Compounds > 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine

2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine and 6-nitroquipazine

2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine has been researched along with 6-nitroquipazine* in 1 studies

Other Studies

1 other study(ies) available for 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine and 6-nitroquipazine

Article	Year
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorganic & medicinal chemistry letters, 2002, Mar-11, Volume: 12, Issue:5 Eleven 4-substituted derivatives of 6-nitroquipazine were synthesized and evaluated for their abilities to displace [3H]citalopram binding to the rat cortical synaptic membranes. Among them, 4-chloro-6-nitroquipazine was shown to possess the highest binding affinity (K(i=)0.03 nM) which was approximately 6 times higher than that of 6-nitroquipazine (K(i)=0.17 nM) itself. In this paper, we describe the syntheses of 4-substituted 6-nitroquipazine derivatives, the results of corresponding biological evaluation and the SAR study. Topics: Animals; Binding, Competitive; Carrier Proteins; Cerebral Cortex; Citalopram; Drug Design; Fluoxetine; Inhibitory Concentration 50; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Structural; Nerve Tissue Proteins; Paroxetine; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship	2002

Article

Year

Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.

Bioorganic & medicinal chemistry letters, 2002, Mar-11, Volume: 12, Issue:5

Eleven 4-substituted derivatives of 6-nitroquipazine were synthesized and evaluated for their abilities to displace [3H]citalopram binding to the rat cortical synaptic membranes. Among them, 4-chloro-6-nitroquipazine was shown to possess the highest binding affinity (K(i=)0.03 nM) which was approximately 6 times higher than that of 6-nitroquipazine (K(i)=0.17 nM) itself. In this paper, we describe the syntheses of 4-substituted 6-nitroquipazine derivatives, the results of corresponding biological evaluation and the SAR study.

Topics: Animals; Binding, Competitive; Carrier Proteins; Cerebral Cortex; Citalopram; Drug Design; Fluoxetine; Inhibitory Concentration 50; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Models, Structural; Nerve Tissue Proteins; Paroxetine; Quipazine; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

2002