15-hydroxy-11-alpha-9-alpha-(epoxymethano)prosta-5-13-dienoic-acid and parthenolide

Reactive oxygen species are increased in multiple gastrointestinal diseases and contribute to their pathogenesis. glutathione (GSH) is an antioxidant that helps to prevent reactive oxygen species-mediated mucosal damage. This study examines the mechanisms by which GSH attenuates hydrogen peroxide (H. IEC-6 cells were cultured and treated with H. Pretreatment with GSH attenuates the activation of NF-κB and P38 MAPK signaling pathways by H. GSH appears to ameliorate oxidative injury in intestinal epithelial cells by attenuating H

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apoptosis; Cell Line; Drug Evaluation, Preclinical; Glutathione; Hydrogen Peroxide; Interleukin-1beta; Intestinal Diseases; Intestinal Mucosa; MAP Kinase Signaling System; NF-kappa B; Oxidative Stress; Rats; Sesquiterpenes