Page last updated: 2024-09-02

16-hydroxyestrone and estrone

16-hydroxyestrone has been researched along with estrone in 136 studies

Compound Research Comparison

Studies (16-hydroxyestrone)	Trials (16-hydroxyestrone)	Recent Studies (post-2010) (16-hydroxyestrone)	Studies (estrone)	Trials (estrone)	Recent Studies (post-2010) (estrone)
149	17	25	10,266	432	1,372

Protein Interaction Comparison

Protein	Taxonomy	estrone (IC50)
Estrogen receptor	Homo sapiens (human)	0.1261
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	6.589
17-beta-hydroxysteroid dehydrogenase type 1	Homo sapiens (human)	0.4134
Sodium-dependent serotonin transporter	Homo sapiens (human)	5.301
Estrogen receptor beta	Homo sapiens (human)	0.3743
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	3

Research

Studies (136)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (19.85)	18.7374
1990's	45 (33.09)	18.2507
2000's	39 (28.68)	29.6817
2010's	22 (16.18)	24.3611
2020's	3 (2.21)	2.80

Authors

Authors	Studies
Bradlow, HL; Osborne, MP; Suto, A; Telang, NT; Wong, GY	2
Imoto, S	1
Ichikawa, T; Miyairi, S; Nambara, T	1
Furukawa, F; Imamura, S; Norris, DA	1
Fishman, J; Swaneck, GE	2
Arts, CJ; de Bie, AT; van den Berg, H; Wilmer, JW	1
Hoberg, L; Longcope, C	1
Blankenstein, MA; Thijssen, JH	1
Furihata, R; Ishikawa, S; Konno, T; Numazawa, M	1
Fishman, J; Lustig, RH; Mobbs, CV; Pfaff, DW	1
Oakey, RE; Purohit, A	1
Bradlow, HL; Lustig, RH; McEwen, BS; Mobbs, CV; Pfaff, DW	1
Akiyama, T; Hashino, M; Kawamura, E; Kosaki, T; Mori, H; Nakayama, T; Yanaihara, T	1
Bencsath, FA; Bucala, R; Cerami, A; Chait, BT; Ulrich, PC	1
Blankenstein, MA; Donker, GH; Gramberg, LG; Tas, AA; Thijssen, JH; van Haaften, M	1
Bucala, R; Cerami, A; Fishman, J; Lahita, RG	2
Numazawa, M; Osada, R; Osawa, Y; Tsuji, M	1
Bradlow, HL; Bucala, R; Fishman, J; Lahita, RG	1
Fishman, J; Yu, SC	1
Brand, H; Henderson, C; Hodges, JK; Kelly, RW	1
Bucala, R; Cerami, A	1
Bucala, R; Cerami, A; Fishman, J	2
Akiyama, T; Hashino, M; Kawamura, E; Kosaki, T; Mori, A; Nakayama, T; Yanaihara, T	1
Fishman, J; Ikegawa, S; Lahita, R	1
Bradlow, HL; Fishman, J; Kunkel, HG; Lahita, RG	1
Fishman, J; Ikegawa, S	1
Fishman, J; Martucci, C	1
Bradlow, HL; Klug, TL; Sepkovic, DW	1
Adlercreutz, H; Carson, M; Loukovaara, M	1
Bradlow, HL; Fishman, J; Gong, L; Hankinson, SE; Ho, G; Osborne, MP; Sepkovic, DW	1
Bradlow, HL; Davis, DL; Lin, G; Sepkovic, D; Tiwari, R	1
Clausen, J; Kall, MA; Vang, O	2
Bradlow, HL; Buhari, AM; Kuller, LH; Meilahn, EN; Pasagian-Macaulay, A; Sepkovic, DW; Simkin-Silverman, L; Wing, RR	1
Chen, C; Daling, JR; Malone, KE; Prunty, J	1
Chung, BC; Huh, KB; Kim, KR; Kwon, SH; Lee, EJ; Lee, HC; Lee, JH; Lim, SK; Won, YJ	1
Gentzschein, E; London, S; Paganini-Hill, A; Pike, MC; Ross, RK; Stanczyk, FZ; Ursin, G	2
Adlercreutz, H; Bradlow, HL; Donaldson, JL; Falk, RT; Fears, TR; Fillmore, CM; Gail, MH; Hoover, RN; Kiuru, P; Rossi, SC; Sepkovic, D; Siiteri, PK; Vaught, JB; Wahala, K; Ziegler, RG	1
Bradlow, HL; Chang, CJ; Hu, XP; Kabat, GC; Khalil, A; Rosenblatt, R; Sepkovie, DW; Sparano, JA	1
Lippert, TH; Mueck, AO; Seeger, H	4
Auborn, K; Bradlow, HL; Newfield, L; Sepkovic, DW	1
McDougal, A; Safe, S	1
Service, RF	1
Evans, GL; Gibson, KJ; Malone, P; Turner, RT; Westerlind, KC	1
Foo, SC; Ho, GH; Ji, CY; Luo, XW; Ng, EH	1
Brewer, E; Henion, J; Rule, G	1
Allen, DS; Bradlow, HL; De Stavola, B; Fentiman, I; Kuller, LH; Meilahn, EN; Sepkovic, DW	1
Gupta, M; McDougal, A; Safe, S	1
Ramirez, VD; Zheng, J	1
Bradlow, HL; Ganguly, S; Garbers, SV; Garte, SJ; Osborne, MP; Sepkovic, DW; Taioli, E; Trachman, J	1
Kato, T; Maeda, K; Miyairi, S; Naganuma, A; Oe, T	1
Gibson, KJ; Westerlind, KC; Wolfe, P	1
Bradlow, HL; Kabat, GC	1
Carruba, G; Castagnetta, LA	1
Duncan, AM; Kurzer, MS; Merz-Demlow, BE; Phipps, WR; Xu, X	1
Anderson, KG; Chen, Z; Dunning, LM; Holtzman, JL; Parrish, RS; Zheng, W	1
Barbieri, RL; Bradlow, HL; Hankinson, SE; Manson, JE; Michaud, DS; Sepkovic, DW; Spiegelman, D	1
Adlercreutz, H; Bradlow, HL; Donaldson, J; Falk, RT; Fears, TR; Migella, A; Rossi, SC; Sepkovic, DW; Ziegler, RG	1
Bradlow, HL; Guo, L; Mittelman, A; Singhal, H; Tiwari, RK	1
Anderson, KE; Cree, M; Grady, JJ; Josyula, S; Lu, LJ; Nagamani, M	1
Robinson, JA; Spelsberg, TC; Turner, RT; Waters, KM	1
Gruber, DM; Huber, JC	1
Bell, MC; Bradlow, HL; Crowley-Nowick, P; Howell, P; Mathis, JM; Mayeaux, EJ; Schmidt-Grimminger, D; Sepkovic, DW; Tucker, A; Turbat-Herrera, EA	1
Fowke, JH; Hebert, JR; Longcope, C	1
Bradlow, HL; Jernström, H; Narod, SA; Vesprini, D	1
Bradlow, HL; De Stavola, B; dos Santos Silva, I; Linos, A; Linos, D; Riza, E; Sepkovic, DW	1
Lotinun, S; Turner, RT; Westerlind, KC	1
Beppu, M; Ebihara, K; Izumi, T; Kishida, T; Nashiki, K	1
Gallo, MA; Klinge, CM; Lewis, JS; Thomas, T; Thomas, TJ	1
Mercado, E; Salazar, EL; Salcedo, M; Sojo, I	1
Cheng, ZN; Huang, SL; Tan, ZR; Wang, W; Zhou, HH	1
Gräser, T; Lippert, TH; Mueck, AO; Oettel, M; Seeger, H	1
Bernstein, L; Gentzschein, E; London, S; Pike, MC; Stanczyk, FZ; Tseng, CC; Ursin, G; Yang, D	1
Agostara, B; Amoroso, M; Bellavia, V; Carruba, G; Castagnetta, LA; Granata, OM; Miele, M; Ravazzolo, B; Traina, A	1
Chung, BC; Chung, WY; Jung, BH; Kim, KM; Lee, SH; Park, CS	1
Almario, RU; Gregory, L; Kasim-Karakas, SE; Lasley, BL; Todd, H; Wong, R	1
Bradlow, HL; Cheng, JR; Fowke, JH; Gao, YT; Jin, F; Qi, D; Shu, XO; Zheng, W	1
Kastango, KB; Kirshner, MA; Klug, TL; Pollock, BG; Thompson, DS	1
Bradlow, HL; Jernström, H; Klug, TL; Narod, SA; Sepkovic, DW	1
Alvarez-Vasquez, RB; Axelrod, D; Bradlow, HL; Frenkel, K; Newman, MC; Sepkovic, DW; Zumoff, B	1
BROWN, JB; MARRIAN, GF	1
LAYNE, DS; MARRIAN, GF	2
BROWN, BT; FISHMAN, J; GALLAGHER, TF	1
BREUER, H; KNUPPEN, R; NOCKE, L	1
BREUER, H; KNUPPEN, R; NOCKE, W	1
Bauer, DC; Cauley, JA; Cummings, SR; Danielson, ME; Kuller, LH; Ljung, BM; Zmuda, JM	1
Carruba, G; Castagnetta, LA; Cutolo, M; Granata, OM; Miele, M; Schmidt, M; Stefano, R; Straub, RH	1
Mueck, AO; Seeger, H; Wallwiener, D	1
Dott, W; Hollender, J; Kämpfer, P; Leuschner, P; Weber, S	1
Albanese, C; Gallo, MA; Lewis, JS; Pestell, RG; Thomas, T; Thomas, TJ	1
Loft, S; Olsen, A; Overvad, K; Thomsen, BL; Tjonneland, A; Wellejus, A	1
Bradlow, HL; Garte, S; Paracchini, V; Pedotti, P; Raimondi, S; Sepkovic, DW; Taioli, E	1
Bradlow, HL; Britton, JA; Gammon, MD; Kabat, GC; Neugut, AI; O'Leary, ES; Sepkovic, DW; Teitelbaum, SL; Terry, MB	1
Crawford, S; Gold, EB; Lasley, B; McConnell, DS; Randolph, JF; Sowers, MR; Wilkin, MK	1
Buyuktur, AG; Hochberg, M; Jamadar, DA; Jannausch, M; McConnell, D; Sowers, MR	1
Hsu, IP; Huang, CW; Jou, HJ; Wang, TA; Wu, WH	1
Kim, SH; Lee, SU; Min, YK; Rhee, Mc	1
Calabrò, M; Campisi, I; Carruba, G; Cocciadiferro, L; Granata, OM; Polito, LM	1
Byers, T; Lezotte, D; Risendal, B; Wacker, M; Westerlind, K	1
Ahrendt, G; Garte, S; Im, A; Lloyd, S; Ragin, C; Taioli, E; Vogel, VG	1
Cacioppo, JT; Hawkley, LC; Masi, CM; Veenstra, TD; Xu, X	1
Capellino, S; Cutolo, M; Hartung, R; Pfeifer-Leeg, A; Schmidt, M; Straub, RH	1
Bertone-Johnson, ER; Bigelow, C; Heersink, J; Kurzer, MS; Puleo, E; Sabelawski, S; Sturgeon, SR; Volpe, SL; Wahala, K	1
Afanasyeva, Y; Arslan, AA; Berrino, F; Hallmans, G; Idahl, A; Koenig, KL; Krogh, V; Lenner, P; Liu, M; Lukanova, A; Lundin, E; Muti, P; Ohlson, N; Shore, RE; Sieri, S; Toniolo, P; Zeleniuch-Jacquotte, A	1
Bradlow, HL; Li, G; Sepkovic, DW; Telang, NT; Wong, GY	1
Conroy, SM; Franke, AA; Isaki, M; Maskarinec, G; Morimoto, Y; Nordt, FJ; Pagano, IS	1
Custer, L; Franke, AA; Heak, S; Maskarinec, G; Morimoto, Y	1
Custer, L; Franke, AA; Heak, S; Isaki, M; Maskarinec, G; Morimoto, Y; Steinbrecher, A	1
Campbell, A; Ciuclan, L; Johansen, AK; Loughlin, L; MacLean, MR; Mair, KM; McClure, JD; Morecroft, I; Nilsen, M; Paton, L; Thomas, M; Wallace, E; White, K	1
Bazzan, AJ; Newberg, AB; Zabrecky, GP	1
Kurzer, MS; Samavat, H	1
Huober, J; Mueck, AO; Ruan, X; Seeger, H; Wallwiener, D	1
Cassorla, F; Codner, E; Iñiguez, G; Lopez, P; Martínez, D; Merino, PM; Perez-Bravo, F	1
Cai, DZ; Gao, WL; Li, YZ; Song, YC; Wu, B; Wu, LS; Zi, JH	1
Bradlow, HL; Kotsopoulos, J; Llacuachaqui, M; Narod, SA; Nikitina, D; Sepkovic, D	1
Godínez Martínez, EY; Juárez González, AR; Lemus Bravo, AE; Rodríguez Ventura, AL; Sámano, R; Santillán Ballesteros, R; Tolentino Dolores, M	1
Fuhrman, BJ; Matthews, CE; Moore, SC; Ziegler, RG	1
Dikshit, A; Eilati, E; Gao, C; Gomes Filho, MA; Hales, DB; Klug, T; McGee, S; Small, C	1
Finel, M; Järvinen, E; Kallionpää, RA	1
Austin, ED; Chen, X; Cogan, JD; Dawson, EP; Fessel, JP; French, J; Gladson, S; Hamid, R; Hedges, LK; Hemnes, AR; Loyd, JE; Majka, SJ; Martinez, EG; Phillips, JA; Shay, S; Talati, M; Trammell, A; West, J; Wheeler, LA; Womble, KE	1
Gheldiu, AM; Loghin, F; Popa, DS; Vlase, L	1
Altbach, M; Chalasani, P; Chow, HHS; Galons, JP; Huang, C; Maskarinec, G; Roe, DJ; Stopeck, A; Strom, MB; Thompson, PA; Thomson, CA; Wertheim, BC	1
Boucher, BA; Chang, VC; Cotterchio, M; Jenkins, DJA; McCann, SE; Mirea, L; Thompson, LU	1
Khan, WA	1
Kulbacka, J; Piwowar, A; Roik, J; Saczko, J; Sawicka, E	1
Hu, Z; Huang, T; Li, Y; Peng, T; Wang, H; Ye, X	1
Brix, J; Gahler, RJ; Gerry, A; Glover, M; Green, T; Li, K; Newman, M; Reil, J; Schauch, M; See, J; Wood, S	1

Reviews

3 review(s) available for 16-hydroxyestrone and estrone

Article	Year
Conjugated estrogens--the natural SERMs. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13 Suppl 6 Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Cardiovascular Diseases; Dihydrotestosterone; Equilin; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hydroxyestrones; Osteoporosis; Progesterone; Selective Estrogen Receptor Modulators; Testosterone; Thyroxine; Triiodothyronine	1999
Estrogen metabolism and breast cancer. Cancer letters, 2015, Jan-28, Volume: 356, Issue:2 Pt A Topics: Breast Neoplasms; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Estradiol; Estrogens; Female; Humans; Hydroxyestrones; Postmenopause; Premenopause; Receptors, Estrogen; Risk; Risk Factors	2015
Epidemiologic studies of estrogen metabolism and breast cancer. Steroids, 2015, Volume: 99, Issue:Pt A Topics: Breast Neoplasms; Chromatography, Liquid; Epidemiologic Studies; Estrogens; Female; Humans; Hydroxyestrones; Postmenopause; Premenopause; Prospective Studies; Risk Factors; Tandem Mass Spectrometry	2015

Trials

15 trial(s) available for 16-hydroxyestrone and estrone

Article	Year
Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. Carcinogenesis, 1996, Volume: 17, Issue:4 Topics: Adult; Caffeine; Chlorzoxazone; Diet; Female; Humans; Hydroxyestrones; Male; Reference Values; Vegetables	1996
Urinary markers of estrogen metabolism 2- and 16 alpha-hydroxylation in premenopausal women. Steroids, 1996, Volume: 61, Issue:8 Topics: Adult; Body Weight; Female; Humans; Hydroxyestrones; Hydroxylation; Immunoassay; Middle Aged; Premenopause; Reference Values; Reproducibility of Results; Risk Factors; Steroid 16-alpha-Hydroxylase; Time Factors	1996
Effects of dietary broccoli on human drug metabolising activity. Cancer letters, 1997, Mar-19, Volume: 114, Issue:1-2 Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Diet; Glutathione Transferase; Humans; Hydroxyestrones; Intestines; Liver; Lymphocytes; Vegetables	1997
Estradiol metabolism during oral and transdermal estradiol replacement therapy in postmenopausal women. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1998, Volume: 30, Issue:9 Topics: Administration, Cutaneous; Administration, Oral; Estradiol; Estrone; Female; Hormone Replacement Therapy; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Radioimmunoassay	1998
Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk. Cancer detection and prevention, 1999, Volume: 23, Issue:3 Topics: Adult; Black People; Breast Neoplasms; Case-Control Studies; Cytochrome P-450 CYP1A1; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Hydroxyestrones; Indoles; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; RNA, Messenger; White People	1999
Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecologic oncology, 2000, Volume: 78, Issue:2 Topics: Administration, Oral; Anticarcinogenic Agents; DNA, Viral; Dose-Response Relationship, Drug; Female; Humans; Hydroxyestrones; Indoles; Papillomaviridae; Papillomavirus Infections; Placebos; Polymerase Chain Reaction; Precancerous Conditions; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms	2000
Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:8 Topics: Aged; Analysis of Variance; Anticarcinogenic Agents; Brassica; Breast Neoplasms; Estrogens; Female; Humans; Hydroxyestrones; Least-Squares Analysis; Middle Aged; Phytotherapy; Postmenopause	2000
Effect of norethisterone acetate on estrogen metabolism in postmenopausal women. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:10 Topics: Anticarcinogenic Agents; Contraceptives, Oral, Synthetic; Estradiol; Estrogen Replacement Therapy; Female; Humans; Hydroxyestrones; Male; Middle Aged; Norethindrone; Postmenopause	2000
The effects of soygerm extracts on blood lipoproteins, antioxidative capacity and urinary estrogen metabolites in postmenopausal women on hormone therapy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 98, Issue:1 Topics: Antioxidants; Cholesterol, HDL; Cholesterol, LDL; Copper; Estrogen Replacement Therapy; Estrogens; Female; Glycine max; Humans; Hydroxyestrones; Isoflavones; Lipoproteins, LDL; Middle Aged; Oxidation-Reduction; Pilot Projects; Plant Extracts; Postmenopause; Taiwan; Thiobarbituric Acid Reactive Substances; Triglycerides	2007
Urinary estrogen metabolites during a randomized soy trial. Nutrition and cancer, 2012, Volume: 64, Issue:2 Topics: Adult; China; Cross-Over Studies; Diet; Equol; Estrogens; Ethnicity; Female; Flavonoids; Hawaii; Humans; Hydroxyestrones; Isoflavones; Japan; Korea; Middle Aged; Philippines; Premenopause; Soy Foods; White People	2012
The relation of urinary estrogen metabolites with mammographic densities in premenopausal women. Cancer epidemiology, 2012, Volume: 36, Issue:5 Topics: Adult; Asian People; Breast; Breast Neoplasms; Cell Count; Estrogens; Female; Humans; Hydroxyestrones; Mammography; Middle Aged; Premenopause; Progesterone; Risk Assessment; Testosterone	2012
Urinary estrogen metabolites in two soy trials with premenopausal women. European journal of clinical nutrition, 2012, Volume: 66, Issue:9 Topics: Adult; Chromatography, Liquid; Cross-Over Studies; Diet; Estrogens; Female; Humans; Hydroxyestrones; Isoflavones; Mass Spectrometry; Premenopause; Regression Analysis; Soy Foods	2012
A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast cancer research and treatment, 2017, Volume: 165, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Humans; Hydroxyestrones; Indoles; Mammography; Middle Aged; Sex Hormone-Binding Globulin; Tamoxifen; Time Factors; Treatment Outcome	2017
Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial. Nutrition and cancer, 2019, Volume: 71, Issue:3 Topics: Breast Neoplasms; Canada; Diet; Female; Flax; Gonadal Steroid Hormones; Humans; Hydroxyestrones; Lignans; Middle Aged; Postmenopause; Prolactin	2019
A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense Journal of complementary & integrative medicine, 2023, Mar-01, Volume: 20, Issue:1 Topics: Biomarkers; Breast Neoplasms; Cross-Over Studies; Estrogens; Female; Humans; Hydroxyestrones	2023

Other Studies

118 other study(ies) available for 16-hydroxyestrone and estrone

Article	Year
Induction by estrogen metabolite 16 alpha-hydroxyestrone of genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. Journal of the National Cancer Institute, 1992, Apr-15, Volume: 84, Issue:8 Topics: Animals; Cell Division; Cell Transformation, Neoplastic; DNA Repair; Estradiol; Female; Hydroxyestrones; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Tumor Cells, Cultured	1992
[Biological effect of estrogen metabolites in human breast cancer]. Nihon Geka Gakkai zasshi, 1992, Volume: 93, Issue:5 Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Breast Neoplasms; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; Receptors, Estrogen; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tumor Cells, Cultured	1992
Structure of the adduct of 16 alpha-hydroxyestrone with a primary amine: evidence for the Heyns rearrangement of steroidal D-ring alpha-hydroxyimines. Steroids, 1991, Volume: 56, Issue:7 Topics: Amines; Estrogens; Hydroxyestrones; Steroid 16-alpha-Hydroxylase	1991
Stimulation of anti-RNP antibody binding to cultured keratinocytes by estradiol. Archives of dermatological research, 1991, Volume: 283, Issue:4 Topics: Antibodies, Antinuclear; Autoantibodies; Autoantigens; Binding Sites, Antibody; Cells, Cultured; Estradiol; Flow Cytometry; Fluorescent Antibody Technique; Humans; Hydroxyestrones; Keratinocytes; snRNP Core Proteins	1991
Effects of estrogens on MCF-7 cells: positive or negative regulation by the nature of the ligand-receptor complex. Biochemical and biophysical research communications, 1991, Jan-15, Volume: 174, Issue:1 Topics: Breast Neoplasms; Cell Count; Estradiol; Estrogens; Female; Humans; Hydroxyestrones; Ligands; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured	1991
In vitro synthesis of 16 alpha-hydroxyestrone by female rat liver microsomes: its possible role in the etiology of breast cancer. Journal of steroid biochemistry, 1990, Aug-28, Volume: 36, Issue:6 Topics: Animals; Breast Neoplasms; Chromatography, High Pressure Liquid; Estrone; Female; Hydroxyestrones; In Vitro Techniques; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains	1990
Estrogen metabolism as measured in blood and urine in female rhesus monkeys. Journal of steroid biochemistry, 1990, Volume: 35, Issue:5 Topics: Animals; Estradiol; Estrogens; Estrone; Female; Hydroxyestrones; Macaca mulatta; Uterus	1990
Uptake and metabolism of estradiol by normal and abnormal breast tissues. Annals of the New York Academy of Sciences, 1990, Volume: 586 Topics: Adult; Breast; Breast Neoplasms; Estradiol; Estriol; Estrone; Female; Fibrocystic Breast Disease; Humans; Hydroxyestrones	1990
Determination of aromatization of 19-oxygenated 16 alpha-hydroxyandrostenedione with human placental microsomes by high-performance liquid chromatography coupled with coulometric detection. Journal of steroid biochemistry, 1990, Jul-04, Volume: 36, Issue:4 Topics: Androstenedione; Aromatase; Chromatography, High Pressure Liquid; Estriol; Female; Humans; Hydroxyestrones; Kinetics; Microsomes; Placenta; Substrate Specificity	1990
Temporal actions of 16 alpha-hydroxyestrone in the rat: comparisons of lordosis dynamics with other estrogen metabolites and between sexes. Journal of steroid biochemistry, 1989, Volume: 33, Issue:3 Topics: Animals; Castration; Estradiol; Estriol; Estrogens; Estrone; Female; Hydroxyestrones; Male; Rats; Receptors, Estrogen; Sex Factors; Sexual Behavior, Animal; Time Factors	1989
Evidence for separate sites for aromatisation of androstenedione and 16 alpha-hydroxyandrostenedione in human placental microsomes. Journal of steroid biochemistry, 1989, Volume: 33, Issue:3 Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones; In Vitro Techniques; Kinetics; Microsomes; Placenta; Pregnancy; Radioimmunoassay	1989
Differential effects of estradiol and 16 alpha-hydroxyestrone on pituitary and preoptic estrogen receptor regulation. Endocrinology, 1989, Volume: 125, Issue:5 Topics: Aging; Animals; Cell Nucleus; Cytosol; Estradiol; Estrone; Female; Hydroxyestrones; Male; Orchiectomy; Ovariectomy; Pituitary Gland; Posture; Preoptic Area; Rats; Rats, Inbred F344; Receptors, Estrogen; Sexual Behavior, Animal	1989
[Determination of serum 16 alpha-hydroxydehydroepiandrosterone, 16 alpha-hydroxyestrone and estriol by gas chromatography-mass spectrometry and their perinatal movement]. Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:4 Topics: Dehydroepiandrosterone; Estriol; Estrone; Female; Fetal Blood; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Labor, Obstetric; Pregnancy	1986
Structure of lysine adducts with 16 alpha-hydroxyestrone and cortisol. Journal of steroid biochemistry, 1986, Volume: 25, Issue:1 Topics: Estrone; Hydrocortisone; Hydroxyestrones; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Schiff Bases	1986
Covalent binding of the endogenous estrogen 16 alpha-hydroxyestrone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:21 Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Division; Cell Line; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrone; Humans; Hydroxyestrones; Receptors, Estradiol; Steroid 16-alpha-Hydroxylase	1988
Identification of 16 alpha-hydroxy-estrone as a metabolite of estriol. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1988, Volume: 2, Issue:3 Topics: Biotransformation; Estriol; Estrone; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Hysterectomy; Myometrium	1988
Anti-oestrogen antibodies in users of oral contraceptives and in patients with systemic lupus erythematosus. Clinical and experimental immunology, 1987, Volume: 67, Issue:1 Topics: Adult; Antibodies; Contraceptives, Oral; Enzyme-Linked Immunosorbent Assay; Estrogens; Female; Humans; Hydroxyestrones; Lupus Erythematosus, Systemic; Male; Middle Aged	1987
Increased levels of 16 alpha-hydroxyestrone-modified proteins in pregnancy and in systemic lupus erythematosus. The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:5 Topics: Adolescent; Adult; Amino Acids; Basement Membrane; Chemical Phenomena; Chemistry; Erythrocyte Membrane; Estrone; Female; Humans; Hydrolysis; Hydroxyestrones; Kidney Glomerulus; Lupus Erythematosus, Systemic; Lymphocytes; Lysine; Male; Membrane Proteins; Middle Aged; Pregnancy; Radioimmunoassay	1985
High-performance liquid chromatographic determination of aromatization of 16 alpha-hydroxylated androgens with human placental microsomes. Analytical biochemistry, 1985, Volume: 146, Issue:1 Topics: Androgens; Androstenedione; Chromatography, Gel; Chromatography, High Pressure Liquid; Estriol; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Hydroxytestosterones; In Vitro Techniques; Kinetics; Microchemistry; Microsomes; Placenta	1985
Determination of 16 alpha-hydroxyestrone by radioimmunoassay in systemic lupus erythematosus. Arthritis and rheumatism, 1985, Volume: 28, Issue:10 Topics: Adult; Estradiol; Estrone; Female; Humans; Hydroxyestrones; Lupus Erythematosus, Systemic; Male; Menstrual Cycle; Middle Aged; Pregnancy; Radioimmunoassay; Reference Values	1985
Interaction of histones with estrogens. Covalent adduct formation with 16 alpha-hydroxyestrone. Biochemistry, 1985, Dec-31, Volume: 24, Issue:27 Topics: Estradiol; Estrogens; Estrone; Histones; Hydroxyestrones; Kinetics; Protein Binding; Thymus Gland	1985
Levels of circulating and urinary oestrogens during pregnancy in the marmoset monkey (Callithrix jacchus). Journal of reproduction and fertility, 1983, Volume: 67, Issue:1 Topics: Animals; Callitrichinae; Chromatography, High Pressure Liquid; Estradiol; Estriol; Estrogens; Estrone; Female; Gas Chromatography-Mass Spectrometry; Hydroxyestrones; Pregnancy; Pregnancy, Animal	1983
Characterization of antisera to the addition product formed by the nonenzymatic reaction of 16 alpha-hydroxyestrone with albumin. Molecular immunology, 1983, Volume: 20, Issue:12 Topics: Animals; Antibody Formation; Antigens; Cross Reactions; Dose-Response Relationship, Immunologic; Estrone; Hydroxyestrones; Immune Sera; Macromolecular Substances; Rabbits; Serum Albumin	1983
The reaction of 16 alpha-hydroxyestrone with erythrocytes in vitro and in vivo. European journal of biochemistry, 1984, May-02, Volume: 140, Issue:3 Topics: Blood Proteins; Chromatography; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Estrone; Humans; Hydrolysis; Hydroxyestrones; In Vitro Techniques; Membrane Proteins; Protein Binding; Radioimmunoassay	1984
[Determination of free and conjugated 16 alpha-hydroxyestrone (16 alpha-OH E1) in serum by mass fragmentography using gas chromatography mass spectrometry]. Nihon Naibunpi Gakkai zasshi, 1984, Feb-20, Volume: 60, Issue:2 Topics: Chromatography, Gas; Estradiol; Estrone; Female; Fetal Blood; Fetal Death; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Mass Spectrometry; Pregnancy	1984
Formation of covalent adducts between cortisol and 16 alpha-hydroxyestrone and protein: possible role in the pathogenesis of cortisol toxicity and systemic lupus erythematosus. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:10 Topics: Acetylation; Chemical Phenomena; Chemistry; Estrone; Hydrocortisone; Hydroxyestrones; Lupus Erythematosus, Systemic; Lysine; Serum Albumin	1982
Concentration of 16 alpha-hydroxyestrone in human plasma as measured by a specific RIA. Journal of steroid biochemistry, 1983, Volume: 18, Issue:3 Topics: Animals; Cross Reactions; Estrone; Female; Humans; Hydroxyestrones; Immune Sera; Male; Menstruation; Pregnancy; Rabbits; Radioimmunoassay; Sex Factors	1983
Abnormal estrogen and androgen metabolism in the human with systemic lupus erythematosus. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1982, Volume: 2, Issue:1 Suppl 1 Topics: Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones; Hydroxylation; Lupus Erythematosus, Systemic; Male; Oxidation-Reduction; Testosterone	1982
Synthesis of 3, 6 alpha-trihydroxy-1, 3, 5 (10)-estratrien-17-one 6-hemisuccinate and [6,7 3H]-3,16 alpha-dihydroxy-1,3,5,(10)-estratrien-17-one. Steroids, 1982, Volume: 39, Issue:5 Topics: Chemical Phenomena; Chemistry; Estrone; Hydroxyestrones; Isotope Labeling; Magnetic Resonance Spectroscopy; Methods; Radioimmunoassay; Spectrophotometry, Ultraviolet; Tritium	1982
Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology. The Journal of clinical endocrinology and metabolism, 1980, Volume: 51, Issue:3 Topics: Animals; Castration; Estradiol; Estriol; Estrogens; Estrone; Female; Hydroxyestrones; Luteinizing Hormone; Rats; Receptors, Estrogen; Sex Hormone-Binding Globulin; Uterus	1980
Monoclonal antibody-based enzyme immunoassay for simultaneous quantitation of 2- and 16 alpha-hydroxyestrone in urine. Steroids, 1994, Volume: 59, Issue:11 Topics: Antibodies, Monoclonal; Autoanalysis; Cost-Benefit Analysis; Estrogens, Catechol; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Immunoenzyme Techniques; Time Factors	1994
Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro. Biochemical and biophysical research communications, 1995, Jan-26, Volume: 206, Issue:3 Topics: 2-Methoxyestradiol; Carcinoma, Hepatocellular; Estradiol; Estriol; Estrogens; Estrone; Humans; Hydroxyestrones; Liver Neoplasms; Receptors, Estrogen; RNA, Messenger; Sex Hormone-Binding Globulin; Tumor Cells, Cultured	1995
Genotoxic damage and aberrant proliferation in mouse mammary epithelial cells. Recent progress in hormone research, 1993, Volume: 48 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cells, Cultured; DNA Damage; DNA Repair; Epithelial Cells; Epithelium; Estradiol; Estriol; Female; Hydroxyestrones; Mammary Glands, Animal; Mice; Mice, Inbred C57BL	1993
Estrogen metabolite ratios and risk assessment of hormone-related cancers. Assay validation and prediction of cervical cancer risk. Annals of the New York Academy of Sciences, 1995, Sep-30, Volume: 768 Topics: Biopsy; Estriol; Estrogens, Catechol; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Menstrual Cycle; Predictive Value of Tests; Premenopause; Reference Values; Reproducibility of Results; Risk Assessment; Risk Factors; Surveys and Questionnaires; Uterine Cervical Neoplasms; Vaginal Smears	1995
Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. Environmental health perspectives, 1995, Volume: 103 Suppl 7 Topics: Biomarkers; Breast Neoplasms; Estradiol; Estrogens, Catechol; Humans; Hydroxyestrones; Insecticides; Tumor Cells, Cultured	1995
Measurement of urinary estrogen metabolites using a monoclonal enzyme-linked immunoassay kit: assay performance and feasibility for epidemiological studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:9 Topics: Adolescent; Adult; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Epidemiologic Methods; Estrogens; Estrogens, Catechol; Evaluation Studies as Topic; Feasibility Studies; Female; Follicular Phase; Humans; Hydroxyestrones; Luteal Phase; Menstrual Cycle; Middle Aged; Premenopause; Reagent Kits, Diagnostic; Time Factors	1996
Altered hydroxylation of estrogen in patients with postmenopausal osteopenia. The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:4 Topics: Aged; Body Height; Body Mass Index; Body Weight; Bone Density; Bone Diseases, Metabolic; Estrogens; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Hydroxylation; Middle Aged; Postmenopause; Steroid 16-alpha-Hydroxylase	1997
A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer. Environmental health perspectives, 1997, Volume: 105 Suppl 3 Topics: Breast Neoplasms; Case-Control Studies; Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones; Menopause; Middle Aged; Neoplasms, Hormone-Dependent; Pilot Projects; Risk Factors; Steroid 16-alpha-Hydroxylase	1997
Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine. Environmental health perspectives, 1997, Volume: 105 Suppl 3 Topics: Adult; Biomarkers; Breast Neoplasms; Estrogens; Evaluation Studies as Topic; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Immunoenzyme Techniques; Luteal Phase; Menopause; Middle Aged; Neoplasms, Hormone-Dependent; Reproducibility of Results; Risk Factors	1997
Urinary estrogen metabolites and breast cancer: a case-control study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:7 Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; New York; Postmenopause; Risk	1997
Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation. Life sciences, 1997, Volume: 61, Issue:9 Topics: Estradiol; Estrogens, Catechol; Humans; Hydroxyestrones; Kinetics; Lipoproteins, LDL; Oxidation-Reduction; Vitamin E	1997
Estrogen metabolism and the malignant potential of human papillomavirus immortalized keratinocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1998, Volume: 217, Issue:3 Topics: Aryl Hydrocarbon Hydroxylases; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; DNA Damage; Estradiol; Humans; Hydroxyestrones; Keratinocytes; Papillomaviridae; Steroid 16-alpha-Hydroxylase	1998
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. Environmental health perspectives, 1998, Volume: 106, Issue:4 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 Enzyme System; Drug Screening Assays, Antitumor; Estrogen Antagonists; Female; Humans; Hydroxyestrones; Mammary Neoplasms, Experimental; Pesticides; Predictive Value of Tests; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tumor Cells, Cultured	1998
New role for estrogen in cancer? Science (New York, N.Y.), 1998, Mar-13, Volume: 279, Issue:5357 Topics: Animals; Carcinogens; Estrogens; Female; Humans; Hydroxyestrones; Mutagens; Neoplasms	1998
Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:6 Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Division; Cholesterol; Epithelial Cells; Estradiol; Estrogens, Catechol; Female; Hydroxyestrones; Hypercholesterolemia; Mammary Glands, Animal; Ovariectomy; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Structure-Activity Relationship; Tibia; Uterus	1998
Urinary 2/16 alpha-hydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein-3 and a potential biomarker of breast cancer risk. Annals of the Academy of Medicine, Singapore, 1998, Volume: 27, Issue:2 Topics: Age Factors; Anticarcinogenic Agents; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Cell Transformation, Neoplastic; Confidence Intervals; Contraceptives, Oral; Disease Progression; Estradiol; Estrogens, Catechol; Female; Forecasting; Humans; Hydroxyestrones; Hydroxylation; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Linear Models; Logistic Models; Menopause; Middle Aged; Odds Ratio; Parity; Risk Factors	1998
Sample preparation for LC/MS/MS: analyzing biological and environmental samples. Analytical chemistry, 1998, Oct-01, Volume: 70, Issue:19 Topics: Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Liquid; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Mass Spectrometry; Urine	1998
Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. British journal of cancer, 1998, Volume: 78, Issue:9 Topics: Adult; Breast Neoplasms; Cohort Studies; Female; Follow-Up Studies; Humans; Hydroxyestrones; Incidence; Predictive Value of Tests; Prospective Studies; Risk Factors	1998
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of steroid biochemistry and molecular biology, 1998, Volume: 67, Issue:5-6 Topics: Breast Neoplasms; Cathepsin D; Cell Division; Creatine Kinase; Estradiol; Estriol; Female; Humans; Hydroxyestrones; Isoenzymes; Promoter Regions, Genetic; Receptors, Estrogen; Recombinant Proteins; Transfection; Tumor Cells, Cultured	1998
Rapid inhibition of rat brain mitochondrial proton F0F1-ATPase activity by estrogens: comparison with Na+, K+ -ATPase of porcine cortex. European journal of pharmacology, 1999, Feb-26, Volume: 368, Issue:1 Topics: Animals; Brain; Cholesterol; Corticosterone; Dehydroepiandrosterone; Detergents; Diethylstilbestrol; Enzyme Inhibitors; Estrogens; Female; Hydroxyestrones; Microsomes; Mitochondria; Ouabain; Progesterone; Proton-Translocating ATPases; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Solubility; Swine; Testosterone; Zeranol	1999
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute, 1999, Jun-16, Volume: 91, Issue:12 Topics: Aged; Breast Neoplasms; Case-Control Studies; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; Odds Ratio; Postmenopause; Radioimmunoassay; Risk; Risk Factors; Steroid 16-alpha-Hydroxylase	1999
Effect of metal ions on the stable adduct formation of 16alpha-hydroxyestrone with a primary amine via the Heyns rearrangement. Steroids, 1999, Volume: 64, Issue:4 Topics: Cations; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cobalt; Copper; Drug Stability; Erythrocyte Membrane; Hydrogen-Ion Concentration; Hydrolysis; Hydroxyestrones; Membrane Proteins; Metals; Molecular Structure; Nickel; Platinum; Serum Albumin; Structure-Activity Relationship	1999
The effect of diurnal and menstrual cyclicity and menopausal status on estrogen metabolites: implications for disease-risk assessment. Steroids, 1999, Volume: 64, Issue:3 Topics: Adult; Circadian Rhythm; Female; Humans; Hydroxyestrones; Menopause; Menstrual Cycle; Risk Assessment	1999
Re: "A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer". Environmental health perspectives, 1998, Volume: 106, Issue:3 Topics: Female; Humans; Hydroxyestrones; Middle Aged; Postmenopause	1998
Effect of estradiol metabolites on prostacyclin synthesis in human endothelial cell cultures. Life sciences, 1999, Volume: 65, Issue:13 Topics: 2-Methoxyestradiol; Cells, Cultured; Endothelium, Vascular; Epoprostenol; Estradiol; Estrone; Humans; Hydroxyestrones	1999
Re: Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute, 1999, Nov-03, Volume: 91, Issue:21 Topics: Adult; Breast Neoplasms; Female; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Research Design; Risk; Risk Factors	1999
Menstrual cycle effects on urinary estrogen metabolites. The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:11 Topics: Adult; Body Weight; Diet; Estradiol; Estrogens; Estrogens, Catechol; Estrone; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Luteal Phase; Menstruation; Ovulation	1999
Within-person variability of the ratios of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone in Caucasian women. Steroids, 1999, Volume: 64, Issue:12 Topics: Adult; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; Reproducibility of Results; White People	1999
Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:12 Topics: Adult; Body Mass Index; Estradiol; Estrone; Female; Follicular Phase; Gonadal Steroid Hormones; Humans; Hydroxyestrones; Luteal Phase; Menarche; Middle Aged; Parity; Premenopause; Progesterone; Reproducibility of Results; Time Factors	1999
A new ELISA kit for measuring urinary 2-hydroxyestrone, 16alpha-hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:1 Topics: Boric Acids; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Estrogens, Catechol; Female; Freezing; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Population Surveillance; Postmenopause; Premenopause; Preservatives, Pharmaceutical; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Time Factors	2000
Endocrine characteristics of human breast epithelial cells, MCF-10F. Hormone research, 1999, Volume: 52, Issue:4 Topics: 9,10-Dimethyl-1,2-benzanthracene; Aromatase; Aryl Hydrocarbon Hydroxylases; Breast; Breast Neoplasms; Carcinogens; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Epithelial Cells; Estradiol; Estriol; Female; Humans; Hydroxyestrones; Steroid 16-alpha-Hydroxylase; Tumor Cells, Cultured	1999
Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. Cancer research, 2000, Mar-01, Volume: 60, Issue:5 Topics: Adult; Breast Neoplasms; Diet; Female; Glycine max; Humans; Hydroxyestrones; Isoflavones; Neoplasms, Hormone-Dependent; Premenopause	2000
Direct action of naturally occurring estrogen metabolites on human osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:3 Topics: Alkaline Phosphatase; Bone Matrix; Cell Differentiation; Cell Line; Enzyme Induction; Estradiol; Estrogen Receptor alpha; Estrogens; Fulvestrant; Humans; Hydroxyestrones; Osteoblasts; Osteocalcin; Receptors, Estrogen; Recombinant Fusion Proteins; RNA, Messenger	2000
Re: CYP17 promoter polymorphism and breast cancer in Australian women under age forty years. Journal of the National Cancer Institute, 2001, Apr-04, Volume: 93, Issue:7 Topics: Adolescent; Adult; Asian People; Australia; Black People; Breast Neoplasms; Female; Genotype; Humans; Hydroxyestrones; Native Hawaiian or Other Pacific Islander; Polymorphism, Genetic; Promoter Regions, Genetic; Steroid 17-alpha-Hydroxylase; White People	2001
Urinary estrogen metabolites and mammographic parenchymal patterns in postmenopausal women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:6 Topics: Adult; Aged; Breast Neoplasms; Case-Control Studies; Epidemiologic Studies; Estrogens; Female; Humans; Hydroxyestrones; Mammography; Middle Aged; Postmenopause; Risk Factors; Steroid 16-alpha-Hydroxylase	2001
Tissue-selective effects of continuous release of 2-hydroxyestrone and 16alpha-hydroxyestrone on bone, uterus and mammary gland in ovariectomized growing rats. The Journal of endocrinology, 2001, Volume: 170, Issue:1 Topics: Animals; Bone Remodeling; Cholesterol; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Humans; Hydroxyestrones; Mammary Glands, Animal; Models, Animal; Organ Size; Ovariectomy; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Uterus	2001
Effect of dietary soy isoflavone aglycones on the urinary 16alpha-to-2-hydroxyestrone ratio in C3H/HeJ mice. Nutrition and cancer, 2000, Volume: 38, Issue:2 Topics: Animals; Anticarcinogenic Agents; Biomarkers; Cytochrome P-450 Enzyme System; Female; Genistein; Glycine max; Hydroxyestrones; Indoles; Isoflavones; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Microsomes, Liver; Organ Size; Plant Extracts	2000
Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells. Journal of molecular endocrinology, 2001, Volume: 27, Issue:3 Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins; DNA, Neoplasm; Estradiol; Female; Genes, Reporter; Humans; Hydroxyestrones; Luciferases; Neoplasms, Hormone-Dependent; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Estrogen; Retinoblastoma Protein; RNA, Messenger; Transcriptional Activation; Tumor Cells, Cultured	2001
Relationship between estradiol 16 alpha-hydroxylation and human papillomavirus infection in cervical cell transformation. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:5 Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Biopsy; Cell Transformation, Viral; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Estradiol; Female; Humans; Hydroxyestrones; Middle Aged; Papillomaviridae; Papillomavirus Infections; Statistics, Nonparametric; Steroid 16-alpha-Hydroxylase; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms	2001
Determination of estradiol metabolites in human liver microsome by high performance liquid chromatography-electrochemistry detector. Acta pharmacologica Sinica, 2001, Volume: 22, Issue:4 Topics: Adult; Chromatography, High Pressure Liquid; Estradiol; Estriol; Estrone; Humans; Hydroxyestrones; Microsomes, Liver	2001
The effects of postmenopausal hormone replacement therapy and oral contraceptives on the endogenous estradiol metabolism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:12 Topics: Adult; Contraceptives, Oral; Estradiol; Estrogen Replacement Therapy; Estrogens, Catechol; Ethinyl Estradiol; Female; Humans; Hydroxyestrones; Middle Aged; Nandrolone; Norethindrone; Norethindrone Acetate; Postmenopause	2001
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. Breast cancer research and treatment, 2002, Volume: 72, Issue:2 Topics: Adult; Biomarkers; Breast Neoplasms; Estradiol; Estriol; Estrogens; Estrone; Female; Genetic Predisposition to Disease; Humans; Hydroxyestrones; Middle Aged; Premenopause	2002
Tissue content of hydroxyestrogens in relation to survival of breast cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:10 Topics: Adult; Aged; Binding Sites; Breast Neoplasms; Chromatography, High Pressure Liquid; Estradiol; Estrogens; Estrogens, Catechol; Female; Follow-Up Studies; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; Receptors, Estrogen; Survival Rate	2002
Estrogens in female thyroid cancer: alteration of urinary profiles in pre- and post-operative cases. Cancer letters, 2003, Jan-10, Volume: 189, Issue:1 Topics: Adult; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; Postoperative Period; Thyroid Neoplasms	2003
Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. The American journal of clinical nutrition, 2002, Volume: 76, Issue:6 Topics: Body Composition; Body Constitution; Body Mass Index; Body Weight; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Energy Intake; Follicular Phase; Fruit; Hydroxyestrones; Luteal Phase; Premenopause; Prunus	2002
Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre- versus post-treatment collection. Steroids, 2003, Volume: 68, Issue:1 Topics: Adult; Breast Neoplasms; Case-Control Studies; China; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; Odds Ratio; Postmenopause; Premenopause; Risk Factors	2003
A preliminary study of the effect of fluoxetine treatment on the 2:16-alpha-hydroxyestrone ratio in young women. Therapeutic drug monitoring, 2003, Volume: 25, Issue:1 Topics: Adult; Cytochrome P-450 Enzyme System; Female; Fluoxetine; Humans; Hydroxyestrones; Isoenzymes; Pilot Projects	2003
Predictors of the plasma ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone among pre-menopausal, nulliparous women from four ethnic groups. Carcinogenesis, 2003, Volume: 24, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Black People; Breast Neoplasms; Contraceptive Agents; Estrogen Replacement Therapy; Ethnicity; Female; Humans; Hydroxyestrones; Menstrual Cycle; Parity; Premenopause; Risk Factors; White People	2003
Influence of postmenopausal hormone replacement therapy on an estrogen metabolite biomarker of risk for breast cancer. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2003, Volume: 35, Issue:6 Topics: Biomarkers, Tumor; Breast Neoplasms; Cross-Sectional Studies; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hydroxyestrones; Medroxyprogesterone Acetate; Postmenopause; Risk Factors	2003
The metabolic reduction of 16 alpha-hydroxyoestrone to oestriol in man. The Journal of endocrinology, 1957, Volume: 15, Issue:3 Topics: Estriol; Estrogens; Hydroxyestrones; Lipid Metabolism	1957
Isolation of 16 beta-hydroxyoestrone from the urine of pregnant women. Nature, 1958, Jul-05, Volume: 182, Issue:4627 Topics: Body Fluids; Contraceptive Agents, Female; Estrogens; Female; Humans; Hydroxyestrones; Pregnancy	1958
16 beta-Hydroxyoestrone, a metabolite of oestradiol in man. Nature, 1958, Jul-05, Volume: 182, Issue:4627 Topics: Body Fluids; Contraceptive Agents, Female; Estradiol; Estrogens; Female; Humans; Hydroxyestrones	1958
The isolation of 16 beta-hydroxyoestrone and 16-oxo-oestradiol-17 beta from the urine of pregnant women. The Biochemical journal, 1958, Volume: 70, Issue:2 Topics: Estradiol; Estrogens; Female; Humans; Hydroxyestrones; Pregnancy	1958
[Reduction of 16 alpha-hydroxyestrone and 16-keto-estradiol-(17 beta) by human liver tissue in vitro]. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1958, Volume: 311, Issue:4-6 Topics: Estradiol; Estrogens; Humans; Hydroxyestrones; In Vitro Techniques; Lipid Metabolism; Liver	1958
[Isolation and quantitative determination of the 4 epimeric estriols after the injection of 16 alpha- and 16 beta-hydroxyestrone in man]. Acta endocrinologica, 1961, Volume: 36 Topics: Contraceptive Agents, Female; Estradiol Congeners; Estriol; Estrogens; Female; Humans; Hydroxyestrones; Male	1961
Estrogen metabolites and the risk of breast cancer in older women. Epidemiology (Cambridge, Mass.), 2003, Volume: 14, Issue:6 Topics: Aged; Breast Neoplasms; Case-Control Studies; Cohort Studies; Estrogens; Female; Humans; Hydroxyestrones; Risk Factors; Steroid 16-alpha-Hydroxylase; Surveys and Questionnaires	2003
Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis. The Journal of rheumatology, 2003, Volume: 30, Issue:12 Topics: Adjuvants, Immunologic; Adult; Androgens; Arthritis, Rheumatoid; Dehydroepiandrosterone; Estradiol; Estrogens; Estrogens, Catechol; Estrone; Female; Humans; Hydroxyestrones; Male; Middle Aged; Synovial Fluid; Synovial Membrane	2003
Endogenous estradiol metabolism during treatment with oral contraceptives. International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:3 Topics: Adult; Contraceptives, Oral, Combined; Estradiol; Ethinyl Estradiol; Female; Humans; Hydroxyestrones; Levonorgestrel; Nandrolone; Norethindrone; Premenopause; Randomized Controlled Trials as Topic	2004
Degradation of estradiol and ethinyl estradiol by activated sludge and by a defined mixed culture. Applied microbiology and biotechnology, 2005, Volume: 67, Issue:1 Topics: Achromobacter denitrificans; Benzhydryl Compounds; Biodegradation, Environmental; Estradiol; Estriol; Estrone; Ethinyl Estradiol; Hydroxyestrones; Mestranol; Phenols; Ralstonia; Sewage; Water Purification; Zeranol	2005
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. Journal of molecular endocrinology, 2005, Volume: 34, Issue:1 Topics: 2-Methoxyestradiol; Activating Transcription Factor 2; Blotting, Western; Breast Neoplasms; Cyclic AMP Response Element-Binding Protein; Cyclin D1; DNA Replication; Enzyme Activation; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyestrones; p38 Mitogen-Activated Protein Kinases; Transcription Factors	2005
Urinary hydroxyestrogens and breast cancer risk among postmenopausal women: a prospective study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005, Volume: 14, Issue:9 Topics: Biomarkers; Breast Neoplasms; Case-Control Studies; Estriol; Female; Hormone Replacement Therapy; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Receptors, Estrogen	2005
A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:7 Topics: Adult; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Base Sequence; Black or African American; Cytochrome P-450 CYP1B1; Deoxyribonuclease HpaII; DNA; Estradiol; Female; Genetics, Population; Humans; Hydroxyestrones; Male; Middle Aged; Polymorphism, Genetic; White People	2005
Estrogen metabolism and breast cancer. Epidemiology (Cambridge, Mass.), 2006, Volume: 17, Issue:1 Topics: Aged; Breast Neoplasms; Case-Control Studies; Estrogens; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; New York; Surveys and Questionnaires	2006
Selected diet and lifestyle factors are associated with estrogen metabolites in a multiracial/ethnic population of women. The Journal of nutrition, 2006, Volume: 136, Issue:6 Topics: Anticarcinogenic Agents; Body Size; Diet; Estrogens; Ethnicity; Exercise; Female; Flavonoids; Humans; Hydroxyestrones; Life Style; Middle Aged; Phenols; Polyphenols; Population Surveillance; Smoking; United States	2006
Estradiol and its metabolites and their association with knee osteoarthritis. Arthritis and rheumatism, 2006, Volume: 54, Issue:8 Topics: Adult; Estradiol; Female; Humans; Hydroxyestrones; Longitudinal Studies; Michigan; Middle Aged; Odds Ratio; Osteoarthritis, Knee; Radiography; Risk Factors	2006
Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. Cell biology international, 2008, Volume: 32, Issue:4 Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Hydroxyestrones; Peroxiredoxins; Protein Isoforms	2008
16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells. Annals of the New York Academy of Sciences, 2009, Volume: 1155 Topics: Cell Line, Tumor; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Hydroxyestrones; Liver Neoplasms; Selective Estrogen Receptor Modulators; Sulfotransferases	2009
Ethnicity, body size, and estrogen levels in postmenopausal Hispanic and non-Hispanic white women. Journal of women's health (2002), 2009, Volume: 18, Issue:4 Topics: Aged; Body Size; Breast Neoplasms; Cross-Sectional Studies; Female; Follow-Up Studies; Hispanic or Latino; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Risk; White People	2009
Urinary estrogen metabolites in women at high risk for breast cancer. Carcinogenesis, 2009, Volume: 30, Issue:9 Topics: Adult; Aged; Alcohol Drinking; Body Mass Index; Breast Neoplasms; Female; Humans; Hydroxyestrones; Linear Models; Middle Aged; Smoking	2009
Serum estrogen metabolites and systolic blood pressure among middle-aged and older women and men. American journal of hypertension, 2009, Volume: 22, Issue:11 Topics: Aged; Blood Pressure; Cross-Sectional Studies; Demography; Estradiol; Estrogens; Female; Humans; Hydroxyestrones; Hypertension; Male; Middle Aged	2009
Estrone/17beta-estradiol conversion to, and tumor necrosis factor inhibition by, estrogen metabolites in synovial cells of patients with rheumatoid arthritis and patients with osteoarthritis. Arthritis and rheumatism, 2009, Volume: 60, Issue:10 Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Cells, Cultured; Cohort Studies; Cytochrome P-450 Enzyme System; Estradiol; Estrogens; Estrone; Female; Humans; Hydroxyestrones; Male; Middle Aged; Osteoarthritis; Synovial Membrane; Tumor Necrosis Factor-alpha	2009
Effect of flaxseed consumption on urinary levels of estrogen metabolites in postmenopausal women. Nutrition and cancer, 2010, Volume: 62, Issue:2 Topics: 2-Methoxyestradiol; Body Mass Index; Diet; Energy Intake; Estradiol; Estrogens; Female; Flax; Humans; Hydroxyestrones; Middle Aged; Postmenopause	2010
Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer. British journal of cancer, 2011, Oct-25, Volume: 105, Issue:9 Topics: Aged; Case-Control Studies; Endometrial Neoplasms; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; Prospective Studies	2011
Anti-proliferative effects of Chinese herb Cornus officinalis in a cell culture model for estrogen receptor-positive clinical breast cancer. Molecular medicine reports, 2012, Volume: 5, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Aggregation; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cornus; Drugs, Chinese Herbal; Estradiol; Female; Fruit; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Models, Biological; Plant Extracts; Receptors, Estrogen	2012
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. Circulation, 2012, Aug-28, Volume: 126, Issue:9 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Hypoxia; Cells, Cultured; Chronic Disease; Cytochrome P-450 CYP1B1; Enzyme Induction; Estradiol; Estrogens; Female; Humans; Hydroxyestrones; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Lung; Male; Mice; Mice, Knockout; Myocytes, Smooth Muscle; Pulmonary Artery; Reverse Transcriptase Polymerase Chain Reaction; Stilbenes; Up-Regulation	2012
Multi-nutrient supplement improves hormone ratio associated with cancer risk. Journal of translational medicine, 2013, Oct-08, Volume: 11 Topics: Case-Control Studies; Dietary Supplements; Female; Follow-Up Studies; Humans; Hydroxyestrones; Middle Aged; Neoplasms; Risk Factors	2013
The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies. Archives of gynecology and obstetrics, 2015, Volume: 291, Issue:5 Topics: Adult; Biomarkers; Breast Neoplasms; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogens; Female; Genetic Predisposition to Disease; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Premenopause; Sensitivity and Specificity	2015
Elevation of C-reactive protein during the luteal phase in healthy adolescents. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2015, Volume: 31, Issue:4 Topics: Adolescent; Adolescent Development; Biomarkers; C-Reactive Protein; Chile; Female; Follicular Phase; Humans; Hydroxyestrones; Luteal Phase; Progesterone; Reference Values; Up-Regulation; Urban Health	2015
Measurement of serum estrogen and estrogen metabolites in pre- and postmenopausal women with osteoarthritis using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:2 Topics: Adult; Aged; Chromatography, High Pressure Liquid; Estradiol; Estriol; Estrogens; Estrone; Female; Follicular Phase; Humans; Hydroxyestrones; Limit of Detection; Luteal Phase; Middle Aged; Osteoarthritis; Postmenopause; Premenopause; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric	2015
The effect of oral 3,3'-diindolylmethane supplementation on the 2:16α-OHE ratio in BRCA1 mutation carriers. Familial cancer, 2015, Volume: 14, Issue:2 Topics: Administration, Oral; Adult; Female; Genes, BRCA1; Heterozygote; Humans; Hydroxyestrones; Indoles; Middle Aged; Mutation	2015
[Determination of 2-hydroxyestrone /16α-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors]. Nutricion hospitalaria, 2014, Oct-25, Volume: 31, Issue:2 Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Cross-Sectional Studies; Female; Humans; Hydroxyestrones; Male; Mexico; Middle Aged; Risk Factors; Young Adult	2014
Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. The British journal of nutrition, 2015, May-14, Volume: 113, Issue:9 Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP3A; Diet; Dietary Supplements; Dinoprostone; Estrogen Receptor alpha; Estrogens; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Flax; Hydroxyestrones; Lignans; Liver; Ovarian Neoplasms; Ovary; RNA, Messenger	2015
Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7. The Journal of steroid biochemistry and molecular biology, 2015, Volume: 154 Topics: Estrone; Glucuronides; Glucuronosyltransferase; Hydroxyestrones; Intestines; Kinetics; Microsomes, Liver; Substrate Specificity	2015
Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism. Circulation, 2016, Jan-05, Volume: 133, Issue:1 Topics: Animals; Bone Morphogenetic Protein Receptors, Type II; Cellular Microenvironment; Female; Humans; Hydroxyestrones; Hypertension, Pulmonary; Male; Mice; Mice, Transgenic; MicroRNAs	2016
Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes. Biomedical and environmental sciences : BES, 2015, Volume: 28, Issue:11 Topics: Animals; Benzhydryl Compounds; Biomarkers; Breast Neoplasms; Drug Synergism; Endocrine Disruptors; Estrone; Genistein; Hydroxyestrones; Male; Microsomes, Liver; Oxidation-Reduction; Phenols; Rats, Wistar	2015
16 α-Hydroxyestrone induced adduct generate high affinity autoantibodies in SLE. Advances in medical sciences, 2019, Volume: 64, Issue:1 Topics: Adult; Antibody Affinity; Autoantibodies; Epitopes; Female; Histones; Humans; Hydroxyestrones; Kinetics; Lupus Erythematosus, Systemic; Male; Middle Aged	2019
Effect of Interaction between 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone with Chromium (VI) on Ovary Cancer Line SKOV-3: Preliminary Study. Molecules (Basel, Switzerland), 2020, Nov-09, Volume: 25, Issue:21 Topics: 2-Methoxyestradiol; Apoptosis; Cell Line, Tumor; Cell Survival; Chromates; Chromium; Drug Antagonism; Drug Synergism; Estradiol; Female; Humans; Hydroxyestrones; Ovarian Neoplasms; Potassium Compounds	2020
Identification of an important function of CYP123: Role in the monooxygenase activity in a novel estradiol degradation pathway in bacteria. The Journal of steroid biochemistry and molecular biology, 2022, Volume: 215 Topics: Biotransformation; Carbon; Carbonyl Reductase (NADPH); Citric Acid Cycle; Cytochrome P-450 Enzyme System; Estradiol; Estrone; Gene Expression Regulation, Bacterial; Gene Ontology; Hydroxyestrones; Lipid Metabolism; Molecular Sequence Annotation; Multigene Family; Phylogeny; Rhodococcus; RNA, Messenger; Transcriptome	2022