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17 alpha-hydroxyprogesterone caproate and tamoxifen

17 alpha-hydroxyprogesterone caproate has been researched along with tamoxifen in 14 studies

Compound Research Comparison

Studies
(17 alpha-hydroxyprogesterone caproate)
Trials
(17 alpha-hydroxyprogesterone caproate)
Recent Studies (post-2010)
(17 alpha-hydroxyprogesterone caproate)
Studies
(tamoxifen)
Trials
(tamoxifen)
Recent Studies (post-2010) (tamoxifen)
5178825120,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomy17 alpha-hydroxyprogesterone caproate (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19906 (42.86)18.7374
1990's6 (42.86)18.2507
2000's1 (7.14)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bobrov, JF; Bokhman, JV; Chepick, OF; Shtofmakher, JA; Sofroniy, DF; Tsyrlina, EV; Vishnevsky, AS1
Bakhidze, EV1
Bokhman, IaV; Chepik, OF; Vishnevskiĭ, AS; Volkova, AT1
Iglódi, F1
Bobrov, IuF; Bokhman, IaV; Shtofmakher, IA; Tsyrlina, EV; Vishnevskiĭ, AS2
Fujimoto, J; Fujita, H; Nakata, Y; Okada, H1
Gerhard, I; Runnebaum, B1
Loktionov, AS; Prianishnikov, VA1
Loutfi, G; Vishnevsky, AS1
Bokhman, IV; Chepik, OF; Ermakova, NA; Maksimov, SI; Mikaia, NA; Nezhentseva, EL; Tsyrlina, EV; Vishnevskiĭ, AS1
Cao, B; Zhang, X1
Izutsu, T; Sugiyama, T1

Reviews

2 review(s) available for 17 alpha-hydroxyprogesterone caproate and tamoxifen

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Hormone therapy for uterine corpus cancer--introduction].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 10

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Agents, Hormonal; Endometrial Neoplasms; Estrogens; Female; Gonadotropin-Releasing Hormone; Humans; Hydroxyprogesterones; Leuprolide; Medroxyprogesterone Acetate; Raloxifene Hydrochloride; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome

2004

Trials

2 trial(s) available for 17 alpha-hydroxyprogesterone caproate and tamoxifen

ArticleYear
Favourable influence of adjuvant hormone therapy by oxyprogesterone caproate (OPC) and by its combination with tamoxifen on 5-year survival rate of surgical and combined treatment of primary endometrial carcinoma patients.
    European journal of gynaecological oncology, 1993, Volume: 14, Issue:2

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Endometrial Neoplasms; Female; Humans; Hydroxyprogesterones; Hysterectomy; Middle Aged; Neoplasms, Hormone-Dependent; Prospective Studies; Survival Rate; Tamoxifen

1993
Exploration for drug therapy in endometrial carcinoma.
    Chinese medical journal, 1996, Volume: 109, Issue:5

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adenocarcinoma; Aged; Aged, 80 and over; Aminoglutethimide; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Carcinoma, Squamous Cell; Double-Blind Method; Endometrial Neoplasms; Female; Humans; Hydroxyprogesterones; Middle Aged; Tamoxifen

1996

Other Studies

10 other study(ies) available for 17 alpha-hydroxyprogesterone caproate and tamoxifen

ArticleYear
Effect of oxyprogesterone caproate, tamoxifen and their combination on the level of steroid hormone receptors in the tumor, and some parameters of the reproductive system in patients with endometrial cancer.
    Clinical and experimental obstetrics & gynecology, 1990, Volume: 17, Issue:3-4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Combined Chemotherapy Protocols; Cytoplasm; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hydroxyprogesterones; Luteinizing Hormone; Middle Aged; Receptors, Estradiol; Receptors, Progesterone; Tamoxifen; Uterine Neoplasms; Vagina

1990
Application of thymic factor "Thymalin" in complex treatment of endometrial cancer patients.
    European journal of gynaecological oncology, 1990, Volume: 11, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adjuvants, Immunologic; Antineoplastic Agents; Cells, Cultured; Combined Modality Therapy; Estradiol; Female; Humans; Hydroxyprogesterones; Immunity, Cellular; Middle Aged; Rosette Formation; Survival Rate; T-Lymphocyte Subsets; Tamoxifen; Thymus Hormones; Uterine Neoplasms

1990
[Regularities and paradoxes of endocrine dependence and hormonal therapy of endometrial cancer].
    Voprosy onkologii, 1990, Volume: 36, Issue:11

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adenocarcinoma; Adult; Delayed-Action Preparations; Estrogen Antagonists; Female; Humans; Hydroxyprogesterones; Middle Aged; Pregnancy; Pregnancy Complications, Neoplastic; Progesterone Congeners; Tamoxifen; Uterine Neoplasms

1990
Endocrine therapy monitored by hormone cytological examination in advanced female breast cancer.
    Therapia Hungarica (English edition), 1989, Volume: 37, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Antineoplastic Agents; Breast Neoplasms; Cell Differentiation; Drug Therapy, Combination; Female; Humans; Hydroxyprogesterones; Menopause; Tamoxifen; Testosterone; Vaginal Smears

1989
[The effect of hydroxyprogesterone caproate and its combination with tamoxifen on steroid hormone receptors in the tumor and on the basic parameters of reproductive homeostasis in patients with cancer of the corpus uteri].
    Voprosy onkologii, 1989, Volume: 35, Issue:9

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Combined Modality Therapy; Drug Evaluation; Drug Therapy, Combination; Female; Homeostasis; Humans; Hydroxyprogesterones; Middle Aged; Preoperative Care; Progesterone Congeners; Receptors, Estradiol; Receptors, Progesterone; Reproduction; Tamoxifen; Uterine Neoplasms

1989
[Hormone dependency and progestogen therapy in the treatment of endometrial cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Cell Division; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Neoplasms, Hormone-Dependent; Norethindrone; Tamoxifen; Tumor Stem Cell Assay; Uterine Neoplasms

1987
[Effects of tamoxifen and oxyprogesterone caproate on steroid hormone receptors in tumors and indicators of reproductive homeostasis in patients with cancer of the uterine body].
    Akusherstvo i ginekologiia, 1988, Issue:11

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Endometrium; Female; Gonadotropins, Pituitary; Humans; Hydroxyprogesterones; Middle Aged; Prolactin; Receptors, Estradiol; Receptors, Progesterone; Tamoxifen; Uterine Neoplasms

1988
Hormone load tests in the first half of pregnancy--a diagnostic and therapeutic approach.
    Biological research in pregnancy and perinatology, 1984, Volume: 5, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Abortion, Spontaneous; Abortion, Threatened; Allylestrenol; Betamethasone; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Dehydroepiandrosterone; Endocrine Glands; Estradiol; Female; Hormones; Humans; Hydroxyprogesterones; Peptide Fragments; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Progesterone; Promegestone; Tamoxifen

1984
[Autoradiographic study of hormonal regulation of proliferating golden hamster uterus cells during postnatal ontogeny].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 92, Issue:9

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Animals; Autoradiography; Cricetinae; Female; Hexestrol; Hydroxyprogesterones; Mesocricetus; Mitotic Index; Tamoxifen; Thymidine; Uterus

1981
[Parameters of estrogen expression in patients with endometrial tumors as prognostic signs of the effectiveness of neoadjuvant antitumor hormone therapy].
    Voprosy onkologii, 1996, Volume: 42, Issue:5

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Aged; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Endometrial Neoplasms; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprogesterones; Middle Aged; Postmenopause; Prognosis; Tamoxifen

1996