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17-alpha-hydroxypregnenolone and desoxycorticosterone

17-alpha-hydroxypregnenolone has been researched along with desoxycorticosterone in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199016 (57.14)18.7374
1990's8 (28.57)18.2507
2000's3 (10.71)29.6817
2010's0 (0.00)24.3611
2020's1 (3.57)2.80

Authors

AuthorsStudies
Chapman, D; Jain, AN; Koile, K1
Good, AC; Peterson, SJ; Richards, WG1
Good, AC; Richards, WG; So, SS1
Platt, DE; Silverman, BD1
Crippen, GM1
Karplus, M; So, SS1
Strassburg, CP; Tukey, RH1
Ban, F; Cherkasov, A; Fallahi, M; Hammond, GL; Santos-Filho, O; Thorsteinson, N1
Bellavance, E; Luu-The, V; Poirier, D1
Colombo, L; Yaron, Z1
Berg, G; Di Martino-Nardi, J; Fishman, K; Gautier, T; Lashansky, G; Mayes, D; Reiter, E; Saenger, P1
Goshima, E; Hirai, M; Miura, K; Murase, H; Murayama, M; Noritake, N; Takeda, N; Yamakita, N; Yasuda, K1
Casey, ML; Guerami, A; MacDonald, PC; Shackleton, CH; Varner, MW1
Dehennin, L; Nahoul, K; Scholler, R1
Makino, K; Miura, K; Ojima, M; Okuyama, M; Sasano, N; Yasuda, K1
Schuetz, AW1
Anderson, JM; McCormick, MH; Neville, AM; Webb, JL1
Gupta, C; Karavolas, HJ1
Camacho, AM; Hagen, AA; Trouy, RL; Wilroy, RS1
Cheng, SC; Harding, BW1
Hurst, L; Jayle, MF; Lacassagne, A1
Blank, IH; Brauner, GJ; MacFarlane, DJ; Scheuplein, RJ1
Meyer, RK; Ying, SY1
Vinson, GP1
Fukuchi, S; Ojima, M; Saito, M1
Altare, S; Canivet, B; Hadjali, Y; Kézachian, B; Sadoul, JL1
LORING, JM; VILLEE, CA1
Akıncı, E; Bal, C; Erel, Ö; Eser, F; Güner, R; Hasanoglu, İ; Kalem, AK; Kayaaslan, B; Sezer, S; Yılmaz, G1

Reviews

1 review(s) available for 17-alpha-hydroxypregnenolone and desoxycorticosterone

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000

Other Studies

27 other study(ies) available for 17-alpha-hydroxypregnenolone and desoxycorticosterone

ArticleYear
Compass: predicting biological activities from molecular surface properties. Performance comparisons on a steroid benchmark.
    Journal of medicinal chemistry, 1994, Jul-22, Volume: 37, Issue:15

    Topics: Algorithms; Models, Molecular; Models, Statistical; Molecular Conformation; Sex Hormone-Binding Globulin; Steroids; Structure-Activity Relationship; Surface Properties; Transcortin

1994
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship

1993
Structure-activity relationships from molecular similarity matrices.
    Journal of medicinal chemistry, 1993, Feb-19, Volume: 36, Issue:4

    Topics: Computer Simulation; Electrochemistry; Models, Molecular; Molecular Structure; Neural Networks, Computer; Sex Hormone-Binding Globulin; Steroids; Structure-Activity Relationship; Transcortin

1993
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
    Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11

    Topics: Adrenal Cortex Hormones; Binding Sites; Mathematics; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Predictive Value of Tests; Steroids; Structure-Activity Relationship; Testosterone

1996
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
    Journal of medicinal chemistry, 1997, Sep-26, Volume: 40, Issue:20

    Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin

1997
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 1. Method and validations.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Algorithms; Models, Chemical; Molecular Structure; Neural Networks, Computer; Protein Binding; Static Electricity; Steroids; Structure-Activity Relationship; Transcortin

1997
An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: Binding Sites; Binding, Competitive; Computer Simulation; Databases as Topic; Humans; Ligands; Linear Models; Models, Molecular; Predictive Value of Tests; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Sex Hormone-Binding Globulin; Steroids

2008
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity

2009
Steroid 21-hydroxylase activity in the ovary of the snake Storeria dekayi during pregnancy.
    General and comparative endocrinology, 1976, Volume: 28, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Animals; Corpus Luteum; Desoxycorticosterone; Female; Hydroxysteroid Dehydrogenases; Lyases; Ovary; Pregnancy; Pregnancy, Animal; Pregnenolone; Progesterone; Snakes; Steroid Hydroxylases; Steroid Isomerases; Testosterone; Time Factors

1976
Normative data for adrenal steroidogenesis in a healthy pediatric population: age- and sex-related changes after adrenocorticotropin stimulation.
    The Journal of clinical endocrinology and metabolism, 1991, Volume: 73, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Aging; Androstenedione; Child; Child, Preschool; Cortodoxone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Infant; Male; Radioimmunoassay; Reference Values; Sex Characteristics; Steroids; Testosterone

1991
Response of plasma adrenal steroids to synthetic ACTH under ketoconazole in man.
    Endocrinologia japonica, 1987, Volume: 34, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldehyde-Lyases; Aldosterone; Corticosterone; Cosyntropin; Cytochrome P-450 Enzyme Inhibitors; Dehydroepiandrosterone; Desoxycorticosterone; Dexamethasone; Humans; Hydrocortisone; Hydroxyprogesterones; Ketoconazole; Male; Progesterone; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase

1987
Origin of deoxycorticosterone and deoxycorticosterone sulfate in human pregnancy: absence of steroid 21-sulfatase activity in sulfatase-deficient placenta.
    Journal of steroid biochemistry, 1988, Volume: 29, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Adult; Desoxycorticosterone; Female; Humans; Microsomes; Placenta; Pregnancy; Progesterone; Substrate Specificity; Sulfatases

1988
Steroid 21-hydroxylation by human preovulatory follicles from stimulated cycles: a mass spectrometrical study of deoxycorticosterone, 21-hydroxypregnenolone and 11-deoxycortisol in follicular fluid.
    Journal of steroid biochemistry, 1987, Volume: 26, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Body Fluids; Clomiphene; Cortodoxone; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Humans; Ovarian Follicle; Ovary; Ovulation; Steroid 21-Hydroxylase; Steroid Hydroxylases

1987
An adrenocortical tumor secreting weak mineralocorticoids.
    Endocrinologia japonica, 1987, Volume: 34, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; 18-Hydroxycorticosterone; Adrenal Cortex Neoplasms; Adult; Carcinoma; Corticosterone; Desoxycorticosterone; Female; Humans; Hydroxyprogesterones; Hypertension; Mineralocorticoids; Pregnenolone; Progesterone

1987
Effect of steroids on germinal vesicle of oocytes of the frog (Rana pipiens) in vitro.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Aldosterone; Androgens; Animals; Anura; Cell Nucleus; Cholesterol; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Estradiol; Female; Hydrocortisone; In Vitro Techniques; Ovum; Pregnanediol; Pregnenolone; Progesterone; Steroids; Testosterone

1967
Steroid biosynthesis in vitro and in tissue culture by adrenal tumours of mice of the CE strain.
    The Journal of endocrinology, 1968, Volume: 41, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Adrenal Gland Neoplasms; Animals; Autoradiography; Carbon Isotopes; Chromatography, Paper; Culture Techniques; Dehydroepiandrosterone; Desoxycorticosterone; Female; Histocytochemistry; Hydrocortisone; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Mice; Pregnenolone; Rodent Diseases; Steroids; Tritium

1968
Adrenal steroid biosynthesis from 4-14C-cholesterol (in vitro) during phenobarbital block of PMS-induced ovulation in immature rats.
    Endocrinology, 1973, Volume: 92, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Animals; Cholesterol; Chorionic Gonadotropin; Chromatography, Gas; Chromatography, Thin Layer; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Female; Gonadotropins, Equine; Hydroxyprogesterones; In Vitro Techniques; Ovulation; Phenobarbital; Pregnenolone; Progesterone; Rats

1973
Inhibition of adrenal cortical secretion by amino-glutethimide in dogs.
    Endocrinology, 1968, Volume: 83, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Chromatography, Paper; Corticosterone; Dehydroepiandrosterone; Depression, Chemical; Desoxycorticosterone; Dogs; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Pyridones; Veins

1968
Substrate-induced difference spectral, electron paramagnetic resonance, and enzymatic properties of cholesterol-depleted mitochondrial cytochrome P-450 of bovine adrenal cortex.
    The Journal of biological chemistry, 1973, Oct-25, Volume: 248, Issue:20

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Acetone; Adrenal Glands; Animals; Cattle; Cholesterol; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Drug Resistance, Microbial; Drug Synergism; Electron Spin Resonance Spectroscopy; Electron Transport; Hydroxylation; Iron; Mitochondria; Oxidation-Reduction; Pregnenolone; Spectrophotometry, Ultraviolet; Surface-Active Agents

1973
[Action of C 21 steroids on cancerization of rat liver by para-dimethylaminoazobenzene (DAB)].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, Jan-27, Volume: 268, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Animals; Cell Transformation, Neoplastic; Corticosterone; Desoxycorticosterone; Dexamethasone; Dichlorodiphenyldichloroethane; Hydrocortisone; Hydroxyprogesterones; Liver Neoplasms; Liver Regeneration; Male; p-Dimethylaminoazobenzene; Pregnenolone; Progesterone; Rats

1969
Percutaneous absorption of steroids.
    The Journal of investigative dermatology, 1969, Volume: 52, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Administration, Topical; Aldosterone; Anti-Inflammatory Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Corticosterone; Cortisone; Desoxycorticosterone; Diffusion; Estradiol; Estriol; Estrone; Humans; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Skin Absorption; Steroids; Testosterone

1969
Effect of steroids on neuropharmacologic blockade of ovulation in pregnant mare's serum (PMS)-primed immature rats.
    Endocrinology, 1969, Volume: 84, Issue:6

    Topics: 17-alpha-Hydroxypregnenolone; Androstanes; Androsterone; Animals; Depression, Chemical; Desoxycorticosterone; Estradiol; Estrone; Female; Gonadotropins, Equine; Hydrocortisone; Hydroxyprogesterones; Luteinizing Hormone; Medroxyprogesterone; Organ Size; Ovulation; Phenobarbital; Progesterone; Rats

1969
Role of 21-hydroxypregnenolone in the synthesis of corticosterone from pregnenolone by sheep adrenal tissue in vitro.
    General and comparative endocrinology, 1967, Volume: 9, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Animals; Carbon Isotopes; Corticosterone; Desoxycorticosterone; Hydroxyprogesterones; In Vitro Techniques; Pregnenolone; Progesterone; Sheep; Tritium

1967
[The effects of o,p'-DDD on human adrenal steroid synthesis].
    Nihon Naibunpi Gakkai zasshi, 1984, Jul-20, Volume: 60, Issue:7

    Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Child, Preschool; Cushing Syndrome; Desoxycorticosterone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Male; Middle Aged; Mitotane; Pregnenolone

1984
Apparent activities of 21-hydroxylase, 17alpha-hydroxylase and 17,20-lyase are impaired in adrenal incidentalomas.
    European journal of endocrinology, 1999, Volume: 141, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Aldosterone; Androstenedione; Cortodoxone; Dehydroepiandrosterone; Desoxycorticosterone; Dexamethasone; Female; Glucocorticoids; Humans; Hydrocortisone; Male; Middle Aged; Progesterone; Prospective Studies; Renin; Steroid 17-alpha-Hydroxylase; Steroid 21-Hydroxylase

1999
SYNTHESIS OF STEROIDS IN THE NEWBORN HUMAN ADRENAL IN VITRO.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Adrenal Glands; Aging; Carbon Isotopes; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Humans; Hydrocortisone; In Vitro Techniques; Infant, Newborn; Metabolism; NADP; Pregnenolone; Progesterone; Radiometry; Steroids

1965
COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity.
    Endocrine, 2022, Volume: 78, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Aldosterone; Androstenedione; Androsterone; Chromatography, Liquid; Corticosterone; Cortodoxone; COVID-19; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dihydrotestosterone; Estradiol; Estrone; Humans; Hydrocortisone; Pregnenolone; Progesterone; Severity of Illness Index; Tandem Mass Spectrometry

2022