Page last updated: 2024-09-02

16-hydroxyestrone and 2-hydroxyestrone

16-hydroxyestrone has been researched along with 2-hydroxyestrone in 71 studies

Compound Research Comparison

Studies (16-hydroxyestrone)	Trials (16-hydroxyestrone)	Recent Studies (post-2010) (16-hydroxyestrone)	Studies (2-hydroxyestrone)	Trials (2-hydroxyestrone)	Recent Studies (post-2010) (2-hydroxyestrone)
149	17	25	193	21	24

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	28 (39.44)	18.2507
2000's	25 (35.21)	29.6817
2010's	17 (23.94)	24.3611
2020's	1 (1.41)	2.80

Authors

Authors	Studies
Imoto, S	1
Bradlow, HL; Klug, TL; Sepkovic, DW	1
Bradlow, HL; Fishman, J; Gong, L; Hankinson, SE; Ho, G; Osborne, MP; Sepkovic, DW	1
Bradlow, HL; Davis, DL; Lin, G; Sepkovic, D; Tiwari, R	1
Clausen, J; Kall, MA; Vang, O	2
Bradlow, HL; Buhari, AM; Kuller, LH; Meilahn, EN; Pasagian-Macaulay, A; Sepkovic, DW; Simkin-Silverman, L; Wing, RR	1
Chen, C; Daling, JR; Malone, KE; Prunty, J	1
Chung, BC; Huh, KB; Kim, KR; Kwon, SH; Lee, EJ; Lee, HC; Lee, JH; Lim, SK; Won, YJ	1
Gentzschein, E; London, S; Paganini-Hill, A; Pike, MC; Ross, RK; Stanczyk, FZ; Ursin, G	2
Adlercreutz, H; Bradlow, HL; Donaldson, JL; Falk, RT; Fears, TR; Fillmore, CM; Gail, MH; Hoover, RN; Kiuru, P; Rossi, SC; Sepkovic, D; Siiteri, PK; Vaught, JB; Wahala, K; Ziegler, RG	1
Bradlow, HL; Chang, CJ; Hu, XP; Kabat, GC; Khalil, A; Rosenblatt, R; Sepkovie, DW; Sparano, JA	1
Lippert, TH; Mueck, AO; Seeger, H	3
McDougal, A; Safe, S	1
Service, RF	1
Evans, GL; Gibson, KJ; Malone, P; Turner, RT; Westerlind, KC	1
Foo, SC; Ho, GH; Ji, CY; Luo, XW; Ng, EH	1
Allen, DS; Bradlow, HL; De Stavola, B; Fentiman, I; Kuller, LH; Meilahn, EN; Sepkovic, DW	1
Gupta, M; McDougal, A; Safe, S	1
Bradlow, HL; Ganguly, S; Garbers, SV; Garte, SJ; Osborne, MP; Sepkovic, DW; Taioli, E; Trachman, J	1
Gibson, KJ; Westerlind, KC; Wolfe, P	1
Bradlow, HL; Kabat, GC	1
Carruba, G; Castagnetta, LA	1
Anderson, KG; Chen, Z; Dunning, LM; Holtzman, JL; Parrish, RS; Zheng, W	1
Barbieri, RL; Bradlow, HL; Hankinson, SE; Manson, JE; Michaud, DS; Sepkovic, DW; Spiegelman, D	1
Adlercreutz, H; Bradlow, HL; Donaldson, J; Falk, RT; Fears, TR; Migella, A; Rossi, SC; Sepkovic, DW; Ziegler, RG	1
Anderson, KE; Cree, M; Grady, JJ; Josyula, S; Lu, LJ; Nagamani, M	1
Robinson, JA; Spelsberg, TC; Turner, RT; Waters, KM	1
Gruber, DM; Huber, JC	1
Bell, MC; Bradlow, HL; Crowley-Nowick, P; Howell, P; Mathis, JM; Mayeaux, EJ; Schmidt-Grimminger, D; Sepkovic, DW; Tucker, A; Turbat-Herrera, EA	1
Fowke, JH; Hebert, JR; Longcope, C	1
Bradlow, HL; Jernström, H; Narod, SA; Vesprini, D	1
Bradlow, HL; De Stavola, B; dos Santos Silva, I; Linos, A; Linos, D; Riza, E; Sepkovic, DW	1
Lotinun, S; Turner, RT; Westerlind, KC	1
Beppu, M; Ebihara, K; Izumi, T; Kishida, T; Nashiki, K	1
Gräser, T; Lippert, TH; Mueck, AO; Oettel, M; Seeger, H	1
Bernstein, L; Gentzschein, E; London, S; Pike, MC; Stanczyk, FZ; Tseng, CC; Ursin, G; Yang, D	1
Almario, RU; Gregory, L; Kasim-Karakas, SE; Lasley, BL; Todd, H; Wong, R	1
Kastango, KB; Kirshner, MA; Klug, TL; Pollock, BG; Thompson, DS	1
Bradlow, HL; Jernström, H; Klug, TL; Narod, SA; Sepkovic, DW	1
Alvarez-Vasquez, RB; Axelrod, D; Bradlow, HL; Frenkel, K; Newman, MC; Sepkovic, DW; Zumoff, B	1
Bauer, DC; Cauley, JA; Cummings, SR; Danielson, ME; Kuller, LH; Ljung, BM; Zmuda, JM	1
Mueck, AO; Seeger, H; Wallwiener, D	1
Bradlow, HL; Garte, S; Paracchini, V; Pedotti, P; Raimondi, S; Sepkovic, DW; Taioli, E	1
Bradlow, HL; Britton, JA; Gammon, MD; Kabat, GC; Neugut, AI; O'Leary, ES; Sepkovic, DW; Teitelbaum, SL; Terry, MB	1
Crawford, S; Gold, EB; Lasley, B; McConnell, DS; Randolph, JF; Sowers, MR; Wilkin, MK	1
Buyuktur, AG; Hochberg, M; Jamadar, DA; Jannausch, M; McConnell, D; Sowers, MR	1
Hsu, IP; Huang, CW; Jou, HJ; Wang, TA; Wu, WH	1
Byers, T; Lezotte, D; Risendal, B; Wacker, M; Westerlind, K	1
Ahrendt, G; Garte, S; Im, A; Lloyd, S; Ragin, C; Taioli, E; Vogel, VG	1
Bertone-Johnson, ER; Bigelow, C; Heersink, J; Kurzer, MS; Puleo, E; Sabelawski, S; Sturgeon, SR; Volpe, SL; Wahala, K	1
Afanasyeva, Y; Arslan, AA; Berrino, F; Hallmans, G; Idahl, A; Koenig, KL; Krogh, V; Lenner, P; Liu, M; Lukanova, A; Lundin, E; Muti, P; Ohlson, N; Shore, RE; Sieri, S; Toniolo, P; Zeleniuch-Jacquotte, A	1
Bradlow, HL; Li, G; Sepkovic, DW; Telang, NT; Wong, GY	1
Conroy, SM; Franke, AA; Isaki, M; Maskarinec, G; Morimoto, Y; Nordt, FJ; Pagano, IS	1
Custer, L; Franke, AA; Heak, S; Maskarinec, G; Morimoto, Y	1
Custer, L; Franke, AA; Heak, S; Isaki, M; Maskarinec, G; Morimoto, Y; Steinbrecher, A	1
Bazzan, AJ; Newberg, AB; Zabrecky, GP	1
Huober, J; Mueck, AO; Ruan, X; Seeger, H; Wallwiener, D	1
Cassorla, F; Codner, E; Iñiguez, G; Lopez, P; Martínez, D; Merino, PM; Perez-Bravo, F	1
Cai, DZ; Gao, WL; Li, YZ; Song, YC; Wu, B; Wu, LS; Zi, JH	1
Bradlow, HL; Kotsopoulos, J; Llacuachaqui, M; Narod, SA; Nikitina, D; Sepkovic, D	1
Godínez Martínez, EY; Juárez González, AR; Lemus Bravo, AE; Rodríguez Ventura, AL; Sámano, R; Santillán Ballesteros, R; Tolentino Dolores, M	1
Fuhrman, BJ; Matthews, CE; Moore, SC; Ziegler, RG	1
Dikshit, A; Eilati, E; Gao, C; Gomes Filho, MA; Hales, DB; Klug, T; McGee, S; Small, C	1
Gheldiu, AM; Loghin, F; Popa, DS; Vlase, L	1
Altbach, M; Chalasani, P; Chow, HHS; Galons, JP; Huang, C; Maskarinec, G; Roe, DJ; Stopeck, A; Strom, MB; Thompson, PA; Thomson, CA; Wertheim, BC	1
Boucher, BA; Chang, VC; Cotterchio, M; Jenkins, DJA; McCann, SE; Mirea, L; Thompson, LU	1
Brix, J; Gahler, RJ; Gerry, A; Glover, M; Green, T; Li, K; Newman, M; Reil, J; Schauch, M; See, J; Wood, S	1

Reviews

2 review(s) available for 16-hydroxyestrone and 2-hydroxyestrone

Article	Year
Conjugated estrogens--the natural SERMs. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13 Suppl 6 Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Cardiovascular Diseases; Dihydrotestosterone; Equilin; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hydroxyestrones; Osteoporosis; Progesterone; Selective Estrogen Receptor Modulators; Testosterone; Thyroxine; Triiodothyronine	1999
Epidemiologic studies of estrogen metabolism and breast cancer. Steroids, 2015, Volume: 99, Issue:Pt A Topics: Breast Neoplasms; Chromatography, Liquid; Epidemiologic Studies; Estrogens; Female; Humans; Hydroxyestrones; Postmenopause; Premenopause; Prospective Studies; Risk Factors; Tandem Mass Spectrometry	2015

Article

Year

Conjugated estrogens--the natural SERMs.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13 Suppl 6

Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Cardiovascular Diseases; Dihydrotestosterone; Equilin; Estradiol; Estradiol Congeners; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hydroxyestrones; Osteoporosis; Progesterone; Selective Estrogen Receptor Modulators; Testosterone; Thyroxine; Triiodothyronine

1999

Epidemiologic studies of estrogen metabolism and breast cancer.

Steroids, 2015, Volume: 99, Issue:Pt A

Topics: Breast Neoplasms; Chromatography, Liquid; Epidemiologic Studies; Estrogens; Female; Humans; Hydroxyestrones; Postmenopause; Premenopause; Prospective Studies; Risk Factors; Tandem Mass Spectrometry

2015

Trials

15 trial(s) available for 16-hydroxyestrone and 2-hydroxyestrone

Article	Year
Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. Carcinogenesis, 1996, Volume: 17, Issue:4 Topics: Adult; Caffeine; Chlorzoxazone; Diet; Female; Humans; Hydroxyestrones; Male; Reference Values; Vegetables	1996
Urinary markers of estrogen metabolism 2- and 16 alpha-hydroxylation in premenopausal women. Steroids, 1996, Volume: 61, Issue:8 Topics: Adult; Body Weight; Female; Humans; Hydroxyestrones; Hydroxylation; Immunoassay; Middle Aged; Premenopause; Reference Values; Reproducibility of Results; Risk Factors; Steroid 16-alpha-Hydroxylase; Time Factors	1996
Effects of dietary broccoli on human drug metabolising activity. Cancer letters, 1997, Mar-19, Volume: 114, Issue:1-2 Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Diet; Glutathione Transferase; Humans; Hydroxyestrones; Intestines; Liver; Lymphocytes; Vegetables	1997
Estradiol metabolism during oral and transdermal estradiol replacement therapy in postmenopausal women. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1998, Volume: 30, Issue:9 Topics: Administration, Cutaneous; Administration, Oral; Estradiol; Estrone; Female; Hormone Replacement Therapy; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Radioimmunoassay	1998
Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk. Cancer detection and prevention, 1999, Volume: 23, Issue:3 Topics: Adult; Black People; Breast Neoplasms; Case-Control Studies; Cytochrome P-450 CYP1A1; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Hydroxyestrones; Indoles; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; RNA, Messenger; White People	1999
Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecologic oncology, 2000, Volume: 78, Issue:2 Topics: Administration, Oral; Anticarcinogenic Agents; DNA, Viral; Dose-Response Relationship, Drug; Female; Humans; Hydroxyestrones; Indoles; Papillomaviridae; Papillomavirus Infections; Placebos; Polymerase Chain Reaction; Precancerous Conditions; Tumor Virus Infections; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms	2000
Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:8 Topics: Aged; Analysis of Variance; Anticarcinogenic Agents; Brassica; Breast Neoplasms; Estrogens; Female; Humans; Hydroxyestrones; Least-Squares Analysis; Middle Aged; Phytotherapy; Postmenopause	2000
Effect of norethisterone acetate on estrogen metabolism in postmenopausal women. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2000, Volume: 32, Issue:10 Topics: Anticarcinogenic Agents; Contraceptives, Oral, Synthetic; Estradiol; Estrogen Replacement Therapy; Female; Humans; Hydroxyestrones; Male; Middle Aged; Norethindrone; Postmenopause	2000
The effects of soygerm extracts on blood lipoproteins, antioxidative capacity and urinary estrogen metabolites in postmenopausal women on hormone therapy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 98, Issue:1 Topics: Antioxidants; Cholesterol, HDL; Cholesterol, LDL; Copper; Estrogen Replacement Therapy; Estrogens; Female; Glycine max; Humans; Hydroxyestrones; Isoflavones; Lipoproteins, LDL; Middle Aged; Oxidation-Reduction; Pilot Projects; Plant Extracts; Postmenopause; Taiwan; Thiobarbituric Acid Reactive Substances; Triglycerides	2007
Urinary estrogen metabolites during a randomized soy trial. Nutrition and cancer, 2012, Volume: 64, Issue:2 Topics: Adult; China; Cross-Over Studies; Diet; Equol; Estrogens; Ethnicity; Female; Flavonoids; Hawaii; Humans; Hydroxyestrones; Isoflavones; Japan; Korea; Middle Aged; Philippines; Premenopause; Soy Foods; White People	2012
The relation of urinary estrogen metabolites with mammographic densities in premenopausal women. Cancer epidemiology, 2012, Volume: 36, Issue:5 Topics: Adult; Asian People; Breast; Breast Neoplasms; Cell Count; Estrogens; Female; Humans; Hydroxyestrones; Mammography; Middle Aged; Premenopause; Progesterone; Risk Assessment; Testosterone	2012
Urinary estrogen metabolites in two soy trials with premenopausal women. European journal of clinical nutrition, 2012, Volume: 66, Issue:9 Topics: Adult; Chromatography, Liquid; Cross-Over Studies; Diet; Estrogens; Female; Humans; Hydroxyestrones; Isoflavones; Mass Spectrometry; Premenopause; Regression Analysis; Soy Foods	2012
A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast cancer research and treatment, 2017, Volume: 165, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Humans; Hydroxyestrones; Indoles; Mammography; Middle Aged; Sex Hormone-Binding Globulin; Tamoxifen; Time Factors; Treatment Outcome	2017
Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial. Nutrition and cancer, 2019, Volume: 71, Issue:3 Topics: Breast Neoplasms; Canada; Diet; Female; Flax; Gonadal Steroid Hormones; Humans; Hydroxyestrones; Lignans; Middle Aged; Postmenopause; Prolactin	2019
A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense Journal of complementary & integrative medicine, 2023, Mar-01, Volume: 20, Issue:1 Topics: Biomarkers; Breast Neoplasms; Cross-Over Studies; Estrogens; Female; Humans; Hydroxyestrones	2023

Other Studies

54 other study(ies) available for 16-hydroxyestrone and 2-hydroxyestrone

Article	Year
[Biological effect of estrogen metabolites in human breast cancer]. Nihon Geka Gakkai zasshi, 1992, Volume: 93, Issue:5 Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Breast Neoplasms; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; Receptors, Estrogen; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tumor Cells, Cultured	1992
Monoclonal antibody-based enzyme immunoassay for simultaneous quantitation of 2- and 16 alpha-hydroxyestrone in urine. Steroids, 1994, Volume: 59, Issue:11 Topics: Antibodies, Monoclonal; Autoanalysis; Cost-Benefit Analysis; Estrogens, Catechol; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Immunoenzyme Techniques; Time Factors	1994
Estrogen metabolite ratios and risk assessment of hormone-related cancers. Assay validation and prediction of cervical cancer risk. Annals of the New York Academy of Sciences, 1995, Sep-30, Volume: 768 Topics: Biopsy; Estriol; Estrogens, Catechol; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Menstrual Cycle; Predictive Value of Tests; Premenopause; Reference Values; Reproducibility of Results; Risk Assessment; Risk Factors; Surveys and Questionnaires; Uterine Cervical Neoplasms; Vaginal Smears	1995
Effects of pesticides on the ratio of 16 alpha/2-hydroxyestrone: a biologic marker of breast cancer risk. Environmental health perspectives, 1995, Volume: 103 Suppl 7 Topics: Biomarkers; Breast Neoplasms; Estradiol; Estrogens, Catechol; Humans; Hydroxyestrones; Insecticides; Tumor Cells, Cultured	1995
Measurement of urinary estrogen metabolites using a monoclonal enzyme-linked immunoassay kit: assay performance and feasibility for epidemiological studies. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1996, Volume: 5, Issue:9 Topics: Adolescent; Adult; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Epidemiologic Methods; Estrogens; Estrogens, Catechol; Evaluation Studies as Topic; Feasibility Studies; Female; Follicular Phase; Humans; Hydroxyestrones; Luteal Phase; Menstrual Cycle; Middle Aged; Premenopause; Reagent Kits, Diagnostic; Time Factors	1996
Altered hydroxylation of estrogen in patients with postmenopausal osteopenia. The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:4 Topics: Aged; Body Height; Body Mass Index; Body Weight; Bone Density; Bone Diseases, Metabolic; Estrogens; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Hydroxylation; Middle Aged; Postmenopause; Steroid 16-alpha-Hydroxylase	1997
A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer. Environmental health perspectives, 1997, Volume: 105 Suppl 3 Topics: Breast Neoplasms; Case-Control Studies; Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones; Menopause; Middle Aged; Neoplasms, Hormone-Dependent; Pilot Projects; Risk Factors; Steroid 16-alpha-Hydroxylase	1997
Quantifying estrogen metabolism: an evaluation of the reproducibility and validity of enzyme immunoassays for 2-hydroxyestrone and 16alpha-hydroxyestrone in urine. Environmental health perspectives, 1997, Volume: 105 Suppl 3 Topics: Adult; Biomarkers; Breast Neoplasms; Estrogens; Evaluation Studies as Topic; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Immunoenzyme Techniques; Luteal Phase; Menopause; Middle Aged; Neoplasms, Hormone-Dependent; Reproducibility of Results; Risk Factors	1997
Urinary estrogen metabolites and breast cancer: a case-control study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:7 Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; New York; Postmenopause; Risk	1997
Effect of estradiol metabolites on the susceptibility of low density lipoprotein to oxidation. Life sciences, 1997, Volume: 61, Issue:9 Topics: Estradiol; Estrogens, Catechol; Humans; Hydroxyestrones; Kinetics; Lipoproteins, LDL; Oxidation-Reduction; Vitamin E	1997
Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. Environmental health perspectives, 1998, Volume: 106, Issue:4 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cytochrome P-450 Enzyme System; Drug Screening Assays, Antitumor; Estrogen Antagonists; Female; Humans; Hydroxyestrones; Mammary Neoplasms, Experimental; Pesticides; Predictive Value of Tests; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Tumor Cells, Cultured	1998
New role for estrogen in cancer? Science (New York, N.Y.), 1998, Mar-13, Volume: 279, Issue:5357 Topics: Animals; Carcinogens; Estrogens; Female; Humans; Hydroxyestrones; Mutagens; Neoplasms	1998
Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:6 Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Division; Cholesterol; Epithelial Cells; Estradiol; Estrogens, Catechol; Female; Hydroxyestrones; Hypercholesterolemia; Mammary Glands, Animal; Ovariectomy; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Structure-Activity Relationship; Tibia; Uterus	1998
Urinary 2/16 alpha-hydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein-3 and a potential biomarker of breast cancer risk. Annals of the Academy of Medicine, Singapore, 1998, Volume: 27, Issue:2 Topics: Age Factors; Anticarcinogenic Agents; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Cell Transformation, Neoplastic; Confidence Intervals; Contraceptives, Oral; Disease Progression; Estradiol; Estrogens, Catechol; Female; Forecasting; Humans; Hydroxyestrones; Hydroxylation; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Linear Models; Logistic Models; Menopause; Middle Aged; Odds Ratio; Parity; Risk Factors	1998
Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. British journal of cancer, 1998, Volume: 78, Issue:9 Topics: Adult; Breast Neoplasms; Cohort Studies; Female; Follow-Up Studies; Humans; Hydroxyestrones; Incidence; Predictive Value of Tests; Prospective Studies; Risk Factors	1998
Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of steroid biochemistry and molecular biology, 1998, Volume: 67, Issue:5-6 Topics: Breast Neoplasms; Cathepsin D; Cell Division; Creatine Kinase; Estradiol; Estriol; Female; Humans; Hydroxyestrones; Isoenzymes; Promoter Regions, Genetic; Receptors, Estrogen; Recombinant Proteins; Transfection; Tumor Cells, Cultured	1998
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute, 1999, Jun-16, Volume: 91, Issue:12 Topics: Aged; Breast Neoplasms; Case-Control Studies; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; Odds Ratio; Postmenopause; Radioimmunoassay; Risk; Risk Factors; Steroid 16-alpha-Hydroxylase	1999
The effect of diurnal and menstrual cyclicity and menopausal status on estrogen metabolites: implications for disease-risk assessment. Steroids, 1999, Volume: 64, Issue:3 Topics: Adult; Circadian Rhythm; Female; Humans; Hydroxyestrones; Menopause; Menstrual Cycle; Risk Assessment	1999
Re: "A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer". Environmental health perspectives, 1998, Volume: 106, Issue:3 Topics: Female; Humans; Hydroxyestrones; Middle Aged; Postmenopause	1998
Re: Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. Journal of the National Cancer Institute, 1999, Nov-03, Volume: 91, Issue:21 Topics: Adult; Breast Neoplasms; Female; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Research Design; Risk; Risk Factors	1999
Within-person variability of the ratios of urinary 2-hydroxyestrone to 16alpha-hydroxyestrone in Caucasian women. Steroids, 1999, Volume: 64, Issue:12 Topics: Adult; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; Reproducibility of Results; White People	1999
Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:12 Topics: Adult; Body Mass Index; Estradiol; Estrone; Female; Follicular Phase; Gonadal Steroid Hormones; Humans; Hydroxyestrones; Luteal Phase; Menarche; Middle Aged; Parity; Premenopause; Progesterone; Reproducibility of Results; Time Factors	1999
A new ELISA kit for measuring urinary 2-hydroxyestrone, 16alpha-hydroxyestrone, and their ratio: reproducibility, validity, and assay performance after freeze-thaw cycling and preservation by boric acid. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:1 Topics: Boric Acids; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Estrogens, Catechol; Female; Freezing; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Population Surveillance; Postmenopause; Premenopause; Preservatives, Pharmaceutical; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Time Factors	2000
Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. Cancer research, 2000, Mar-01, Volume: 60, Issue:5 Topics: Adult; Breast Neoplasms; Diet; Female; Glycine max; Humans; Hydroxyestrones; Isoflavones; Neoplasms, Hormone-Dependent; Premenopause	2000
Direct action of naturally occurring estrogen metabolites on human osteoblastic cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2000, Volume: 15, Issue:3 Topics: Alkaline Phosphatase; Bone Matrix; Cell Differentiation; Cell Line; Enzyme Induction; Estradiol; Estrogen Receptor alpha; Estrogens; Fulvestrant; Humans; Hydroxyestrones; Osteoblasts; Osteocalcin; Receptors, Estrogen; Recombinant Fusion Proteins; RNA, Messenger	2000
Re: CYP17 promoter polymorphism and breast cancer in Australian women under age forty years. Journal of the National Cancer Institute, 2001, Apr-04, Volume: 93, Issue:7 Topics: Adolescent; Adult; Asian People; Australia; Black People; Breast Neoplasms; Female; Genotype; Humans; Hydroxyestrones; Native Hawaiian or Other Pacific Islander; Polymorphism, Genetic; Promoter Regions, Genetic; Steroid 17-alpha-Hydroxylase; White People	2001
Urinary estrogen metabolites and mammographic parenchymal patterns in postmenopausal women. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:6 Topics: Adult; Aged; Breast Neoplasms; Case-Control Studies; Epidemiologic Studies; Estrogens; Female; Humans; Hydroxyestrones; Mammography; Middle Aged; Postmenopause; Risk Factors; Steroid 16-alpha-Hydroxylase	2001
Tissue-selective effects of continuous release of 2-hydroxyestrone and 16alpha-hydroxyestrone on bone, uterus and mammary gland in ovariectomized growing rats. The Journal of endocrinology, 2001, Volume: 170, Issue:1 Topics: Animals; Bone Remodeling; Cholesterol; Dose-Response Relationship, Drug; Drug Implants; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Humans; Hydroxyestrones; Mammary Glands, Animal; Models, Animal; Organ Size; Ovariectomy; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Uterus	2001
Effect of dietary soy isoflavone aglycones on the urinary 16alpha-to-2-hydroxyestrone ratio in C3H/HeJ mice. Nutrition and cancer, 2000, Volume: 38, Issue:2 Topics: Animals; Anticarcinogenic Agents; Biomarkers; Cytochrome P-450 Enzyme System; Female; Genistein; Glycine max; Hydroxyestrones; Indoles; Isoflavones; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Microsomes, Liver; Organ Size; Plant Extracts	2000
The effects of postmenopausal hormone replacement therapy and oral contraceptives on the endogenous estradiol metabolism. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:12 Topics: Adult; Contraceptives, Oral; Estradiol; Estrogen Replacement Therapy; Estrogens, Catechol; Ethinyl Estradiol; Female; Humans; Hydroxyestrones; Middle Aged; Nandrolone; Norethindrone; Norethindrone Acetate; Postmenopause	2001
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and family history of breast cancer in premenopausal women. Breast cancer research and treatment, 2002, Volume: 72, Issue:2 Topics: Adult; Biomarkers; Breast Neoplasms; Estradiol; Estriol; Estrogens; Estrone; Female; Genetic Predisposition to Disease; Humans; Hydroxyestrones; Middle Aged; Premenopause	2002
Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. The American journal of clinical nutrition, 2002, Volume: 76, Issue:6 Topics: Body Composition; Body Constitution; Body Mass Index; Body Weight; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Energy Intake; Follicular Phase; Fruit; Hydroxyestrones; Luteal Phase; Premenopause; Prunus	2002
A preliminary study of the effect of fluoxetine treatment on the 2:16-alpha-hydroxyestrone ratio in young women. Therapeutic drug monitoring, 2003, Volume: 25, Issue:1 Topics: Adult; Cytochrome P-450 Enzyme System; Female; Fluoxetine; Humans; Hydroxyestrones; Isoenzymes; Pilot Projects	2003
Predictors of the plasma ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone among pre-menopausal, nulliparous women from four ethnic groups. Carcinogenesis, 2003, Volume: 24, Issue:5 Topics: Administration, Oral; Adolescent; Adult; Black People; Breast Neoplasms; Contraceptive Agents; Estrogen Replacement Therapy; Ethnicity; Female; Humans; Hydroxyestrones; Menstrual Cycle; Parity; Premenopause; Risk Factors; White People	2003
Influence of postmenopausal hormone replacement therapy on an estrogen metabolite biomarker of risk for breast cancer. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2003, Volume: 35, Issue:6 Topics: Biomarkers, Tumor; Breast Neoplasms; Cross-Sectional Studies; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hydroxyestrones; Medroxyprogesterone Acetate; Postmenopause; Risk Factors	2003
Estrogen metabolites and the risk of breast cancer in older women. Epidemiology (Cambridge, Mass.), 2003, Volume: 14, Issue:6 Topics: Aged; Breast Neoplasms; Case-Control Studies; Cohort Studies; Estrogens; Female; Humans; Hydroxyestrones; Risk Factors; Steroid 16-alpha-Hydroxylase; Surveys and Questionnaires	2003
Endogenous estradiol metabolism during treatment with oral contraceptives. International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:3 Topics: Adult; Contraceptives, Oral, Combined; Estradiol; Ethinyl Estradiol; Female; Humans; Hydroxyestrones; Levonorgestrel; Nandrolone; Norethindrone; Premenopause; Randomized Controlled Trials as Topic	2004
A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clinical chemistry and laboratory medicine, 2005, Volume: 43, Issue:7 Topics: Adult; Amino Acid Substitution; Aryl Hydrocarbon Hydroxylases; Base Sequence; Black or African American; Cytochrome P-450 CYP1B1; Deoxyribonuclease HpaII; DNA; Estradiol; Female; Genetics, Population; Humans; Hydroxyestrones; Male; Middle Aged; Polymorphism, Genetic; White People	2005
Estrogen metabolism and breast cancer. Epidemiology (Cambridge, Mass.), 2006, Volume: 17, Issue:1 Topics: Aged; Breast Neoplasms; Case-Control Studies; Estrogens; Female; Humans; Hydroxyestrones; Immunoenzyme Techniques; Middle Aged; New York; Surveys and Questionnaires	2006
Selected diet and lifestyle factors are associated with estrogen metabolites in a multiracial/ethnic population of women. The Journal of nutrition, 2006, Volume: 136, Issue:6 Topics: Anticarcinogenic Agents; Body Size; Diet; Estrogens; Ethnicity; Exercise; Female; Flavonoids; Humans; Hydroxyestrones; Life Style; Middle Aged; Phenols; Polyphenols; Population Surveillance; Smoking; United States	2006
Estradiol and its metabolites and their association with knee osteoarthritis. Arthritis and rheumatism, 2006, Volume: 54, Issue:8 Topics: Adult; Estradiol; Female; Humans; Hydroxyestrones; Longitudinal Studies; Michigan; Middle Aged; Odds Ratio; Osteoarthritis, Knee; Radiography; Risk Factors	2006
Ethnicity, body size, and estrogen levels in postmenopausal Hispanic and non-Hispanic white women. Journal of women's health (2002), 2009, Volume: 18, Issue:4 Topics: Aged; Body Size; Breast Neoplasms; Cross-Sectional Studies; Female; Follow-Up Studies; Hispanic or Latino; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Risk; White People	2009
Urinary estrogen metabolites in women at high risk for breast cancer. Carcinogenesis, 2009, Volume: 30, Issue:9 Topics: Adult; Aged; Alcohol Drinking; Body Mass Index; Breast Neoplasms; Female; Humans; Hydroxyestrones; Linear Models; Middle Aged; Smoking	2009
Effect of flaxseed consumption on urinary levels of estrogen metabolites in postmenopausal women. Nutrition and cancer, 2010, Volume: 62, Issue:2 Topics: 2-Methoxyestradiol; Body Mass Index; Diet; Energy Intake; Estradiol; Estrogens; Female; Flax; Humans; Hydroxyestrones; Middle Aged; Postmenopause	2010
Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer. British journal of cancer, 2011, Oct-25, Volume: 105, Issue:9 Topics: Aged; Case-Control Studies; Endometrial Neoplasms; Estrogens; Female; Humans; Hydroxyestrones; Middle Aged; Prospective Studies	2011
Anti-proliferative effects of Chinese herb Cornus officinalis in a cell culture model for estrogen receptor-positive clinical breast cancer. Molecular medicine reports, 2012, Volume: 5, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Aggregation; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Cornus; Drugs, Chinese Herbal; Estradiol; Female; Fruit; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Models, Biological; Plant Extracts; Receptors, Estrogen	2012
Multi-nutrient supplement improves hormone ratio associated with cancer risk. Journal of translational medicine, 2013, Oct-08, Volume: 11 Topics: Case-Control Studies; Dietary Supplements; Female; Follow-Up Studies; Humans; Hydroxyestrones; Middle Aged; Neoplasms; Risk Factors	2013
The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies. Archives of gynecology and obstetrics, 2015, Volume: 291, Issue:5 Topics: Adult; Biomarkers; Breast Neoplasms; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogens; Female; Genetic Predisposition to Disease; Humans; Hydroxyestrones; Middle Aged; Postmenopause; Premenopause; Sensitivity and Specificity	2015
Elevation of C-reactive protein during the luteal phase in healthy adolescents. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2015, Volume: 31, Issue:4 Topics: Adolescent; Adolescent Development; Biomarkers; C-Reactive Protein; Chile; Female; Follicular Phase; Humans; Hydroxyestrones; Luteal Phase; Progesterone; Reference Values; Up-Regulation; Urban Health	2015
Measurement of serum estrogen and estrogen metabolites in pre- and postmenopausal women with osteoarthritis using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:2 Topics: Adult; Aged; Chromatography, High Pressure Liquid; Estradiol; Estriol; Estrogens; Estrone; Female; Follicular Phase; Humans; Hydroxyestrones; Limit of Detection; Luteal Phase; Middle Aged; Osteoarthritis; Postmenopause; Premenopause; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric	2015
The effect of oral 3,3'-diindolylmethane supplementation on the 2:16α-OHE ratio in BRCA1 mutation carriers. Familial cancer, 2015, Volume: 14, Issue:2 Topics: Administration, Oral; Adult; Female; Genes, BRCA1; Heterozygote; Humans; Hydroxyestrones; Indoles; Middle Aged; Mutation	2015
[Determination of 2-hydroxyestrone /16α-hydroxyestrone ratio in urine of Mexican women as a risk indicator for breast cancer and its relationship with other risk factors]. Nutricion hospitalaria, 2014, Oct-25, Volume: 31, Issue:2 Topics: Adolescent; Adult; Aged; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Cross-Sectional Studies; Female; Humans; Hydroxyestrones; Male; Mexico; Middle Aged; Risk Factors; Young Adult	2014
Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. The British journal of nutrition, 2015, May-14, Volume: 113, Issue:9 Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Chickens; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 CYP3A; Diet; Dietary Supplements; Dinoprostone; Estrogen Receptor alpha; Estrogens; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Flax; Hydroxyestrones; Lignans; Liver; Ovarian Neoplasms; Ovary; RNA, Messenger	2015
Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes. Biomedical and environmental sciences : BES, 2015, Volume: 28, Issue:11 Topics: Animals; Benzhydryl Compounds; Biomarkers; Breast Neoplasms; Drug Synergism; Endocrine Disruptors; Estrone; Genistein; Hydroxyestrones; Male; Microsomes, Liver; Oxidation-Reduction; Phenols; Rats, Wistar	2015