Compounds > 2-(2,3-dicarboxycyclopropyl)glycine

Page last updated: 2024-09-03

2-(2,3-dicarboxycyclopropyl)glycine and 2-amino-4-phosphonobutyric acid

2-(2,3-dicarboxycyclopropyl)glycine has been researched along with 2-amino-4-phosphonobutyric acid in 14 studies

Compound Research Comparison

Studies (2-(2,3-dicarboxycyclopropyl)glycine)	Trials (2-(2,3-dicarboxycyclopropyl)glycine)	Recent Studies (post-2010) (2-(2,3-dicarboxycyclopropyl)glycine)	Studies (2-amino-4-phosphonobutyric acid)	Trials (2-amino-4-phosphonobutyric acid)	Recent Studies (post-2010) (2-amino-4-phosphonobutyric acid)
14	0	1	35	0	7
166	0	27	547	0	41

Protein Interaction Comparison

Protein	Taxonomy	2-(2,3-dicarboxycyclopropyl)glycine (IC50)	2-amino-4-phosphonobutyric acid (IC50)
Metabotropic glutamate receptor 8	Homo sapiens (human)		0.0051

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (35.71)	18.2507
2000's	5 (35.71)	29.6817
2010's	4 (28.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Allgeier, H; Knöpfel, T; Kuhn, R	1
Faull, RL; Kratzeisen, C; Lundstrom, K; Malherbe, P; Mutel, V; Richards, JG	1
Arnold, MB; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA	1
Acher, FC; Bertrand, HO; Bessis, AS; Pin, JP	1
Blanco-Urgoiti, J; Bueno, AB; Collado, I; González, R; Griffey, KI; Hoard, DW; Johnson, BG; Kingston, AE; Marcos, A; Moher, ED; Pedregal, C; Pérez-Castells, J; Schoepp, DD; Tizzano, JP; Wright, RA	1
Acher, FC; Bertrand, HO; Brabet, I; Cesarini, S; Courtiol, T; Goudet, C; Lemasson, IA; Oueslati, N; Pin, JP; Rigault, D; Selvam, C; Triballeau, N	1
Assaf, Z; Bjørn-Yoshimoto, WE; Brodbeck, R; Bunch, L; Erichsen, MN; Gefflaut, T; Goudet, C; Huynh, TH; Nielsen, B; Pin, JP; Sagot, E; Stensbøl, TB; Thomsen, C; Tora, AS	1
Kamiya, H; Sawada, S; Yamamoto, C; Yoshino, M	1
Coderre, TJ; Fisher, K	1
Cassidy, EM; O'Connor, JJ; O'Leary, DM	1
Batchelor, AM; Garthwaite, J; Neale, SA	1
Abeniyi, OA; Conn, PJ; Poisik, O; Raju, DV; Rodriguez, A; Smith, Y; Verreault, M	1
Barrionuevo, G; Cosgrove, KE; Meriney, SD	1
Mitchell, VA; Vaughan, CW; Wilson-Poe, AR	1

Reviews

1 review(s) available for 2-(2,3-dicarboxycyclopropyl)glycine and 2-amino-4-phosphonobutyric acid

Article	Year
Metabotropic glutamate receptors: novel targets for drug development. Journal of medicinal chemistry, 1995, Apr-28, Volume: 38, Issue:9 Topics: Animals; Cloning, Molecular; Drug Design; Humans; Receptors, Metabotropic Glutamate	1995

Other Studies

13 other study(ies) available for 2-(2,3-dicarboxycyclopropyl)glycine and 2-amino-4-phosphonobutyric acid

Article	Year
Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain research. Molecular brain research, 1999, Apr-20, Volume: 67, Issue:2 Topics: Adult; Alternative Splicing; Animals; Blotting, Northern; Blotting, Southern; Brain Chemistry; CHO Cells; Cloning, Molecular; Cricetinae; DNA Probes; DNA, Complementary; Fetus; Gene Expression Regulation, Viral; Humans; In Situ Hybridization; Kidney; Molecular Sequence Data; Propionates; Receptors, Metabotropic Glutamate; RNA, Messenger; Semliki forest virus; Sequence Homology, Amino Acid; Transfection; Tritium	1999
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:6 Topics: Amino Acids; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Substrate Specificity; Tritium; Xanthenes	2000
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15 Topics: Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Agonists; Glutamic Acid; Ligands; Models, Molecular; Receptors, Metabotropic Glutamate; Sequence Homology, Amino Acid; Structure-Activity Relationship	2002
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity. Journal of medicinal chemistry, 2004, Jan-15, Volume: 47, Issue:2 Topics: Administration, Oral; Animals; Cerebral Cortex; Cyclic AMP; Fear; Glycine; In Vitro Techniques; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reflex, Startle; Stereoisomerism; Structure-Activity Relationship	2004
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7 Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Phosphinic Acids; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism; Structure-Activity Relationship; User-Computer Interface	2010
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; Glutamic Acid; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship	2016
A metabotropic glutamate receptor agonist DCG-IV suppresses synaptic transmission at mossy fiber pathway of the guinea pig hippocampus. Neuroscience letters, 1996, Mar-22, Volume: 207, Issue:1 Topics: Aminobutyrates; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Receptors, Metabotropic Glutamate	1996
The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception. Pain, 1996, Volume: 68, Issue:2-3 Topics: Aminobutyrates; Analysis of Variance; Animals; Benzoates; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glycine; Male; Pain; Rats; Receptors, Metabotropic Glutamate; Resorcinols	1996
Group II and III metabotropic glutamate receptors modulate paired pulse depression in the rat dentate gyrus in vitro. European journal of pharmacology, 1997, Dec-04, Volume: 340, Issue:1 Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Benzoates; Cycloleucine; Cyclopropanes; Dentate Gyrus; Evoked Potentials, Somatosensory; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Resorcinols	1997
Metabotropic glutamate receptor subtypes modulating neurotransmission at parallel fibre-Purkinje cell synapses in rat cerebellum. Neuropharmacology, 2001, Volume: 41, Issue:1 Topics: Aminobutyrates; Animals; Anticonvulsants; Cerebellum; Cyclopropanes; Glycine; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Purkinje Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission	2001
Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology, 2005, Volume: 49 Suppl 1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Aminobutyrates; Anesthetics, Local; Animals; Animals, Newborn; Cyclopropanes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Globus Pallidus; Glycine; In Vitro Techniques; Lidocaine; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Patch-Clamp Techniques; Proline; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides; Synaptic Transmission; Xanthenes	2005
High affinity group III mGluRs regulate mossy fiber input to CA3 interneurons. Hippocampus, 2011, Volume: 21, Issue:12 Topics: Action Potentials; Aminobutyrates; Animals; CA3 Region, Hippocampal; Cyclopropanes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glycine; Interneurons; Male; Mossy Fibers, Hippocampal; Patch-Clamp Techniques; Phosphoserine; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, Presynaptic	2011
Postsynaptic mGluR mediated excitation of neurons in midbrain periaqueductal grey. Neuropharmacology, 2013, Volume: 66 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Aspartic Acid; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glycine; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Neurons; Periaqueductal Gray; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate	2013