14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid

14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with 8,9-epoxyeicosatrienoic acid in 70 studies

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-19906 (8.57)18.7374
1990's26 (37.14)18.2507
2000's25 (35.71)29.6817
2010's12 (17.14)24.3611
2020's1 (1.43)2.80

Authors

AuthorsStudies
Capdevila, JH; Falck, JR; Karara, A; Spady, D; Swift, L; Wei, S1
Braden, G; Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, J; Shipp, E1
Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC1
Ellis, EF; Heizer, ML; McKinney, JS1
Amruthesh, SC; Ellis, EF; Police, RJ; Yancey, LM1
Campbell, WB; Falck, JR; Rosolowsky, M1
Campbell, WB; Falck, JR; Pfister, SL1
Capdevila, J; Harris, RC; Homma, T; Jacobson, HR1
Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, JA1
Teien, G; Ulsaker, GA1
Capdevila, JH; Falck, JR; Guenguerich, FP; Karara, A; Martin, MV; Waxman, DJ1
Capdevila, JH; Dishman, E; Falck, JR; Jacobson, H; Karara, A1
Falck, JR; Snyder, GD; Yadagiri, P1
Blair, I; Capdevila, JH; Dishman, E; Falck, JR; Karara, A1
Blair, IA; Capdevila, JH; Falck, JR; Hammonds, TD1
Baze, ME; Ennis, MD; Fitzpatrick, FA; Liggett, WF; McGee, JE; Wynalda, MA1
Capdevila, J; Falck, JR; Proctor, KG1
Capdevila, J; Carroll, MA; Falck, JR; McGiff, JC; Schwartzman, M1
Fang, X; Kaduce, TL; Spector, AA; VanRollins, M1
Balazy, M; McGiff, JC; Schieber, EB1
Abraham, N; Escalante, BA; Schwartzman, M; Staudinger, R1
Evans, RW; Kochanek, PM; Nemoto, EM; Schiding, JK; VanRollins, M1
Daikh, BE; Koop, DR; Lasker, JM; Raucy, JL1
Bend, JR; Farhangkhoee, P; Karmazyn, M; Mock, T; Moffat, MP; Ward, CA1
Boyle, JE; Foley, J; Ma, J; Moomaw, CR; Pascual, JM; Steenbergen, C; Tomer, KB; Wu, S; Zeldin, DC1
Gimeno, MA; Gonzalez, E; Jawerbaum, A; Novaro, V1
Chatterjee, P; Fang, X; Kaduce, TL; Spector, AA; VanRollins, M; Weintraub, NL1
Fedinec, AL; Leffler, CW1
Baron, A; Bény, JL; Frieden, M1
Lee, HC; Lu, T; Shibata, EF; Spector, AA; VanRollins, M; Weintraub, NL1
Huo, Y; Ley, K; Liao, JK; Node, K; Ruan, X; Spiecker, M; Yang, B; Zeldin, DC1
Fang, X; Spector, AA; Stoll, LL; Weintraub, NL1
Bousamra, M; Falck, JR; Harder, DR; Jacobs, ER; Roman, RJ; Townsley, M; Zeldin, DC; Zhu, D1
Campbell, WB; Nithipatikom, K; Pratt, PF1
Draper, AJ; Engler, MM; Graham, L; Hammock, BD; Huse, LM; Kroetz, DL; Morisseau, C; Newman, JW; Parker, C; Xu, F; Yu, Z; Zeldin, DC1
Dai, J; Graham, L; Liao, JK; Node, K; Ruan, XL; Yang, SX; Zeldin, DC1
Benoit, C; Renaudon, B; Rousseau, E; Salvail, D1
Dellsperger, KC; Lee, HC; Lu, T; Oltman, CL; VanRollins, M; Zhang, Y1
Capdevila, JH; Falck, JR; Imig, JD; Wei, S; Zhao, X1
Harder, D; Medhora, M; Narayanan, J1
Balazy, M; Falck, JR; Krishna, UM; Reddy, MM; Xia, J1
Cloutier, M; Rousseau, E; Salvail, D1
Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK1
Harder, DR; Zhang, C1
Callewaert, DM; Campbell, WB; Falck, JR; Gikas, K; Nithipatikom, K; Reddy, M; Sasaki, DM; Yuan, Y1
Alvarez, DF; Gjerde, EA; Townsley, MI1
Buerkle, MA; Campbell, WB; Gloe, T; Krötz, F; Nithipatikom, K; Pohl, U; Riexinger, T; Sohn, HY1
Lee, HC; Ye, D; Zhou, W1
Liao, JK; Spiecker, M1
Dunn, BE; Dunn, LK; Falck, JR; Gruenloh, SK; Jacobs, ER; Medhora, M; Reddy, DS1
Chen, R; Jiang, J; Wang, D; Xiao, X1
Anjaiah, S; Brittin, JJ; Campbell, WB; Capdevila, JH; Cui, L; Falck, JR; Nithipatikom, K; Wei, S1
Abraham, NG; Bolognesi, M; Di Pascoli, M; Gatta, A; McGiff, JC; Sacerdoti, D; Schwartzman, ML1
Cao, S; Lee, HC; Lu, T; Shah, VH; Wang, XL1
Chen, RJ; Cowart, LA; Jiang, JG; Wang, DW; Wang, JN; Wang, Y; Xia, Y; Xiao, B; Xiao, X; Yang, S1
Falck, JR; Gross, GJ; Hsu, A; Nithipatikom, K1
Fu, XN; Jiang, JG; Shen, GF; Wang, DW1
Ilatovskaya, DV; Levchenko, V; Mattson, DL; Pavlov, TS; Roman, RJ; Staruschenko, A1
Cracowski, C; Cracowski, JL; Gaillard-Bigot, F; Millet, C; Roustit, M; Sors, C1
Chen, C; Duan, Q; Edin, ML; Ni, L; Wang, DW; Wang, X; Yang, L; Zeldin, DC1
Althurwi, HN; El-Kadi, AO; Elshenawy, OH1
Diani-Moore, S; Gross, SS; Ma, Y; Rifkind, AB1
Feng, YQ; Hao, YH; Liu, MZ; Ni, J; Yuan, BF; Yue, J; Zhu, QF1
Froogh, G; Huang, A; Kandhi, S; Luo, M; Qin, J; Sun, D; Wolin, MS1
Funk, DJ; Kopka, K; Schmeiser, HH; Sorg, BL1
Eliasson, E; Hayakawa, T; Inotsume, N; Kato, Y; Mukai, Y; Rane, A; Senda, A; Toda, T1
Barnych, B; Cajka, T; Hammock, BD; Lee, KSS; Morisseau, C; Panigrahy, D; Rand, AA1
Aliwarga, T; Gharib, SA; Lemaitre, RN; Raccor, BS; Sotoodehnia, N; Totah, RA; Xu, L1
Chan, ECY; Hagen, T; Karkhanis, A; Leow, JWH1
Imig, JD; Jankiewicz, WK; Khan, AH1

Reviews

2 review(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid

ArticleYear
Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.
    Trends in cardiovascular medicine, 2001, Volume: 11, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain Chemistry; Cerebrovascular Circulation; Endothelium, Vascular; Humans; Microcirculation; Muscle, Smooth, Vascular; Vasodilation

2001
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
    Archives of biochemistry and biophysics, 2005, Jan-15, Volume: 433, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Movement; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Fibrinolysis; Humans; Inflammation; Isoenzymes; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Cardiac; NF-kappa B; Oxygenases; Protective Agents; Stereoisomerism; Vasodilation

2005

Trials

1 trial(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid

ArticleYear
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 2013, Jan-15, Volume: 114, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Adult; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Fluconazole; Humans; Hyperemia; Lidocaine; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Diseases

2013

Other Studies

67 other study(ies) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid

ArticleYear
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
    Biochemical and biophysical research communications, 1992, Feb-14, Volume: 182, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Isomerism; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Oxygenases; Rats; Rats, Inbred Strains

1992
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Angina, Unstable; Angioplasty, Balloon, Coronary; Arachidonic Acid; Arachidonic Acids; Colforsin; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Oxygenases; Platelet Activation; Pre-Eclampsia; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thrombin

1991
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance

1992
14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles.
    Stroke, 1991, Volume: 22, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Blood Platelets; Cerebrovascular Circulation; Indomethacin; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2

1991
Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Cerebrovascular Circulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Free Radicals; Indomethacin; Mice; Oxygen; Oxygenases; Prostaglandins; Vasodilation

1991
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Cells, Cultured; Coronary Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Vasodilation

1991
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Carbon Radioisotopes; Cholesterol, Dietary; Clotrimazole; Diet, Atherogenic; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; Metyrapone; Muscle, Smooth, Vascular; Rabbits; Reference Values; Stereoisomerism

1991
Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells.
    Journal of cellular physiology, 1990, Volume: 144, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Carrier Proteins; Cell Division; Cells, Cultured; Fatty Acids, Unsaturated; Glomerular Mesangium; Mitogens; Rats; Sodium-Hydrogen Exchangers; Thymidine

1990
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:15

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Dogs; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Radioisotope Dilution Technique; Reference Values; Tritium

1990
Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma.
    The Analyst, 1990, Volume: 115, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Aluminum; Aluminum Compounds; Deuterium; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Lithium; Lithium Compounds; Molecular Structure; Oxidation-Reduction

1990
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
    The Journal of biological chemistry, 1990, Jul-05, Volume: 265, Issue:19

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Substrate Specificity

1990
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
    FEBS letters, 1990, Jul-30, Volume: 268, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Humans; Kidney Cortex; Male; Mass Spectrometry; Oxygenases; Stereoisomerism

1990
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs.
    The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Fatty Acids, Unsaturated; Growth Hormone; Growth Hormone-Releasing Hormone; Indomethacin; Kinetics; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin

1989
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.
    The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonate Lipoxygenases; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Liver; Male; Mass Spectrometry; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism

1989
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
    Analytical biochemistry, 1989, Nov-01, Volume: 182, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Stereoisomerism

1989
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry.
    The Journal of biological chemistry, 1986, Nov-15, Volume: 261, Issue:32

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Humans; Kinetics; Male; Platelet Aggregation; Seminal Vesicles; Sheep; Structure-Activity Relationship

1986
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
    Circulation research, 1987, Volume: 60, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Intestinal Mucosa; Intestines; Male; Rats; Regional Blood Flow; Structure-Activity Relationship; Vasodilation

1987
Vasoactivity of arachidonic acid epoxides.
    European journal of pharmacology, 1987, Jun-19, Volume: 138, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rats; Vasodilator Agents

1987
Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells.
    Journal of lipid research, 1995, Volume: 36, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Kinetics; Muscle, Smooth, Vascular; Phospholipids; Swine; Tritium

1995
Identification of arachidonate epoxides in human platelets.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: 8,11,14-Eicosatrienoic Acid; Blood Platelets; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Phospholipids

1995
Amiloride-sensitive ion transport inhibition by epoxyeicosatrienoic acids in renal epithelial cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: 8,11,14-Eicosatrienoic Acid; Amiloride; Animals; Biological Transport; Cell Line; Epithelium; Kidney; Rubidium; Rubidium Radioisotopes; Structure-Activity Relationship

1995
Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo.
    Biochimica et biophysica acta, 1995, Jun-06, Volume: 1256, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Infusions, Intravenous; Male; Rats; Rats, Wistar

1995
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Sequence Data; Rabbits; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

1994
Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes.
    The American journal of physiology, 1993, Volume: 264, Issue:4 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Rate; Heart Ventricles; Male; Myocardium; Reperfusion Injury; Time Factors

1993
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance.
    Molecular pharmacology, 1996, Volume: 50, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes; Lung; Macrophages, Alveolar; Muscle, Smooth, Vascular; Rats

1996
Influence of epoxyeicosatrienoic acids on uterine function.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Uterine Contraction

1997
Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids.
    Circulation research, 1997, Volume: 81, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilation

1997
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arterioles; Carbon Dioxide; Cyclic AMP; Dose-Response Relationship, Drug; Iloprost; Indomethacin; Muscle, Smooth, Vascular; Nitroprusside; Pia Mater; Structure-Activity Relationship; Swine; Vasodilation; Vasodilator Agents

1997
Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells.
    The Journal of physiology, 1997, Nov-01, Volume: 504 ( Pt 3)

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Membrane Potentials; Potassium Channels; Swine

1997
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes.
    The Journal of physiology, 1999, Aug-15, Volume: 519 Pt 1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arachidonic Acid; Cells, Cultured; Heart; Heart Ventricles; Membrane Potentials; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Channels; Structure-Activity Relationship

1999
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
    Science (New York, N.Y.), 1999, Aug-20, Volume: 285, Issue:5431

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; I-kappa B Kinase; I-kappa B Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oxygenases; Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

1999
Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Fluid; Muscle Contraction; Muscle, Smooth, Vascular; Structure-Activity Relationship; Swine; Vasoconstrictor Agents; Vasodilator Agents

1999
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Male; Pressure; Pulmonary Artery; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System

2000
Determination of EETs using microbore liquid chromatography with fluorescence detection.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Methacholine Chloride; Microchemistry; Spectrometry, Fluorescence

2000
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
    Circulation research, 2000, Nov-24, Volume: 87, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Blood Pressure; Cytosol; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Hydrolysis; Hypertension; Kidney Cortex; Male; Microsomes; Microsomes, Liver; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity; Urea

2000
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
    The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Atropine Derivatives; Cattle; Cells, Cultured; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Oxygenases; Polymerase Chain Reaction; Proadifen; Promoter Regions, Genetic; Saphenous Vein; Tissue Plasminogen Activator; Transcription, Genetic; Transfection

2001
EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biological Factors; Bronchoconstriction; Cattle; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscarinic Agonists; Muscle, Smooth; Nitric Oxide Synthase; Peptides; Potassium Channels; Potassium Channels, Calcium-Activated; Rabbits; Trachea

2001
EET homologs potently dilate coronary microvessels and activate BK(Ca) channels.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Calcium Channel Agonists; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Microcirculation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Stereoisomerism; Swine; Vasodilation; Vasodilator Agents

2001
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.
    Journal of hypertension, 2001, Volume: 19, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II; Animals; Arterioles; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Drug Synergism; Hypertension; Kidney Cortex; Male; Microcirculation; Microsomes; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides; Vasoconstriction

2001
Stereospecific synthesis of trans-arachidonic acids.
    Bioorganic & medicinal chemistry letters, 2001, Sep-17, Volume: 11, Issue:18

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Biochemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Stereoisomerism

2001
Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle.
    American journal of physiology. Cell physiology, 2002, Volume: 282, Issue:3

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cattle; Cell Fractionation; Chloride Channels; Electric Conductivity; Electrophysiology; Immunoblotting; Lipid Bilayers; Liposomes; Muscle, Smooth; Sarcolemma; Trachea; Vasodilator Agents

2002
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
    Circulation research, 2002, May-17, Volume: 90, Issue:9

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2002
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.
    Stroke, 2002, Volume: 33, Issue:12

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain; Capillaries; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Lymphokines; Mitosis; Neovascularization, Physiologic; Rats; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: 8,11,14-Eicosatrienoic Acid; Antibodies; Arachidonic Acids; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Hydroxylation; Isomerism; Sensitivity and Specificity

2002
Role of EETs in regulation of endothelial permeability in rat lung.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Capillary Permeability; Endothelium, Vascular; Lung; Male; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasodilator Agents

2004
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Apamin; Aryl Hydrocarbon Hydroxylases; Biological Factors; Blood Platelets; Cells, Cultured; Charybdotoxin; Cytochrome P-450 CYP2C9; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Ion Channels; Membrane Potentials; Peptides; Platelet Adhesiveness; Platelet Aggregation; Potassium Channels; Recombinant Fusion Proteins; Transfection; Umbilical Veins

2004
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Rats; Vasodilation; Vasodilator Agents

2005
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
    The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, 2005, Volume: 285, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillaries; Chick Embryo; Chorioallantoic Membrane; Culture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperemia; Neovascularization, Physiologic; Nitric Oxide Donors; Time Factors; Vasodilator Agents; Vitelline Membrane

2005
Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved.
    Science in China. Series C, Life sciences, 2005, Volume: 48, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cattle; Cells, Cultured; Cytochrome P450 Family 2; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Unsaturated; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Steroid 16-alpha-Hydroxylase; Up-Regulation

2005
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
    Analytical biochemistry, 2006, May-01, Volume: 352, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents

2006
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Carbon Monoxide; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Male; Mesenteric Arteries; Mesoporphyrins; Organometallic Compounds; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2006
Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids.
    Biochimica et biophysica acta, 2006, Volume: 1761, Issue:9

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Glutathione Transferase; Humans; Ion Channel Gating; Mice; Potassium Channels, Inwardly Rectifying; Protein Binding; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors

2006
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.
    Prostaglandins & other lipid mediators, 2007, Volume: 82, Issue:1-4

    Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Aorta, Thoracic; Apigenin; Cattle; Cells, Cultured; Chromones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxy Compounds; Flavonoids; Inositol; Male; MAP Kinase Signaling System; Morpholines; Nitric Oxide Synthase Type III; Oxygenases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rats; Serine

2007
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
    Journal of molecular and cellular cardiology, 2007, Volume: 42, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Male; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tiopronin

2007
[Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells].
    Ai zheng = Aizheng = Chinese journal of cancer, 2008, Volume: 27, Issue:11

    Topics: 8,11,14-Eicosatrienoic Acid; Apigenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction

2008
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).
    American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Diclofenac; Epithelial Sodium Channels; Female; Ibuprofen; Kidney Tubules, Collecting; Mice; Models, Animal; Ovary; Patch-Clamp Techniques; Transfection

2011
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
    Molecular pharmacology, 2014, Volume: 85, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Calcium; Cardiomegaly; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum Stress; Heart Failure; Humans; In Vitro Techniques; Major Histocompatibility Complex; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2014
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fenofibrate; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Isoproterenol; Male; Rats; Rats, Sprague-Dawley

2014
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolas
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Chick Embryo; Enzyme Inhibitors; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Hydroxyeicosatetraenoic Acids; Lauric Acids; Liver; Polychlorinated Dibenzodioxins; RNA, Messenger

2014
Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
    Journal of chromatography. A, 2015, Sep-04, Volume: 1410

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Diabetes Mellitus, Type 2; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Leukemia, Myeloid; Liver; Male; Myocardium; Organ Specificity; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2015
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice.
    American journal of hypertension, 2016, Volume: 29, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Male; Mice, Inbred C57BL; Pulmonary Artery; Time Factors; Ventricular Function, Right; Ventricular Pressure

2016
Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro.
    Prostaglandins & other lipid mediators, 2016, Volume: 123

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; Hydrogen-Ion Concentration; Kinetics; Phosphorus Radioisotopes; Solutions; Stereoisomerism

2016
Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II Type 1 Receptor Blockers; Arachidonic Acid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver; Microsomes, Liver; Recombinant Proteins

2017
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 04-25, Volume: 114, Issue:17

    Topics: 8,11,14-Eicosatrienoic Acid; Angiogenesis Inducing Agents; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Humans

2017
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
    Free radical biology & medicine, 2017, Volume: 112

    Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Arachidonic Acid; Benzene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythrocyte Membrane; Female; Humans; Liposomes; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Peroxides; Stereoisomerism; Tandem Mass Spectrometry

2017
Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.
    Toxicological sciences : an official journal of the Society of Toxicology, 2018, 05-01, Volume: 163, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Line; Cell Survival; Dronedarone; Humans; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac

2018
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 76, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Forecasting; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Natriuresis; Potassium; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Vasodilation; Water-Electrolyte Balance; Water-Electrolyte Imbalance

2020