19-hydroxy-4-androstene-3-17-dione has been researched along with 11-hydroxyandrostenedione* in 1 studies
1 other study(ies) available for 19-hydroxy-4-androstene-3-17-dione and 11-hydroxyandrostenedione
| Article | Year |
|---|---|
19-hydroxyandrostenedione as a new hypertensinogenic agent.
The hypertensiogenic effects of 19-hydroxyandrostenedione (19-OH-A-dione) reported previously to be an amplifier of the action of aldosterone were evaluated using the same experimental procedures as for DOCA-salt hypertension in rats. The 19-OH-A-dione treated rats developed high blood pressure, hypokalemia, suppressed plasma renin activity and low plasma aldosterone and corticosterone concentrations as the DOCA treated rats did. The results demonstrate that 19-OH-A-dione amplifies the action of endogenous aldosterone and causes a hypertensive state simulating mineralocorticoid excess. Amplifiers of the action of aldosterone are considered to work as hypertensinogenic agents in the presence of the adrenal cortex. Topics: Aldosterone; Androstenedione; Animals; Blood Pressure; Corticosterone; Desoxycorticosterone; Hypertension; Male; Potassium; Rats; Renin | 1982 |