Compounds > 15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid

15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid and dazoxiben

15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid has been researched along with dazoxiben* in 2 studies

Other Studies

2 other study(ies) available for 15-hydroperoxy-5-8-11-13-eicosatetraenoic-acid and dazoxiben

Article	Year
A biological method for studying the interaction between platelets and vascular endothelium. Thrombosis research, 1990, Feb-01, Volume: 57, Issue:3 A segment of fresh rabbit thoracic aorta (RbA) was turned inside out and superfused (1.5 ml/min) with citrated (3.8%) or heparinized (10 U/ml) blood of rabbit and the superfusate was discarded. RbA gained in weight due to deposition of thrombi on its endothelial surface. These thrombi were mainly composed of platelets. The interaction between platelets and endothelium was augmented in RbAs from animals with atherosclerosis and in RbAs pretreated with aspirin (110 microM) or 15-HPETE (150 microM) or by the enzymatic system generating oxygen free radicals (xanthine:xanthine oxidase - 100 microM: 0.1 U/ml). On the other hand, this interaction was impaired by superoxide dismutase (20 U/ml) or catalase (0.2 U/ml). Finally, the dissipation of thrombi by thromboxane A2-synthetase inhibitor--dazoxiben was found to be related to an increase in endothelial generation of prostacyclin. Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Aspirin; Blood Platelets; Endothelium, Vascular; Epoprostenol; Imidazoles; Indomethacin; Leukotrienes; Lipid Peroxides; Platelet Adhesiveness; Rabbits; Superoxide Dismutase; Thrombosis; Xanthine; Xanthine Oxidase; Xanthines	1990
Effect of dazoxiben on platelet-vessel wall interaction. British journal of clinical pharmacology, 1983, Volume: 15 Suppl 1 1 Platelet monolayer adhesion to damaged rabbit aorta and to collagen-coated glass was quantified in a perfusion device. Addition of the thromboxane synthetase inhibitor dazoxiben (UK 37248) 1 and 10 microM reduced adhesion to damaged blood vessel by about 45% at both concentrations, but did not affect adhesion to collagen-coated glass. 2 Measurement by RIA indicated virtual abolition of thromboxane B2 production in the presence of the drug and a slight trend to an increase of 6-oxo-prostaglandin F1 alpha concentration in experiments using aorta. Inhibitory activity of dazoxiben was abolished by previous exposure of the aorta to 15-HPETE(?), an inhibitor of prostacyclin synthetase. 3 The results indicate that dazoxiben inhibits platelet adhesion to vascular subendothelium possibly by promoting synthesis of PGI2 from re-directed platelet endoperoxides. Topics: Animals; Arachidonic Acids; Blood Platelets; Blood Vessels; Imidazoles; In Vitro Techniques; Leukotrienes; Lipid Peroxides; Oxidoreductases; Rabbits; Thromboxane-A Synthase	1983

Article

Year

A biological method for studying the interaction between platelets and vascular endothelium.

Thrombosis research, 1990, Feb-01, Volume: 57, Issue:3

A segment of fresh rabbit thoracic aorta (RbA) was turned inside out and superfused (1.5 ml/min) with citrated (3.8%) or heparinized (10 U/ml) blood of rabbit and the superfusate was discarded. RbA gained in weight due to deposition of thrombi on its endothelial surface. These thrombi were mainly composed of platelets. The interaction between platelets and endothelium was augmented in RbAs from animals with atherosclerosis and in RbAs pretreated with aspirin (110 microM) or 15-HPETE (150 microM) or by the enzymatic system generating oxygen free radicals (xanthine:xanthine oxidase - 100 microM: 0.1 U/ml). On the other hand, this interaction was impaired by superoxide dismutase (20 U/ml) or catalase (0.2 U/ml). Finally, the dissipation of thrombi by thromboxane A2-synthetase inhibitor--dazoxiben was found to be related to an increase in endothelial generation of prostacyclin.

Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Aspirin; Blood Platelets; Endothelium, Vascular; Epoprostenol; Imidazoles; Indomethacin; Leukotrienes; Lipid Peroxides; Platelet Adhesiveness; Rabbits; Superoxide Dismutase; Thrombosis; Xanthine; Xanthine Oxidase; Xanthines

1990

Effect of dazoxiben on platelet-vessel wall interaction.

British journal of clinical pharmacology, 1983, Volume: 15 Suppl 1

1 Platelet monolayer adhesion to damaged rabbit aorta and to collagen-coated glass was quantified in a perfusion device. Addition of the thromboxane synthetase inhibitor dazoxiben (UK 37248) 1 and 10 microM reduced adhesion to damaged blood vessel by about 45% at both concentrations, but did not affect adhesion to collagen-coated glass. 2 Measurement by RIA indicated virtual abolition of thromboxane B2 production in the presence of the drug and a slight trend to an increase of 6-oxo-prostaglandin F1 alpha concentration in experiments using aorta. Inhibitory activity of dazoxiben was abolished by previous exposure of the aorta to 15-HPETE(?), an inhibitor of prostacyclin synthetase. 3 The results indicate that dazoxiben inhibits platelet adhesion to vascular subendothelium possibly by promoting synthesis of PGI2 from re-directed platelet endoperoxides.

Topics: Animals; Arachidonic Acids; Blood Platelets; Blood Vessels; Imidazoles; In Vitro Techniques; Leukotrienes; Lipid Peroxides; Oxidoreductases; Rabbits; Thromboxane-A Synthase

1983