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16-hydroxyandrost-4-en-3,17-dione and estriol

16-hydroxyandrost-4-en-3,17-dione has been researched along with estriol in 7 studies

*Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol. [MeSH]

*Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol. [MeSH]

Compound Research Comparison

Studies
(16-hydroxyandrost-4-en-3,17-dione)
Trials
(16-hydroxyandrost-4-en-3,17-dione)
Recent Studies (post-2010)
(16-hydroxyandrost-4-en-3,17-dione)
Studies
(estriol)
Trials
(estriol)
Recent Studies (post-2010) (estriol)
20016,243309447

Protein Interaction Comparison

ProteinTaxonomy16-hydroxyandrost-4-en-3,17-dione (IC50)estriol (IC50)
Estrogen receptorHomo sapiens (human)0.0017
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)8.635

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Numazawa, M; Osawa, Y1
Furihata, R; Ishikawa, S; Konno, T; Numazawa, M1
Oakey, RE; Purohit, A1
Numazawa, M; Osada, R; Osawa, Y; Tsuji, M1
Biener, A; Bulletti, C; Guller, S; Gurpide, E1
Oakey, RE; Othman, YS1
Matsuzaki, H; Numazawa, M; Watari, Y; Yoshimura, A1

Other Studies

7 other study(ies) available for 16-hydroxyandrost-4-en-3,17-dione and estriol

ArticleYear
Improved synthesis of 16alpha-hydroxylated androgens: intermediates of estriol formation in pregnancy.
    Steroids, 1978, Volume: 32, Issue:4

    Topics: Androgens; Androstenedione; Animals; Dehydroepiandrosterone; Estriol; Female; Hydroxytestosterones; Magnetic Resonance Spectroscopy; Methods; Oxidation-Reduction; Pregnancy; Spectrophotometry, Infrared

1978
Determination of aromatization of 19-oxygenated 16 alpha-hydroxyandrostenedione with human placental microsomes by high-performance liquid chromatography coupled with coulometric detection.
    Journal of steroid biochemistry, 1990, Jul-04, Volume: 36, Issue:4

    Topics: Androstenedione; Aromatase; Chromatography, High Pressure Liquid; Estriol; Female; Humans; Hydroxyestrones; Kinetics; Microsomes; Placenta; Substrate Specificity

1990
Evidence for separate sites for aromatisation of androstenedione and 16 alpha-hydroxyandrostenedione in human placental microsomes.
    Journal of steroid biochemistry, 1989, Volume: 33, Issue:3

    Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Estradiol; Estriol; Estrone; Female; Humans; Hydroxyestrones; In Vitro Techniques; Kinetics; Microsomes; Placenta; Pregnancy; Radioimmunoassay

1989
High-performance liquid chromatographic determination of aromatization of 16 alpha-hydroxylated androgens with human placental microsomes.
    Analytical biochemistry, 1985, Volume: 146, Issue:1

    Topics: Androgens; Androstenedione; Chromatography, Gel; Chromatography, High Pressure Liquid; Estriol; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyestrones; Hydroxytestosterones; In Vitro Techniques; Kinetics; Microchemistry; Microsomes; Placenta

1985
Relative distribution of estrone, estradiol and estriol between fetal and maternal perfusates during perfusions of human term placentas with labelled C19 precursors.
    Journal of steroid biochemistry, 1984, Volume: 20, Issue:4B

    Topics: Androstenedione; Estradiol; Estriol; Estrone; Ethinyl Estradiol; Female; Humans; In Vitro Techniques; Perfusion; Placenta; Pregnancy; Time Factors; Tissue Distribution

1984
Why so much oestriol? A comparison of the aromatisation of androstenedione and 16 alpha-hydroxyandrostenedione when incubated alone or together with human placental microsomes.
    The Journal of endocrinology, 1996, Volume: 148, Issue:3

    Topics: Androstenedione; Aromatase; Estradiol; Estriol; Humans; In Vitro Techniques; Microsomes; Placenta; Radioimmunoassay

1996
Aromatase inhibition by 4 beta,5 beta-epoxides of 16 alpha-hydroxyandrostenedione and its 19-oxygenated analogs, potential precursors of estriol production in the feto-placental unit.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:12

    Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Enzyme Inhibitors; Epoxy Compounds; Estriol; Fetus; Humans; Placenta

2002