19-20-epoxycytochalasin-q and anibamine

19-20-epoxycytochalasin-q has been researched along with anibamine* in 1 studies

Other Studies

1 other study(ies) available for 19-20-epoxycytochalasin-q and anibamine

Article	Year
Isolation and structure of antagonists of chemokine receptor (CCR5). Journal of natural products, 2004, Volume: 67, Issue:6 Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this binding by a small molecule receptor antagonist could lead to a new mode of action agent for HIV-1 and AIDS. Screening of natural product extracts led to the identification of anibamine (1), a novel pyridine quaternary alkaloid as a TFA salt, from Aniba sp.; ophiobolin C from fermentation extracts of fungi Mollisia sp.; and 19,20-epoxycytochalasin Q from Xylaria sp. Formation of the TFA salt of anibamine is plausibly an artifact of the isolation. The identity of the natural counterion is unknown. Anibamine.TFA competed for the binding of 125I-gp120 to human CCR5 with an IC50 of 1 microM. Ophiobolin C and 19,20-epoxycytochalasin Q exhibited binding IC50) values of 40 and 60 microM, respectively. Topics: CCR5 Receptor Antagonists; CD4 Antigens; Cytochalasins; Fungi; HIV Envelope Protein gp120; Humans; Inhibitory Concentration 50; Lauraceae; Molecular Structure; Pyridines; Sesterterpenes; Terpenes	2004

Article

Year

Isolation and structure of antagonists of chemokine receptor (CCR5).

Journal of natural products, 2004, Volume: 67, Issue:6

Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this binding by a small molecule receptor antagonist could lead to a new mode of action agent for HIV-1 and AIDS. Screening of natural product extracts led to the identification of anibamine (1), a novel pyridine quaternary alkaloid as a TFA salt, from Aniba sp.; ophiobolin C from fermentation extracts of fungi Mollisia sp.; and 19,20-epoxycytochalasin Q from Xylaria sp. Formation of the TFA salt of anibamine is plausibly an artifact of the isolation. The identity of the natural counterion is unknown. Anibamine.TFA competed for the binding of 125I-gp120 to human CCR5 with an IC50 of 1 microM. Ophiobolin C and 19,20-epoxycytochalasin Q exhibited binding IC50) values of 40 and 60 microM, respectively.

Topics: CCR5 Receptor Antagonists; CD4 Antigens; Cytochalasins; Fungi; HIV Envelope Protein gp120; Humans; Inhibitory Concentration 50; Lauraceae; Molecular Structure; Pyridines; Sesterterpenes; Terpenes

2004