2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole and indomethacin

2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole has been researched along with indomethacin in 5 studies

Compound Research Comparison

Studies (2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole)	Trials (2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole)	Recent Studies (post-2010) (2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole)	Studies (indomethacin)	Trials (indomethacin)	Recent Studies (post-2010) (indomethacin)
16	0	0	29,527	1,838	3,396

Protein Interaction Comparison

Protein	Taxonomy	indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2	Macaca fascicularis (crab-eating macaque)	1000
Prostaglandin-H2 D-isomerase	Mus musculus (house mouse)	1.1
Multidrug resistance-associated protein 4	Homo sapiens (human)	5.8
Prostaglandin G/H synthase 1	Bos taurus (cattle)	0.9994
Prostaglandin G/H synthase 2	Bos taurus (cattle)	0.7764
Cytochrome c oxidase subunit 2	Homo sapiens (human)	0.34
Prostaglandin G/H synthase 1	Ovis aries (sheep)	0.5605
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	0.004
Interleukin-8	Homo sapiens (human)	0.05
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	0.004
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	6
Aldo-keto reductase family 1 member B1	Bos taurus (cattle)	5
Prostaglandin G/H synthase 1	Mus musculus (house mouse)	0.011
Prostaglandin G/H synthase 1	Homo sapiens (human)	0.4848
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	0.2
Thromboxane-A synthase	Homo sapiens (human)	0.1
Indoleamine 2,3-dioxygenase 1	Mus musculus (house mouse)	0.082
Nitric oxide synthase, inducible	Mus musculus (house mouse)	4.5
Substance-P receptor	Cavia porcellus (domestic guinea pig)	5.7
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	0.2
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	0.2
Prostaglandin G/H synthase 2	Homo sapiens (human)	1.5128
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	0.5504
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	3.4486
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	0.2
C-X-C chemokine receptor type 3	Homo sapiens (human)	0.05
Aldo-keto reductase family 1 member C2	Homo sapiens (human)	8.97
Prostaglandin G/H synthase 2	Ovis aries (sheep)	3.4647
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	0.4233
Solute carrier family 22 member 6	Homo sapiens (human)	3
Sigma intracellular receptor 2	Rattus norvegicus (Norway rat)	0.49
Rho-associated protein kinase 2	Rattus norvegicus (Norway rat)	7.7
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	0.5461
P2Y purinoceptor 12	Rattus norvegicus (Norway rat)	0.96

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (60.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Akimoto, Y; Kuwahara, K; Okabe, S; Yamasaki, S	1
Miyake, H; Okabe, S; Yamasaki, S	1
Hara, K; Higaki, E; Higuchi, T; Okabe, S; Sato, M	1
Awane, Y; Miyake, H; Okabe, S	1
Inoue, K; Okabe, S; Takagi, K	1

Other Studies

5 other study(ies) available for 2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole and indomethacin

Article	Year
Effects of a new benzimidazole derivative, NC-1300-O-3, on gastric secretion and gastroduodenal lesions in rats. Japanese journal of pharmacology, 1991, Volume: 55, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Benzimidazoles; Dogs; Duodenal Ulcer; Female; Gastric Mucosa; Histamine; Immersion; In Vitro Techniques; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Psychological	1991
Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats. Digestive diseases and sciences, 1989, Volume: 34, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Administration, Oral; Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; Male; Omeprazole; Rats; Stomach Ulcer	1989
Biochemical and pharmacological analysis of 2-[(2-dimethylaminobenzyl)sulfinyl] benzimidazole (NC-1300), a new proton pump inhibitor. Japanese journal of pharmacology, 1986, Volume: 40, Issue:2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetylcholine; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Duodenum; Gastric Mucosa; Guinea Pigs; H(+)-K(+)-Exchanging ATPase; Heart Rate; Histamine; Ileum; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Omeprazole; Peptic Ulcer; Rabbits; Rats; Stress, Physiological	1986
Cytoprotective effects of NC-1300 and omeprazole on Hcl . ethanol-induced gastric lesions in rats. Japanese journal of pharmacology, 1986, Volume: 42, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Ethanol; Ethylmaleimide; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer; Sulfones	1986
Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats. Japanese journal of pharmacology, 1993, Volume: 62, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimidazoles; Gastric Acid; Gastric Mucosa; Histamine; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer	1993