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17-alpha-hydroxypregnenolone and corticosterone

17-alpha-hydroxypregnenolone has been researched along with corticosterone in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199018 (56.25)18.7374
1990's7 (21.88)18.2507
2000's3 (9.38)29.6817
2010's3 (9.38)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Chapman, D; Jain, AN; Koile, K1
Good, AC; Peterson, SJ; Richards, WG1
Good, AC; Richards, WG; So, SS1
Platt, DE; Silverman, BD1
Crippen, GM1
Karplus, M; So, SS1
Strassburg, CP; Tukey, RH1
Ban, F; Cherkasov, A; Fallahi, M; Hammond, GL; Santos-Filho, O; Thorsteinson, N1
Bellavance, E; Luu-The, V; Poirier, D1
Couch, RA; Doouss, TW; Skinner, SJ1
Itakura, M; Koide, Y; Kuzuya, N; Matsumara, M; Murayama, Y; Nakamura, S; Okuda, Y; Takuwa, Y; Tomizawa, H; Watanabe, Y1
Claus, M; Schöneshöfer, M1
Goshima, E; Hirai, M; Miura, K; Murase, H; Murayama, M; Noritake, N; Takeda, N; Yamakita, N; Yasuda, K1
Makino, K; Miura, K; Ojima, M; Okuyama, M; Sasano, N; Yasuda, K1
Schuetz, AW1
Ebersohl, C; Oertel, GW; Rindt, W1
Gupta, C; Karavolas, HJ1
Davies, IJ; Ryan, KJ1
Camacho, AM; Hagen, AA; Trouy, RL; Wilroy, RS1
Berger, GM1
Kurachi, K; Matsumoto, K; Miyazaki, M; Mori, H1
Hurst, L; Jayle, MF; Lacassagne, A1
Cameron, EH; Cunningham, D; Griffiths, K1
Vinson, GP; Whitehouse, BJ1
Blank, IH; Brauner, GJ; MacFarlane, DJ; Scheuplein, RJ1
Vinson, GP1
Homoki, J; Roitman, E; Shackleton, CH1
LORING, JM; VILLEE, CA1
Do Rego, JL; Haraguchi, S; Hasunuma, I; Kikuyama, S; Koyama, T; Okuyama, S; Tsutsui, K; Ubuka, T; Vaudry, H1
Bahtiyar, G; Kalani, A; Sacerdote, A1
Fukada, Y; Haraguchi, S; Tsutsui, K; Vaudry, H1
Akıncı, E; Bal, C; Erel, Ö; Eser, F; Güner, R; Hasanoglu, İ; Kalem, AK; Kayaaslan, B; Sezer, S; Yılmaz, G1

Reviews

1 review(s) available for 17-alpha-hydroxypregnenolone and corticosterone

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000

Other Studies

31 other study(ies) available for 17-alpha-hydroxypregnenolone and corticosterone

ArticleYear
Compass: predicting biological activities from molecular surface properties. Performance comparisons on a steroid benchmark.
    Journal of medicinal chemistry, 1994, Jul-22, Volume: 37, Issue:15

    Topics: Algorithms; Models, Molecular; Models, Statistical; Molecular Conformation; Sex Hormone-Binding Globulin; Steroids; Structure-Activity Relationship; Surface Properties; Transcortin

1994
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
    Journal of medicinal chemistry, 1993, Oct-01, Volume: 36, Issue:20

    Topics: Carbolines; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Imidazoles; Indoles; Molecular Structure; Pyridines; Structure-Activity Relationship

1993
Structure-activity relationships from molecular similarity matrices.
    Journal of medicinal chemistry, 1993, Feb-19, Volume: 36, Issue:4

    Topics: Computer Simulation; Electrochemistry; Models, Molecular; Molecular Structure; Neural Networks, Computer; Sex Hormone-Binding Globulin; Steroids; Structure-Activity Relationship; Transcortin

1993
Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.
    Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11

    Topics: Adrenal Cortex Hormones; Binding Sites; Mathematics; Models, Molecular; Molecular Conformation; Molecular Structure; Molecular Weight; Predictive Value of Tests; Steroids; Structure-Activity Relationship; Testosterone

1996
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.
    Journal of medicinal chemistry, 1997, Sep-26, Volume: 40, Issue:20

    Topics: Algorithms; Animals; Binding Sites; Computer Simulation; Folic Acid Antagonists; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Steroids; Testosterone; Tetrahydrofolate Dehydrogenase; Transcortin

1997
Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 1. Method and validations.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Algorithms; Models, Chemical; Molecular Structure; Neural Networks, Computer; Protein Binding; Static Electricity; Steroids; Structure-Activity Relationship; Transcortin

1997
An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.
    Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

    Topics: Binding Sites; Binding, Competitive; Computer Simulation; Databases as Topic; Humans; Ligands; Linear Models; Models, Molecular; Predictive Value of Tests; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Sex Hormone-Binding Globulin; Steroids

2008
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity

2009
Synthesis of dehydroepiandrosterone and dehydroepiandrosterone sulphate by the human adrenal.
    The Journal of endocrinology, 1975, Volume: 66, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Corticosterone; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; In Vitro Techniques; Pregnenolone; Sulfates

1975
Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection.
    Endocrinologia japonica, 1990, Volume: 37, Issue:5

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Gland Neoplasms; Adult; Aldosterone; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Corticosterone; Heart Neoplasms; Humans; Hydrocortisone; Liver Neoplasms; Lung Neoplasms; Male; Mitotane; Pregnenolone; Tegafur; Testosterone

1990
Multiple-sites of inhibition by intravenous metyrapone of human adrenal steroidogenesis.
    Acta endocrinologica, 1985, Volume: 109, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; 18-Hydroxycorticosterone; 18-Hydroxydesoxycorticosterone; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aldosterone; Corticosterone; Cortodoxone; Humans; Hydrocortisone; Hydroxyprogesterones; Infusions, Parenteral; Male; Metyrapone; Pregnenolone; Progesterone

1985
Response of plasma adrenal steroids to synthetic ACTH under ketoconazole in man.
    Endocrinologia japonica, 1987, Volume: 34, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aldehyde-Lyases; Aldosterone; Corticosterone; Cosyntropin; Cytochrome P-450 Enzyme Inhibitors; Dehydroepiandrosterone; Desoxycorticosterone; Dexamethasone; Humans; Hydrocortisone; Hydroxyprogesterones; Ketoconazole; Male; Progesterone; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase

1987
An adrenocortical tumor secreting weak mineralocorticoids.
    Endocrinologia japonica, 1987, Volume: 34, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; 18-Hydroxycorticosterone; Adrenal Cortex Neoplasms; Adult; Carcinoma; Corticosterone; Desoxycorticosterone; Female; Humans; Hydroxyprogesterones; Hypertension; Mineralocorticoids; Pregnenolone; Progesterone

1987
Effect of steroids on germinal vesicle of oocytes of the frog (Rana pipiens) in vitro.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Aldosterone; Androgens; Animals; Anura; Cell Nucleus; Cholesterol; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Estradiol; Female; Hydrocortisone; In Vitro Techniques; Ovum; Pregnanediol; Pregnenolone; Progesterone; Steroids; Testosterone

1967
[Effect of gonadotropins on the adrenal cortex. II. Incubation of adrenal homogenates from normal and castrated guinea pigs with 7alpha-3H-cholesterol under the influence of serum gonadotropin].
    Endokrinologie, 1967, Volume: 52, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Androgens; Animals; Cholesterol; Chromatography, Thin Layer; Corticosterone; Dehydroepiandrosterone; Glucuronates; Glycolipids; Gonadotropins; Guinea Pigs; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Male; Pregnenolone; Progesterone; Steroids; Sulfates; Tritium

1967
Adrenal steroid biosynthesis from 4-14C-cholesterol (in vitro) during phenobarbital block of PMS-induced ovulation in immature rats.
    Endocrinology, 1973, Volume: 92, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Animals; Cholesterol; Chorionic Gonadotropin; Chromatography, Gas; Chromatography, Thin Layer; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Female; Gonadotropins, Equine; Hydroxyprogesterones; In Vitro Techniques; Ovulation; Phenobarbital; Pregnenolone; Progesterone; Rats

1973
Glucocorticoid synthesis from pregnenolone by sheep foetal adrenals in vitro.
    The Journal of endocrinology, 1973, Volume: 58, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Androstenedione; Animals; Chromatography; Corticosterone; Dehydroepiandrosterone; Fetus; Gestational Age; Glucocorticoids; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Pregnenolone; Progesterone; Radioisotope Dilution Technique; Sheep

1973
Inhibition of adrenal cortical secretion by amino-glutethimide in dogs.
    Endocrinology, 1968, Volume: 83, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Chromatography, Paper; Corticosterone; Dehydroepiandrosterone; Depression, Chemical; Desoxycorticosterone; Dogs; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Pyridones; Veins

1968
Possible role of cyclic AMP in the short term regulation of adrenal steroidogenesis.
    Nature, 1971, Aug-13, Volume: 232, Issue:5311

    Topics: 17-alpha-Hydroxypregnenolone; Adenine Nucleotides; Adrenal Glands; Adrenocorticotropic Hormone; Androgens; Animals; Cholesterol; Corticosterone; Cyclic AMP; Dehydroepiandrosterone; Humans; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Steroids

1971
In vitro steroid synthesis by foetal rabbit adrenals.
    Acta endocrinologica, 1971, Volume: 68, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Animals; Corticosterone; Crystallization; Enzyme Activation; Female; Fetus; Gestational Age; Hydrocortisone; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Mixed Function Oxygenases; Pregnancy; Pregnenolone; Progesterone; Rabbits; Radioisotope Dilution Technique; Steroids; Tritium

1971
[Action of C 21 steroids on cancerization of rat liver by para-dimethylaminoazobenzene (DAB)].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, Jan-27, Volume: 268, Issue:4

    Topics: 17-alpha-Hydroxypregnenolone; Animals; Cell Transformation, Neoplastic; Corticosterone; Desoxycorticosterone; Dexamethasone; Dichlorodiphenyldichloroethane; Hydrocortisone; Hydroxyprogesterones; Liver Neoplasms; Liver Regeneration; Male; p-Dimethylaminoazobenzene; Pregnenolone; Progesterone; Rats

1969
A comparison of the conversion in vitro of pregnenolone sulphate and pregnenolone to steroid hormones by tissue from a clear cell adenoma of the adrenal gland.
    The Journal of endocrinology, 1968, Volume: 40, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; Androgens; Carbon Isotopes; Chromatography, Thin Layer; Corticosterone; Female; Humans; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Pregnenolone; Progesterone; Sulfates; Testosterone; Tritium

1968
Corticosteroid biosynthesis from pregnenolone and progesterone by human adrenal tissue in vitro. A kinetic study.
    Steroids, 1968, Volume: 11, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Adult; Carbon Isotopes; Chromatography, Paper; Corticosterone; Fetus; Humans; Hydrocortisone; In Vitro Techniques; Kinetics; Pregnenolone; Progesterone; Tritium

1968
Percutaneous absorption of steroids.
    The Journal of investigative dermatology, 1969, Volume: 52, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Administration, Topical; Aldosterone; Anti-Inflammatory Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Corticosterone; Cortisone; Desoxycorticosterone; Diffusion; Estradiol; Estriol; Estrone; Humans; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Skin Absorption; Steroids; Testosterone

1969
Role of 21-hydroxypregnenolone in the synthesis of corticosterone from pregnenolone by sheep adrenal tissue in vitro.
    General and comparative endocrinology, 1967, Volume: 9, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Animals; Carbon Isotopes; Corticosterone; Desoxycorticosterone; Hydroxyprogesterones; In Vitro Techniques; Pregnenolone; Progesterone; Sheep; Tritium

1967
Characterization of the major steroids present in amniotic fluid obtained between the 15th and 17th weeks of gestation.
    Journal of steroid biochemistry, 1983, Volume: 19, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Amniotic Fluid; Corticosterone; Dehydroepiandrosterone; Estriol; Gestational Age; Glucuronates; Humans; Hydrocortisone; Progesterone; Sulfates

1983
SYNTHESIS OF STEROIDS IN THE NEWBORN HUMAN ADRENAL IN VITRO.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Adrenal Glands; Aging; Carbon Isotopes; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Humans; Hydrocortisone; In Vitro Techniques; Infant, Newborn; Metabolism; NADP; Pregnenolone; Progesterone; Radiometry; Steroids

1965
Acute stress increases the synthesis of 7α-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts.
    Endocrinology, 2012, Volume: 153, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; Amino Acid Sequence; Animals; Base Sequence; Brain; Corticosterone; Cytochrome P-450 Enzyme System; Male; Models, Animal; Molecular Sequence Data; Motor Activity; Neurons; Receptors, Glucocorticoid; Salamandridae; Serotonin; Stress, Physiological

2012
Ashwagandha root in the treatment of non-classical adrenal hyperplasia.
    BMJ case reports, 2012, Sep-17, Volume: 2012

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Hyperplasia, Congenital; Corticosterone; Diagnosis, Differential; Female; Humans; Middle Aged; Phytotherapy; Plant Extracts; Plant Roots; Withania

2012
Brain and pineal 7α-hydroxypregnenolone stimulating locomotor activity: identification, mode of action and regulation of biosynthesis.
    Frontiers in neuroendocrinology, 2013, Volume: 34, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; Animals; Brain; Corticosterone; Female; Light; Locomotion; Male; Melatonin; Motor Activity; Pineal Gland; Prolactin; Salamandridae

2013
COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity.
    Endocrine, 2022, Volume: 78, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Aldosterone; Androstenedione; Androsterone; Chromatography, Liquid; Corticosterone; Cortodoxone; COVID-19; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dihydrotestosterone; Estradiol; Estrone; Humans; Hydrocortisone; Pregnenolone; Progesterone; Severity of Illness Index; Tandem Mass Spectrometry

2022