1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one has been researched along with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 17 (65.38) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Hebeiss, K; Kilbinger, H | 1 |
| Behrends, S; Harteneck, C; Koesling, D; Russwurm, M | 1 |
| Faraci, FM; Sobey, CG | 1 |
| Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U | 1 |
| Clement, B; Feelisch, M; Kotsonis, P; Schmidt, HH; Siebe, J | 1 |
| Lee, YC; Martin, E; Murad, F | 1 |
| Bellamy, TC; Garthwaite, J | 1 |
| Homer, KL; Wanstall, JC | 1 |
| Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP | 1 |
| Browner, NC; Lincoln, TM; Sellak, H | 1 |
| Cheng, JT; Liao, CH; Teng, CM | 1 |
| Chlopicki, S; Lomnicka, M; Marcinkiewicz, E; Motterlini, R; Olszanecki, R | 1 |
| Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF | 1 |
| Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM | 1 |
| Grześk, G; Jasiński, M; Masztalerz, M; Piotrowiak, I; Slupski, M; Szadujkis-Szadurska, K; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R; Wlodarczyk, Z | 1 |
| Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J | 1 |
| Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S | 1 |
| Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P | 1 |
| Dismuke, WM; Ellis, DZ; Sharif, NA | 1 |
| Agar, A; Akpinar, D; Savcioglu, F; Yargicoglu, P | 1 |
| Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z | 1 |
| Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS | 1 |
| Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R | 1 |
| Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M | 1 |
26 other study(ies) available for 1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Ileum; Indazoles; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Synaptic Transmission | 1998 |
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera | 1998 |
Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation.
Topics: Acetylcholine; Adenosine; Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Growth Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indazoles; Microcirculation; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Rabbits; Solubility; Vasodilation; Vasodilator Agents | 1999 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents | 1999 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation.
Topics: Animals; Aorta; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hemeproteins; Indazoles; Male; Microsomes, Liver; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 1999 |
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility | 2001 |
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Topics: Animals; Cerebellum; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Kinetics; Nitric Oxide; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2002 |
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction | 2002 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activators; Enzyme Inhibitors; Humans; Indazoles; Interleukin-1; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroso Compounds; Nucleotides, Cyclic; Oxadiazoles; Quinoxalines; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2004 |
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors | 2005 |
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
Topics: Analysis of Variance; Blood Platelets; Carbon Monoxide; Collagen; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide Donors; Organometallic Compounds; Oxadiazoles; Penicillamine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Spectrophotometry; Statistics, Nonparametric; Thrombin; Time Factors | 2006 |
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines | 2007 |
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides | 2007 |
Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Topics: Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indazoles; Kidney Transplantation; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Organ Preservation; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Retrospective Studies; Vasodilation; Vasodilator Agents | 2007 |
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents | 2007 |
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation | 2007 |
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork | 2009 |
The effect of heme oxygenase inhibition on visual evoked potentials.
Topics: Animals; Arsenites; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Evoked Potentials, Visual; Heme Oxygenase (Decyclizing); Indazoles; Male; Metalloporphyrins; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Compounds; Visual Pathways | 2009 |
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling | 2011 |
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic | 2011 |
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea | 2011 |
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2016 |