Page last updated: 2024-09-04

2-(1-octynyl)adenosine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

2-(1-octynyl)adenosine has been researched along with 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine in 6 studies

Compound Research Comparison

Studies
(2-(1-octynyl)adenosine)
Trials
(2-(1-octynyl)adenosine)
Recent Studies (post-2010)
(2-(1-octynyl)adenosine)
Studies
(2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine)
Trials
(2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine)
Recent Studies (post-2010) (2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine)
23039522169

Protein Interaction Comparison

ProteinTaxonomy2-(1-octynyl)adenosine (IC50)2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine (IC50)
Adenosine receptor A2aHomo sapiens (human)0.019

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abiru, T; Homma, H; Matsuda, A; Murayama, T; Nomura, Y; Watanabe, Y1
Abiru, T; Machida, H; Matsuda, A; Miyashita, T; Watanabe, Y; Yamaguchi, T1
Abiru, T; Homma, H; Matsuda, A; Miyasaka, T; Nomoto, R; Shinozaki, M; Watanabe, Y; Yamaguchi, T1
Jacobson, KA; van Galen, PJ; Williams, M1
Donegan, RK; Lieberman, RL1
Harada, N; Katsuragi, T; Murakami, K; Ohshima, K; Okajima, K; Sato, C; Usune, S1

Reviews

2 review(s) available for 2-(1-octynyl)adenosine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

ArticleYear
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship

1992
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Adrenergic Agonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Drug Discovery; Glaucoma; Humans; Ligands; Protein Kinase Inhibitors; rho-Associated Kinases; Sympathomimetics

2016

Other Studies

4 other study(ies) available for 2-(1-octynyl)adenosine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

ArticleYear
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.
    Journal of medicinal chemistry, 1992, Jul-24, Volume: 35, Issue:15

    Topics: Adenosine; Animals; Antihypertensive Agents; Brain; Male; Molecular Structure; Rats; Rats, Inbred SHR; Receptors, Purinergic; Substrate Specificity

1992
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.
    Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12

    Topics: Adenosine; Animals; Antihypertensive Agents; Brain; Cell Membrane; Heart Rate; Hypertension; Molecular Structure; Rats; Rats, Inbred SHR; Receptors, Purinergic; Structure-Activity Relationship

1992
Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects.
    Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2

    Topics: Adenosine; Adenosine Deaminase; Animals; Antihypertensive Agents; Blood Pressure; Brain; Female; Heart Rate; In Vitro Techniques; Male; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Purinergic; Structure-Activity Relationship

1992
Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Adenosine; Alkynes; Animals; Calcium; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Growth Substances; Humans; Intercellular Signaling Peptides and Proteins; Ischemia; Leukocyte Elastase; Lipopolysaccharides; Liver; Male; Monocytes; Neutrophil Activation; Peroxidase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Reperfusion Injury; Triazines; Triazoles; Tumor Necrosis Factor-alpha

2000