Compounds > 14,15-epoxy-5,8,11-eicosatrienoic acid

14,15-epoxy-5,8,11-eicosatrienoic acid and arachidonic acid

14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with arachidonic acid in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19904 (6.67)18.7374
1990's23 (38.33)18.2507
2000's17 (28.33)29.6817
2010's14 (23.33)24.3611
2020's2 (3.33)2.80

Authors

AuthorsStudies
Hasunuma, K; Tamura, Y; Terano, T; Yoshida, S1
Braden, G; Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, J; Shipp, E1
Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC1
Bernstrom, K; Fitzpatrick, FA; Kayganich, K; Murphy, RC1
Amruthesh, SC; Ellis, EF; Police, RJ; Yancey, LM1
Bonventre, JV; Force, T; Hajjar, R; Hyman, G; Sellmayer, A1
Amruthesh, SC; Ellis, EF; McKinney, JS; Police, RJ; Yancey, L1
Falck, JR; Fitzpatrick, FA; Malcolm, K1
Jacoby, M; Levine, SD; Oates, JA; Petty, E; Schlondorff, D1
Capdevila, J; Falck, JR; Proctor, KG1
Ballou, LR; Cheung, WY; Lam, BK; Wong, PY1
Capdevila, J; Estabrook, RW; Falck, JR; Kim, YR; Manna, S; Martin-Wixtrom, C1
Elder, MG; Rendell, NB; Sullivan, MH; Taylor, GW; Zosmer, A1
Balazy, M; McGiff, JC; Schieber, EB; Zhu, Y1
Ellis, EF; Shivachar, AC; Willoughby, KA1
Daikh, BE; Koop, DR; Lasker, JM; Raucy, JL1
Ma, YH; Roman, RJ; Schwartzman, ML1
Imig, JD; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP1
Campbell, WB; Rosolowsky, M1
Belosludtsev, Y; Capdevila, JH; Falck, JR; Graham-Lorence, SE; Helvig, C; Peterson, JA; Truan, G; Wei, S1
Boyle, JE; Foley, J; Ma, J; Moomaw, CR; Pascual, JM; Steenbergen, C; Tomer, KB; Wu, S; Zeldin, DC1
Fang, X; Kaduce, TL; Spector, AA; Weintraub, NL1
Ellis, EF; Falck, JR; Hoffman, SW; Rzigalinski, BA; Willoughby, KA1
Huang, S; Konieczkowski, M; Schelling, JR; Sedor, JR1
Lee, HC; Lu, T; Shibata, EF; Spector, AA; VanRollins, M; Weintraub, NL1
Chatterjee, P; Fang, X; Kaduce, TL; Spector, AA; VanRollins, M; Weintraub, NL1
Barac-Nieto, M; Silverstein, DM; Spitzer, A1
Bousamra, M; Falck, JR; Harder, DR; Jacobs, ER; Roman, RJ; Townsley, M; Zeldin, DC; Zhu, D1
Benech, H; Chéron, G; Colin, I; Cresteil, T; Pruvost, A; Tréluyer, JM1
Falck, JR; Lai, PS; Wong, PY1
Campbell, WB; DiCamelli, RF; Falck, JR; Gross, GJ; Gumina, RJ; Kohler, S; Nithipatikom, K1
Chiribiri, A; Gattullo, D; Pagliaro, P; Paolocci, N; Penna, C; Rastaldo, R1
Balazy, M; Falck, JR; Krishna, UM; Reddy, MM; Xia, J1
Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK1
Vandernoot, VA; VanRollins, M1
Liu, YC; Wu, SN1
Cox, R; Oleksiak, MF; Parker, C; Qu, W; Stegeman, JJ; Wu, S; Zeldin, DC1
Carter, EP; Jacobs, ER; Miyazono, M; Nemenoff, R; Zhu, D1
Campbell, WB; Falck, JR; Gauthier, KM; Jagadeesh, SG1
Baewer, DV; Campbell, WB; Falck, JR; Gauthier, KM; Hillard, CJ; Hittner, S; Nithipatikom, K; Reddy, DS1
Liao, JK; Spiecker, M1
Anjaiah, S; Capdevila, JH; Chen, J; Chen, JK; Falck, JR; Guthi, JS; Harris, RC1
Feuerstein, TJ; Hollenberg, PF; Rae, JM; Sikora, MJ; Snider, NT; Sridar, C1
Blough, DK; Davis, CL; Farin, FM; Hebert, MF; Jones, JP; Kalhorn, TF; Perkins, JD; Smith, HE; Stapleton, PL; Thummel, KE; Totah, RA1
Dawson, ES; Dyson, PJ; Hachey, DL; Jackson, CJ; Kelly, SL; Lamb, DC; Lei, L; Skaug, T; Warrilow, AG; Waterman, MR; Yuan, H; Zhao, B1
Campbell, WB; Falck, JR; Gauthier, KM; Kopf, PG; Zhang, DX1
Barden, A; Beer, CD; Blacker, D; Croft, KD; Hankey, GJ; Mori, TA; Puddey, IB; Ward, NC1
Ilatovskaya, DV; Levchenko, V; Mattson, DL; Pavlov, TS; Roman, RJ; Staruschenko, A1
Albadine, R; Morin, C; Rousseau, E; Senouvo, FY; Sirois, C; Tabet, Y1
Althurwi, HN; El-Kadi, AO; Elshenawy, OH1
Abdelrady, M; Amara, IE; El-Kadi, AO; Elshenawy, OH1
Feng, YQ; Hao, YH; Liu, MZ; Ni, J; Yuan, BF; Yue, J; Zhu, QF1
Fleming, I1
Eliasson, E; Hayakawa, T; Inotsume, N; Kato, Y; Mukai, Y; Rane, A; Senda, A; Toda, T1
Barnych, B; Cajka, T; Hammock, BD; Lee, KSS; Morisseau, C; Panigrahy, D; Rand, AA1
Aliwarga, T; Gharib, SA; Lemaitre, RN; Raccor, BS; Sotoodehnia, N; Totah, RA; Xu, L1
Lemaitre, RN; Sotoodehnia, N; Totah, RA; Whittington, D; Zeigler, M1
Imaoka, S; Inoue, T; Kudoh, SN; Oguro, A1
Imig, JD; Jankiewicz, WK; Khan, AH1
Alaeddine, LM; Azar, NS; Dia, B; Eid, AA; El Khoury, M; Hamza, M; Harb, F; Mogharbil, N; Noureldein, MH; Sabra, R1

Reviews

2 review(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and arachidonic acid

ArticleYear
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
    Archives of biochemistry and biophysics, 2005, Jan-15, Volume: 433, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Movement; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Fibrinolysis; Humans; Inflammation; Isoenzymes; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Cardiac; NF-kappa B; Oxygenases; Protective Agents; Stereoisomerism; Vasodilation

2005
The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling.
    Vascular pharmacology, 2016, Volume: 86

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Docosahexaenoic Acids; Eicosapentaenoic Acid; Endothelium, Vascular; Epoxide Hydrolases; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Humans; Signal Transduction

2016

Other Studies

58 other study(ies) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and arachidonic acid

ArticleYear
Formation of epoxyeicosatrienoic acids from arachidonic acid by cultured rat aortic smooth muscle cell microsomes.
    Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 42, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Metyrapone; Microsomes; Mixed Function Oxygenases; Muscle, Smooth, Vascular; NADP; NADPH-Ferrihemoprotein Reductase; Pyridines; Rats; Rats, Inbred WKY

1991
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Angina, Unstable; Angioplasty, Balloon, Coronary; Arachidonic Acid; Arachidonic Acids; Colforsin; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Oxygenases; Platelet Activation; Pre-Eclampsia; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thrombin

1991
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance

1992
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids.
    The Journal of biological chemistry, 1992, Feb-25, Volume: 267, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Acylation; Animals; Arachidonic Acid; Calcimycin; Cell Line, Transformed; Chromatography, High Pressure Liquid; Kinetics; Mast Cells; Mice; Phospholipids; Spectrometry, Mass, Fast Atom Bombardment

1992
Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Cerebrovascular Circulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Free Radicals; Indomethacin; Mice; Oxygen; Oxygenases; Prostaglandins; Vasodilation

1991
Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores.
    The Journal of biological chemistry, 1991, Mar-05, Volume: 266, Issue:7

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Calcium; Cells, Cultured; Dinoprostone; Eicosanoids; Eicosapentaenoic Acid; Glomerular Mesangium; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Inositol Phosphates; Leukotrienes; Lipid Peroxides; Masoprocol; Pyridines; Rats; Rats, Inbred Strains; Signal Transduction; Type C Phospholipases

1991
Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid.
    The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Arterioles; Brain; Cats; Cerebrovascular Circulation; Cytochrome P-450 Enzyme System; Rabbits; Vasodilation

1990
Novel eicosanoids generated by cytochrome P450: effects on platelet aggregation and protein phosphorylation.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1990, Volume: 20

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Aza Compounds; Blood Platelets; Calcimycin; Collagen; Cytochrome P-450 Enzyme System; Eicosanoids; Humans; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Sulfides; Thromboxane B2

1990
Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder.
    The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Bufo marinus; Colforsin; Cyclic AMP; Epithelium; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Urinary Bladder; Vasopressins; Water-Electrolyte Balance

1987
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
    Circulation research, 1987, Volume: 60, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Intestinal Mucosa; Intestines; Male; Rats; Regional Blood Flow; Structure-Activity Relationship; Vasodilation

1987
Formation of cis-14,15-oxido-5,8,11-icosatrienoic acid from phosphatidylinositol in human platelets.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:20

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; NADP; Oxygenases; Phosphatidylinositols; Phospholipases A; Substrate Specificity; Thrombin

1987
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
    Archives of biochemistry and biophysics, 1985, Nov-15, Volume: 243, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Benzphetamine; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Fibric Acids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Lauric Acids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains

1985
Formation and metabolism of 14,15-epoxyeicosatrienoic acid by human reproductive tissues.
    Biochimica et biophysica acta, 1995, Oct-05, Volume: 1258, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Blood; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Female; Gas Chromatography-Mass Spectrometry; Granulosa Cells; Humans; Molecular Structure; Tumor Cells, Cultured

1995
Identification of arachidonate P-450 metabolites in human platelet phospholipids.
    Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Blood Platelets; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyeicosatetraenoic Acids; Phospholipids

1995
Effect of protein kinase C modulators on 14,15-epoxyeicosatrienoic acid incorporation into astroglial phospholipids.
    Journal of neurochemistry, 1995, Volume: 65, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Astrocytes; Cells, Cultured; Chromatography, High Pressure Liquid; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipids; Protein Kinase C; Rats; Rats, Sprague-Dawley

1995
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Sequence Data; Rabbits; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

1994
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats.
    The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Sodium Chloride

1994
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure.
    The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Miconazole; Microsomes; Muscle, Smooth, Vascular; Oxazines; Perfusion; Rats; Rats, Sprague-Dawley; Renal Circulation

1994
Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid.
    The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Cattle; Coronary Vessels; Epoprostenol; Vasodilation

1993
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3.
    The Journal of biological chemistry, 1996, Sep-13, Volume: 271, Issue:37

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Bacterial Proteins; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Mass Spectrometry; Mixed Function Oxygenases; Models, Molecular; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Plasmids; Spectrophotometry, Atomic; Stereoisomerism

1996
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance.
    Molecular pharmacology, 1996, Volume: 50, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes; Lung; Macrophages, Alveolar; Muscle, Smooth, Vascular; Rats

1996
Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 57, Issue:4-5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Muscle Relaxation; Muscle, Smooth, Vascular; Phospholipids; Swine

1997
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.
    The Journal of biological chemistry, 1999, Jan-01, Volume: 274, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Astrocytes; Calcium; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Ion Transport; Phospholipases A; Phospholipases A2; Rats; Signal Transduction; Thapsigargin

1999
Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells.
    Kidney international, 1999, Volume: 55, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Aristolochic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glomerular Mesangium; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Leukotrienes; Lipid Peroxides; Mitogen-Activated Protein Kinases; Nephritis; Phenanthrenes; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Rats; Signal Transduction; Stearic Acids; Tritium; Vasoconstrictor Agents

1999
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes.
    The Journal of physiology, 1999, Aug-15, Volume: 519 Pt 1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arachidonic Acid; Cells, Cultured; Heart; Heart Ventricles; Membrane Potentials; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Channels; Structure-Activity Relationship

1999
Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids.
    The American journal of physiology, 1999, Volume: 277, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Bradykinin; Cells, Cultured; Chalcone; Chalcones; Coenzyme A Ligases; Coronary Vessels; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Epoxide Hydrolases; Hydroxyeicosatetraenoic Acids; Lipid Metabolism; Phospholipids; Swine; Vasodilation

1999
Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Transport; Cell Line; Electrolytes; Hydroxyeicosatetraenoic Acids; Ion Transport; Kidney Cortex; Kidney Tubules, Proximal; Opossums; Oxazines; Phosphates; Renin; Sodium

1999
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Male; Pressure; Pulmonary Artery; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System

2000
Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome.
    Pediatric research, 2000, Volume: 47, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Adult; Age Factors; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Infant; Isoenzymes; Liver; Microsomes, Liver; NADP; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sudden Infant Death; Up-Regulation

2000
Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes.
    Prostaglandins & other lipid mediators, 2000, Volume: 62, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Bucladesine; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Leukocytes, Mononuclear; Oxygenases; Signal Transduction; Tritium

2000
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs.
    Analytical biochemistry, 2001, May-01, Volume: 292, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Coronary Vessels; Cytochrome P-450 Enzyme System; Dogs; Eicosanoids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Ischemia; Reference Standards; Reperfusion

2001
Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Bradykinin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Octoxynol; Proadifen; Rats; Rats, Wistar; Tachyphylaxis; Triazoles; Ventricular Function, Left

2001
Stereospecific synthesis of trans-arachidonic acids.
    Bioorganic & medicinal chemistry letters, 2001, Sep-17, Volume: 11, Issue:18

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Biochemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Stereoisomerism

2001
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
    Circulation research, 2002, May-17, Volume: 90, Issue:9

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2002
Capillary electrophoresis of cytochrome P-450 epoxygenase metabolites of arachidonic acid. 2. Resolution of stereoisomers.
    Analytical chemistry, 2002, Nov-15, Volume: 74, Issue:22

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calibration; Cyclodextrins; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Liver; Mice; Oxygenases; Spectrophotometry, Ultraviolet; Stereoisomerism

2002
Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells.
    European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2

    Topics: 8,11,14-Eicosatrienoic Acid; alpha-Linolenic Acid; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Hydantoins; Imidazoles; Imidazolidines; Infant, Newborn; Linoleic Acids; Membrane Potentials; Neuroblastoma; Patch-Clamp Techniques; Piperazines; Piperidines; Pituitary Neoplasms; Polyunsaturated Alkamides; Potassium Channels; Pyridines; Tumor Cells, Cultured

2003
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.
    Archives of biochemistry and biophysics, 2003, Mar-15, Volume: 411, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Benzphetamine; Cloning, Molecular; Conserved Sequence; Cytochrome P-450 Enzyme System; Fasting; Fundulidae; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Male; Molecular Sequence Data; Multigene Family; Organ Specificity; Phylogeny; Rats; Rats, Inbred F344; RNA, Messenger; Sequence Alignment; Tetradecanoylphorbol Acetate; Vertebrates

2003
Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis.
    Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:7

    Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Arachidonic Acid; Bile Ducts; Blotting, Western; Body Weight; Cell Division; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hemodynamics; Kidney; Liver Cirrhosis; Nitric Oxide; Perfusion; Phospholipases A; Protein Isoforms; Rats; Time Factors

2003
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cattle; Coronary Vessels; Culture Techniques; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Rats; Sulfonamides; Vasodilator Agents

2003
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cattle; Cells, Cultured; Coronary Vessels; Endocannabinoids; Endothelium, Vascular; Glycerides; Hydroxyeicosatetraenoic Acids; Vasodilation

2005
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.
    Molecular and cellular biology, 2007, Volume: 27, Issue:8

    Topics: 8,11,14-Eicosatrienoic Acid; ADAM Proteins; ADAM17 Protein; Animals; Arachidonic Acid; Cell Line; Cytochrome P-450 Enzyme System; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Glycerol; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Membrane Proteins; Mitogens; Models, Biological; Monoglycerides; Receptors, Cannabinoid; RNA, Small Interfering; Signal Transduction; Swine; Transforming Growth Factor alpha

2007
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 327, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Brain; Cytochrome P-450 CYP2D6; Endocannabinoids; Epoxy Compounds; Humans; Hydroxylation; Microsomes; Mitochondria; Polyunsaturated Alkamides; Time Factors

2008
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
    Pharmacogenetics and genomics, 2008, Volume: 18, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Demography; Female; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Kidney Failure, Chronic; Kidney Function Tests; Kidney Transplantation; Kinetics; Male; Middle Aged; Tacrolimus; United States

2008
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner.
    Applied and environmental microbiology, 2010, Volume: 76, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Transposable Elements; Escherichia coli; Ferredoxin-NADP Reductase; Ferredoxins; Gene Expression; Mixed Function Oxygenases; Mutagenesis, Insertional; NADP; Streptomyces coelicolor; Substrate Specificity

2010
Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Adrenal Glands; Aldosterone; Angiotensin II; Animals; Arachidonic Acid; Arteries; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Epoxide Hydrolases; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Potassium Channels; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Zona Glomerulosa

2011
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
    Clinical science (London, England : 1979), 2011, Volume: 121, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Case-Control Studies; Cytochrome P-450 Enzyme System; F2-Isoprostanes; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Oxidative Stress; Stroke

2011
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).
    American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Diclofenac; Epithelial Sodium Channels; Female; Ibuprofen; Kidney Tubules, Collecting; Mice; Models, Animal; Ovary; Patch-Clamp Techniques; Transfection

2011
Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoates; Blotting, Western; Bronchi; Cells, Cultured; Eicosapentaenoic Acid; Electrophoresis, Polyacrylamide Gel; Epoxide Hydrolases; Epoxy Compounds; Fluorescent Antibody Technique; Guinea Pigs; Humans; Mice; Muscle Tonus; Muscle, Smooth; Myocytes, Smooth Muscle; Rats; Receptors, Prostaglandin E; Receptors, Thromboxane; Signal Transduction; Thromboxane A2; Urea

2011
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fenofibrate; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Isoproterenol; Male; Rats; Rats, Sprague-Dawley

2014
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.
    Toxicology letters, 2014, Apr-07, Volume: 226, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Atrial Natriuretic Factor; Biomarkers; Cardiomegaly; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Injections, Intraperitoneal; Isoenzymes; Male; Mercuric Chloride; Mice; Mice, Inbred C57BL; Myocardium; Natriuretic Peptide, Brain; RNA, Messenger

2014
Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
    Journal of chromatography. A, 2015, Sep-04, Volume: 1410

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Diabetes Mellitus, Type 2; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Leukemia, Myeloid; Liver; Male; Myocardium; Organ Specificity; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2015
Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II Type 1 Receptor Blockers; Arachidonic Acid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver; Microsomes, Liver; Recombinant Proteins

2017
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 04-25, Volume: 114, Issue:17

    Topics: 8,11,14-Eicosatrienoic Acid; Angiogenesis Inducing Agents; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Humans

2017
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
    Free radical biology & medicine, 2017, Volume: 112

    Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Arachidonic Acid; Benzene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythrocyte Membrane; Female; Humans; Liposomes; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Peroxides; Stereoisomerism; Tandem Mass Spectrometry

2017
A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma.
    Chemistry and physics of lipids, 2018, Volume: 216

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Humans; Molecular Structure; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry

2018
14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.
    Pharmacology research & perspectives, 2018, Volume: 6, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calcium; Capsaicin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Hippocampus; Neurites; Neuronal Outgrowth; PC12 Cells; Primary Cell Culture; Rats; Rats, Wistar; TRPV Cation Channels

2018
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 76, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Forecasting; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Natriuresis; Potassium; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Vasodilation; Water-Electrolyte Balance; Water-Electrolyte Imbalance

2020
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.
    Translational research : the journal of laboratory and clinical medicine, 2021, Volume: 235

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomyopathies; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hydroxyeicosatetraenoic Acids; Male; NADPH Oxidase 4; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Streptozocin

2021