17-hydroxy-4-7-10-13-15-19-docosahexaenoic-acid and 20-hydroxy-5-8-11-14-eicosatetraenoic-acid

Dexamethasone is an antiemetic that is frequently administered before or after the induction of anesthesia for prevention and treatment of perioperative nausea and vomiting. Dexamethasone has anti-inflammatory and immunosuppressive effects primarily via suppression of expression of inflammatory mediators. However, its effect on the eicosanoids and docosanoids that mediate the inflammatory response and inflammation resolution are unclear. We aimed to assess the effect of a single dose of intra-operative dexamethasone on peri‑operative eicosanoids involved in inflammation including leukotriene B. A subgroup of 80 patients from the randomised controlled PADDAG trial was enrolled into this substudy. They were allocated to receive 0, 4 or 8 mg dexamethasone administered intravenously at induction of anesthesia. Blood samples were collected before and 24 h after dexamethasone, for measurement of leukocytes, hs-CRP, LTB. Compared to the administration of placebo, neutrophil count was elevated (P<0.05) 24 h after administration of 4 and 8 mg dexamethasone. Dexamethasone (8 mg) resulted in increased levels of LTB. Antiemetic doses of dexamethasone given during surgery increased plasma LTB

Topics: Adult; Antiemetics; C-Reactive Protein; Dexamethasone; Docosahexaenoic Acids; Eicosanoids; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Female; Humans; Hydroxyeicosatetraenoic Acids; Inflammation; Leukocyte Count; Leukotriene B4; Lymphocyte Count; Male; Middle Aged; Neutrophils; Perioperative Care