14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with 8,9-epoxyeicosatrienoic acid in 70 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (8.57) | 18.7374 |
1990's | 26 (37.14) | 18.2507 |
2000's | 25 (35.71) | 29.6817 |
2010's | 12 (17.14) | 24.3611 |
2020's | 1 (1.43) | 2.80 |
Authors | Studies |
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Capdevila, JH; Falck, JR; Karara, A; Spady, D; Swift, L; Wei, S | 1 |
Braden, G; Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, J; Shipp, E | 1 |
Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC | 1 |
Ellis, EF; Heizer, ML; McKinney, JS | 1 |
Amruthesh, SC; Ellis, EF; Police, RJ; Yancey, LM | 1 |
Campbell, WB; Falck, JR; Rosolowsky, M | 1 |
Campbell, WB; Falck, JR; Pfister, SL | 1 |
Capdevila, J; Harris, RC; Homma, T; Jacobson, HR | 1 |
Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, JA | 1 |
Teien, G; Ulsaker, GA | 1 |
Capdevila, JH; Falck, JR; Guenguerich, FP; Karara, A; Martin, MV; Waxman, DJ | 1 |
Capdevila, JH; Dishman, E; Falck, JR; Jacobson, H; Karara, A | 1 |
Falck, JR; Snyder, GD; Yadagiri, P | 1 |
Blair, I; Capdevila, JH; Dishman, E; Falck, JR; Karara, A | 1 |
Blair, IA; Capdevila, JH; Falck, JR; Hammonds, TD | 1 |
Baze, ME; Ennis, MD; Fitzpatrick, FA; Liggett, WF; McGee, JE; Wynalda, MA | 1 |
Capdevila, J; Falck, JR; Proctor, KG | 1 |
Capdevila, J; Carroll, MA; Falck, JR; McGiff, JC; Schwartzman, M | 1 |
Fang, X; Kaduce, TL; Spector, AA; VanRollins, M | 1 |
Balazy, M; McGiff, JC; Schieber, EB | 1 |
Abraham, N; Escalante, BA; Schwartzman, M; Staudinger, R | 1 |
Evans, RW; Kochanek, PM; Nemoto, EM; Schiding, JK; VanRollins, M | 1 |
Daikh, BE; Koop, DR; Lasker, JM; Raucy, JL | 1 |
Bend, JR; Farhangkhoee, P; Karmazyn, M; Mock, T; Moffat, MP; Ward, CA | 1 |
Boyle, JE; Foley, J; Ma, J; Moomaw, CR; Pascual, JM; Steenbergen, C; Tomer, KB; Wu, S; Zeldin, DC | 1 |
Gimeno, MA; Gonzalez, E; Jawerbaum, A; Novaro, V | 1 |
Chatterjee, P; Fang, X; Kaduce, TL; Spector, AA; VanRollins, M; Weintraub, NL | 1 |
Fedinec, AL; Leffler, CW | 1 |
Baron, A; Bény, JL; Frieden, M | 1 |
Lee, HC; Lu, T; Shibata, EF; Spector, AA; VanRollins, M; Weintraub, NL | 1 |
Huo, Y; Ley, K; Liao, JK; Node, K; Ruan, X; Spiecker, M; Yang, B; Zeldin, DC | 1 |
Fang, X; Spector, AA; Stoll, LL; Weintraub, NL | 1 |
Bousamra, M; Falck, JR; Harder, DR; Jacobs, ER; Roman, RJ; Townsley, M; Zeldin, DC; Zhu, D | 1 |
Campbell, WB; Nithipatikom, K; Pratt, PF | 1 |
Draper, AJ; Engler, MM; Graham, L; Hammock, BD; Huse, LM; Kroetz, DL; Morisseau, C; Newman, JW; Parker, C; Xu, F; Yu, Z; Zeldin, DC | 1 |
Dai, J; Graham, L; Liao, JK; Node, K; Ruan, XL; Yang, SX; Zeldin, DC | 1 |
Benoit, C; Renaudon, B; Rousseau, E; Salvail, D | 1 |
Dellsperger, KC; Lee, HC; Lu, T; Oltman, CL; VanRollins, M; Zhang, Y | 1 |
Capdevila, JH; Falck, JR; Imig, JD; Wei, S; Zhao, X | 1 |
Harder, D; Medhora, M; Narayanan, J | 1 |
Balazy, M; Falck, JR; Krishna, UM; Reddy, MM; Xia, J | 1 |
Cloutier, M; Rousseau, E; Salvail, D | 1 |
Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK | 1 |
Harder, DR; Zhang, C | 1 |
Callewaert, DM; Campbell, WB; Falck, JR; Gikas, K; Nithipatikom, K; Reddy, M; Sasaki, DM; Yuan, Y | 1 |
Alvarez, DF; Gjerde, EA; Townsley, MI | 1 |
Buerkle, MA; Campbell, WB; Gloe, T; Krötz, F; Nithipatikom, K; Pohl, U; Riexinger, T; Sohn, HY | 1 |
Lee, HC; Ye, D; Zhou, W | 1 |
Liao, JK; Spiecker, M | 1 |
Dunn, BE; Dunn, LK; Falck, JR; Gruenloh, SK; Jacobs, ER; Medhora, M; Reddy, DS | 1 |
Chen, R; Jiang, J; Wang, D; Xiao, X | 1 |
Anjaiah, S; Brittin, JJ; Campbell, WB; Capdevila, JH; Cui, L; Falck, JR; Nithipatikom, K; Wei, S | 1 |
Abraham, NG; Bolognesi, M; Di Pascoli, M; Gatta, A; McGiff, JC; Sacerdoti, D; Schwartzman, ML | 1 |
Cao, S; Lee, HC; Lu, T; Shah, VH; Wang, XL | 1 |
Chen, RJ; Cowart, LA; Jiang, JG; Wang, DW; Wang, JN; Wang, Y; Xia, Y; Xiao, B; Xiao, X; Yang, S | 1 |
Falck, JR; Gross, GJ; Hsu, A; Nithipatikom, K | 1 |
Fu, XN; Jiang, JG; Shen, GF; Wang, DW | 1 |
Ilatovskaya, DV; Levchenko, V; Mattson, DL; Pavlov, TS; Roman, RJ; Staruschenko, A | 1 |
Cracowski, C; Cracowski, JL; Gaillard-Bigot, F; Millet, C; Roustit, M; Sors, C | 1 |
Chen, C; Duan, Q; Edin, ML; Ni, L; Wang, DW; Wang, X; Yang, L; Zeldin, DC | 1 |
Althurwi, HN; El-Kadi, AO; Elshenawy, OH | 1 |
Diani-Moore, S; Gross, SS; Ma, Y; Rifkind, AB | 1 |
Feng, YQ; Hao, YH; Liu, MZ; Ni, J; Yuan, BF; Yue, J; Zhu, QF | 1 |
Froogh, G; Huang, A; Kandhi, S; Luo, M; Qin, J; Sun, D; Wolin, MS | 1 |
Funk, DJ; Kopka, K; Schmeiser, HH; Sorg, BL | 1 |
Eliasson, E; Hayakawa, T; Inotsume, N; Kato, Y; Mukai, Y; Rane, A; Senda, A; Toda, T | 1 |
Barnych, B; Cajka, T; Hammock, BD; Lee, KSS; Morisseau, C; Panigrahy, D; Rand, AA | 1 |
Aliwarga, T; Gharib, SA; Lemaitre, RN; Raccor, BS; Sotoodehnia, N; Totah, RA; Xu, L | 1 |
Chan, ECY; Hagen, T; Karkhanis, A; Leow, JWH | 1 |
Imig, JD; Jankiewicz, WK; Khan, AH | 1 |
2 review(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid
Article | Year |
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Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain Chemistry; Cerebrovascular Circulation; Endothelium, Vascular; Humans; Microcirculation; Muscle, Smooth, Vascular; Vasodilation | 2001 |
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Movement; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Fibrinolysis; Humans; Inflammation; Isoenzymes; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Cardiac; NF-kappa B; Oxygenases; Protective Agents; Stereoisomerism; Vasodilation | 2005 |
1 trial(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid
Article | Year |
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Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Fluconazole; Humans; Hyperemia; Lidocaine; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Diseases | 2013 |
67 other study(ies) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,9-epoxyeicosatrienoic acid
Article | Year |
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Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Isomerism; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Oxygenases; Rats; Rats, Inbred Strains | 1992 |
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Angina, Unstable; Angioplasty, Balloon, Coronary; Arachidonic Acid; Arachidonic Acids; Colforsin; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Oxygenases; Platelet Activation; Pre-Eclampsia; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1991 |
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance | 1992 |
14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Blood Platelets; Cerebrovascular Circulation; Indomethacin; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1991 |
Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Cerebrovascular Circulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Free Radicals; Indomethacin; Mice; Oxygen; Oxygenases; Prostaglandins; Vasodilation | 1991 |
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Cells, Cultured; Coronary Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Vasodilation | 1991 |
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Carbon Radioisotopes; Cholesterol, Dietary; Clotrimazole; Diet, Atherogenic; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; Metyrapone; Muscle, Smooth, Vascular; Rabbits; Reference Values; Stereoisomerism | 1991 |
Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Carrier Proteins; Cell Division; Cells, Cultured; Fatty Acids, Unsaturated; Glomerular Mesangium; Mitogens; Rats; Sodium-Hydrogen Exchangers; Thymidine | 1990 |
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Dogs; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Radioisotope Dilution Technique; Reference Values; Tritium | 1990 |
Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma.
Topics: 8,11,14-Eicosatrienoic Acid; Aluminum; Aluminum Compounds; Deuterium; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Lithium; Lithium Compounds; Molecular Structure; Oxidation-Reduction | 1990 |
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Substrate Specificity | 1990 |
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
Topics: 8,11,14-Eicosatrienoic Acid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Humans; Kidney Cortex; Male; Mass Spectrometry; Oxygenases; Stereoisomerism | 1990 |
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Fatty Acids, Unsaturated; Growth Hormone; Growth Hormone-Releasing Hormone; Indomethacin; Kinetics; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin | 1989 |
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonate Lipoxygenases; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Liver; Male; Mass Spectrometry; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1989 |
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
Topics: 8,11,14-Eicosatrienoic Acid; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Stereoisomerism | 1989 |
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Humans; Kinetics; Male; Platelet Aggregation; Seminal Vesicles; Sheep; Structure-Activity Relationship | 1986 |
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Intestinal Mucosa; Intestines; Male; Rats; Regional Blood Flow; Structure-Activity Relationship; Vasodilation | 1987 |
Vasoactivity of arachidonic acid epoxides.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rats; Vasodilator Agents | 1987 |
Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Kinetics; Muscle, Smooth, Vascular; Phospholipids; Swine; Tritium | 1995 |
Identification of arachidonate epoxides in human platelets.
Topics: 8,11,14-Eicosatrienoic Acid; Blood Platelets; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Phospholipids | 1995 |
Amiloride-sensitive ion transport inhibition by epoxyeicosatrienoic acids in renal epithelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Amiloride; Animals; Biological Transport; Cell Line; Epithelium; Kidney; Rubidium; Rubidium Radioisotopes; Structure-Activity Relationship | 1995 |
Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Infusions, Intravenous; Male; Rats; Rats, Wistar | 1995 |
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Sequence Data; Rabbits; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1994 |
Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Rate; Heart Ventricles; Male; Myocardium; Reperfusion Injury; Time Factors | 1993 |
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes; Lung; Macrophages, Alveolar; Muscle, Smooth, Vascular; Rats | 1996 |
Influence of epoxyeicosatrienoic acids on uterine function.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Uterine Contraction | 1997 |
Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilation | 1997 |
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids.
Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arterioles; Carbon Dioxide; Cyclic AMP; Dose-Response Relationship, Drug; Iloprost; Indomethacin; Muscle, Smooth, Vascular; Nitroprusside; Pia Mater; Structure-Activity Relationship; Swine; Vasodilation; Vasodilator Agents | 1997 |
Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Membrane Potentials; Potassium Channels; Swine | 1997 |
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arachidonic Acid; Cells, Cultured; Heart; Heart Ventricles; Membrane Potentials; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Channels; Structure-Activity Relationship | 1999 |
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; I-kappa B Kinase; I-kappa B Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oxygenases; Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1999 |
Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Fluid; Muscle Contraction; Muscle, Smooth, Vascular; Structure-Activity Relationship; Swine; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Male; Pressure; Pulmonary Artery; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System | 2000 |
Determination of EETs using microbore liquid chromatography with fluorescence detection.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Methacholine Chloride; Microchemistry; Spectrometry, Fluorescence | 2000 |
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Blood Pressure; Cytosol; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Hydrolysis; Hypertension; Kidney Cortex; Male; Microsomes; Microsomes, Liver; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity; Urea | 2000 |
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Atropine Derivatives; Cattle; Cells, Cultured; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Oxygenases; Polymerase Chain Reaction; Proadifen; Promoter Regions, Genetic; Saphenous Vein; Tissue Plasminogen Activator; Transcription, Genetic; Transfection | 2001 |
EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biological Factors; Bronchoconstriction; Cattle; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscarinic Agonists; Muscle, Smooth; Nitric Oxide Synthase; Peptides; Potassium Channels; Potassium Channels, Calcium-Activated; Rabbits; Trachea | 2001 |
EET homologs potently dilate coronary microvessels and activate BK(Ca) channels.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Calcium Channel Agonists; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Microcirculation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Stereoisomerism; Swine; Vasodilation; Vasodilator Agents | 2001 |
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II; Animals; Arterioles; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Drug Synergism; Hypertension; Kidney Cortex; Male; Microcirculation; Microsomes; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides; Vasoconstriction | 2001 |
Stereospecific synthesis of trans-arachidonic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Biochemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Stereoisomerism | 2001 |
Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cattle; Cell Fractionation; Chloride Channels; Electric Conductivity; Electrophysiology; Immunoblotting; Lipid Bilayers; Liposomes; Muscle, Smooth; Sarcolemma; Trachea; Vasodilator Agents | 2002 |
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain; Capillaries; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Lymphokines; Mitosis; Neovascularization, Physiologic; Rats; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs.
Topics: 8,11,14-Eicosatrienoic Acid; Antibodies; Arachidonic Acids; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Hydroxylation; Isomerism; Sensitivity and Specificity | 2002 |
Role of EETs in regulation of endothelial permeability in rat lung.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Capillary Permeability; Endothelium, Vascular; Lung; Male; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasodilator Agents | 2004 |
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Apamin; Aryl Hydrocarbon Hydroxylases; Biological Factors; Blood Platelets; Cells, Cultured; Charybdotoxin; Cytochrome P-450 CYP2C9; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Ion Channels; Membrane Potentials; Peptides; Platelet Adhesiveness; Platelet Aggregation; Potassium Channels; Recombinant Fusion Proteins; Transfection; Umbilical Veins | 2004 |
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Rats; Vasodilation; Vasodilator Agents | 2005 |
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillaries; Chick Embryo; Chorioallantoic Membrane; Culture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperemia; Neovascularization, Physiologic; Nitric Oxide Donors; Time Factors; Vasodilator Agents; Vitelline Membrane | 2005 |
Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cattle; Cells, Cultured; Cytochrome P450 Family 2; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Unsaturated; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Steroid 16-alpha-Hydroxylase; Up-Regulation | 2005 |
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents | 2006 |
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Carbon Monoxide; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Male; Mesenteric Arteries; Mesoporphyrins; Organometallic Compounds; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2006 |
Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Glutathione Transferase; Humans; Ion Channel Gating; Mice; Potassium Channels, Inwardly Rectifying; Protein Binding; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors | 2006 |
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Aorta, Thoracic; Apigenin; Cattle; Cells, Cultured; Chromones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxy Compounds; Flavonoids; Inositol; Male; MAP Kinase Signaling System; Morpholines; Nitric Oxide Synthase Type III; Oxygenases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rats; Serine | 2007 |
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Male; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tiopronin | 2007 |
[Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells].
Topics: 8,11,14-Eicosatrienoic Acid; Apigenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2008 |
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Diclofenac; Epithelial Sodium Channels; Female; Ibuprofen; Kidney Tubules, Collecting; Mice; Models, Animal; Ovary; Patch-Clamp Techniques; Transfection | 2011 |
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Calcium; Cardiomegaly; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum Stress; Heart Failure; Humans; In Vitro Techniques; Major Histocompatibility Complex; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2014 |
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fenofibrate; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Isoproterenol; Male; Rats; Rats, Sprague-Dawley | 2014 |
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolas
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Chick Embryo; Enzyme Inhibitors; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Hydroxyeicosatetraenoic Acids; Lauric Acids; Liver; Polychlorinated Dibenzodioxins; RNA, Messenger | 2014 |
Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Diabetes Mellitus, Type 2; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Leukemia, Myeloid; Liver; Male; Myocardium; Organ Specificity; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Male; Mice, Inbred C57BL; Pulmonary Artery; Time Factors; Ventricular Function, Right; Ventricular Pressure | 2016 |
Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; Hydrogen-Ion Concentration; Kinetics; Phosphorus Radioisotopes; Solutions; Stereoisomerism | 2016 |
Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II Type 1 Receptor Blockers; Arachidonic Acid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver; Microsomes, Liver; Recombinant Proteins | 2017 |
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Angiogenesis Inducing Agents; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Humans | 2017 |
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Arachidonic Acid; Benzene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythrocyte Membrane; Female; Humans; Liposomes; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Peroxides; Stereoisomerism; Tandem Mass Spectrometry | 2017 |
Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Line; Cell Survival; Dronedarone; Humans; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac | 2018 |
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Forecasting; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Natriuresis; Potassium; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Vasodilation; Water-Electrolyte Balance; Water-Electrolyte Imbalance | 2020 |