Compounds > 15-hydroxy-5-8-11-13-eicosatetraenoic-acid

15-hydroxy-5-8-11-13-eicosatetraenoic-acid and pyrazole

15-hydroxy-5-8-11-13-eicosatetraenoic-acid has been researched along with pyrazole* in 1 studies

Other Studies

1 other study(ies) available for 15-hydroxy-5-8-11-13-eicosatetraenoic-acid and pyrazole

Article	Year
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase. Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14 A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays. Topics: Amides; Animals; Arachidonate 15-Lipoxygenase; CHO Cells; Cricetinae; Cricetulus; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase Inhibitors; Pyrazoles; Rabbits; Structure-Activity Relationship; Sulfonamides	2011

Article

Year

Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase.

Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.

Topics: Amides; Animals; Arachidonate 15-Lipoxygenase; CHO Cells; Cricetinae; Cricetulus; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase Inhibitors; Pyrazoles; Rabbits; Structure-Activity Relationship; Sulfonamides

2011