Compounds > 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a
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2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a and chlorophyll a

2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a has been researched along with chlorophyll a in 58 studies

Compound Research Comparison

Studies
(2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a)		Trials
(2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a)		Recent Studies (post-2010)
(2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a)		Studies
(chlorophyll a)		Trials
(chlorophyll a)		Recent Studies (post-2010) (chlorophyll a)
6953920,512299,862

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (12.07)18.2507
2000's16 (27.59)29.6817
2010's30 (51.72)24.3611
2020's5 (8.62)2.80

Authors

AuthorsStudies
Bellnier, DA; Dougherty, TJ; Henderson, BW; Pandey, RK; Potter, WR1
Bellnier, DA; Greco, WR; Henderson, BW; Johnson, P; Parsons, JC; Potter, WR; Sitnik, TM; Vaughan, LA; Whitaker, J1
Casteel, SW; Frazier, D; McCaw, DL; Payne, JT; Rogers, K; Tompson, RV1
Crean, DH; Furukawa, K; Kato, H; Mang, TS; Yamamoto, H1
Autry, SA; Edwards, BF; Madewell, BR; Magne, ML; Rodriguez, CO; Theon, AP1
De Voss, JJ; Dickinson, RG; Gillam, EM; Hooper, WD; Munns, AJ1
Ball, DE; Kamali, F; McLaughlin, WS; Seymour, RA1
Gurfinkel, M; Gust, JD; Hawrysz, DJ; Mayer, RH; Moore, AL; Moore, TA; Muggenburg, B; Nikula, K; Pandey, R; Ralston, W; Reynolds, JS; Sevick-Muraca, EM; Tatman, D; Thompson, AB; Troy, TL1
Barone, T; Ciesielski, MJ; Dougherty, TJ; Fenstermaker, RA; Lobel, J; MacDonald, IJ; Plunkett, RJ; Pollina, J; Potter, WR1
Kalhorn, TF; Lakehal, F; Levy, RH; Wurden, CJ1
Bellnier, DA; Dougherty, TJ; Greco, WR; Loewen, GM; Nava, H; Oseroff, AR; Pandey, RK; Tsuchida, T1
Baumann, H; Evans, SS; Gollnick, SO; Henderson, BW; Maier, P; Owczarczak, B; Unger, E; Vaughan, L; Wang, WC1
Bergey, EJ; Dougherty, TJ; Morgan, J; Ohulchanskyy, TY; Oseroff, AR; Prasad, PN; Pudavar, HE; Roy, I1
Bergey, EJ; Davies, SR; Detty, MR; Gibson, SL; Hilf, R; Ohulchanskyy, TY; Oseroff, AR; Roy, I; You, Y1
Bellnier, DA; Greco, WR; Henderson, BW; Snyder, JW; Vaughan, L1
Busch, TM; Cheney, RT; Gollnick, SO; Henderson, BW; Kousis, PC; Morgan, J; Snyder, JW1
Bellnier, DA; Camacho, SH; Cheney, RT; Mazurchuk, R; Oseroff, AR; Seshadri, M; Spernyak, JA1
Bellnier, DA; Dougherty, TJ; Greco, WR; Loewen, GM; Nava, H; Oseroff, AR1
Kim, S; Ohulchanskyy, TY; Pandey, RK; Prasad, PN; Pudavar, HE1
Baumann, H; Henderson, BW; Hutson, A; Rose-John, S; Tracy, E; Wang, Y; Wei, LH1
Baumann, H; Chen, Y; Ciesielski, M; Erin, T; Fenstermaker, R; Fukuzumi, S; Kadish, KM; Liu, W; Ohkubo, K; Oseroff, A; Pandey, RK; Pandey, SK; Wenbo, E; Zhang, M1
Bellnier, DA; Foster, TH; Henderson, BW; Mazurchuk, R; Seshadri, M; Spernyak, JA; Vaughan, LA1
Batt, C; Baumann, H; Bellnier, DA; Chen, Y; Henderson, BW; Jackson, J; Missert, JR; Morgan, J; Pandey, RK; Pandey, SK; Tracy, E; Zheng, X1
Batt, C; Chen, Y; Ethirajan, M; Goswami, L; Mazurchuk, R; Missert, JR; Pandey, RK; Patel, NJ; Spernyak, JA; Turowski, S; White, WH1
Baumann, H; Cooper, MT; Henderson, BH; Keymel, K; Rigual, N; Rohrbach, D; Sunar, U; Tracy, E1
Chen, Y; Ethirajan, M; Joshi, P; Pandey, RK1
Dubey, S; Ethirajan, M; Liu, TH; Missert, J; Morgan, J; Pandey, RK; Pandey, SK; Shibata, M; Srivatsan, A; Zheng, X1
Busch, TM; Durham, A; Grossman, CE; Pickup, S; Putt, ME; Wileyto, EP1
Brackett, CM; Gollnick, SO; Maier, PG; Owczarczak, B; Ramsey, K1
Ethirajan, M; Fan, W; Goswami, LN; Gupta, A; Hah, HJ; Kim, G; Kopelman, R; Lee, YE; Morgan, J; Pandey, RK; Pera, P; Wang, S1
Allamaneni, SS; Cooper, MT; Dougherty, TJ; Henderson, BW; Nava, HR; Tan, W; Wilding, G1
Mo, W; Rohrbach, D; Sunar, U1
Anderson, MA; Gorospe, EC; Leggett, CL; Levy, M; Lutzke, LS; Sun, G; Wang, KK; Wong Kee Song, LM1
Cooper, M; Frustino, J; Henderson, B; Rigual, NR; Seshadri, M; Shafirstein, G; Sullivan, MA; Wilding, G1
Chen, Y; Goswami, LN; James, NS; Joshi, P; Ohulchanskyy, TY; Pandey, RK; Zheng, X1
Baumann, H; Bellnier, DA; Cooper, MT; Henderson, BW; Merzianu, M; Rigual, N; Rohrbach, DJ; Shafirstein, G; Sullivan, M; Sunar, U; Tan, W; Tracy, EC; Wilding, G1
Intes, X; Ozturk, MS; Rohrbach, D; Sunar, U1
Bhirde, A; Chen, X; Kiesewetter, DO; Liu, Z; Nie, L; Niu, G; Rong, P; Srivastan, A; Wang, F; Wang, W; Wang, Z; Yang, K; Yue, X1
Bellnier, DA; Gollnick, SO; Manderscheid-Kern, P; Owczarczak, B; Shams, M1
Fan, L; Liu, L; Liu, Z; Tao, L; Wang, Q; Wu, DP; Zhang, Y1
Blumenthal, R; Charron, H; Joshi, A; Puri, A; Schiff, R; Sine, J; Tata, DB; Thayer, D; Urban, C; Valim, N1
Chen, J; Gao, F; Heyes, CD; Jenkins, SV; Pandey, RK; Reynolds, KY; Srivatsan, A; Zhang, Y1
Carter, KA; Geng, J; Lin, C; Lovell, JF; Luo, D; Ortega, J; Razi, A; Shao, S1
Cooper, M; Demmy, TL; Dhillon, SS; Henderson, BW; Loewen, G; Nwogu, C; Yendamuri, S1
Kim, MM; Liu, B; Penjweini, R; Zhu, TC1
Chen, L; Xiao, Q; Yang, J; Zhang, X1
Busch, TM; Carter, SL; Czupryna, J; Grossman, CE; Putt, ME; Wang, L1
Baumann, H; Chen, Y; Cheruku, RR; Joshi, P; Marko, A; Missert, JR; Ohulchanskyy, TY; Pandey, RK; Pera, P; Rohrbach, D; Saenz, C; Sunar, U; Tabaczynski, WA; Tracy, E1
Bigliardi, PL; Bigliardi-Qi, M; Burkett, BA; Eberle, AN; Krishnan-Kutty, V; Pant, A; Rout, B; Srinivas, R1
Cheruku, RR; James, NS; Missert, JR; Pandey, RK; Sunar, U1
Baumann, H; Bowman, MJ; Pandey, RK; Tracy, EC1
Cao, Q; Chen, L; Tong, H; Wang, X; Wu, Y; Yang, J; Zhang, T; Zhang, X1
Dubey, SK; Krishna, KV; Puri, A; Saha, RN; Shapiro, BA; Viard, M1
Busch, TM; Cengel, KA; Dimofte, A; Finlay, JC; Friedberg, JS; Glatstein, E; Kim, MM; Liang, X; Ong, Y; Simone, CB; Zhu, TC1
Borah, B; Cacaccio, J; Cheruku, RR; Durrani, F; Ethirajan, M; Missert, JR; Pandey, RK; Pera, P; Tabaczynski, W1
Bricks, JL; Chepurna, OM; Levchenko, SM; Losytskyy, MY; Nikolaeva, OA; Ohulchanskyy, TY; Qu, J; Slominskii, YL; Vretik, LO; Xu, H; Yakovliev, A; Ziniuk, R1
Cheruku, RR; Dukh, M; Missert, JR; Pandey, RK; Patel, NJ; Spernyak, JA; Tabaczynski, W; White, WH; Zhang, S1
Borah, BM; Bshara, W; Cacaccio, J; Durrani, FA; Pandey, RK; Spernyak, JA; Turowski, SG1

Reviews

2 review(s) available for 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a and chlorophyll a

ArticleYear
The role of porphyrin chemistry in tumor imaging and photodynamic therapy.
    Chemical Society reviews, 2011, Volume: 40, Issue:1

    Topics: Animals; Chlorophyll; Esophageal Neoplasms; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Porphyrins

2011
Mesoscopic fluorescence tomography of a photosensitizer (HPPH) 3D biodistribution in skin cancer.
    Academic radiology, 2014, Volume: 21, Issue:2

    Topics: Administration, Topical; Animals; Carcinoma, Basal Cell; Chlorophyll; Dermoscopy; Imaging, Three-Dimensional; Mice; Mice, Transgenic; Microscopy, Fluorescence; Photosensitizing Agents; Reproducibility of Results; Sensitivity and Specificity; Skin Absorption; Skin Neoplasms; Spectrometry, Fluorescence; Tissue Distribution; Tomography, Optical

2014

Trials

5 trial(s) available for 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a and chlorophyll a

ArticleYear
Photodynamic therapy (PDT) using HPPH for the treatment of precancerous lesions associated with Barrett's esophagus.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Barrett Esophagus; Chlorophyll; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Schedule; Esophageal Neoplasms; Esophagoscopy; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Treatment Outcome

2011
Adjuvant intraoperative photodynamic therapy in head and neck cancer.
    JAMA otolaryngology-- head & neck surgery, 2013, Volume: 139, Issue:7

    Topics: Aged; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Chlorophyll; Female; Head and Neck Neoplasms; Humans; Intraoperative Care; Lasers; Male; Photochemotherapy; Treatment Outcome

2013
Photodynamic therapy with 3-(1'-hexyloxyethyl) pyropheophorbide a for cancer of the oral cavity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Dec-01, Volume: 19, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Chlorophyll; Disease-Free Survival; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; STAT3 Transcription Factor; Tissue Distribution; Treatment Outcome

2013
A Phase I Study of Light Dose for Photodynamic Therapy Using 2-[1-Hexyloxyethyl]-2 Devinyl Pyropheophorbide-a for the Treatment of Non-Small Cell Carcinoma In Situ or Non-Small Cell Microinvasive Bronchogenic Carcinoma: A Dose Ranging Study.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2016, Volume: 11, Issue:2

    Topics: Aged; Aged, 80 and over; Carcinoma in Situ; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Chlorophyll; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents

2016
Development and application of a physiologically based pharmacokinetic model for HPPH in rats and extrapolate to humans.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Mar-01, Volume: 129

    Topics: Animals; Chlorophyll; Female; Humans; Male; Mice; Photochemotherapy; Photosensitizing Agents; Rats; Rats, Sprague-Dawley; Skin Neoplasms; Tissue Distribution

2019

Other Studies

51 other study(ies) available for 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a and chlorophyll a

ArticleYear
Murine pharmacokinetics and antitumor efficacy of the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a.
    Journal of photochemistry and photobiology. B, Biology, 1993, Volume: 20, Issue:1

    Topics: Animals; Biological Transport, Active; Chlorophyll; Female; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Inbred ICR; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents; Tissue Distribution

1993
The validation of a new vascular damage assay for photodynamic therapy agents.
    Photochemistry and photobiology, 1995, Volume: 62, Issue:5

    Topics: Animals; Blood Vessels; Chlorophyll; Fluorescein; Fluoresceins; Mice; Mice, Inbred C3H; Photochemotherapy; Photosensitizing Agents; Reproducibility of Results; Skin; Spectrometry, Fluorescence

1995
Pharmacokinetics of pyropheophorbide-a-hexyl ether in the dog.
    Lasers in surgery and medicine, 1996, Volume: 18, Issue:4

    Topics: Animals; Chlorophyll; Dogs; Female; Half-Life; Male; Photochemotherapy; Photosensitizing Agents

1996
Localization and treatment of transformed tissues using the photodynamic sensitizer 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a.
    Lasers in surgery and medicine, 1996, Volume: 18, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Transformation, Neoplastic; Cheek; Chlorophyll; Cricetinae; Fluorescence; Lasers; Male; Mesocricetus; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents

1996
Photodynamic therapy of facial squamous cell carcinoma in cats using a new photosensitizer.
    Lasers in surgery and medicine, 1997, Volume: 20, Issue:2

    Topics: Animals; Carcinoma, Squamous Cell; Cats; Chlorophyll; Edema; Inflammation; Opportunistic Infections; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms

1997
Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Chemical research in toxicology, 1997, Volume: 10, Issue:9

    Topics: Animals; Biotransformation; Blotting, Northern; Cats; Chlorophyll; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Weight; Phenytoin; Photosensitizing Agents; Protein Binding; Rats; Rats, Wistar; Reactive Oxygen Species; Spectrometry, Fluorescence

1997
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
    Journal of periodontal research, 1999, Volume: 34, Issue:3

    Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chromatography, High Pressure Liquid; Epilepsy; Female; Gingival Overgrowth; Humans; Hydroxylation; Liver; Male; Microsomes; Middle Aged; Phenytoin; Photosensitizing Agents; Rats; Rats, Wistar; Species Specificity; Statistics, Nonparametric; Sulfaphenazole; Tolbutamide

1999
Pharmacokinetics of ICG and HPPH-car for the detection of normal and tumor tissue using fluorescence, near-infrared reflectance imaging: a case study.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:1

    Topics: Adenocarcinoma; Animals; Carotenoids; Chlorophyll; Dog Diseases; Dogs; Female; Indocyanine Green; Mammary Neoplasms, Animal; Photosensitizing Agents; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared

2000
2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) in a nude rat glioma model: implications for photodynamic therapy.
    Lasers in surgery and medicine, 2001, Volume: 29, Issue:5

    Topics: Animals; Brain Neoplasms; Chlorophyll; Glioma; Humans; Male; Models, Animal; Photochemotherapy; Photosensitizing Agents; Rats; Rats, Nude; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Survival Analysis

2001
Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19.
    Epilepsy research, 2002, Volume: 52, Issue:2

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chlorophyll; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Liver; Mephenytoin; Microsomes; Mixed Function Oxygenases; Oxcarbazepine; Phenytoin; Recombinant Proteins

2002
Population pharmacokinetics of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a in cancer patients.
    Cancer research, 2003, Apr-15, Volume: 63, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Barrett Esophagus; Blood Proteins; Carcinoma, Basal Cell; Chlorophyll; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Esophageal Neoplasms; Humans; Lung Neoplasms; Middle Aged; Neoplasms; Photochemotherapy; Photosensitizing Agents; Skin; Skin Neoplasms

2003
Role of cytokines in photodynamic therapy-induced local and systemic inflammation.
    British journal of cancer, 2003, Jun-02, Volume: 88, Issue:11

    Topics: Animals; Cell Adhesion; Cell Movement; Chemokine CXCL1; Chemokine CXCL2; Chemokines; Chemokines, CXC; Chemotactic Factors; Chlorophyll; Cytokines; E-Selectin; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Inflammation; Intercellular Adhesion Molecule-1; Intercellular Signaling Peptides and Proteins; Interleukin-6; Leukocytes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Monokines; Neutrophils; Photochemotherapy; Photosensitizing Agents; Up-Regulation

2003
Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy.
    Journal of the American Chemical Society, 2003, Jul-02, Volume: 125, Issue:26

    Topics: Antineoplastic Agents; Ceramics; Chlorophyll; Drug Carriers; Hydrolysis; Micelles; Nanotechnology; Particle Size; Photochemotherapy; Photosensitizing Agents; Silanes; Solubility; Spectrometry, Fluorescence; Water

2003
Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives.
    Journal of medicinal chemistry, 2003, Aug-14, Volume: 46, Issue:17

    Topics: Animals; Antineoplastic Agents; Carboxylic Acids; Cell Survival; Chlorophyll; Darkness; Dihematoporphyrin Ether; Electron Transport Complex IV; Fluorescence; Light; Mice; Microscopy, Confocal; Mitochondria; Photochemotherapy; Photosensitizing Agents; Porphyrins; Rats; Singlet Oxygen; Solubility; Spectrophotometry; Tumor Cells, Cultured

2003
Photodynamic therapy: a means to enhanced drug delivery to tumors.
    Cancer research, 2003, Dec-01, Volume: 63, Issue:23

    Topics: Animals; Antibiotics, Antineoplastic; Capillary Permeability; Chlorophyll; Colonic Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Delivery Systems; Drug Synergism; Female; Mice; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents

2003
Choice of oxygen-conserving treatment regimen determines the inflammatory response and outcome of photodynamic therapy of tumors.
    Cancer research, 2004, Mar-15, Volume: 64, Issue:6

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Chemokine CCL4; Chlorophyll; Colonic Neoplasms; Endothelium; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; In Situ Nick-End Labeling; Interleukin-6; Macrophage Inflammatory Proteins; Mice; Mice, Inbred BALB C; Neutrophils; Nitroimidazoles; Oxygen; Photochemotherapy; Photosensitizing Agents

2004
Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: implications for combination therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jun-01, Volume: 11, Issue:11

    Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Capillary Permeability; Chlorophyll; Combined Modality Therapy; Dose-Response Relationship, Drug; Immunohistochemistry; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Photochemotherapy; Platelet Endothelial Cell Adhesion Molecule-1; Treatment Outcome; Xanthones

2005
Clinical pharmacokinetics of the PDT photosensitizers porfimer sodium (Photofrin), 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (Photochlor) and 5-ALA-induced protoporphyrin IX.
    Lasers in surgery and medicine, 2006, Volume: 38, Issue:5

    Topics: Administration, Topical; Aminolevulinic Acid; Chlorophyll; Dihematoporphyrin Ether; Fluorometry; Half-Life; Humans; Infusions, Intravenous; Neoplasms; Photosensitizing Agents

2006
Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy.
    Journal of the American Chemical Society, 2007, Mar-07, Volume: 129, Issue:9

    Topics: Absorption; Antineoplastic Agents; Chemical Precipitation; Chlorophyll; Fluorescent Dyes; HeLa Cells; Humans; Intracellular Space; Micelles; Nanoparticles; Photochemotherapy; Photons; Photosensitizing Agents; Singlet Oxygen; Spectrometry, Fluorescence

2007
Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling.
    British journal of cancer, 2007, Dec-03, Volume: 97, Issue:11

    Topics: Animals; Blotting, Western; cdc25 Phosphatases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chlorophyll; Colonic Neoplasms; Culture Media, Conditioned; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; HeLa Cells; Humans; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Photochemotherapy; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor

2007
Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007, Volume: 6, Issue:12

    Topics: Animals; Carbocyanines; Chlorophyll; Cross-Linking Reagents; Electrochemistry; Fluorescence; Glioma; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Singlet Oxygen; STAT3 Transcription Factor

2007
Light delivery over extended time periods enhances the effectiveness of photodynamic therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, May-01, Volume: 14, Issue:9

    Topics: Animals; Cell Hypoxia; Chlorophyll; Colonic Neoplasms; Female; Light; Oxygen; Photochemotherapy; Photosensitizing Agents; Rats; Rats, Inbred F344; Treatment Outcome

2008
Conjugation of 2-(1'-hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to carbohydrates changes its subcellular distribution and enhances photodynamic activity in vivo.
    Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14

    Topics: Animals; Biological Transport; Carbohydrates; Cell Line, Tumor; Chlorophyll; Clinical Trials as Topic; Galactose; Hydrophobic and Hydrophilic Interactions; Intracellular Space; Mice; Photochemotherapy; Photosensitizing Agents; Protein Multimerization; Protein Structure, Quaternary; Skin; STAT3 Transcription Factor; Tissue Distribution

2009
Hexylether derivative of pyropheophorbide-a (HPPH) on conjugating with 3gadolinium(III) aminobenzyldiethylenetriaminepentaacetic acid shows potential for in vivo tumor imaging (MR, Fluorescence) and photodynamic therapy.
    Bioconjugate chemistry, 2010, May-19, Volume: 21, Issue:5

    Topics: Animals; Chlorophyll; Fluorescence; Gadolinium; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms; Photochemotherapy; Rats

2010
Monitoring photobleaching and hemodynamic responses to HPPH-mediated photodynamic therapy of head and neck cancer: a case report.
    Optics express, 2010, Jul-05, Volume: 18, Issue:14

    Topics: Chlorophyll; Cross-Linking Reagents; Fiber Optic Technology; Head and Neck Neoplasms; Hemodynamics; Humans; Male; Photobleaching; Photochemotherapy; STAT3 Transcription Factor

2010
Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics with enhanced tumor-imaging and photosensitizing (PDT) efficacy.
    Molecular pharmaceutics, 2011, Aug-01, Volume: 8, Issue:4

    Topics: Cell Line, Tumor; Chlorophyll; Chlorophyll A; Chromatography, High Pressure Liquid; Humans; Integrin alphaVbeta3; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Photochemotherapy; Photosensitizing Agents

2011
Photodynamic therapy of disseminated non-small cell lung carcinoma in a murine model.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlorophyll; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Tumor Burden

2011
IL-6 potentiates tumor resistance to photodynamic therapy (PDT).
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chlorophyll; Colonic Neoplasms; Dihematoporphyrin Ether; Drug Resistance, Neoplasm; Female; Interleukin-6; Lymphocyte Activation; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neutrophils; Photochemotherapy; Photosensitizing Agents; T-Lymphocytes

2011
Novel methods to incorporate photosensitizers into nanocarriers for cancer treatment by photodynamic therapy.
    Lasers in surgery and medicine, 2011, Volume: 43, Issue:7

    Topics: Acrylic Resins; Animals; Cell Line, Tumor; Chlorophyll; Colonic Neoplasms; Drug Carriers; Mice; Mice, Inbred BALB C; Nanoparticles; Photochemotherapy; Photosensitizing Agents

2011
Imaging a photodynamic therapy photosensitizer in vivo with a time-gated fluorescence tomography system.
    Journal of biomedical optics, 2012, Volume: 17, Issue:7

    Topics: Cell Line, Tumor; Chlorophyll; Equipment Design; Equipment Failure Analysis; Humans; Image Enhancement; Imaging, Three-Dimensional; Metabolic Clearance Rate; Microscopy, Fluorescence; Molecular Imaging; Neoplasms, Experimental; Photochemotherapy; Photosensitizing Agents; Reproducibility of Results; Sensitivity and Specificity; Tomography, Optical; Treatment Outcome

2012
Synergistic effects of photodynamic therapy with HPPH and gemcitabine in pancreatic cancer cell lines.
    Lasers in surgery and medicine, 2012, Volume: 44, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Chlorophyll; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; Humans; Pancreatic Neoplasms; Photochemotherapy; Photosensitizing Agents

2012
Comparative tumor imaging and PDT Efficacy of HPPH conjugated in the mono- and di-forms to various polymethine cyanine dyes: part - 2.
    Theranostics, 2013, Volume: 3, Issue:9

    Topics: Animals; Chlorophyll; Disease Models, Animal; Fluorescent Dyes; Humans; Indoles; Mice, Nude; Neoplasms; Optical Imaging; Pathology, Clinical; Photochemotherapy; Staining and Labeling

2013
Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.
    Theranostics, 2014, Volume: 4, Issue:3

    Topics: Animals; Cell Line, Tumor; Cell Survival; Chlorophyll; Copper Radioisotopes; Graphite; Mice; Microscopy, Fluorescence; Multimodal Imaging; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Positron-Emission Tomography

2014
Development of photodynamic therapy regimens that control primary tumor growth and inhibit secondary disease.
    Cancer immunology, immunotherapy : CII, 2015, Volume: 64, Issue:3

    Topics: Animals; Antineoplastic Agents; Chlorophyll; Colonic Neoplasms; Dihematoporphyrin Ether; Female; Lymphocyte Activation; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Photochemotherapy; Photosensitizing Agents; Random Allocation; T-Lymphocytes; Transfection

2015
Gap junction enhances phototoxicity of photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a (HPPH).
    Lasers in surgery and medicine, 2015, Volume: 47, Issue:1

    Topics: Apoptosis; Biomarkers; Bystander Effect; Caspase 3; Cell Survival; Chlorophyll; Gap Junctions; HeLa Cells; Humans; Photosensitizing Agents; Reactive Oxygen Species

2015
Photo activation of HPPH encapsulated in "Pocket" liposomes triggers multiple drug release and tumor cell killing in mouse breast cancer xenografts.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chlorophyll; Drug Liberation; Female; Fluoresceins; Humans; Lasers; Light; Liposomes; Luminescent Measurements; Mice; Mice, Nude; Photochemotherapy; Tissue Distribution; Xenograft Model Antitumor Assays

2015
Understanding the interactions between porphyrin-containing photosensitizers and polymer-coated nanoparticles in model biological environments.
    Journal of colloid and interface science, 2016, Jan-01, Volume: 461

    Topics: Cell Membrane; Chlorophyll; Drug Delivery Systems; Gold; Humans; Kinetics; Metal Nanoparticles; Models, Biological; Photosensitizing Agents; Polyethylene Glycols; Porphyrins; Surface Properties

2016
Porphyrin-phospholipid liposomes with tunable leakiness.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Dec-28, Volume: 220, Issue:Pt A

    Topics: Animals; Antibiotics, Antineoplastic; Biological Availability; Chlorophyll; Doxorubicin; Drug Compounding; Drug Stability; Female; HeLa Cells; Humans; Injections, Intravenous; Liposomes; Mice, Nude; Neoplasms; Phospholipids; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Solubility; Tumor Burden; Xenograft Model Antitumor Assays

2015
Explicit dosimetry for 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a-mediated photodynamic therapy: macroscopic singlet oxygen modeling.
    Journal of biomedical optics, 2015, Volume: 20, Issue:12

    Topics: Animals; Chlorophyll; Disease Models, Animal; Female; Fibrosarcoma; Light; Mice; Mice, Inbred C3H; Necrosis; Neoplasms; Photochemotherapy; Photosensitizing Agents; Radiometry; Singlet Oxygen

2015
Establishment and comparison of three novel methods for the determination of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) in human serum.
    Journal of pharmaceutical and biomedical analysis, 2016, Mar-20, Volume: 121

    Topics: Chlorophyll; Chromatography, High Pressure Liquid; Fluorescence; Humans; Photochemotherapy; Photosensitizing Agents; Serum; Tandem Mass Spectrometry

2016
Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity.
    International journal of molecular sciences, 2016, Jan-14, Volume: 17, Issue:1

    Topics: Animals; Autoantigens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlorophyll; ErbB Receptors; Female; Humans; Lung Neoplasms; Mice; Photochemotherapy; Proteasome Endopeptidase Complex

2016
Structural and Epimeric Isomers of HPPH [3-Devinyl 3-{1-(1-hexyloxy) ethyl}pyropheophorbide-a]: Effects on Uptake and Photodynamic Therapy of Cancer.
    ACS chemical biology, 2017, 04-21, Volume: 12, Issue:4

    Topics: Animals; Cell Line, Tumor; Chlorophyll; Head and Neck Neoplasms; Humans; Isomerism; Lung Neoplasms; Mice; Mice, Inbred BALB C; Molecular Structure; Photochemotherapy; Photosensitizing Agents

2017
Specific Targeting of Melanotic Cells with Peptide Ligated Photosensitizers for Photodynamic Therapy.
    Scientific reports, 2017, 11-16, Volume: 7, Issue:1

    Topics: Animals; Cell Proliferation; Chlorophyll; Humans; Ligands; Melanoma; Methylene Blue; Mice; Peptides; Photochemotherapy; Photosensitizing Agents; Receptors, Melanocortin

2017
Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer.
    Molecules (Basel, Switzerland), 2018, Jul-24, Volume: 23, Issue:8

    Topics: Animals; Carbocyanines; Chlorophyll; Colonic Neoplasms; Dose-Response Relationship, Radiation; Fluorescent Dyes; Glycoconjugates; Indoles; Infrared Rays; Mice; Mice, Inbred BALB C; Optical Imaging; Photobleaching; Photochemotherapy; Photosensitizing Agents; Propionates; Radiometry; Singlet Oxygen; Spectrometry, Fluorescence; Xenograft Model Antitumor Assays

2018
Cell-specific Retention and Action of Pheophorbide-based Photosensitizers in Human Lung Cancer Cells.
    Photochemistry and photobiology, 2019, Volume: 95, Issue:3

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Chlorophyll; Female; Humans; Lung Neoplasms; Male; Mice; Mice, SCID; Photochemotherapy; Photosensitizing Agents; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2019
Pre-clinical compartmental pharmacokinetic modeling of 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) as a photosensitizer in rat plasma by validated HPLC method.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2019, May-15, Volume: 18, Issue:5

    Topics: Animals; Chlorophyll; Chromatography, High Pressure Liquid; Injections, Intravenous; Kinetics; Photosensitizing Agents; Rats; Rats, Wistar

2019
Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT).
    Photochemistry and photobiology, 2020, Volume: 96, Issue:2

    Topics: Chlorophyll; Humans; Infrared Rays; Photochemotherapy; Pleural Neoplasms

2020
Pluronic F-127: An Efficient Delivery Vehicle for 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH or Photochlor).
    Photochemistry and photobiology, 2020, Volume: 96, Issue:3

    Topics: Animals; Cell Line, Tumor; Chlorophyll; Humans; Mice; Mice, Inbred BALB C; Neoplasms; Photochemotherapy; Photosensitizing Agents; Poloxamer; Xenograft Model Antitumor Assays

2020
Core-shell polymeric nanoparticles co-loaded with photosensitizer and organic dye for photodynamic therapy guided by fluorescence imaging in near and short-wave infrared spectral regions.
    Journal of nanobiotechnology, 2020, Jan-23, Volume: 18, Issue:1

    Topics: Acrylic Resins; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chlorophyll; Drug Compounding; Fluorescent Dyes; Humans; Hydrophobic and Hydrophilic Interactions; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Nanocapsules; Neoplasms; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Polymers; Polystyrenes; Singlet Oxygen; Tissue Distribution

2020
The Structures of Gd(III) Chelates Conjugated at the Periphery of 3-(1'-Hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer.
    ChemMedChem, 2020, 11-04, Volume: 15, Issue:21

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chelating Agents; Chlorophyll; Colonic Neoplasms; Drug Screening Assays, Antitumor; Gadolinium; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Optical Imaging; Photosensitizing Agents

2020
Sonodynamic therapy in combination with photodynamic therapy shows enhanced long-term cure of brain tumor.
    Scientific reports, 2020, 12-11, Volume: 10, Issue:1

    Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Chlorophyll; Mice; Mice, SCID; Photochemotherapy; Ultrasonic Waves; Xenograft Model Antitumor Assays

2020