Page last updated: 2024-09-03

2-(2,3-dicarboxycyclopropyl)glycine and 2-amino-5-phosphonovalerate

2-(2,3-dicarboxycyclopropyl)glycine has been researched along with 2-amino-5-phosphonovalerate in 15 studies

Compound Research Comparison

Studies
(2-(2,3-dicarboxycyclopropyl)glycine)
Trials
(2-(2,3-dicarboxycyclopropyl)glycine)
Recent Studies (post-2010)
(2-(2,3-dicarboxycyclopropyl)glycine)
Studies
(2-amino-5-phosphonovalerate)
Trials
(2-amino-5-phosphonovalerate)
Recent Studies (post-2010) (2-amino-5-phosphonovalerate)
1660274,3931539

Protein Interaction Comparison

ProteinTaxonomy2-(2,3-dicarboxycyclopropyl)glycine (IC50)2-amino-5-phosphonovalerate (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.29
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.29

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (26.67)18.2507
2000's9 (60.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Opitz, T; Pidoplichko, VI; Reymann, KG; Shinozaki, H; Wilsch, VW1
Glitsch, M; Llano, I; Marty, A1
Anwyl, R; Breakwell, NA; Huang, L; Rowan, MJ1
Bruno, V; Fiore, L; Nicoletti, F; Wroblewska, B; Wroblewski, JT1
Clarke, G; Collingridge, GL; Fitzjohn, SM; Tolchard, S1
Savić, N; Sciancalepore, M1
Lei, S; McBain, CJ1
Johnson, SW; Shen, KZ1
Inoue, M; Kawamura, Y; Kudo, Y; Manita, S; Miyakawa, H; Nakamura, T1
Arif, M; Dionísio, JC; Matias, CM; Quinta-Ferreira, ME1
Breustedt, J; Schmitz, D1
Brose, N; Gibson, HE; Jones, S; Morton, AJ; Reim, K1
Hsu, KS; Huang, CC1
Hagena, H; Manahan-Vaughan, D1
Aksoy-Aksel, A; Manahan-Vaughan, D1

Other Studies

15 other study(ies) available for 2-(2,3-dicarboxycyclopropyl)glycine and 2-amino-5-phosphonovalerate

ArticleYear
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons.
    European journal of pharmacology, 1994, Sep-12, Volume: 262, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Glycine; Hippocampus; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism

1994
Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.
    The Journal of physiology, 1996, Dec-01, Volume: 497 ( Pt 2)

    Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Benzoates; Colforsin; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Interneurons; Kinetics; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin

1996
DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus.
    European journal of pharmacology, 1997, Mar-19, Volume: 322, Issue:2-3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclopropanes; Evoked Potentials; Glycine; Purinergic P1 Receptor Antagonists; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Xanthines

1997
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells.
    Neuroscience, 1998, Volume: 85, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Dipeptides; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate

1998
Modulation of synaptic transmission in the rat ventral septal area by the pharmacological activation of metabotropic glutamate receptors.
    The European journal of neuroscience, 2000, Volume: 12, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cyclopropanes; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Methoxyhydroxyphenylglycol; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Septum of Brain; Synaptic Transmission

2000
Electrophysiological characterization of "giant" cells in stratum radiatum of the CA3 hippocampal region.
    Journal of neurophysiology, 2001, Volume: 85, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; 3,3'-Diaminobenzidine; Action Potentials; Animals; Axons; Bicuculline; Calcium; Cesium; Chlorides; Choline; Cyclopropanes; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Immunoenzyme Techniques; Microscopy, Video; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin

2001
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
    Neuron, 2002, Mar-14, Volume: 33, Issue:6

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine

2002
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
    The Journal of physiology, 2003, Dec-01, Volume: 553, Issue:Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclase Inhibitors; Amino Acids; Amino Acids, Dicarboxylic; Animals; Colforsin; Cyclopropanes; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Imines; In Vitro Techniques; Isoquinolines; Male; Picrotoxin; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Subthalamic Nucleus; Sulfonamides; Synaptic Transmission; Tetradecanoylphorbol Acetate; Xanthenes

2003
Glutamate release increases during mossy-CA3 LTP but not during Schaffer-CA1 LTP.
    The European journal of neuroscience, 2004, Volume: 19, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Colforsin; Coloring Agents; Cyclopropanes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Magnesium; Male; Mossy Fibers, Hippocampal; Neuroglia; Rats; Rats, Sprague-Dawley; Time Factors

2004
Measurement of presynaptic zinc changes in hippocampal mossy fibers.
    Brain research, 2004, Nov-05, Volume: 1026, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminoquinolines; Animals; Anticonvulsants; Cholinesterase Inhibitors; Cyclopropanes; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Ethylenediamines; Excitatory Amino Acid Antagonists; Fluorescent Dyes; GABA Antagonists; Glycine; In Vitro Techniques; Long-Term Potentiation; Mossy Fibers, Hippocampal; Picrotoxin; Rats; Rats, Inbred WF; Synapses; Time Factors; Tosyl Compounds; Zinc

2004
Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Nov-10, Volume: 24, Issue:45

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids, Dicarboxylic; Animals; Benzodiazepines; Cyclopropanes; Excitatory Postsynaptic Potentials; Gene Deletion; GluK2 Kainate Receptor; Glycine; Isoquinolines; Isoxazoles; Kainic Acid; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neuronal Plasticity; Patch-Clamp Techniques; Potassium; Propionates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission

2004
A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.
    The European journal of neuroscience, 2005, Volume: 22, Issue:7

    Topics: 2-Amino-5-phosphonovalerate; Adaptor Proteins, Vesicular Transport; Age Factors; Animals; Anticonvulsants; Colforsin; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; Huntington Disease; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Patch-Clamp Techniques; Time Factors

2005
The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex.
    Neuropharmacology, 2008, Volume: 54, Issue:7

    Topics: Amino Acids; Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Male; N-Methylaspartate; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Valine

2008
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
    Cerebral cortex (New York, N.Y. : 1991), 2010, Volume: 20, Issue:5

    Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Biophysics; CA3 Region, Hippocampal; Cyclopropanes; Dihydropyridines; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Long-Term Synaptic Depression; Male; Mossy Fibers, Hippocampal; Rats; Rats, Wistar; Receptor, Adenosine A1; Statistics as Topic; Time Factors; Valine; Wakefulness; Xanthines; Xylenes

2010
Synaptic strength at the temporoammonic input to the hippocampal CA1 region in vivo is regulated by NMDA receptors, metabotropic glutamate receptors and voltage-gated calcium channels.
    Neuroscience, 2015, Nov-19, Volume: 309

    Topics: Animals; CA1 Region, Hippocampal; Calcium Channels, L-Type; Cyclopropanes; Dentate Gyrus; Dose-Response Relationship, Drug; Electric Stimulation; Electrocorticography; Electrodes, Implanted; Excitatory Postsynaptic Potentials; Gallopamil; Glycine; Long-Term Potentiation; Male; Neurotransmitter Agents; Perforant Pathway; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Valine

2015