18f-fluoroethyl-l-tyrosine and fluorocholine

We report on a 71-year-old woman presenting with biochemical features indicating recurrent disease in long-term follow-up of left-sided parathyroid carcinoma. She had undergone several surgical procedures including total thyroidectomy, partial resection of the esophageal wall, and curative neck radiation 12 years previously. PET/CT using F-fluorocholine revealed high uptake in local relapse in the lower neck, comparable to F-FDG, whereas only faint uptake was observed with F-fluoroethyl tyrosine. As shown in this case, imaging with FDG and F-fluorocholine is feasible in (recurrent) parathyroid carcinoma and clearly superior to F-fluoroethyl tyrosine.

Topics: Aged; Choline; Female; Fluorodeoxyglucose F18; Humans; Parathyroid Neoplasms; Positron Emission Tomography Computed Tomography; Recurrence; Thyroidectomy; Tyrosine

The differential diagnosis between recurrence of gliomas or brain metastases and this phenomenon is important in order to choose the best therapy and predict the prognosis but is still a big problem for physicians. The new emerging MRI, CT, and PET diagnostic modalities still lack sufficient accuracy. Radiolabeled choline and amino acids have been reported to show great tumor specificity. We studied the uptake kinetics of [

Topics: Carbon; Cell Line, Tumor; Choline; Diagnosis, Differential; Glioblastoma; Humans; Ions; Neoplasm Metastasis; Photons; Tyrosine