Compounds > 15-hydroxy-5-8-11-13-eicosatetraenoic-acid

15-hydroxy-5-8-11-13-eicosatetraenoic-acid and imidazole

15-hydroxy-5-8-11-13-eicosatetraenoic-acid has been researched along with imidazole* in 2 studies

Other Studies

2 other study(ies) available for 15-hydroxy-5-8-11-13-eicosatetraenoic-acid and imidazole

Article	Year
Effect of intravenously administered lipoxygenase metabolites on rat tracheal mucous gel layer thickness. International archives of allergy and applied immunology, 1989, Volume: 90, Issue:3 The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Injections, Intravenous; Leukotriene E4; Leukotrienes; Mucous Membrane; Mucus; Rats; SRS-A; Trachea	1989
Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries. Japanese journal of pharmacology, 1985, Volume: 37, Issue:4 The vascular effects of 15-hydroperoxyeicosatetraenoic acid (15-HPETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) were investigated on isolated helical strips of canine cerebral and coronary arteries. 15-HPETE caused strong concentration-related contraction of cerebral arteries under resting tension. After contraction with prostaglandin F2 alpha (PGF2 alpha), 15-HPETE caused marked relaxation of coronary arteries. The effects of 15-HETE on isolated canine arteries were similar to those of 15-HPETE. The relaxation of coronary arteries caused by both 15-HPETE and 15-HETE was completely inhibited in the presence of aspirin, but not in the presence of tranylcypromine. Preincubation of coronary and cerebral arterial strips with 15-HPETE or 15-HETE resulted in suppression of the production of 6-keto-PGF1 alpha from exogenously added arachidonic acid; and 15-HPETE, but not 15-HETE, enhanced the production of HETE(s) significantly. Aspirin blocked 15-HPETE induced HETE(s) production in coronary arteries. On cerebral angiography, strong contraction of intracranial arteries was observed after intracisternal injection of 15-HPETE. On the other hand, 15-HETE had little effect on intracranial arteries in vivo. The mechanism of the vascular effects of 15-HPETE and 15-HETE will be discussed. Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Cerebral Angiography; Cerebral Arteries; Coronary Vessels; Dogs; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Leukotrienes; Lipid Peroxides; Male; Tranylcypromine; Vasoconstrictor Agents	1985

Article

Year

Effect of intravenously administered lipoxygenase metabolites on rat tracheal mucous gel layer thickness.

International archives of allergy and applied immunology, 1989, Volume: 90, Issue:3

The effect of intravenous injections of 5-, 12- and 15-hydroxyeicosatetraenoic acids (HETE), leukotrienes D4 and E4 (LTD4, LTE4) on tracheal mucous gel layer (TMGL) thickness was assessed in rats. When administered in doses ranging from 0.03 pg to 33 ng per rat, the lipoxygenase metabolites produced significant increases in TMGL thickness. The order of potency of the metabolites was 15-HETE greater than 12-HETE greater than or equal to 5-HETE greater than LTD4 greater than or equal to LTE4. Imidazole (31.6 mg/kg), intravenously, significantly decreased this response. These findings suggest that the mono-HETEs, especially 15-HETE, may be important modulators of airway mucus in the rat.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Injections, Intravenous; Leukotriene E4; Leukotrienes; Mucous Membrane; Mucus; Rats; SRS-A; Trachea

1989

Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries.

Japanese journal of pharmacology, 1985, Volume: 37, Issue:4

The vascular effects of 15-hydroperoxyeicosatetraenoic acid (15-HPETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) were investigated on isolated helical strips of canine cerebral and coronary arteries. 15-HPETE caused strong concentration-related contraction of cerebral arteries under resting tension. After contraction with prostaglandin F2 alpha (PGF2 alpha), 15-HPETE caused marked relaxation of coronary arteries. The effects of 15-HETE on isolated canine arteries were similar to those of 15-HPETE. The relaxation of coronary arteries caused by both 15-HPETE and 15-HETE was completely inhibited in the presence of aspirin, but not in the presence of tranylcypromine. Preincubation of coronary and cerebral arterial strips with 15-HPETE or 15-HETE resulted in suppression of the production of 6-keto-PGF1 alpha from exogenously added arachidonic acid; and 15-HPETE, but not 15-HETE, enhanced the production of HETE(s) significantly. Aspirin blocked 15-HPETE induced HETE(s) production in coronary arteries. On cerebral angiography, strong contraction of intracranial arteries was observed after intracisternal injection of 15-HPETE. On the other hand, 15-HETE had little effect on intracranial arteries in vivo. The mechanism of the vascular effects of 15-HPETE and 15-HETE will be discussed.

Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Aspirin; Cerebral Angiography; Cerebral Arteries; Coronary Vessels; Dogs; Hydroxyeicosatetraenoic Acids; Imidazoles; In Vitro Techniques; Leukotrienes; Lipid Peroxides; Male; Tranylcypromine; Vasoconstrictor Agents

1985