1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and indomethacin

Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

Topics: Analysis of Variance; Animals; Blood Pressure; Carmustine; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Glyburide; Guanylate Cyclase; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Superoxide Dismutase; Vasodilation; Ventricular Function, Left

Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Trachea

Topics: Acetylcholine; Animals; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Norepinephrine; Oxadiazoles; Potassium; Quinoxalines; Vasoconstrictor Agents; Vasodilator Agents

Topics: Acetylcholine; Animals; Barium Compounds; Chlorides; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Indomethacin; Isometric Contraction; Male; Mesenteric Arteries; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

Topics: Acetylcholine; Animals; Carbachol; Charybdotoxin; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indomethacin; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ouabain; Oxadiazoles; Peptides; Phenylephrine; Potassium; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Artery; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

Topics: 4-Aminopyridine; Acetylcholine; Animals; Arachidonic Acids; Biological Factors; Cerebral Arteries; Charybdotoxin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Ouabain; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Vasodilation; Vasodilator Agents

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Calcium; Colforsin; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Indomethacin; Ionophores; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Potassium Chloride; Quinoxalines; Saphenous Vein; Vasoconstrictor Agents; Vasodilation

Topics: Acetylcholine; Animals; Barium; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Glycyrrhetinic Acid; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Ouabain; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Inbred WKY; Renal Artery; Vasodilation; Vasodilator Agents

Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Hydrazones; In Vitro Techniques; Indomethacin; Male; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Thiophenes; Vasoconstriction; Vasodilator Agents

Topics: Adenosine Triphosphate; Animals; Biological Factors; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Long-Evans; Thionucleotides; Vasodilation

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Body Temperature Regulation; Carbon Monoxide; Cerebrospinal Fluid; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hemin; Hypothalamus; Indomethacin; Injections, Intraventricular; Male; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley

Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carotid Arteries; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Retina; Sarcoplasmic Reticulum; Thapsigargin; Vasodilation; Vasodilator Agents

Topics: Animals; Aorta, Thoracic; Asteraceae; Brazil; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethanol; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Oxadiazoles; Phenylephrine; Plant Extracts; Plant Roots; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasoconstriction; Vasodilation

Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide

Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Endocardium; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Hemodynamics; Hypertrophy, Left Ventricular; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium Channels; Quinoxalines; Swine; Vascular Resistance; Vasodilation

Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cyclic GMP; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Hemoglobins; Hypertension, Renovascular; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Vasodilator Agents

Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Horses; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Phenylephrine; Potassium; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Sodium Nitrite; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Veins

Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Dideoxyadenosine; Enzyme Inhibitors; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Nitroarginine; Oxadiazoles; Peptide Fragments; Peptides; Pupil; Quinoxalines; Signal Transduction

Topics: Amides; Animals; Blotting, Western; Celiac Artery; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Guanine Nucleotide Exchange Factors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil

Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Dinoprost; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Female; Flavonoids; Glyburide; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Oxytocics; Potassium Channel Blockers; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Vasodilation

Topics: Animals; Ascorbic Acid; Boron Compounds; Connexin 43; Connexins; Dose-Response Relationship, Drug; Endothelium, Vascular; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Gap Junctions; Hydrazines; Iliac Artery; Indoles; Indomethacin; Male; Membrane Potentials; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rabbits; Vasodilation

Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Charybdotoxin; Cholesterol; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hypercholesterolemia; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Oxidative Stress; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Vasodilation; Vasodilator Agents

Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Autonomic Denervation; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Phenylephrine; Quinoxalines; Rats

Topics: Acetylcholine; Amidohydrolases; Animals; Arginase; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin-1; Indomethacin; Lung Diseases; Male; Models, Biological; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasoconstriction

Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Free Radical Scavengers; Guanylate Cyclase; Humans; Hydrogen Peroxide; Hydroquinones; In Vitro Techniques; Indomethacin; Mannitol; Mesenteric Artery, Superior; Methylene Blue; Muramidase; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Prostaglandins; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sepsis; Signal Transduction; Soluble Guanylyl Cyclase; Thionucleotides; Time Factors; Vasoconstrictor Agents; Vasodilation

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta, Thoracic; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Potassium; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Thiourea; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Female; Indomethacin; Naltrexone; Oxadiazoles; Oxidative Stress; Pyrithioxin; Quinoxalines; Rats; Rats, Wistar; Streptozocin

Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dopamine; Drug Interactions; Enzyme Inhibitors; Indomethacin; Interleukin-1beta; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar; Sensory Receptor Cells; Signal Transduction

Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Oxadiazoles; Penis; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rabbits; Stephania tetrandra; Tetraethylammonium

Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels, L-Type; Desoxycorticosterone; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypertension; Indomethacin; Male; Nitroarginine; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

Topics: Analysis of Variance; Animals; Aorta; Barium Compounds; Calcium Chloride; Chlorides; Endothelium, Vascular; Glyburide; Indomethacin; Male; Methoxamine; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasodilation; Vasodilator Agents; Xanthones

Topics: Animals; Calcium; Cyclooxygenase Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Potassium; Potassium Channel Blockers; Potassium Channels; Progesterone; Quinoxalines; Receptors, Progesterone; Swine; Urinary Bladder; Urothelium

Topics: Animals; Biological Factors; Electric Stimulation; Glyburide; Hemodynamics; Indomethacin; Male; Nitric Oxide; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Succinates; Sympathetic Nervous System; Synaptic Transmission

Topics: Animals; Bradykinin; Carbenoxolone; Catalase; Colforsin; Coronary Vessels; Female; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Ouabain; Oxadiazoles; Peptides; Polyethylene Glycols; Quinoxalines; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents; Vasodilation; Verapamil

Topics: Coculture Techniques; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelial Cells; Humans; Indomethacin; Myocytes, Smooth Muscle; Nitroarginine; Oxadiazoles; Quinoxalines; Receptors, G-Protein-Coupled; Receptors, Peptide; Recombinant Proteins; Relaxin; Signal Transduction; Umbilical Arteries; Umbilical Veins

Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents