17-(3-pyridyl)androsta-5,16-dien-3-one has been researched along with abiraterone in 6 studies
| Studies (17-(3-pyridyl)androsta-5,16-dien-3-one) | Trials (17-(3-pyridyl)androsta-5,16-dien-3-one) | Recent Studies (post-2010) (17-(3-pyridyl)androsta-5,16-dien-3-one) | Studies (abiraterone) | Trials (abiraterone) | Recent Studies (post-2010) (abiraterone) |
|---|---|---|---|---|---|
| 8 | 0 | 6 | 942 | 97 | 854 |
| Protein | Taxonomy | 17-(3-pyridyl)androsta-5,16-dien-3-one (IC50) | abiraterone (IC50) |
|---|---|---|---|
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | 0.2557 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 2.0643 | |
| Steroid 21-hydroxylase | Homo sapiens (human) | 0.1642 | |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Norway rat) | 0.0674 | |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | 1.5714 | |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | 1.722 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Aubé, J; Fehl, C; Li, K; Scott, EE; Vogt, CD; Yadav, R | 1 |
| Barrie, SE; Dowsett, M; Goddard, PM; Haynes, BP; Jarman, M; Potter, GA | 1 |
| Alyamani, M; Auchus, RJ; Bishop, AC; Bunch, D; Dreicer, R; Garcia, JA; Li, Z; Liu, J; Sharifi, N; Upadhyay, SK | 1 |
| Ahire, K; Bhatnagar, A; Crumbaker, M; Gurney, H; Karuso, P; McKay, MJ; Molloy, MP | 1 |
| Arasaratnam, M; Bhatnagar, A; Crumbaker, M; Gurney, H; McKay, MJ; Molloy, MP; Thaysen-Andersen, M | 1 |
| Antunes, MV; Furtado, CM; Gössling, G; Linden, R; Schwartsmann, G; Verza, SG; Weiss, TLD | 1 |
6 other study(ies) available for 17-(3-pyridyl)androsta-5,16-dien-3-one and abiraterone
| Article | Year |
|---|---|
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
Topics: Androstenes; Catalytic Domain; Cytochrome P-450 Enzyme Inhibitors; Drug Design; Humans; Molecular Docking Simulation; Steroid 17-alpha-Hydroxylase; Steroid 21-Hydroxylase | 2018 |
Pharmacology of novel steroidal inhibitors of cytochrome P450(17) alpha (17 alpha-hydroxylase/C17-20 lyase).
Topics: Abiraterone Acetate; Adrenal Glands; Aldehyde-Lyases; Androgens; Androstadienes; Androstenes; Androstenols; Animals; Cytochrome P-450 Enzyme Inhibitors; Flutamide; Guinea Pigs; Ketoconazole; Kidney; Luteinizing Hormone; Male; Mice; Orchiectomy; Organ Size; Prostate; Seminal Vesicles; Steroid 17-alpha-Hydroxylase; Testis; Testosterone | 1994 |
Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Androgen Receptor Antagonists; Androgens; Androstenes; Animals; Benzamides; Biosynthetic Pathways; Biotransformation; Cell Division; Chromatin; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Steroid 17-alpha-Hydroxylase; Survival Analysis; Xenograft Model Antitumor Assays | 2015 |
Quantitation of the anticancer drug abiraterone and its metabolite Δ(4)-abiraterone in human plasma using high-resolution mass spectrometry.
Topics: Androgen Receptor Antagonists; Androstenes; Antineoplastic Agents; Biological Variation, Population; Chromatography, High Pressure Liquid; Humans; Male; Prodrugs; Prostatic Neoplasms, Castration-Resistant; Sensitivity and Specificity; Steroid 17-alpha-Hydroxylase; Tandem Mass Spectrometry | 2018 |
Bioanalytical evaluation of dried plasma spots for monitoring of abiraterone and ∆(4)-abiraterone from cancer patients.
Topics: Androstenes; Chromatography, Liquid; Dried Blood Spot Testing; Drug Monitoring; Humans; Linear Models; Male; Prostatic Neoplasms, Castration-Resistant; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2019 |
A quick UPLC-MS/MS method for therapeutic drug monitoring of abiraterone and delta(4)-abiraterone in human plasma.
Topics: Androstenes; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Limit of Detection; Linear Models; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |