2-(1-octynyl)adenosine has been researched along with adenosine in 18 studies
| Studies (2-(1-octynyl)adenosine) | Trials (2-(1-octynyl)adenosine) | Recent Studies (post-2010) (2-(1-octynyl)adenosine) | Studies (adenosine) | Trials (adenosine) | Recent Studies (post-2010) (adenosine) |
|---|---|---|---|---|---|
| 23 | 0 | 3 | 32,536 | 1,075 | 8,930 |
| Protein | Taxonomy | 2-(1-octynyl)adenosine (IC50) | adenosine (IC50) |
|---|---|---|---|
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | 0.3851 | |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | 5.5 | |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | 5.5 | |
| Adenosine receptor A3 | Homo sapiens (human) | 0.0011 | |
| Adenosine receptor A1 | Homo sapiens (human) | 0.0023 | |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | 63 | |
| Solute carrier family 28 member 3 | Homo sapiens (human) | 3.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (66.67) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donegan, RK; Lieberman, RL | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Abiru, T; Aihara, K; Kogi, K; Uchibori, T; Yamaguchi, T | 1 |
| Abiru, T; Aihara, K; Kogi, K; Matsuda, A; Watanabe, Y; Yamaguchi, T | 1 |
| Ikeda, Y; Nagano, M; Nakashima, M; Takiguchi, Y | 1 |
| Hirawa, N; Ishii, M; Iwamoto, T; Kihara, M; Takeda, K; Toya, Y; Umemura, S | 1 |
| Ishii, M; Iwamoto, T; Kogi, K; Takagi, N; Toya, Y; Uchibori, T; Umemura, S | 1 |
| Furukawa, S; Satoh, K; Taira, N | 1 |
| Abiru, T; Endo, K; Machida, H | 1 |
| Itoh, H; Nakagawa, M; Nakata, T; Sasaki, S; Takeda, K; Takenaka, K; Takesako, T; Tanaka, M | 1 |
| Kimura, J; Matsuoka, I; Nakanishi, H; Ohkubo, S; Ono, T | 1 |
| Aihara, K; Kogi, K; Satoh, K; Taira, N; Yoneyama, F | 1 |
| Harada, N; Katsuragi, T; Okajima, K | 1 |
| Harada, N; Katsuragi, T; Murakami, K; Ohshima, K; Okajima, K; Sato, C; Usune, S | 1 |
| Kogi, K; Konno, T; Murakami, A; Nagai, A; Nakahata, N; Uchibori, T | 1 |
| Aihara, K; Kogi, K; Sasamori, J; Sato, I; Takeo, S; Yoneyama, F | 1 |
| Aihara, K; Sasamori, J; Takahashi, A; Takeo, S; Tanonaka, K; Uchibori, T | 1 |
| Abe, Y; Manome, Y; Marunouchi, T; Sasamori, J; Tanonaka, K; Uchibori, T | 1 |
1 review(s) available for 2-(1-octynyl)adenosine and adenosine
| Article | Year |
|---|---|
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Drug Discovery; Glaucoma; Humans; Ligands; Protein Kinase Inhibitors; rho-Associated Kinases; Sympathomimetics | 2016 |
17 other study(ies) available for 2-(1-octynyl)adenosine and adenosine
| Article | Year |
|---|---|
Vasodepressor mechanisms of 2-(1-octynyl)-adenosine (YT-146), a selective adenosine A2 receptor agonist, involve the opening of glibenclamide-sensitive K+ channels.
Topics: Adenosine; Alkynes; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Injections, Intravenous; Male; Norepinephrine; Potassium Channels; Receptors, Purinergic; Theophylline | 1992 |
Pharmacological profile of the 2-alkynyladenosine derivative 2-octynyladenosine (YT-146) in the cardiovascular system.
Topics: Adenosine; Alkynes; Anesthesia; Animals; Antihypertensive Agents; Atrial Function; Atrioventricular Node; Blood Pressure; Cardiovascular System; Coronary Circulation; Coronary Vessels; Depression, Chemical; Female; Guinea Pigs; Heart; Heart Atria; Male; Muscle Contraction; Platelet Aggregation; Potassium Chloride; Rabbits; Rats; Rats, Inbred WKY; Swine; Vasodilator Agents | 1991 |
The antihypertensive effect of 2-alkynyladenosines and their selective affinity for adenosine A2 receptors.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alkynes; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Brain; Cardiovascular System; Consciousness; Female; Heart Rate; Kinetics; Male; Rats; Rats, Inbred SHR; Receptors, Purinergic; Tritium; Vasodilator Agents | 1991 |
Early administration of YT-146, an adenosine A2 receptor agonist, inhibits neointimal thickening after rat femoral artery endothelium injury.
Topics: Adenosine; Alkynes; Animals; Antihypertensive Agents; Femoral Artery; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Thrombosis; Time Factors | 1995 |
Antihypertensive effects of 2-octynyladenosine (YT-146), a selective adenosine A2 receptor agonist, in Dahl salt-sensitive rats.
Topics: Adenosine; Administration, Oral; Alkynes; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Hypertension; Male; Pulse; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred Strains | 1994 |
Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells.
Topics: Acetylcholine; Adenosine; Alkynes; Animals; Antihypertensive Agents; Aorta; Aorta, Thoracic; Base Sequence; Cells, Cultured; Cyclic AMP; DNA Primers; Endothelium, Vascular; Humans; In Vitro Techniques; Kinetics; Male; Molecular Sequence Data; Muscle Relaxation; Muscle, Smooth, Vascular; Phenylephrine; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Theophylline | 1994 |
Opening of ATP-sensitive K+ channels responsible for adenosine A2 receptor-mediated vasodepression does not involve a pertussis toxin-sensitive G protein.
Topics: Adenosine; Adenosine Triphosphate; Alkynes; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glyburide; GTP-Binding Proteins; Heart Rate; Male; Pertussis Toxin; Potassium Channels; Rats; Rats, Wistar; Receptors, Purinergic; Vagus Nerve; Virulence Factors, Bordetella | 1993 |
Differential vasodilatory action of 2-octynyladenosine (YT-146), an adenosine A2 receptor agonist, in the isolated rat femoral artery and vein.
Topics: Adenosine; Alkynes; Animals; Endothelium, Vascular; Femoral Artery; Femoral Vein; Male; Muscle Contraction; Muscle, Smooth, Vascular; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Serotonin; Vasodilator Agents; Xanthines | 1995 |
Altered cardiovascular responses to purinergic A2 stimulation in the nucleus tractus solitarius of spontaneously hypertensive rats.
Topics: Adenosine; Alkynes; Anesthesia; Animals; Antihypertensive Agents; Cardiovascular System; Hypertension; Male; Microinjections; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Purinergic P1; Reference Values; Solitary Nucleus; Sympathetic Nervous System; Urethane | 1995 |
Effects of YT-146 [2-(1-octynyl) adenosine], an adenosine A2A receptor agonist, on cAMP production and noradrenaline release in PC12 cells.
Topics: Adenosine; Adenosine Triphosphate; Alkynes; Animals; Bucladesine; Calcimycin; Calcium; Carbachol; Cholinergic Agonists; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Ionophores; Isoquinolines; Membrane Potentials; Norepinephrine; PC12 Cells; Potassium Chloride; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Sulfonamides; Thionucleotides; Tritium; Vasodilator Agents | 1998 |
Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts.
Topics: Adenosine; Alkynes; Animals; Atrioventricular Node; Blood Flow Velocity; Coronary Circulation; Dogs; Female; Glyburide; Heart; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Potassium Channel Blockers; Purinergic P1 Receptor Agonists; Vasodilator Agents | 1999 |
[Adenosine reduces ischemia/reperfusion-induced liver injury by inhibiting leukocyte activation].
Topics: Adenosine; Alkynes; Animals; Humans; In Vitro Techniques; Leukocyte Elastase; Liver; Male; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Neutrophil Activation; Neutrophils; Rats; Rats, Wistar; Receptors, Purinergic P1; Reperfusion Injury; Transaminases; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 1999 |
Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation.
Topics: Adenosine; Alkynes; Animals; Calcium; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ischemia; Leukocyte Elastase; Lipopolysaccharides; Liver; Male; Monocytes; Neutrophil Activation; Peroxidase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles; Tumor Necrosis Factor-alpha | 2000 |
Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine.
Topics: Adenosine; Alkynes; Animals; Aqueous Humor; Cyclic AMP; Glaucoma; Humans; Intraocular Pressure; Kinetics; Male; Rabbits; Receptor, Adenosine A2A | 2005 |
Amelioration of ischemia/reperfusion-induced myocardial infarction by the 2-alkynyladenosine derivative 2-octynyladenosine (YT-146).
Topics: Adenosine; Alkynes; Animals; Biomarkers; Blood Pressure; Cardiotonic Agents; Coronary Circulation; Creatine Kinase; Dogs; Female; Heart Rate; Hemodynamics; Ischemic Preconditioning; Male; Myocardial Infarction; Myocardium; Necrosis; Receptors, Adenosine A2; Reperfusion Injury | 2006 |
Cardioprotective effects of 2-octynyladenosine (YT-146) in ischemic/reperfused rat hearts.
Topics: Adenosine; Alkynes; Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley | 2011 |
Effects of 2-Octynyladenosine (YT-146) on Mitochondrial Function in Ischemic/Reperfused Rat Hearts.
Topics: Adenosine; Adenosine Triphosphate; Alkynes; Animals; Cardiovascular Agents; Energy Metabolism; Heart; Male; Mitochondria, Heart; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Purinergic P1 Receptor Agonists; Rats, Wistar; Sodium | 2015 |