16-16-dimethylprostaglandin-e and sulprostone

Sulprostone, enprostil and 16, 16 dimethyl PGE2 have all been found to be potent inhibitors of lipolysis induced by 3-isobutyl-1-methyl-xanthine (IBMX) in rat isolated adipocytes. The potency of sulprostone and enprostil in particular indicates that the response is likely to be mediated through either EP3 or EP1-receptors. However, the EP1-receptor blocking drug, AH6809, had no effect on the antilipolytic response to either PGE2 or sulprostone. We therefore conclude that the receptors mediating prostanoid-induced inhibition of lipolysis in rat adipocytes must principally be of the EP3 sub-type.

Topics: Adipose Tissue; Animals; Dinoprostone; Enprostil; In Vitro Techniques; Lipolysis; Prostaglandin Antagonists; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Receptors, Prostaglandin; Xanthenes; Xanthones

Topics: 16,16-Dimethylprostaglandin E2; Abortifacient Agents, Nonsteroidal; Abortion, Induced; Dinoprostone; Drug Evaluation; Female; Humans; Injections, Intramuscular; Pain; Pregnancy; Prostaglandins E, Synthetic; Self Administration; Suppositories; Vagina