15-hydroxy-5-8-11-13-eicosatetraenoic-acid has been researched along with leukotoxin* in 1 studies
1 other study(ies) available for 15-hydroxy-5-8-11-13-eicosatetraenoic-acid and leukotoxin
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Pasteurella haemolytica leukotoxin enhances production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by bovine polymorphonuclear leukocytes.
The influence of the leukotoxin of Pasteurella haemolytica on the generation of arachidonic acid metabolites by bovine polymorphonuclear leukocytes (PMNs) was investigated. PMNs released 5-, 12-, and 15-hydroxyeicosatetraenoic acids (5-, 12-, and 15-HETE) and leukotriene B4 (LTB4) upon stimulation with arachidonic acid. The leukotoxin preparations dose dependently enhanced the release of the 5-lipoxygenase products 5-HETE and LTB4 in arachidonic acid-stimulated PMNs, whereas the release of 12- and 15-HETE was not affected. The enhanced release of LTB4 and 5-HETE was not due to a decreased cellular retention of the 5-lipoxygenase products. In addition, leukotoxin preparations by themselves were also able to induce LTB4 and 5-HETE production in the absence of exogenous arachidonic acid. Generation of 5-lipoxygenase products by PMNs stimulated by leukotoxin may represent an important cellular event that occurs during infections with P. haemolytica. Topics: Animals; Bacterial Toxins; Cattle; Cells, Cultured; Exotoxins; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Mannheimia haemolytica; Neutrophils; Species Specificity | 1992 |