Compounds > 17-hydroxywortmannin
Page last updated: 2024-09-03

17-hydroxywortmannin and wortmannin

17-hydroxywortmannin has been researched along with wortmannin in 4 studies

Compound Research Comparison

Studies
(17-hydroxywortmannin)		Trials
(17-hydroxywortmannin)		Recent Studies (post-2010)
(17-hydroxywortmannin)		Studies
(wortmannin)		Trials
(wortmannin)		Recent Studies (post-2010) (wortmannin)
15014,0662726

Protein Interaction Comparison

ProteinTaxonomy17-hydroxywortmannin (IC50)wortmannin (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0465
Myosin light chain kinase, smooth muscleGallus gallus (chicken)0.26
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)0.0085
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.2368
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.1309
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.0493
Serine/threonine-protein kinase mTORHomo sapiens (human)0.04
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)0.28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.0492
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4433
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.3567
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.019
Serine/threonine-protein kinase PLK3Homo sapiens (human)0.1057
Phosphatidylinositol 4-kinase betaHomo sapiens (human)0.44

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dodge, JA; Johnson, DW; Norman, BH; Ray, JE; Rutherford, PG; Schultz, RM; Shih, C; Toth, JE; Vlahos, CJ; Worzalla, JF1
Langen, H; Thelen, M; Wymann, MP1
Dixon, SJ; Pilkington, MF; Sims, SM1
Ayral-Kaloustian, S; Cai, P; Chaudhary, I; Desai, P; Fawzi, M; Gibbons, J; Gong, Y; Gu, J; Li, F; Lucas, J; Mansour, T; Ruppen, M; Skotnicki, J; Tsao, R; Yu, K; Zask, A; Zhu, T1

Other Studies

4 other study(ies) available for 17-hydroxywortmannin and wortmannin

ArticleYear
Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs.
    Journal of medicinal chemistry, 1996, Mar-01, Volume: 39, Issue:5

    Topics: Androstadienes; Animals; Antineoplastic Agents; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Mammary Neoplasms, Experimental; Mice; Models, Molecular; Molecular Conformation; Molecular Structure; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Structure-Activity Relationship; Thermodynamics; Tumor Cells, Cultured; Wortmannin

1996
Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, May-24, Volume: 91, Issue:11

    Topics: Androstadienes; Blotting, Western; Exocytosis; GTP-Binding Proteins; Humans; In Vitro Techniques; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Receptors, Cell Surface; Signal Transduction; Superoxides; Wortmannin

1994
Wortmannin inhibits spreading and chemotaxis of rat osteoclasts in vitro.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:4

    Topics: Androstadienes; Animals; Bone Resorption; Cell Movement; Cell Size; Chemotaxis; Chromones; Femur; Macrophage Colony-Stimulating Factor; Microscopy, Video; Morpholines; Osteoclasts; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Structure-Activity Relationship; Tibia; Wortmannin

1998
Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models.
    Journal of medicinal chemistry, 2006, Feb-23, Volume: 49, Issue:4

    Topics: Androstadienes; Animals; Antineoplastic Agents; Humans; Mice; Mice, Nude; Phosphoinositide-3 Kinase Inhibitors; Polyethylene Glycols; Structure-Activity Relationship; Wortmannin; Xenograft Model Antitumor Assays

2006