17-hydroxywortmannin has been researched along with sirolimus in 2 studies
| Studies (17-hydroxywortmannin) | Trials (17-hydroxywortmannin) | Recent Studies (post-2010) (17-hydroxywortmannin) | Studies (sirolimus) | Trials (sirolimus) | Recent Studies (post-2010) (sirolimus) |
|---|---|---|---|---|---|
| 15 | 0 | 1 | 20,711 | 2,368 | 11,516 |
| Protein | Taxonomy | 17-hydroxywortmannin (IC50) | sirolimus (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.25 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 2 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Mus musculus (house mouse) | 0.001 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 4 | |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | 0.0897 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | 0.0042 | |
| Regulatory-associated protein of mTOR | Homo sapiens (human) | 0.225 | |
| Target of rapamycin complex subunit LST8 | Homo sapiens (human) | 0.225 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.9 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ayral-Kaloustian, S; Cai, P; Chaudhary, I; Fawzi, M; Frost, P; Gaydos, C; Gibbons, J; Gu, J; Li, F; Lotvin, J; Lucas, J; Mansour, T; Petersen, R; Ruppen, M; Skotnicki, J; Toral-Barza, L; Yu, K; Zask, A; Zhu, T | 1 |
| Lengauer, C; Samuels, Y; Zhu, J | 1 |
2 other study(ies) available for 17-hydroxywortmannin and sirolimus
| Article | Year |
|---|---|
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Glioma; Humans; Interferon-alpha; Kidney Neoplasms; Lung Neoplasms; Mice; Mice, Nude; Molecular Structure; Molecular Weight; Neoplasm Transplantation; Neoplasms; Paclitaxel; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2005 |
Inhibiting phosphoinositide 3-kinases.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Glioma; Humans; Interferon alpha-2; Interferon-alpha; Mice; Mice, Nude; Neoplasm Transplantation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Sirolimus; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2005 |