals; Binding Sites; Camelids, New World; Cyclic AMP; Cyclopropanes; Fear; Glutamic Acid; Glycine; HEK293 Cells; Hippocampus; Humans; Inositol Phosphates; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Neurons; Receptors, Metabotropic Glutamate; Receptors, Opioid; Single-Domain Antibodies | 2017 |
Acupuncture inhibition of methamphetamine-induced behaviors, dopamine release and hyperthermia in the nucleus accumbens: mediation of group II mGluR.
Topics: Acupuncture Therapy; Animals; Body Temperature; Central Nervous System Stimulants; Cyclopropanes; Dopamine; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Locomotion; Male; Methamphetamine; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Vocalization, Animal | 2019 |
Conformational rearrangement during activation of a metabotropic glutamate receptor.
Topics: Allosteric Regulation; Amino Acids; Binding Sites; Biosensing Techniques; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Fluorescence Resonance Energy Transfer; Gene Expression; Genetic Vectors; Glutamic Acid; Glycine; HEK293 Cells; Humans; Ligands; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Receptors, Metabotropic Glutamate; Single Molecule Imaging | 2021 |