Page last updated: 2024-09-05

17 alpha-hydroxyprogesterone caproate and medroxyprogesterone acetate

17 alpha-hydroxyprogesterone caproate has been researched along with medroxyprogesterone acetate in 25 studies

Compound Research Comparison

Studies
(17 alpha-hydroxyprogesterone caproate)
Trials
(17 alpha-hydroxyprogesterone caproate)
Recent Studies (post-2010)
(17 alpha-hydroxyprogesterone caproate)
Studies
(medroxyprogesterone acetate)
Trials
(medroxyprogesterone acetate)
Recent Studies (post-2010) (medroxyprogesterone acetate)
517882515,1231,1151,099

Protein Interaction Comparison

ProteinTaxonomy17 alpha-hydroxyprogesterone caproate (IC50)medroxyprogesterone acetate (IC50)
Estrogen receptorHomo sapiens (human)0.924
Glucocorticoid receptorHomo sapiens (human)0.013
Progesterone receptorHomo sapiens (human)2.5081
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)0.019
Mineralocorticoid receptor Homo sapiens (human)1.197
Androgen receptorHomo sapiens (human)0.0061
Androgen receptorRattus norvegicus (Norway rat)0.279
Glycine receptor subunit betaRattus norvegicus (Norway rat)0.019
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.019
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.019
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)1.197
Aldo-keto reductase family 1 member C3Homo sapiens (human)1.4059
Aldo-keto reductase family 1 member C2 Homo sapiens (human)4.0405
Aldo-keto reductase family 1 member C1Homo sapiens (human)1.8
Estrogen receptor betaHomo sapiens (human)0.924

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19908 (32.00)18.7374
1990's5 (20.00)18.2507
2000's9 (36.00)29.6817
2010's3 (12.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kollman, PA; Lee, DL; Marsh, FJ; Wolff, ME1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Titova, VA; Voznyĭ, EK1
Bobrov, IuF; Bokhman, IaV; Fel'dkoren, BI; Tsyrlina, EV; Vishnevskiĭ, AS1
Ashkenazy, M; Czernobilsky, B; Kessler, I; Lancet, M; Nahshoni, A1
Fujimoto, J; Fujita, H; Nakata, Y; Okada, H1
Roopnarinesingh, S1
Bauer, J; Papez, L1
Das Gupta, V1
Sang, GW1
Koetsawang, S1
Giwa-Osagie, OF1
Jarvis, G; Kitchener, H; Lilford, R; Martin-Hirsch P, L1
Adamian, RT1
Charkviani, L; Charkviani, T; Kobiashvili, H1
Izutsu, T; Sugiyama, T1
Aoki, D; Banno, K; Nozawa, S; Susumu, N; Suzuki, A; Suzuki, N; Tamada, Y1
Delke, I; Kaunitz, AM; Sanchez-Ramos, L1
Elovitz, MA; Mrinalini, C1
Caritis, S; Mada, SR; Mattison, D; Sharma, S; Torch, M; Venkataramanan, R; Zhang, S1
Huo, Z; Lang, JH; Shen, K; Wu, M; Yang, JX; Yu, M1
Brockbank, E; Bryant, A; Gallagher, C; Kokka, F; Oram, D1
Allen, TK; Buhimschi, IA; Feng, L; Grotegut, CA; Murtha, AP; Nazzal, M1

Reviews

9 review(s) available for 17 alpha-hydroxyprogesterone caproate and medroxyprogesterone acetate

ArticleYear
Pharmacodynamic effects of once-a-month combined injectable contraceptives.
    Contraception, 1994, Volume: 49, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Algestone Acetophenide; China; Contraceptive Agents, Female; Contraceptives, Oral, Combined; Delayed-Action Preparations; Drug Combinations; Estradiol; Female; Humans; Hydroxyprogesterones; Injections, Intramuscular; Latin America; Medroxyprogesterone Acetate; Norethindrone

1994
Once-a-month injectable contraceptives: efficacy and reasons for discontinuation.
    Contraception, 1994, Volume: 49, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Algestone Acetophenide; Clinical Trials, Phase III as Topic; Contraceptive Agents, Female; Contraceptives, Oral, Combined; Delayed-Action Preparations; Drug Combinations; Estradiol; Female; Humans; Hydroxyprogesterones; Injections, Intramuscular; Medroxyprogesterone Acetate; Multicenter Studies as Topic; Norethindrone; Randomized Controlled Trials as Topic

1994
Metabolic effects of once-a-month combined injectable contraceptives. The World Health Organization Task Force on Long-Acting Systemic Agents for Fertility Regulation, Geneva, Switzerland.
    Contraception, 1994, Volume: 49, Issue:5

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Algestone Acetophenide; Carbohydrate Metabolism; Contraceptive Agents, Female; Estradiol; Female; Hemostasis; Humans; Hydroxyprogesterones; Injections; Lipid Metabolism; Medroxyprogesterone Acetate; Norethindrone

1994
Facts about once-a-month injectable contraceptives: memorandum from a WHO meeting.
    Bulletin of the World Health Organization, 1993, Volume: 71, Issue:6

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Animals; Contraceptive Agents, Female; Contraceptives, Oral, Combined; Delayed-Action Preparations; Drug Combinations; Drug Evaluation; Estradiol; Estrogen Antagonists; Estrogens, Conjugated (USP); Female; Humans; Hydroxyprogesterones; Injections, Intramuscular; Medroxyprogesterone Acetate; Norethindrone; World Health Organization

1993
Progestagens for endometrial cancer.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone Acetate; Progestins

2000
[Hormone therapy for uterine corpus cancer--introduction].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 10

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Agents, Hormonal; Endometrial Neoplasms; Estrogens; Female; Gonadotropin-Releasing Hormone; Humans; Hydroxyprogesterones; Leuprolide; Medroxyprogesterone Acetate; Raloxifene Hydrochloride; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome

2004
[Conservative hormonal therapy for endometrial cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 10

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Agents, Hormonal; Endometrial Neoplasms; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone Acetate; Megestrol Acetate; Neoplasm Recurrence, Local; Neoplasm Staging; Treatment Outcome

2004
Progestational agents to prevent preterm birth: a meta-analysis of randomized controlled trials.
    Obstetrics and gynecology, 2005, Volume: 105, Issue:2

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adolescent; Adult; Confidence Intervals; Female; Follow-Up Studies; Gestational Age; Humans; Hydroxyprogesterones; Incidence; Medroxyprogesterone Acetate; Odds Ratio; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Premature Birth; Prenatal Care; Randomized Controlled Trials as Topic; Reference Values; Risk Assessment; Treatment Outcome

2005
Hormonal therapy in advanced or recurrent endometrial cancer.
    The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Antineoplastic Agents, Hormonal; Disease-Free Survival; Drug Therapy, Combination; Endometrial Neoplasms; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone Acetate; Megestrol; Neoplasm Recurrence, Local; Neoplasm Staging; Progestins

2010

Trials

2 trial(s) available for 17 alpha-hydroxyprogesterone caproate and medroxyprogesterone acetate

ArticleYear
Acceptability of drugs for male fertility regulation: a prospectus and some preliminary data. World Health Organization Task Force on Psychosocial Research in Family Planning.
    Contraception, 1980, Volume: 21, Issue:2

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Clinical Trials as Topic; Contraceptive Agents, Male; Contraceptive Devices, Male; Cyproterone; Cyproterone Acetate; Humans; Hydroxyprogesterones; Libido; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; Sexual Behavior; Testosterone; Vasectomy; World Health Organization

1980
[Therapy of atypical hyperplasia and adenocarcinoma of the endometrium with the combination of progestins and anticoagulants].
    Voprosy onkologii, 2001, Volume: 47, Issue:3

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adenocarcinoma; Anticoagulants; Antineoplastic Agents, Hormonal; Drug Therapy, Combination; Endometrial Neoplasms; Endometrium; Estrogen Antagonists; Female; Humans; Hydroxyprogesterones; Hyperplasia; Medroxyprogesterone Acetate; Neoplasm Staging; Progesterone Congeners; Treatment Outcome

2001

Other Studies

14 other study(ies) available for 17 alpha-hydroxyprogesterone caproate and medroxyprogesterone acetate

ArticleYear
Quantitative relationships between steroid structure and binding to putative progesterone receptors.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:9

    Topics: Androstenes; Animals; Guinea Pigs; Humans; Hydroxyprogesterones; Protein Binding; Rabbits; Receptors, Progesterone; Sheep; Steroids; Structure-Activity Relationship

1977
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
[Progestins in combined treatment of endometrial cancer].
    Sovetskaia meditsina, 1990, Issue:9

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Progestins; Uterine Neoplasms

1990
[Effect of progestin therapy on the level of cytoplasmic receptors in patients with cancer of the corpus uteri].
    Voprosy onkologii, 1989, Volume: 35, Issue:5

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Antineoplastic Agents; Cytoplasm; Drug Evaluation; Female; Homeostasis; Humans; Hydroxyprogesterones; Lymphatic Metastasis; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Preoperative Care; Receptors, Cell Surface; Reproduction; Uterine Neoplasms; Vaginal Smears

1989
Ovarian tumors in pregnancy.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1988, Volume: 27, Issue:1

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Abortion, Spontaneous; Adult; Combined Modality Therapy; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Ovarian Neoplasms; Ovariectomy; Pregnancy; Pregnancy Complications, Neoplastic

1988
[Hormone dependency and progestogen therapy in the treatment of endometrial cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Cell Division; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Neoplasms, Hormone-Dependent; Norethindrone; Tamoxifen; Tumor Stem Cell Assay; Uterine Neoplasms

1987
Evaluation of progestational agents for postmenopausal hot flushes.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1982, Volume: 20, Issue:2

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Climacteric; Double-Blind Method; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Progesterone Congeners

1982
[Prevention of dysfunctional metrorrhagia in the climacteric].
    Bratislavske lekarske listy, 1983, Volume: 79, Issue:5

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Climacteric; Clomiphene; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Metrorrhagia; Middle Aged

1983
Quantitation of hydroxyprogesterone caproate, medroxyprogesterone acetate, and progesterone by reversed-phase high-pressure liquid chromatography.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:3

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Chromatography, High Pressure Liquid; Drug Stability; Hydroxyprogesterones; Medroxyprogesterone; Medroxyprogesterone Acetate; Progesterone; Suspensions; Tablets

1982
Organ preserving method in the management of atypical endometrial hyperplasia.
    European journal of gynaecological oncology, 2001, Volume: 22, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Administration, Oral; Adult; Endometrial Hyperplasia; Female; Humans; Hydroxyprogesterones; Injections, Intramuscular; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Pregnancy; Progesterone Congeners

2001
The use of progestational agents for preterm birth: lessons from a mouse model.
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Animals; C-Reactive Protein; Female; Hydroxyprogesterones; Interleukin-10; Interleukin-6; Lipopolysaccharides; Medroxyprogesterone Acetate; Mice; Models, Animal; Pregnancy; Premature Birth; Progestins

2006
Simultaneous quantitation of 17alpha-hydroxyprogesterone caproate, 17alpha-hydroxyprogesterone and progesterone in human plasma using high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS).
    Journal of pharmaceutical and biomedical analysis, 2008, Dec-01, Volume: 48, Issue:4

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Hydroxyprogesterones; Medroxyprogesterone Acetate; Methanol; Pregnancy; Progesterone; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Water

2008
Fertility-preserving treatment in young women with well-differentiated endometrial carcinoma and severe atypical hyperplasia of endometrium.
    Fertility and sterility, 2009, Volume: 92, Issue:6

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Antineoplastic Agents, Hormonal; Cell Differentiation; Combined Modality Therapy; Endometrial Neoplasms; Endometrium; Female; Fertility; Follow-Up Studies; Humans; Hydroxyprogesterones; Hyperplasia; Infertility, Female; Medroxyprogesterone Acetate; Megestrol Acetate; Progestins; Remission Induction; Reproductive Techniques, Assisted; Retrospective Studies; Severity of Illness Index

2009
The Effect of Progestins on Tumor Necrosis Factor α-Induced Matrix Metalloproteinase-9 Activity and Gene Expression in Human Primary Amnion and Chorion Cells In Vitro.
    Anesthesia and analgesia, 2015, Volume: 120, Issue:5

    Topics: 17 alpha-Hydroxyprogesterone Caproate; Amnion; Cells, Cultured; Chorion; Female; Gene Expression Regulation, Enzymologic; Humans; Hydroxyprogesterones; Matrix Metalloproteinase 9; Medroxyprogesterone Acetate; Pregnancy; Progesterone; Progestins; RNA, Messenger; Tumor Necrosis Factor-alpha

2015