1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole

1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (19.23)18.2507
2000's17 (65.38)29.6817
2010's4 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Hebeiss, K; Kilbinger, H1
Behrends, S; Harteneck, C; Koesling, D; Russwurm, M1
Faraci, FM; Sobey, CG1
Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U1
Clement, B; Feelisch, M; Kotsonis, P; Schmidt, HH; Siebe, J1
Lee, YC; Martin, E; Murad, F1
Bellamy, TC; Garthwaite, J1
Homer, KL; Wanstall, JC1
Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP1
Browner, NC; Lincoln, TM; Sellak, H1
Cheng, JT; Liao, CH; Teng, CM1
Chlopicki, S; Lomnicka, M; Marcinkiewicz, E; Motterlini, R; Olszanecki, R1
Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF1
Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM1
Grześk, G; Jasiński, M; Masztalerz, M; Piotrowiak, I; Slupski, M; Szadujkis-Szadurska, K; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R; Wlodarczyk, Z1
Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J1
Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S1
Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P1
Dismuke, WM; Ellis, DZ; Sharif, NA1
Agar, A; Akpinar, D; Savcioglu, F; Yargicoglu, P1
Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z1
Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS1
Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R1
Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M1

Other Studies

26 other study(ies) available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
    Neuroscience, 1998, Volume: 82, Issue:2

    Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Ileum; Indazoles; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Synaptic Transmission

1998
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
    The Biochemical journal, 1998, Oct-01, Volume: 335 ( Pt 1)

    Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera

1998
Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation.
    Brain research, 1999, Mar-13, Volume: 821, Issue:2

    Topics: Acetylcholine; Adenosine; Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Growth Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indazoles; Microcirculation; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Rabbits; Solubility; Vasodilation; Vasodilator Agents

1999
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
    British journal of pharmacology, 1999, Volume: 127, Issue:1

    Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents

1999
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation.
    Molecular pharmacology, 1999, Volume: 56, Issue:2

    Topics: Animals; Aorta; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hemeproteins; Indazoles; Male; Microsomes, Liver; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation

1999
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Nov-06, Volume: 98, Issue:23

    Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility

2001
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
    British journal of pharmacology, 2002, Volume: 136, Issue:1

    Topics: Animals; Cerebellum; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Kinetics; Nitric Oxide; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2002
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
    British journal of pharmacology, 2002, Volume: 137, Issue:7

    Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction

2002
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
    European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2

    Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents

2003
Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
    American journal of physiology. Cell physiology, 2004, Volume: 287, Issue:1

    Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activators; Enzyme Inhibitors; Humans; Indazoles; Interleukin-1; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroso Compounds; Nucleotides, Cyclic; Oxadiazoles; Quinoxalines; Recombinant Proteins; Tumor Necrosis Factor-alpha

2004
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
    European journal of pharmacology, 2005, Sep-05, Volume: 519, Issue:1-2

    Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors

2005
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
    Cardiovascular research, 2006, Jul-15, Volume: 71, Issue:2

    Topics: Analysis of Variance; Blood Platelets; Carbon Monoxide; Collagen; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide Donors; Organometallic Compounds; Oxadiazoles; Penicillamine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Spectrophotometry; Statistics, Nonparametric; Thrombin; Time Factors

2006
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:4

    Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines

2007
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
    British journal of pharmacology, 2007, Volume: 151, Issue:3

    Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides

2007
Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
    Transplantation proceedings, 2007, Volume: 39, Issue:5

    Topics: Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indazoles; Kidney Transplantation; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Organ Preservation; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Retrospective Studies; Vasodilation; Vasodilator Agents

2007
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
    Cardiovascular research, 2007, Oct-01, Volume: 76, Issue:1

    Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents

2007
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
    Canadian journal of physiology and pharmacology, 2007, Volume: 85, Issue:5

    Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation

2007
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:5

    Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2008
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork

2009
The effect of heme oxygenase inhibition on visual evoked potentials.
    The International journal of neuroscience, 2009, Volume: 119, Issue:9

    Topics: Animals; Arsenites; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Evoked Potentials, Visual; Heme Oxygenase (Decyclizing); Indazoles; Male; Metalloporphyrins; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Compounds; Visual Pathways

2009
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
    Cellular and molecular neurobiology, 2011, Volume: 31, Issue:2

    Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling

2011
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 338, Issue:3

    Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic

2011
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
    Postepy higieny i medycyny doswiadczalnej (Online), 2011, Aug-05, Volume: 65

    Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea

2011
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.
    Nitric oxide : biology and chemistry, 2016, 08-31, Volume: 58

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents

2016