14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with 8,11,14-eicosatrienoic acid in 265 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (5.28) | 18.7374 |
| 1990's | 60 (22.64) | 18.2507 |
| 2000's | 78 (29.43) | 29.6817 |
| 2010's | 102 (38.49) | 24.3611 |
| 2020's | 11 (4.15) | 2.80 |
| Authors | Studies |
|---|---|
| Fitzpatrick, FA; Malcolm, KC | 1 |
| Capdevila, JH; Falck, JR; Karara, A; Spady, D; Swift, L; Wei, S | 1 |
| Hasunuma, K; Tamura, Y; Terano, T; Yoshida, S | 1 |
| Braden, G; Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, J; Shipp, E | 1 |
| Amruthesh, SC; Ellis, EF; Falck, JR | 1 |
| Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC | 1 |
| Hirai, A; Kato, I; Noda, M; Seki, K; Tamura, Y; Yoshida, S | 1 |
| Bernstrom, K; Fitzpatrick, FA; Kayganich, K; Murphy, RC | 1 |
| Ellis, EF; Heizer, ML; McKinney, JS | 1 |
| Amruthesh, SC; Ellis, EF; Police, RJ; Yancey, LM | 1 |
| Campbell, WB; Falck, JR; Rosolowsky, M | 1 |
| Campbell, WB; Falck, JR; Pfister, SL | 1 |
| Bonventre, JV; Force, T; Hajjar, R; Hyman, G; Sellmayer, A | 1 |
| Amruthesh, SC; Ellis, EF; McKinney, JS; Police, RJ; Yancey, L | 1 |
| Falck, JR; Fitzpatrick, FA; Malcolm, K | 1 |
| Campbell, WB; Falck, JR; Henrich, WL | 1 |
| Capdevila, J; Harris, RC; Homma, T; Jacobson, HR | 1 |
| Catella, F; Fitzgerald, DJ; FitzGerald, GA; Lawson, JA | 1 |
| Pritchard, KA; Stemerman, MB; Tota, RR; Wong, PY | 1 |
| Falck, JR; Lin, WK; Wong, PY | 1 |
| Teien, G; Ulsaker, GA | 1 |
| Capdevila, JH; Falck, JR; Guenguerich, FP; Karara, A; Martin, MV; Waxman, DJ | 1 |
| Capdevila, JH; Dishman, E; Falck, JR; Jacobson, H; Karara, A | 1 |
| Elder, MG; Patel, L; Sullivan, MH | 1 |
| Falck, JR; Snyder, GD; Yadagiri, P | 1 |
| Blair, I; Capdevila, JH; Dishman, E; Falck, JR; Karara, A | 1 |
| Blair, IA; Capdevila, JH; Falck, JR; Hammonds, TD | 1 |
| Jacoby, M; Levine, SD; Oates, JA; Petty, E; Schlondorff, D | 1 |
| Fitzpatrick, F; McGee, J | 1 |
| Baze, ME; Ennis, MD; Fitzpatrick, FA; Liggett, WF; McGee, JE; Wynalda, MA | 1 |
| Capdevila, J; Falck, JR; Proctor, KG | 1 |
| Ballou, LR; Cheung, WY; Lam, BK; Wong, PY | 1 |
| Capdevila, JH; Falck, JR; Lumin, S; Mosset, P; Yadagiri, P | 1 |
| Ballou, LR; Cheung, WY; Moreno, C; Xiao, ZL | 1 |
| Blair, IA; Capdevila, JH; Dishman, E; Falck, JR; Kishore, V | 1 |
| Capdevila, J; Carroll, MA; Falck, JR; McGiff, JC; Schwartzman, M | 1 |
| Capdevila, J; Estabrook, RW; Falck, JR; Kim, YR; Manna, S; Martin-Wixtrom, C | 1 |
| Elder, MG; Rendell, NB; Sullivan, MH; Taylor, GW; Zosmer, A | 1 |
| Fang, X; Kaduce, TL; Spector, AA; VanRollins, M | 1 |
| Balazy, M; McGiff, JC; Schieber, EB; Zhu, Y | 1 |
| Balazy, M; McGiff, JC; Schieber, EB | 1 |
| Abraham, N; Escalante, BA; Schwartzman, M; Staudinger, R | 1 |
| Evans, RW; Kochanek, PM; Nemoto, EM; Schiding, JK; VanRollins, M | 1 |
| Ellis, EF; Shivachar, AC; Willoughby, KA | 1 |
| Daikh, BE; Koop, DR; Lasker, JM; Raucy, JL | 1 |
| Abraham, NG; Escalante, B; Schwartzman, ML; Staudinger, R | 1 |
| Ma, YH; Roman, RJ; Schwartzman, ML | 1 |
| Imig, JD; Ortiz de Montellano, PR; Roman, RJ; Sui, Z; Zou, AP | 1 |
| Campbell, WB; Rosolowsky, M | 1 |
| Bend, JR; Farhangkhoee, P; Karmazyn, M; Mock, T; Moffat, MP; Ward, CA | 1 |
| Alkayed, NJ; Gebremedhin, D; Harder, DR; Medhora, M; Narayanan, J; Roman, RJ | 1 |
| Belosludtsev, Y; Capdevila, JH; Falck, JR; Graham-Lorence, SE; Helvig, C; Peterson, JA; Truan, G; Wei, S | 1 |
| Boyle, JE; Foley, J; Ma, J; Moomaw, CR; Pascual, JM; Steenbergen, C; Tomer, KB; Wu, S; Zeldin, DC | 1 |
| Falck, JR; Fleming, JT; Gebremedhin, D; Harder, DR; Jacobs, ER; Roman, RJ; Zou, AP | 1 |
| Gimeno, MA; Gonzalez, E; Jawerbaum, A; Novaro, V | 1 |
| Bhatt, RK; Campbell, WB; Falck, JR; Hanke, CJ; Nithipatikom, K | 1 |
| Chatterjee, P; Fang, X; Kaduce, TL; Spector, AA; VanRollins, M; Weintraub, NL | 2 |
| Belosludtsev, YY; Falck, JR; Lai, PS; Shen, SY; Wong, PY | 1 |
| Fedinec, AL; Leffler, CW | 1 |
| Chemtob, S; Peri, KG; Varma, DR | 1 |
| Baron, A; Bény, JL; Frieden, M | 1 |
| Fang, X; Kaduce, TL; Spector, AA; Weintraub, NL | 1 |
| Almazan, G; Chemtob, S; Peri, KG; Varma, DR | 1 |
| Schäfer, W; Schneider, J; Schweer, H; Werner, K; Zahradnik, HP | 1 |
| Fang, X; Kaduce, TL; Moore, SA; Rich, G; Spector, AA; Stoll, LL; Weintraub, NL | 1 |
| Harder, D; Medhora, M | 1 |
| Ellis, EF; Falck, JR; Hoffman, SW; Rzigalinski, BA; Willoughby, KA | 1 |
| Capdevila, J; Chen, JK; Falck, JR; Harris, RC; Wang, DW | 1 |
| Huang, S; Konieczkowski, M; Schelling, JR; Sedor, JR | 1 |
| Lee, HC; Lu, T; Shibata, EF; Spector, AA; VanRollins, M; Weintraub, NL | 1 |
| Huo, Y; Ley, K; Liao, JK; Node, K; Ruan, X; Spiecker, M; Yang, B; Zeldin, DC | 1 |
| Barac-Nieto, M; Silverstein, DM; Spitzer, A | 1 |
| Fang, X; Spector, AA; Stoll, LL; Weintraub, NL | 1 |
| Bousamra, M; Falck, JR; Harder, DR; Jacobs, ER; Roman, RJ; Townsley, M; Zeldin, DC; Zhu, D | 1 |
| Adler, P; Graham, L; Huse, LM; Kroetz, DL; Ma, J; Yu, Z; Zeldin, DC | 1 |
| Capdevila, J; Chen, JK; Harris, RC | 1 |
| Benech, H; Chéron, G; Colin, I; Cresteil, T; Pruvost, A; Tréluyer, JM | 1 |
| Chiang, HT; Li, HF; Wu, SN | 1 |
| Campbell, WB; Nithipatikom, K; Pratt, PF | 1 |
| Falck, JR; Lai, PS; Wong, PY | 1 |
| Draper, AJ; Engler, MM; Graham, L; Hammock, BD; Huse, LM; Kroetz, DL; Morisseau, C; Newman, JW; Parker, C; Xu, F; Yu, Z; Zeldin, DC | 1 |
| Campbell, WB; Hillard, CJ; Kurian, J; Li, P; Pratt, PF | 1 |
| Fang, X; Hammock, BD; Harmon, S; Kaduce, TL; Morisseau, C; Spector, AA; Teesch, LM; Thompson, DA; Weintraub, NL | 1 |
| Dai, J; Graham, L; Liao, JK; Node, K; Ruan, XL; Yang, SX; Zeldin, DC | 1 |
| Benoit, C; Renaudon, B; Rousseau, E; Salvail, D | 1 |
| Campbell, WB; DiCamelli, RF; Falck, JR; Gross, GJ; Gumina, RJ; Kohler, S; Nithipatikom, K | 1 |
| Dellsperger, KC; Lee, HC; Lu, T; Oltman, CL; VanRollins, M; Zhang, Y | 1 |
| Chiribiri, A; Gattullo, D; Pagliaro, P; Paolocci, N; Penna, C; Rastaldo, R | 1 |
| Capdevila, JH; Falck, JR; Imig, JD; Wei, S; Zhao, X | 1 |
| Harder, D; Medhora, M; Narayanan, J | 1 |
| Balazy, M; Falck, JR; Krishna, UM; Reddy, MM; Xia, J | 1 |
| Busija, DW; Carrier, GO; Dimitropoulou, C; Han, G; Miller, AW; White, RE | 1 |
| Busse, R; Fisslthaler, B; Fleming, I; Kiss, L; Michaelis, UR; Popp, R | 1 |
| Cloutier, M; Rousseau, E; Salvail, D | 1 |
| Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Ingraham, RH; Li, PL | 1 |
| Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK | 1 |
| Falck, JR; Krishna, UM; Snyder, GD; Spector, AA | 1 |
| Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Hittner, SB; Krishna, UM; Kumar, PS; Reddy, KM; Reddy, YK; Sharma, KK | 1 |
| Busse, R; Daniels, J; Fisslthaler, B; Harder, DR; Jacobs, ER; Medhora, M; Mundey, K | 1 |
| Dellsperger, KC; Fang, X; Hammock, BD; Harmon, S; Kaduce, TL; Morisseau, C; Oltman, CL; Spector, AA; Stoll, LL; Weintraub, NL | 1 |
| Vandernoot, VA; VanRollins, M | 1 |
| Harder, DR; Zhang, C | 1 |
| Liu, YC; Wu, SN | 1 |
| Cox, R; Oleksiak, MF; Parker, C; Qu, W; Stegeman, JJ; Wu, S; Zeldin, DC | 1 |
| Callewaert, DM; Campbell, WB; Falck, JR; Gikas, K; Nithipatikom, K; Reddy, M; Sasaki, DM; Yuan, Y | 1 |
| Fang, X; Spector, AA; Weintraub, NL | 1 |
| Borrego-Conde, LJ; Falck, JR; Sharma, KK; Umans, JG; Wang, D; Wilcox, CS | 1 |
| Carter, EP; Jacobs, ER; Miyazono, M; Nemenoff, R; Zhu, D | 1 |
| Capdevila, JH; Du, L; Keeney, DS; Ladd, PA; Mernaugh, R | 1 |
| Campbell, WB; Falck, JR; Gauthier, KM; Jagadeesh, SG | 1 |
| Alvarez, DF; Gjerde, EA; Townsley, MI | 1 |
| Buerkle, MA; Campbell, WB; Gloe, T; Krötz, F; Nithipatikom, K; Pohl, U; Riexinger, T; Sohn, HY | 1 |
| Campbell, WB; Falck, JR; Gauthier, KM; Reddy, LM | 1 |
| Fang, X; Hammock, BD; Harmon, SD; Hu, S; McCaw, RB; Rice, JB; Spector, AA; Weintraub, NL | 1 |
| Lee, HC; Ye, D; Zhou, W | 1 |
| Baewer, DV; Campbell, WB; Falck, JR; Gauthier, KM; Hillard, CJ; Hittner, S; Nithipatikom, K; Reddy, DS | 1 |
| Liao, JK; Spiecker, M | 1 |
| Campbell, WB; Edwards, EM; Falck, JR; Gauthier, KM; Reddy, DS | 1 |
| Fang, X; Hammock, BD; Hu, S; Liu, Y; Shyy, JY; Snyder, GD; Spector, AA; Watanabe, T; Weintraub, NL; Yao, J | 1 |
| Card, JW; Chen, CL; Chen, JX; Fu, XN; Jiang, JG; Ning, YG; Wang, DW; Xiao, X; Yang, S; Zeldin, DC | 1 |
| Dunn, BE; Dunn, LK; Falck, JR; Gruenloh, SK; Jacobs, ER; Medhora, M; Reddy, DS | 1 |
| Alvarez, DF; King, JA; Townsley, MI | 1 |
| Falck, JR; Fang, X; Harmon, S; Hu, S; Liu, Y; Sangras, B; Snyder, GD; Spector, AA; Weintraub, NL; Xu, B; Yao, J | 1 |
| Campbell, WB; Capdevila, JH; Falck, JR; Gauthier, KM; Holmes, BB | 1 |
| Cao, H; Rao, GN; Zhang, B | 1 |
| Chen, R; Jiang, J; Wang, D; Xiao, X | 1 |
| Anjaiah, S; Brittin, JJ; Campbell, WB; Capdevila, JH; Cui, L; Falck, JR; Nithipatikom, K; Wei, S | 1 |
| Falck, JR; Jagadeesh, SG; Lee, HC; Lu, T; Ye, D; Zhou, W | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Gatta, A; McGiff, JC; Sacerdoti, D; Schwartzman, ML | 1 |
| Cao, S; Lee, HC; Lu, T; Shah, VH; Wang, XL | 1 |
| Morin, C; Rousseau, E | 1 |
| Chen, RJ; Cowart, LA; Jiang, JG; Wang, DW; Wang, JN; Wang, Y; Xia, Y; Xiao, B; Xiao, X; Yang, S | 1 |
| Falck, JR; Gross, GJ; Hsu, A; Nithipatikom, K | 1 |
| Echave, V; Gomes, MM; Morin, C; Rousseau, E; Sirois, M | 2 |
| Anjaiah, S; Capdevila, JH; Chen, J; Chen, JK; Falck, JR; Guthi, JS; Harris, RC | 1 |
| Campbell, WB; Falck, JR; Gopal, VR; Holmes, BB; Kishore, RV; Sangras, B; Yang, W; Yi, XY | 1 |
| Alkayed, NJ; DeBarber, AE; Grant, DF; Jacks, R; Koerner, IP; Koop, D; Mao, P | 1 |
| Chiang, PC; Fujiwara, H; Ghosh, S; Roberds, SL; Selbo, JG; Wahlstrom, JL | 1 |
| Barbosa-Sicard, E; Falck, JR; Fleming, I; Michaelis, UR; Xia, N | 1 |
| Cheranov, SY; Karpurapu, M; Rao, GN; Venema, RC; Wang, D; Zhang, B | 1 |
| Campbell, WB; Falck, JR; Gauthier, KM; Gross, GJ; Hammock, BD; Moore, J; Nithipatikom, K | 1 |
| Falck, JR; Harder, DR; Hart, LM; Narayanan, J; Pratt, PF; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Feuerstein, TJ; Hollenberg, PF; Rae, JM; Sikora, MJ; Snider, NT; Sridar, C | 1 |
| Echave, V; Morin, C; Rousseau, E; Sirois, M | 1 |
| Blough, DK; Davis, CL; Farin, FM; Hebert, MF; Jones, JP; Kalhorn, TF; Perkins, JD; Smith, HE; Stapleton, PL; Thummel, KE; Totah, RA | 1 |
| Alkayed, NJ; Cao, Z; Iliff, J; Liu, L; Merkel, MJ; Motoki, A; Packwood, WH; Van Winkle, DM | 1 |
| Behm, DJ; Burns-Kurtis, CL; Douglas, SA; Ogbonna, A; Wu, C | 1 |
| Fu, XN; Jiang, JG; Shen, GF; Wang, DW | 1 |
| Atcha, KR; Campbell, WB; Capdevila, JH; Dubasi, N; Falck, JR; Goldman, DH; Hammock, BD; Kodela, R; Manne, R; Manthati, VL; Morisseau, C; Puli, N; Yi, XY | 1 |
| Campbell, WB; Chen, Y; Falck, JR; Tuniki, VR | 1 |
| Alkayed, NJ; Cao, Z; Liu, L; Merkel, MJ; Packwood, W; Van Winkle, DM; Young, J | 1 |
| Albadine, R; Echavé, V; Morin, C; Rousseau, E; Sirois, M | 1 |
| Dawson, ES; Dyson, PJ; Hachey, DL; Jackson, CJ; Kelly, SL; Lamb, DC; Lei, L; Skaug, T; Warrilow, AG; Waterman, MR; Yuan, H; Zhao, B | 1 |
| Croze, R; Levy, BD; Pfeffer, MA; Planagumà, A; Rubin, G; Serhan, CN; Uddin, M | 1 |
| Hammock, B; King, JA; Morisseau, C; Townsley, MI | 1 |
| Baker, JE; Falck, JR; Gross, GJ; Hsu, A; Nithipatikom, K; Wu, HE | 1 |
| Au, AL; Chan, SW; Kwan, YW; Lee, SM; Leung, GP; Poon, CC; Yang, C; Zhang, Q | 1 |
| Anantharamiah, GM; Fogelman, AM; Grijalva, V; Imaizumi, S; Navab, M; Reddy, ST; Van Lenten, BJ; Wagner, AC | 1 |
| Bukhari, IA; Campbell, WB; Falck, JR; Gauthier, KM; Jagadeesh, SG; Sangras, B | 1 |
| Ji, C; Luo, Y; Reidich, B; Shelly, LD; Skepner, JE | 1 |
| Campbell, WB; Falck, JR; Gauthier, KM; Kopf, PG; Zhang, DX | 1 |
| Hollenberg, PF; Snider, NT; Sridar, C | 1 |
| Blair, IA; Capdevila, J; Clarke, D; Donner, DB; Falck, JR; Guo, Z; Gupta, K; Lamba, J; Luo, X; Mesaros, C; Milani, M; Mitra, R; Nguyen, J; Potter, DA; Puli, N; Rodriguez, M; Schuetz, E | 1 |
| Campbell, WB; Chen, Y; Falck, JR; Jat, JL; Manthati, VL | 1 |
| Hammock, BD; Huby, M; Hwang, SH; Morisseau, C; Schebb, NH | 1 |
| Barden, A; Beer, CD; Blacker, D; Croft, KD; Hankey, GJ; Mori, TA; Puddey, IB; Ward, NC | 1 |
| Ilatovskaya, DV; Levchenko, V; Mattson, DL; Pavlov, TS; Roman, RJ; Staruschenko, A | 1 |
| Campbell, WB; Falck, JR; Gauthier, KM; Gutterman, DD; Harder, A; Imig, JD; Isbell, M; Olson, L | 1 |
| David, T; Farr, H | 1 |
| Booth-Genthe, C; Callahan, JF; Licea-Perez, H; Peck, B; Zhu, P | 1 |
| Albadine, R; Morin, C; Rousseau, E; Senouvo, FY; Sirois, C; Tabet, Y | 1 |
| Harder, DR; Narayanan, J; Sarkar, P | 1 |
| Chen, Z; Jiang, J; Li, Q; Liu, F; Shao, J; Wang, H; Zhu, X; Zou, P | 1 |
| Chen, Y; Hammock, BD; Kong, W; Xie, X; Zhang, D; Zhu, Y | 1 |
| Falck, JR; Gross, ER; Gross, GJ; Hsu, A; Nithipatikom, K | 1 |
| Bass, A; Edin, ML; Ellis, K; Hinderliter, AL; Lee, CR; Lih, FB; Poloyac, SM; Schuck, RN; Stouffer, GA; Theken, KN; Tomer, KB; Tran, B; Wu, MC; Zeldin, DC | 1 |
| Alkayed, NJ; Davis, CM; Gupta, NC; Nelson, JW; Young, JM | 1 |
| Belcik, JT; Chadderdon, SM; Grove, KL; Kievit, P; Lindner, JR; Pranger, L; Smith, E | 1 |
| Adamska, M; Arand, M; Burgener, J; Cronin, A; Decker, M; Di Giallonardo, F; Falck, JR; Gruzdev, A; Hammock, BD; Marowsky, A; Morisseau, C; Zeldin, DC | 1 |
| Falck, JR; Harder, DR; Nostrand, MV; Sarkar, P; Terashvili, M | 1 |
| Chen, C; Degraff, LM; Edin, ML; Lee, CR; Li, R; Wang, DW; Xu, X; Yu, X; Zeldin, DC | 1 |
| Du, GH; Fang, LH; Pang, XB; Wang, SB; Wang, YH; Yang, XY; Zhang, L; Zhao, Y | 1 |
| Barker, JH; Fleming, I; Frank, J; Jakob, H; Marzi, I; Neumayer, T; Sander, AL; Sommer, K | 1 |
| Brewer, J; Dechend, R; Ekholm, E; Gauster, M; Herse, F; Hoyer, J; Hubel, CA; Huppertz, B; Kaartokallio, T; Kacik, M; Laivuori, H; Lamarca, B; Lokki, AI; Luft, FC; Muller, DN; Novotny, S; Park, JK; Rothe, M; Ryan, MJ; Schunck, WH; Staff, AC; Sugulle, M; Verlohren, S; Wallukat, G | 1 |
| Cracowski, C; Cracowski, JL; Gaillard-Bigot, F; Millet, C; Roustit, M; Sors, C | 1 |
| Capdevila, JH; Gong, Y; Harris, RC; Mei, S; Pidkovka, N; Rao, R; Wang, WH | 1 |
| Alkayed, NJ; Nelson, JW; Subrahmanyan, RM; Summers, SA; Xiao, X | 1 |
| Rizcallah, E; Rousseau, É; Sirois, C; Sirois, M; Tabet, Y | 1 |
| Gross, GJ; Hsu, A; Nithipatikom, K; Pfeiffer, AW | 1 |
| Eid, AA; Eid, S; Hamdy, A; Jaffa, AA; Maalouf, R; Nassif, J; Rashid, A; Ziyadeh, FN | 1 |
| Chen, C; Duan, Q; Edin, ML; Ni, L; Wang, DW; Wang, X; Yang, L; Zeldin, DC | 1 |
| Guo, Y; Peng, R; Shen, L; Xu, D; Yang, T; Zhao, S | 1 |
| Alsaleh, N; Carter, C; Chen, CB; El-Sikhry, HE; Falck, JR; Jamieson, KL; Light, PE; Lopaschuk, DG; Manne, R; Samokhvalov, V; Seubert, JM | 1 |
| Althurwi, HN; El-Kadi, AO; Elshenawy, OH | 1 |
| Diani-Moore, S; Gross, SS; Ma, Y; Rifkind, AB | 1 |
| Abdelrady, M; Amara, IE; El-Kadi, AO; Elshenawy, OH | 1 |
| Jiang, JX; Lin, XX; Liu, YN; Shen, HJ; Sun, YH; Xie, QM; Yan, XF; Zhang, SJ | 1 |
| Li, Z; Pan, S; Wang, Y; Xiong, Y; Yan, S; Yang, C; Yang, J | 1 |
| Leung, GP; Pan, S; Pan, X; Xu, X; Yan, S; Yang, C; Yang, J; Zhang, C | 1 |
| Chen, M; Wang, L; Xiang, Y; Yuan, L; Zheng, R; Zhu, S | 1 |
| Atcha, KR; Atcha, R; Campbell, WB; Capdevila, JH; Christian, S; Falck, JR; Imig, JD; Koduru, SR; Manne, R; Manthati, VL; Mohapatra, S | 1 |
| Cao, X; Gao, T; Li, X; Lin, L; Liu, S; Luo, P; Qin, X; Sun, A; Wang, X; Wu, Q; Zhu, X | 1 |
| Chen, HY; Lee, KI; Lee, TS; Shyue, SK; Su, KH; Wei, J | 1 |
| Alkayed, NJ; Anderson, VC; Borkar, RN; Cetas, JS; Dogan, A; Fairbanks, SL; Liu, JJ; Martini, RP; Nelson, JW; Raskin, JS; Siler, DA; Wang, RK; Ward, JP; Zuloaga, KL | 1 |
| Boeglin, WE; Brash, AR; Teder, T | 1 |
| Liu, Y; Qu, YY; Xiao, XJ; Yuan, MY; Zhu, YL | 1 |
| Bornstein, SR; Lamounier-Zepter, V; Look, C; Morano, I; Schlottmann, I; Schunck, WH; Woischwill, C; Xu, A | 1 |
| Chen, G; Edin, ML; Wang, DW; Wang, P; Wang, Y; Xu, R; Zeldin, DC; Zhang, S | 1 |
| Bai, J; Dou, X; Huang, W; Niu, N; Wei, X; Zhang, D; Zhang, G | 1 |
| Dong, XW; Jiang, JX; Ma, WJ; Sun, YH; Xie, QM; Zhou, JY | 1 |
| Imig, JD | 1 |
| Hammock, BD; Mamatha, DM; Morisseau, C; Xu, J; Yang, J | 1 |
| Hou, Q; Tan, C; Wang, H; Xu, Q; Yu, G; Zeng, X | 1 |
| Jia, YL; Jiang, JX; Lin, XX; Shen, HJ; Sun, YH; Xie, QM; Xiong, YK; Yan, XF; Zhang, SJ | 1 |
| Barrett, FG; Binder, V; Bowman, TV; Daley, GQ; Heffner, GC; Lahvic, JL; Li, P; McKinney-Freeman, S; Panigrahy, D; Pugach, EK; Riley, EB; Schlaeger, TM; Tamplin, OJ; Zeldin, DC; Zon, LI | 1 |
| Feng, YQ; Hao, YH; Liu, MZ; Ni, J; Yuan, BF; Yue, J; Zhu, QF | 1 |
| Alánová, P; Červenka, L; Červenková, L; Falck, JR; Husková, Z; Imig, JD; Jíchová, Š; Klevstig, M; Kolář, F; Kopkan, L; Kramer, HJ; Kujal, P; Melenovský, V; Neckář, J; Nishiyama, A; Rami Reddy, N; Sadowski, J; Sporková, A; Vernerová, Z | 1 |
| Froogh, G; Huang, A; Kandhi, S; Luo, M; Qin, J; Sun, D; Wolin, MS | 1 |
| Froogh, G; Huang, A; Jiang, H; Kandhi, S; Luo, M; Qin, J; Sun, D; Wolin, MS | 1 |
| Dong, R; Liu, J; Tao, C; Yuan, L; Zheng, R; Zhu, J; Zhu, S | 1 |
| Fang, Y; Huang, X; Liu, Y; Ning, Q; Wan, Y; Wang, W; Xie, M; Xu, S; Yao, E; Zhang, G | 1 |
| Fleming, I | 1 |
| Červenka, L; Falck, JR; Imig, JD; Kopkan, L; Reddy, RN; Sadowski, J; Sporková, A | 1 |
| Funk, DJ; Kopka, K; Schmeiser, HH; Sorg, BL | 1 |
| Feng, XX; Feng, ZH; Li, D; Li, YC; Luo, C; Luo, J; Qin, J; Shu, Y; Tian, DA; Wang, SS; Wang, Y; Zhang, GM; Zou, JM | 1 |
| Alsaleh, N; Dakarapu, R; El-Sikhry, HE; Falck, JR; Seubert, JM | 1 |
| Ding, Y; Fu, L; Hou, Q; Li, Y; Lian, P; Tan, C; Wang, H; Xie, J; Xu, B; Yu, G; Yuan, S | 1 |
| Abraham, NG; McClung, JA; Romashko, M; Schragenheim, J | 1 |
| Alkayed, NJ; Barnes, AP; Fan, W; Kaul, S; Liu, X; Nelson, JW; Qian, ZY; Xiao, X; Xie, F | 1 |
| Dong, L; Duan, JX; Guan, CX; Hammock, BD; Jiang, JX; Lee, KSS; Li, P; Liu, T; Liu, YP; Sun, GY; Zhang, J; Zhou, Y | 1 |
| Červenka, L; Falck, JR; Husková, Z; Rami Reddy, N; Sadowski, J; Škaroupková, P; Sporková, A | 1 |
| Bahl, CD; Bomberger, JM; Eddens, T; Flitter, BA; Hammock, BD; Hampton, TH; Hvorecny, KL; Kolls, JK; Kwak, DH; Lee, JS; Levy, BD; Liu, X; Madden, DR; Morisseau, C; Ono, E; Yang, J | 1 |
| Guan, H; Li, F; Li, J; Li, L; Liu, H; Mi, B; Tan, P; Zhang, Y; Zhao, L | 1 |
| Eliasson, E; Hayakawa, T; Inotsume, N; Kato, Y; Mukai, Y; Rane, A; Senda, A; Toda, T | 1 |
| Barnych, B; Cajka, T; Hammock, BD; Lee, KSS; Morisseau, C; Panigrahy, D; Rand, AA | 1 |
| Deng, JB; Deng, JX; Geng, HX; Li, RP; Li, YG; Wang, L; Wang, XQ; Zhang, L | 1 |
| Arand, M; Falck, JR; Marowsky, A; Mule, NK; Orjuela Leon, AC | 1 |
| Aliwarga, T; Gharib, SA; Lemaitre, RN; Raccor, BS; Sotoodehnia, N; Totah, RA; Xu, L | 1 |
| Campbell, WB; Falck, JR; Imig, JD; Schmitz, JM | 1 |
| Joiakim, A; Kim, H; Park, JA; Putt, DA; Santos, JM; Taylor, RN | 1 |
| Deng, BQ; Hammock, BD; Hu, DY; Huang, J; Kang, X; Lee, KSS; Li, CB; Liu, JY; Luo, Y; Morisseau, C; Peng, A; Wu, MY; Yang, J | 1 |
| Chen, IT; Chen, YJ; Hsing, CH; Huang, CC; Lee, CW; Lee, YC; Lin, HC; Tang, CW; Wu, HF; Wu, SZ | 1 |
| Chan, ECY; Hagen, T; Karkhanis, A; Leow, JWH | 1 |
| Deng, XF; Huang, Y; Jia, M; Luo, J; Wang, YQ; Yao, JF; Zheng, XD; Zhu, JH | 1 |
| Lei, J; Li, Y; Wang, T; Wang, X; Wu, L; Yan, G; Ye, D; Zhang, Q; Zhang, X; Zhou, Y | 1 |
| Abraham, NG; Bellner, L; Bradbury, JA; Cao, J; Liu, L; Puri, N; Raffaele, M; Schragenheim, J; Singh, SP; Vanella, L; Zeldin, DC | 1 |
| Lemaitre, RN; Sotoodehnia, N; Totah, RA; Whittington, D; Zeigler, M | 1 |
| Imaoka, S; Inoue, T; Kudoh, SN; Oguro, A | 1 |
| Choi, SW; Kang, I; Kang, KS; Kim, HS; Kim, JJ; Lee, BC; Lee, JY; Lee, SE; Seo, Y; Shin, N; Sung, EA | 1 |
| Chen, X; Feng, M; Hu, R; Li, J; Li, Z; Wan, L; Yao, W; Zhang, B; Zhang, C; Zhang, Y | 1 |
| Arakelyan, K; Blum, M; Bubalo, G; Dragun, D; Falck, JR; Fechner, M; Flemming, B; Gürgen, D; Haase, M; Hentschel, J; Hoff, U; Manthati, VL; Niendorf, T; Pohlmann, A; Rothe, M; Schunck, WH; Seeliger, E; Zhu, Y | 1 |
| Chang, WK; Gan, YL; Hsu, PC; Hu, YY; Huang, YJ; Hung, CC; Kao, LS; Kuo, YM; Lee, YH; Lin, CH; Shie, FS; Tsou, MY | 1 |
| Guan, Y; Jia, YL; Jiang, JX; Liu, Q; Shen, HJ; Shen, J; Xie, QM; Zhang, LH; Zhu, YL | 1 |
| Chen, J; Chen, Q; Fan, Z; Jiang, X; Sun, Y; Wu, J; Xiao, Q; Zhao, Y | 1 |
| Galdeano, C; Griñán-Ferré, C; Pallàs, M; Sanfeliu, C; Vázquez, S | 1 |
| Imig, JD; Jankiewicz, WK; Khan, AH | 1 |
| Chen, Z; Dong, R; Fu, M; Hu, S; Luo, J; Tang, Y; Tu, L; Xu, X; Yang, Y; Yu, J | 1 |
| Alaeddine, LM; Azar, NS; Dia, B; Eid, AA; El Khoury, M; Hamza, M; Harb, F; Mogharbil, N; Noureldein, MH; Sabra, R | 1 |
| Alkayed, NJ; Barnes, AP; Kaul, S; Marimuthu, P; Nagarajan, S; Qian, ZY | 1 |
| Chen, X; Feng, M; Li, T; Li, Z; Liu, T; Wan, L; Yao, W; Zhang, C; Zhang, Y | 1 |
| Chen, H; Geng, H; Gu, W; Tang, J; Wang, L; Wang, Y; Zhao, H | 1 |
| Chen, X; Li, Z; Liu, T; Wan, L; Yao, W; Zhang, B; Zhang, C; Zhang, Y | 1 |
| Ding, S; Jiang, C; Jiang, Q; Qiu, H; Wu, K; Yang, C; Yang, J; Zhang, J | 1 |
9 review(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,11,14-eicosatrienoic acid
| Article | Year |
|---|---|
Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review).
Topics: 8,11,14-Eicosatrienoic Acid; Adenoviridae; Animals; Astrocytes; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Oxygenases; Platelet Aggregation; Signal Transduction; Steroids; Vasodilation | 1998 |
Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain Chemistry; Cerebrovascular Circulation; Endothelium, Vascular; Humans; Microcirculation; Muscle, Smooth, Vascular; Vasodilation | 2001 |
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Movement; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Fibrinolysis; Humans; Inflammation; Isoenzymes; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Cardiac; NF-kappa B; Oxygenases; Protective Agents; Stereoisomerism; Vasodilation | 2005 |
Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Bronchi; Calcium; Cyclooxygenase Inhibitors; Female; Guinea Pigs; Male; Organ Culture Techniques | 2007 |
Epoxyeicosatrienoic acids, hypertension, and kidney injury.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antihypertensive Agents; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Fatty Acids; Humans; Hypertension; Kidney Diseases; Mice; Rats | 2015 |
The factor in EDHF: Cytochrome P450 derived lipid mediators and vascular signaling.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Docosahexaenoic Acids; Eicosapentaenoic Acid; Endothelium, Vascular; Epoxide Hydrolases; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Humans; Signal Transduction | 2016 |
Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cardiovascular Diseases; Diabetic Cardiomyopathies; Drug Design; Endothelium, Vascular; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Myocardial Ischemia; Vasodilator Agents | 2016 |
Orally Active Epoxyeicosatrienoic Acid Analogs.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Cardiovascular Diseases; Fatty Acids, Monounsaturated; Humans; Hypertension; Kidney Diseases; Muscle, Smooth, Vascular; Structure-Activity Relationship; Vasodilation | 2017 |
Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson's Disease: A New Therapeutic Strategy.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents; Brain; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Neuroprotective Agents; Parkinson Disease | 2020 |
1 trial(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,11,14-eicosatrienoic acid
| Article | Year |
|---|---|
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Fluconazole; Humans; Hyperemia; Lidocaine; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Diseases | 2013 |
255 other study(ies) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 8,11,14-eicosatrienoic acid
| Article | Year |
|---|---|
Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin.
Topics: 8,11,14-Eicosatrienoic Acid; Blood Platelets; Calcium; Cations, Divalent; Cells, Cultured; Humans; Manganese; Platelet Activation; Terpenes; Thapsigargin; Thrombin; Tumor Cells, Cultured | 1992 |
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Isomerism; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Oxygenases; Rats; Rats, Inbred Strains | 1992 |
Formation of epoxyeicosatrienoic acids from arachidonic acid by cultured rat aortic smooth muscle cell microsomes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Metyrapone; Microsomes; Mixed Function Oxygenases; Muscle, Smooth, Vascular; NADP; NADPH-Ferrihemoprotein Reductase; Pyridines; Rats; Rats, Inbred WKY | 1991 |
Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Angina, Unstable; Angioplasty, Balloon, Coronary; Arachidonic Acid; Arachidonic Acids; Colforsin; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Oxygenases; Platelet Activation; Pre-Eclampsia; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1991 |
Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brain; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Male; Mice; Mice, Inbred ICR; Oxygenases | 1992 |
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance | 1992 |
Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate Ribose; Affinity Labels; Animals; Azides; Cholera Toxin; Cytosol; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Liver; Male; Molecular Weight; Pertussis Toxin; Proteins; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1992 |
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids.
Topics: 8,11,14-Eicosatrienoic Acid; Acylation; Animals; Arachidonic Acid; Calcimycin; Cell Line, Transformed; Chromatography, High Pressure Liquid; Kinetics; Mast Cells; Mice; Phospholipids; Spectrometry, Mass, Fast Atom Bombardment | 1992 |
14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Blood Platelets; Cerebrovascular Circulation; Indomethacin; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2 | 1991 |
Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Cerebrovascular Circulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Free Radicals; Indomethacin; Mice; Oxygen; Oxygenases; Prostaglandins; Vasodilation | 1991 |
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Cells, Cultured; Coronary Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Vasodilation | 1991 |
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Carbon Radioisotopes; Cholesterol, Dietary; Clotrimazole; Diet, Atherogenic; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; Metyrapone; Muscle, Smooth, Vascular; Rabbits; Reference Values; Stereoisomerism | 1991 |
Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Arginine Vasopressin; Calcium; Cells, Cultured; Dinoprostone; Eicosanoids; Eicosapentaenoic Acid; Glomerular Mesangium; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Inositol Phosphates; Leukotrienes; Lipid Peroxides; Masoprocol; Pyridines; Rats; Rats, Inbred Strains; Signal Transduction; Type C Phospholipases | 1991 |
Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Arterioles; Brain; Cats; Cerebrovascular Circulation; Cytochrome P-450 Enzyme System; Rabbits; Vasodilation | 1990 |
Novel eicosanoids generated by cytochrome P450: effects on platelet aggregation and protein phosphorylation.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Aza Compounds; Blood Platelets; Calcimycin; Collagen; Cytochrome P-450 Enzyme System; Eicosanoids; Humans; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Sulfides; Thromboxane B2 | 1990 |
Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cyclic AMP; Fatty Acids, Unsaturated; In Vitro Techniques; Isoproterenol; Kidney Cortex; Kinetics; Mass Spectrometry; Rats; Renin; Structure-Activity Relationship | 1990 |
Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Carrier Proteins; Cell Division; Cells, Cultured; Fatty Acids, Unsaturated; Glomerular Mesangium; Mitogens; Rats; Sodium-Hydrogen Exchangers; Thymidine | 1990 |
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Dogs; Fatty Acids, Unsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Radioisotope Dilution Technique; Reference Values; Tritium | 1990 |
14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells.
Topics: 8,11,14-Eicosatrienoic Acid; Cell Adhesion; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium; Fatty Acids, Unsaturated; Fluorescent Dyes; Humans; L-Lactate Dehydrogenase; Prostaglandins; Thrombin; Tumor Cells, Cultured | 1990 |
Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antihypertensive Agents; Blood Pressure; Diterpenes; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Ginkgolides; Hypertension; Indomethacin; Isomerism; Lactones; Male; Plant Extracts; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reference Values | 1990 |
Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma.
Topics: 8,11,14-Eicosatrienoic Acid; Aluminum; Aluminum Compounds; Deuterium; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Lithium; Lithium Compounds; Molecular Structure; Oxidation-Reduction | 1990 |
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Substrate Specificity | 1990 |
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
Topics: 8,11,14-Eicosatrienoic Acid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Humans; Kidney Cortex; Male; Mass Spectrometry; Oxygenases; Stereoisomerism | 1990 |
Production of epoxygenase metabolite by human reproductive tissues.
Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Benzoflavones; Dinoprost; Endothelium; Fatty Acids, Unsaturated; Female; Humans; Hydroxyeicosatetraenoic Acids; Lipoxygenase; Placenta; Pregnancy; Prostaglandin-Endoperoxide Synthases; Trophoblasts; Umbilical Veins | 1989 |
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Fatty Acids, Unsaturated; Growth Hormone; Growth Hormone-Releasing Hormone; Indomethacin; Kinetics; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin | 1989 |
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonate Lipoxygenases; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Liver; Male; Mass Spectrometry; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1989 |
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
Topics: 8,11,14-Eicosatrienoic Acid; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Stereoisomerism | 1989 |
Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder.
Topics: 8,11,14-Eicosatrienoic Acid; Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Bufo marinus; Colforsin; Cyclic AMP; Epithelium; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Urinary Bladder; Vasopressins; Water-Electrolyte Balance | 1987 |
Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Chromatography; Cytosol; Electrophoresis, Polyacrylamide Gel; Epoxide Hydrolases; Erythrocytes; Humans; Isoelectric Point; Leukotriene A4; Leukotriene B4; Molecular Weight; Stilbenes; Substrate Specificity | 1985 |
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Humans; Kinetics; Male; Platelet Aggregation; Seminal Vesicles; Sheep; Structure-Activity Relationship | 1986 |
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Intestinal Mucosa; Intestines; Male; Rats; Regional Blood Flow; Structure-Activity Relationship; Vasodilation | 1987 |
Formation of cis-14,15-oxido-5,8,11-icosatrienoic acid from phosphatidylinositol in human platelets.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; NADP; Oxygenases; Phosphatidylinositols; Phospholipases A; Substrate Specificity; Thrombin | 1987 |
NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols.
Topics: 8,11,14-Eicosatrienoic Acid; Alcohols; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Epoxy Compounds; Fatty Acids, Unsaturated; Male; Mass Spectrometry; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1988 |
Demonstration of endogenous inhibitors for the formation of 14,15-oxido-5,8,11-eicosatrienoic acid from phosphatidylinositol in bovine lung extract.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Epoxide Hydrolases; Fatty Acids, Unsaturated; Hot Temperature; Lung; Molecular Weight; Phosphatidylinositols; Phospholipases A | 1988 |
A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs).
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Fatty Acids, Unsaturated; Liver; Mass Spectrometry; Phosphatidylethanolamines; Phosphatidylinositols; Rats | 1987 |
Vasoactivity of arachidonic acid epoxides.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rats; Vasodilator Agents | 1987 |
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Benzphetamine; Chromatography, High Pressure Liquid; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Fibric Acids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Lauric Acids; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1985 |
Formation and metabolism of 14,15-epoxyeicosatrienoic acid by human reproductive tissues.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Blood; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Female; Gas Chromatography-Mass Spectrometry; Granulosa Cells; Humans; Molecular Structure; Tumor Cells, Cultured | 1995 |
Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Kinetics; Muscle, Smooth, Vascular; Phospholipids; Swine; Tritium | 1995 |
Identification of arachidonate P-450 metabolites in human platelet phospholipids.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Blood Platelets; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyeicosatetraenoic Acids; Phospholipids | 1995 |
Identification of arachidonate epoxides in human platelets.
Topics: 8,11,14-Eicosatrienoic Acid; Blood Platelets; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Phospholipids | 1995 |
Amiloride-sensitive ion transport inhibition by epoxyeicosatrienoic acids in renal epithelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Amiloride; Animals; Biological Transport; Cell Line; Epithelium; Kidney; Rubidium; Rubidium Radioisotopes; Structure-Activity Relationship | 1995 |
Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Infusions, Intravenous; Male; Rats; Rats, Wistar | 1995 |
Effect of protein kinase C modulators on 14,15-epoxyeicosatrienoic acid incorporation into astroglial phospholipids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Astrocytes; Cells, Cultured; Chromatography, High Pressure Liquid; Phosphatidylinositols; Phospholipases; Phospholipases A; Phospholipids; Protein Kinase C; Rats; Rats, Sprague-Dawley | 1995 |
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Sequence Data; Rabbits; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1994 |
Effects of epoxyeicosatrienoic acids on 86Rb uptake in renal epithelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Amiloride; Animals; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Furosemide; Ion Transport; Kidney Tubules, Proximal; Ouabain; Rats; Rubidium Radioisotopes | 1994 |
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; Prostaglandins; Rats; Rats, Inbred Strains; Sodium Chloride | 1994 |
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arterioles; Cytochrome P-450 Enzyme Inhibitors; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Kidney Cortex; Miconazole; Microsomes; Muscle, Smooth, Vascular; Oxazines; Perfusion; Rats; Rats, Sprague-Dawley; Renal Circulation | 1994 |
Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Cattle; Coronary Vessels; Epoprostenol; Vasodilation | 1993 |
Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Rate; Heart Ventricles; Male; Myocardium; Reperfusion Injury; Time Factors | 1993 |
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Animals, Newborn; Antibodies; Aryl Hydrocarbon Hydroxylases; Astrocytes; Base Sequence; Blotting, Southern; Blotting, Western; Cells, Cultured; Cerebral Cortex; Cerebrovascular Circulation; Cloning, Molecular; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA Primers; DNA, Complementary; Immunohistochemistry; Liver; Membrane Potentials; Microcirculation; Molecular Sequence Data; Muscle, Smooth, Vascular; Oxygenases; Patch-Clamp Techniques; Peptide Fragments; Polymerase Chain Reaction; Potassium Channels; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1996 |
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Bacterial Proteins; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Mass Spectrometry; Mixed Function Oxygenases; Models, Molecular; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Plasmids; Spectrophotometry, Atomic; Stereoisomerism | 1996 |
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes; Lung; Macrophages, Alveolar; Muscle, Smooth, Vascular; Rats | 1996 |
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Electric Conductivity; Muscle Tonus; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Renal Artery; Stereoisomerism; Vasoconstriction | 1996 |
Influence of epoxyeicosatrienoic acids on uterine function.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Uterine Contraction | 1997 |
Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antibodies; Cattle; Cells, Cultured; Cross Reactions; Endothelium, Vascular; Fluoroimmunoassay; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Rabbits; Radioimmunoassay; Zona Glomerulosa | 1997 |
Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilation | 1997 |
Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells.
Topics: 8,11,14-Eicosatrienoic Acid; Binding Sites; Bucladesine; Cell Adhesion; Cell Line; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Isoquinolines; Monocytes; Pertussis Toxin; Protein Binding; Receptors, Cell Surface; Signal Transduction; Stereoisomerism; Sulfonamides; Virulence Factors, Bordetella | 1997 |
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids.
Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arterioles; Carbon Dioxide; Cyclic AMP; Dose-Response Relationship, Drug; Iloprost; Indomethacin; Muscle, Smooth, Vascular; Nitroprusside; Pia Mater; Structure-Activity Relationship; Swine; Vasodilation; Vasodilator Agents | 1997 |
Stimulation of prostaglandin G/H synthase-2 expression by arachidonic acid monoxygenase product, 14,15-epoxyeicosatrienoic acid.
Topics: 5,8,11,14-Eicosatetraynoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Cyclooxygenase 2; Cytochrome P450 Family 2; Dactinomycin; Gene Expression Regulation, Enzymologic; Intestinal Mucosa; Isoenzymes; Isomerism; Kinetics; Mixed Function Oxygenases; Oxygenases; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Transcription, Genetic | 1997 |
Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Membrane Potentials; Potassium Channels; Swine | 1997 |
Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme System; Hydroxyeicosatetraenoic Acids; Muscle Relaxation; Muscle, Smooth, Vascular; Phospholipids; Swine | 1997 |
A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid.
Topics: 16,16-Dimethylprostaglandin E2; 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Colforsin; Cyclooxygenase 2; Diclofenac; Epithelial Cells; Intestinal Mucosa; Isoenzymes; Ketoconazole; Metyrapone; Miconazole; Peroxidases; Prostaglandin-Endoperoxide Synthases; Prostaglandins F, Synthetic; Protein Kinase C; Protein Kinase C-alpha; Rats; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1998 |
Formation of cytochrome P450 metabolites of arachidonic acid by human placenta.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Calcimycin; Cytochrome P-450 Enzyme System; Female; Humans; Hydroxyeicosatetraenoic Acids; Organ Culture Techniques; Placenta; Pregnancy; Reference Values | 1997 |
14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Cell Division; Cells, Cultured; Cerebrovascular Circulation; Dinoprostone; Hydroxyeicosatetraenoic Acids; Microcirculation; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Swine | 1998 |
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Astrocytes; Calcium; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Ion Transport; Phospholipases A; Phospholipases A2; Rats; Signal Transduction; Thapsigargin | 1999 |
Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epidermal Growth Factor; LLC-PK1 Cells; Mitogens; Oxygenases; Phosphorylation; Second Messenger Systems; Swine; Transfection | 1999 |
Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Aristolochic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glomerular Mesangium; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Leukotrienes; Lipid Peroxides; Mitogen-Activated Protein Kinases; Nephritis; Phenanthrenes; Phosphodiesterase Inhibitors; Phospholipases A; Phospholipases A2; Rats; Signal Transduction; Stearic Acids; Tritium; Vasoconstrictor Agents | 1999 |
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arachidonic Acid; Cells, Cultured; Heart; Heart Ventricles; Membrane Potentials; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Channels; Structure-Activity Relationship | 1999 |
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; I-kappa B Kinase; I-kappa B Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oxygenases; Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1999 |
Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Bradykinin; Cells, Cultured; Chalcone; Chalcones; Coenzyme A Ligases; Coronary Vessels; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Epoxide Hydrolases; Hydroxyeicosatetraenoic Acids; Lipid Metabolism; Phospholipids; Swine; Vasodilation | 1999 |
Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Transport; Cell Line; Electrolytes; Hydroxyeicosatetraenoic Acids; Ion Transport; Kidney Cortex; Kidney Tubules, Proximal; Opossums; Oxazines; Phosphates; Renin; Sodium | 1999 |
Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Fluid; Muscle Contraction; Muscle, Smooth, Vascular; Structure-Activity Relationship; Swine; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Male; Pressure; Pulmonary Artery; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System | 2000 |
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Hypertension; Kidney; Liver; Male; Oxygenases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger | 2000 |
Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Cell Line; Mitosis; Phosphorylation; Signal Transduction; src-Family Kinases; Tyrosine | 2000 |
Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Age Factors; Arachidonic Acid; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Humans; Hydroxyeicosatetraenoic Acids; Infant; Isoenzymes; Liver; Microsomes, Liver; NADP; Recombinant Proteins; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sudden Infant Death; Up-Regulation | 2000 |
Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Kinetics; Large-Conductance Calcium-Activated Potassium Channels; Pertussis Toxin; Pituitary Gland; Potassium Channels; Potassium Channels, Calcium-Activated; Protein-Tyrosine Kinases; Rats; Virulence Factors, Bordetella | 2000 |
Determination of EETs using microbore liquid chromatography with fluorescence detection.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Methacholine Chloride; Microchemistry; Spectrometry, Fluorescence | 2000 |
Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Bucladesine; Cholera Toxin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Leukocytes, Mononuclear; Oxygenases; Signal Transduction; Tritium | 2000 |
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Blood Pressure; Cytosol; Eicosanoids; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Hydrolysis; Hypertension; Kidney Cortex; Male; Microsomes; Microsomes, Liver; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity; Urea | 2000 |
Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Benzopyrans; Biological Factors; Bradykinin; Cardiotonic Agents; Cattle; Coronary Vessels; Dihydropyridines; Electrophysiology; Endothelium, Vascular; Membrane Potentials; Muscle, Smooth, Vascular; Nitroprusside; Ouabain; Peptides; Potassium; Potassium Channels; Tritium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Endothelium, Vascular; Epoxide Hydrolases; Lipid Metabolism; Solubility; Swine | 2001 |
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Atropine Derivatives; Cattle; Cells, Cultured; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Oxygenases; Polymerase Chain Reaction; Proadifen; Promoter Regions, Genetic; Saphenous Vein; Tissue Plasminogen Activator; Transcription, Genetic; Transfection | 2001 |
EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biological Factors; Bronchoconstriction; Cattle; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscarinic Agonists; Muscle, Smooth; Nitric Oxide Synthase; Peptides; Potassium Channels; Potassium Channels, Calcium-Activated; Rabbits; Trachea | 2001 |
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Biological Factors; Coronary Vessels; Cytochrome P-450 Enzyme System; Dogs; Eicosanoids; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Ischemia; Reference Standards; Reperfusion | 2001 |
EET homologs potently dilate coronary microvessels and activate BK(Ca) channels.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Calcium Channel Agonists; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Microcirculation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Stereoisomerism; Swine; Vasodilation; Vasodilator Agents | 2001 |
Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blood Pressure; Bradykinin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Octoxynol; Proadifen; Rats; Rats, Wistar; Tachyphylaxis; Triazoles; Ventricular Function, Left | 2001 |
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II; Animals; Arterioles; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Drug Synergism; Hypertension; Kidney Cortex; Male; Microcirculation; Microsomes; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides; Vasoconstriction | 2001 |
Stereospecific synthesis of trans-arachidonic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Biochemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Stereoisomerism | 2001 |
Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; In Vitro Techniques; Insulin Resistance; Male; Mesenteric Arteries; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reference Values; Vasodilation; Vasodilator Agents | 2001 |
Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase.
Topics: 8,11,14-Eicosatrienoic Acid; Androstadienes; Animals; Benzoquinones; Cells, Cultured; Coronary Vessels; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Endothelium, Vascular; Enzyme Inhibitors; Humans; Ionomycin; Lactams, Macrocyclic; Oxygenases; Patch-Clamp Techniques; Periodicity; Pulsatile Flow; Quinones; Rifabutin; Sirolimus; Stress, Mechanical; Swine; Umbilical Veins; Vasodilation; Wortmannin | 2001 |
Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cattle; Cell Fractionation; Chloride Channels; Electric Conductivity; Electrophysiology; Immunoblotting; Lipid Bilayers; Liposomes; Muscle, Smooth; Sarcolemma; Trachea; Vasodilator Agents | 2002 |
14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Calcium; Cattle; Charybdotoxin; Coronary Vessels; Electric Conductivity; Endothelium, Vascular; Enzyme Inhibitors; Epoxide Hydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxyeicosatetraenoic Acids; Muscle Relaxation; Muscle, Smooth, Vascular; Peptides; Potassium Channels | 2002 |
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |
Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Aromatase; Carbon Radioisotopes; Cell Membrane; Cells, Cultured; Enzyme Activation; Microspheres; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2002 |
Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arteries; Cattle; Coronary Vessels; In Vitro Techniques; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 2003 |
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Adenoviridae; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2C9; DNA; Endothelium, Vascular; Gene Transfer Techniques; Genetic Vectors; Humans; Microcirculation; Neovascularization, Physiologic; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2003 |
Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide.
Topics: 8,11,14-Eicosatrienoic Acid; Cell Line; Chromatography, Liquid; Coronary Vessels; Culture Media, Conditioned; Endothelium, Vascular; Epoxy Compounds; Fatty Acids, Unsaturated; Humans; Interleukin-8; Mass Spectrometry; Oxidation-Reduction; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2002 |
Capillary electrophoresis of cytochrome P-450 epoxygenase metabolites of arachidonic acid. 2. Resolution of stereoisomers.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calibration; Cyclodextrins; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Liver; Mice; Oxygenases; Spectrophotometry, Ultraviolet; Stereoisomerism | 2002 |
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain; Capillaries; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Lymphokines; Mitosis; Neovascularization, Physiologic; Rats; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells.
Topics: 8,11,14-Eicosatrienoic Acid; alpha-Linolenic Acid; Amides; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Endocannabinoids; Humans; Hydantoins; Imidazoles; Imidazolidines; Infant, Newborn; Linoleic Acids; Membrane Potentials; Neuroblastoma; Patch-Clamp Techniques; Piperazines; Piperidines; Pituitary Neoplasms; Polyunsaturated Alkamides; Potassium Channels; Pyridines; Tumor Cells, Cultured | 2003 |
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Arachidonic Acid; Benzphetamine; Cloning, Molecular; Conserved Sequence; Cytochrome P-450 Enzyme System; Fasting; Fundulidae; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Male; Molecular Sequence Data; Multigene Family; Organ Specificity; Phylogeny; Rats; Rats, Inbred F344; RNA, Messenger; Sequence Alignment; Tetradecanoylphorbol Acetate; Vertebrates | 2003 |
Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs.
Topics: 8,11,14-Eicosatrienoic Acid; Antibodies; Arachidonic Acids; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Hydroxylation; Isomerism; Sensitivity and Specificity | 2002 |
Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcimycin; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Esterification; Muscle, Smooth, Vascular; Phosphatidylcholines; Swine; Tritium; Vasodilator Agents | 2003 |
Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Apamin; Arterioles; Biological Factors; Charybdotoxin; Endothelium, Vascular; Enzyme Inhibitors; Male; Nitric Oxide; Nitroarginine; Nitroprusside; Potassium Channels, Calcium-Activated; Rabbits; Renal Circulation; Vasodilation; Vasodilator Agents | 2003 |
Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Arachidonic Acid; Bile Ducts; Blotting, Western; Body Weight; Cell Division; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Hemodynamics; Kidney; Liver Cirrhosis; Nitric Oxide; Perfusion; Phospholipases A; Protein Isoforms; Rats; Time Factors | 2003 |
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Adenoviridae; Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Biotinylation; Cadaverine; Cell Differentiation; Cells, Cultured; Cytochrome P450 Family 2; Enzyme Activation; Genetic Vectors; Humans; Keratinocytes; Mice; Mixed Function Oxygenases; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Skin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Transglutaminases | 2003 |
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cattle; Coronary Vessels; Culture Techniques; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Rats; Sulfonamides; Vasodilator Agents | 2003 |
Role of EETs in regulation of endothelial permeability in rat lung.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Capillary Permeability; Endothelium, Vascular; Lung; Male; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasodilator Agents | 2004 |
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Apamin; Aryl Hydrocarbon Hydroxylases; Biological Factors; Blood Platelets; Cells, Cultured; Charybdotoxin; Cytochrome P-450 CYP2C9; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Ion Channels; Membrane Potentials; Peptides; Platelet Adhesiveness; Platelet Aggregation; Potassium Channels; Recombinant Fusion Proteins; Transfection; Umbilical Veins | 2004 |
14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Muscle, Smooth, Vascular; Structure-Activity Relationship; Vasodilation | 2004 |
Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels.
Topics: 8,11,14-Eicosatrienoic Acid; Cells, Cultured; Cyclohexanes; Endothelium, Vascular; Epoxide Hydrolases; Epoxy Compounds; Humans; Hydroxyeicosatetraenoic Acids; Lauric Acids; Lipid Metabolism; Muscle, Smooth, Vascular; Oxidation-Reduction; Saphenous Vein; Solubility; Tritium; Vasodilator Agents | 2004 |
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Rats; Vasodilation; Vasodilator Agents | 2005 |
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Carbon Radioisotopes; Cattle; Cells, Cultured; Coronary Vessels; Endocannabinoids; Endothelium, Vascular; Glycerides; Hydroxyeicosatetraenoic Acids; Vasodilation | 2005 |
14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biological Assay; Bradykinin; Cattle; Coronary Vessels; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; In Vitro Techniques; Muscle, Smooth, Vascular; Vasodilation | 2005 |
Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Binding, Competitive; Biotransformation; Blotting, Western; Carnitine O-Palmitoyltransferase; Cell Movement; Chlorocebus aethiops; COS Cells; Cyclohexanes; Enzyme Inhibitors; Epoxide Hydrolases; Lauric Acids; Ligands; Mice; PPAR alpha; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transfection; Urea | 2005 |
Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biomarkers, Tumor; Carcinoma; Cell Growth Processes; Cell Line, Tumor; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; ErbB Receptors; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms; Oxygenases; Phosphatidylinositol 3-Kinases; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transplantation, Heterologous | 2005 |
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillaries; Chick Embryo; Chorioallantoic Membrane; Culture Techniques; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperemia; Neovascularization, Physiologic; Nitric Oxide Donors; Time Factors; Vasodilator Agents; Vitelline Membrane | 2005 |
Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcimycin; Calcium Channels; Calcium-Transporting ATPases; Disease Models, Animal; Endothelium; Enzyme Inhibitors; Heart Failure; Ionophores; Lung; Permeability; Rats; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Tissue Culture Techniques; Vasodilator Agents | 2005 |
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epoxide Hydrolases; Epoxy Compounds; Humans; PPAR alpha; Urea | 2006 |
Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Adenoviridae; Animals; Bacillus megaterium; beta-Galactosidase; Cattle; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytomegalovirus; Methacholine Chloride; Muscle Tonus; Muscle, Smooth, Vascular; Oxygenases; Potassium Channels; Stereoisomerism; Transduction, Genetic | 2006 |
Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Movement; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Endothelium, Vascular; Fibroblast Growth Factor 2; Genetic Vectors; Green Fluorescent Proteins; Humans; Laminin; Mice; Mice, Inbred C57BL; Microcirculation; Neovascularization, Pathologic; Oxygen; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Proteoglycans; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases | 2006 |
Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction pathways involved.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cattle; Cells, Cultured; Cytochrome P450 Family 2; Endothelial Cells; Endothelium, Vascular; Fatty Acids, Unsaturated; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Steroid 16-alpha-Hydroxylase; Up-Regulation | 2005 |
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents | 2006 |
Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Ion Channel Gating; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2006 |
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Carbon Monoxide; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Male; Mesenteric Arteries; Mesoporphyrins; Organometallic Compounds; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2006 |
Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Glutathione Transferase; Humans; Ion Channel Gating; Mice; Potassium Channels, Inwardly Rectifying; Protein Binding; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Receptors | 2006 |
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Amino Acid Sequence; Animals; Aorta, Thoracic; Apigenin; Cattle; Cells, Cultured; Chromones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epoxy Compounds; Flavonoids; Inositol; Male; MAP Kinase Signaling System; Morpholines; Nitric Oxide Synthase Type III; Oxygenases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Proto-Oncogene Proteins c-akt; Rats; Serine | 2007 |
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Male; Myocardial Infarction; Potassium Channels; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Tiopronin | 2007 |
Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi.
Topics: 8,11,14-Eicosatrienoic Acid; Amides; Bronchi; Calcium; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Ion Channel Gating; Membrane Potentials; Muscle Proteins; Muscle Relaxation; Muscle Tonus; Myocytes, Smooth Muscle; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Potassium Channels, Calcium-Activated | 2007 |
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.
Topics: 8,11,14-Eicosatrienoic Acid; ADAM Proteins; ADAM17 Protein; Animals; Arachidonic Acid; Cell Line; Cytochrome P-450 Enzyme System; Down-Regulation; Enzyme Activation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Glycerol; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Membrane Proteins; Mitogens; Models, Biological; Monoglycerides; Receptors, Cannabinoid; RNA, Small Interfering; Signal Transduction; Swine; Transforming Growth Factor alpha | 2007 |
Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Binding, Competitive; Cattle; Cell Membrane; Coronary Vessels; Humans; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Ligands; Molecular Structure; Peptides; Subcellular Fractions; Sulfonamides; U937 Cells; Vasodilation; Vasodilator Agents | 2007 |
Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Epoxide Hydrolases; Female; Gene Expression Regulation, Enzymologic; Humans; Neurons; Polymorphism, Genetic; Pregnancy; Rats; Rats, Sprague-Dawley; Solubility; Stroke; Transduction, Genetic; Vasodilator Agents | 2007 |
EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17.
Topics: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents; Base Sequence; Blotting, Western; Bronchi; Calcium; DNA Primers; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; In Vitro Techniques; NF-kappa B; Phorbol 12,13-Dibutyrate; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2008 |
Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Chromatography, Liquid; Disease Models, Animal; Epoxide Hydrolases; Hypertension; Male; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Solubility; Suspensions; Tandem Mass Spectrometry; Urea | 2008 |
Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Blotting, Western; Cattle; Cell Culture Techniques; Cell Hypoxia; Cell Movement; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Mass Spectrometry; Neovascularization, Physiologic; Oligonucleotides, Antisense; Retinal Vessels; Sulfaphenazole | 2008 |
An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis.
Topics: 8,11,14-Eicosatrienoic Acid; Aorta; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Endothelial Cells; Gene Expression; Humans; Laminin; Myocytes, Smooth Muscle; Neovascularization, Physiologic; Phosphorylation; Proteoglycans; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2008 |
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Diazoxide; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoxide Hydrolases; Female; Heart Rate; Lauric Acids; Male; Mitochondria, Heart; Myocardial Infarction; Myocardium; Potassium Channels | 2008 |
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Microinjections; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time | 2008 |
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Arachidonic Acids; Brain; Cytochrome P-450 CYP2D6; Endocannabinoids; Epoxy Compounds; Humans; Hydroxylation; Microsomes; Mitochondria; Polyunsaturated Alkamides; Time Factors | 2008 |
CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi.
Topics: 8,11,14-Eicosatrienoic Acid; Bronchi; Calcium; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Muscle Proteins; Myosin-Light-Chain Phosphatase; Permeability; Phosphoprotein Phosphatases; Phosphorylation; Respiratory Hypersensitivity; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2008 |
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Calcineurin Inhibitors; Cyclosporine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Demography; Female; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Kidney Failure, Chronic; Kidney Function Tests; Kidney Transplantation; Kinetics; Male; Middle Aged; Tacrolimus; United States | 2008 |
Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Female; Gene Deletion; Heart Ventricles; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Time Factors; Urea | 2008 |
Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Guinea Pigs; Hydroxyeicosatetraenoic Acids; Male; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Splanchnic Circulation; Trachea; TRPV Cation Channels; Vascular Resistance; Vasoconstriction; Vasodilation | 2009 |
[Promotive effects of epoxyeicosatrienoic acids (EETs) on proliferation of tumor cells].
Topics: 8,11,14-Eicosatrienoic Acid; Apigenin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Flavonoids; Humans; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction | 2008 |
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Coronary Vessels; Epoxide Hydrolases; Epoxy Compounds; Humans; In Vitro Techniques; Isometric Contraction; Recombinant Proteins; Solubility; Stereoisomerism; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 2009 |
20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Binding Sites; Blotting, Western; Cattle; Cell Membrane; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Epoxide Hydrolases; Epoxy Compounds; Humans; Iodine Radioisotopes; Ligands; p38 Mitogen-Activated Protein Kinases; Phosphorylation; U937 Cells; Vasodilation | 2009 |
Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Epoxide Hydrolases; Janus Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Myocardial Reperfusion Injury; Myocytes, Cardiac; Polymorphism, Single Nucleotide; Signal Transduction; STAT3 Transcription Factor | 2010 |
17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase.
Topics: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents; Arachidonic Acids; Bronchi; Calcium; Cyclooxygenase 2; Epoxide Hydrolases; Humans; Intracellular Signaling Peptides and Proteins; Lung; Models, Biological; Muscle Proteins; Myosin-Light-Chain Phosphatase; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Pneumonia; PPAR gamma; Protein Kinase Inhibitors; Solubility; Tumor Necrosis Factor-alpha | 2010 |
Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA Transposable Elements; Escherichia coli; Ferredoxin-NADP Reductase; Ferredoxins; Gene Expression; Mixed Function Oxygenases; Mutagenesis, Insertional; NADP; Streptomyces coelicolor; Substrate Specificity | 2010 |
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Disease; Animals; Anticholesteremic Agents; Cell Line; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Inflammation; Inflammation Mediators; Lipoxins; Lovastatin; Male; Mice; Neutrophils; Pneumonia; Respiratory Mucosa | 2010 |
Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capillary Permeability; Cell Adhesion Molecules; Endothelium, Vascular; In Vitro Techniques; Lung; Lung Injury; Rats; Reperfusion Injury; TRPV Cation Channels; Vascular Cell Adhesion Molecule-1 | 2010 |
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics, Opioid; Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin | 2010 |
14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Mesenteric Arteries; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP2 Subtype; Vasodilation; Vasodilator Agents | 2010 |
L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Fatty Acids; Female; Hydroxyeicosatetraenoic Acids; Injections, Subcutaneous; Linoleic Acids; Linoleic Acids, Conjugated; Lipid Peroxides; Lipoproteins, HDL; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Peptides; Species Specificity; Tandem Mass Spectrometry; Time Factors; Up-Regulation | 2010 |
14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; Vasodilation | 2011 |
Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes.
Topics: 8,11,14-Eicosatrienoic Acid; Hep G2 Cells; Hepatocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Phosphorylation; Signal Transduction | 2011 |
Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs.
Topics: 8,11,14-Eicosatrienoic Acid; Adrenal Glands; Aldosterone; Angiotensin II; Animals; Arachidonic Acid; Arteries; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Epoxide Hydrolases; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Potassium Channels; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Zona Glomerulosa | 2011 |
Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.
Topics: 8,11,14-Eicosatrienoic Acid; Amidohydrolases; Animals; Arachidonic Acids; Aryl Hydrocarbon Hydroxylases; Brain; Cannabinoid Receptor Modulators; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6; Endocannabinoids; Epoxide Hydrolases; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Male; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Polymorphism, Genetic; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2011 |
CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).
Topics: 8,11,14-Eicosatrienoic Acid; Active Transport, Cell Nucleus; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cytochrome P-450 CYP3A; Female; G2 Phase; Gene Silencing; Humans; Neoplasm Proteins; Phosphorylation; Signal Transduction; STAT3 Transcription Factor | 2011 |
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Azides; Binding Sites; Cattle; Cell Line; Coronary Vessels; Endothelial Cells; Fatty Acids, Unsaturated; Humans; Inhibitory Concentration 50; Kinetics; Ligands; Photoaffinity Labels; Protein Binding; Sulfonamides; U937 Cells | 2011 |
Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors.
Topics: 8,11,14-Eicosatrienoic Acid; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Solid Phase Extraction; Tandem Mass Spectrometry | 2011 |
Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Case-Control Studies; Cytochrome P-450 Enzyme System; F2-Isoprostanes; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Oxidative Stress; Stroke | 2011 |
Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme System; Diclofenac; Epithelial Sodium Channels; Female; Ibuprofen; Kidney Tubules, Collecting; Mice; Models, Animal; Ovary; Patch-Clamp Techniques; Transfection | 2011 |
Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.
Topics: 8,11,14-Eicosatrienoic Acid; Amitrole; Animals; Arterioles; Benzoates; Catalase; Cattle; Drug Contamination; Enzyme Inhibitors; Epoxide Hydrolases; Kidney; Rats; Urea; Vasodilation; Vasodilator Agents | 2011 |
Models of neurovascular coupling via potassium and EET signalling.
Topics: 8,11,14-Eicosatrienoic Acid; Arterioles; Astrocytes; Calcium; Humans; Models, Neurological; Muscle, Smooth, Vascular; Neurons; Potassium; Potassium Channels; Signal Transduction; Synapses; Vasodilation | 2011 |
Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in
Topics: 8,11,14-Eicosatrienoic Acid; Biomarkers; Chromatography, Liquid; Epoxide Hydrolases; Female; Humans; Linoleic Acids; Male; Reproducibility of Results; Sensitivity and Specificity; Stearic Acids; Tandem Mass Spectrometry | 2011 |
Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzoates; Blotting, Western; Bronchi; Cells, Cultured; Eicosapentaenoic Acid; Electrophoresis, Polyacrylamide Gel; Epoxide Hydrolases; Epoxy Compounds; Fluorescent Antibody Technique; Guinea Pigs; Humans; Mice; Muscle Tonus; Muscle, Smooth; Myocytes, Smooth Muscle; Rats; Receptors, Prostaglandin E; Receptors, Thromboxane; Signal Transduction; Thromboxane A2; Urea | 2011 |
Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain.
Topics: 8,11,14-Eicosatrienoic Acid; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Male; Neuroprotective Agents; Primary Cell Culture; Rats; Rats, Sprague-Dawley | 2011 |
P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Bone Marrow Neoplasms; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelial Cells; Fatty Acids, Unsaturated; Humans; Mice; Mice, Inbred C57BL; Multiple Myeloma; Neovascularization, Pathologic | 2011 |
Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Activating Transcription Factor 6; Animals; Aorta; Base Sequence; DNA Methylation; Endothelial Cells; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Promoter Regions, Genetic; Pyrenes; RNA, Small Interfering; Solubility; Up-Regulation | 2012 |
Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Capsaicin; Cytochrome P-450 Enzyme System; Hemodynamics; Ischemic Preconditioning, Myocardial; KATP Channels; Male; Myocardial Infarction; Rats; Rats, Sprague-Dawley; Sarcolemma; Xanthines | 2013 |
Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease.
Topics: 8,11,14-Eicosatrienoic Acid; Age Factors; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Diabetes Mellitus; Eicosanoids; Epoxide Hydrolases; Female; Humans; Hydroxyeicosatetraenoic Acids; Hydroxylation; Male; Middle Aged; North Carolina; Obesity; Regression Analysis; Risk Assessment; Risk Factors; Severity of Illness Index; Smoking; Tandem Mass Spectrometry | 2012 |
Soluble epoxide hydrolase: sex differences and role in endothelial cell survival.
Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Brain Ischemia; Cell Survival; Cells, Cultured; Endothelial Cells; Epoxide Hydrolases; Female; Male; Mice; Mice, Inbred C57BL; Pyridines; rho-Associated Kinases; Sex Characteristics; Solubility | 2012 |
Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brachial Artery; Capillaries; Contrast Media; Glucose Tolerance Test; Hypertriglyceridemia; Inflammation Mediators; Insulin Resistance; Lipids; Macaca mulatta; Male; Motor Activity; Muscle Contraction; Muscle, Skeletal; Peripheral Vascular Diseases; Regional Blood Flow; Restraint, Physical; Sedentary Behavior; Ultrasonography; Vasodilation | 2012 |
EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Epoxide Hydrolases; Epoxy Compounds; Humans; Inactivation, Metabolic; Mice; Mice, Inbred C57BL; Phylogeny; Stearic Acids; Xenobiotics | 2012 |
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.
Topics: 8,11,14-Eicosatrienoic Acid; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Chromatography, Liquid; Coculture Techniques; Dopaminergic Neurons; Dose-Response Relationship, Drug; Drug Administration Schedule; Eicosanoids; Hippocampus; Hydrogen Peroxide; Mass Spectrometry; Membrane Potential, Mitochondrial; Neuroprostanes; Oxidants; Rats; Rats, Sprague-Dawley; Time Factors | 2012 |
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Cerebral Infarction; Cerebrovascular Circulation; Coronary Occlusion; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gene Expression; Glucose; Male; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction | 2012 |
Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition.
Topics: 8,11,14-Eicosatrienoic Acid; Algorithms; Animals; Caffeic Acids; Epoxide Hydrolases; Hippocampus; Humans; Ischemia; Lactates; Male; Molecular Structure; Rats; Rats, Sprague-Dawley | 2012 |
Soluble epoxide hydrolase disruption as therapeutic target for wound healing.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Epoxide Hydrolases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Re-Epithelialization; Tumor Necrosis Factor-alpha; Wound Healing | 2013 |
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Oligonucleotide Array Sequence Analysis; Placenta; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley | 2012 |
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Cetuximab; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Epidermal Growth Factor; Epithelial Sodium Channels; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypertension; Kidney; Male; Mice; Models, Biological; Phosphorylation | 2013 |
Soluble epoxide hydrolase dimerization is required for hydrolase activity.
Topics: 8,11,14-Eicosatrienoic Acid; Dimerization; DNA Mutational Analysis; Epoxide Hydrolases; Genetic Complementation Test; HEK293 Cells; Humans; Hydrolases; Kinetics; Models, Molecular; Mutation; Polymorphism, Genetic; Solubility; Transfection | 2013 |
Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Amides; Bradykinin; Bronchi; Dose-Response Relationship, Drug; Eicosanoids; Humans; In Vitro Techniques; Membrane Potentials; Muscle Relaxation; Respiratory Muscles | 2013 |
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Heart; Hemodynamics; Imines; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Diabetic Nephropathies; Glucose; Hydroxyeicosatetraenoic Acids; Hypertrophy; Kidney Tubules, Proximal; Oxidative Stress; Rats; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases | 2013 |
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Calcium; Cardiomegaly; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum Stress; Heart Failure; Humans; In Vitro Techniques; Major Histocompatibility Complex; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Rats; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2014 |
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins.
Topics: 8,11,14-Eicosatrienoic Acid; Aged; C-Reactive Protein; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Humans; Inflammation; Male; Middle Aged; Statistics, Nonparametric; Triglycerides | 2013 |
Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Amino Acids; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Autophagy; Benzamides; Cardiotonic Agents; Cell Line; Cell Survival; Cytoprotection; Enzyme Activation; Mitochondria, Heart; Myocytes, Cardiac; Oleic Acids; Phosphorylation; Potassium Channels; Rats; Stress, Physiological | 2013 |
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomegaly; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fenofibrate; Gene Expression Regulation, Enzymologic; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Isoproterenol; Male; Rats; Rats, Sprague-Dawley | 2014 |
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolas
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Chick Embryo; Enzyme Inhibitors; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Hydroxyeicosatetraenoic Acids; Lauric Acids; Liver; Polychlorinated Dibenzodioxins; RNA, Messenger | 2014 |
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Atrial Natriuretic Factor; Biomarkers; Cardiomegaly; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Injections, Intraperitoneal; Isoenzymes; Male; Mercuric Chloride; Mice; Mice, Inbred C57BL; Myocardium; Natriuretic Peptide, Brain; RNA, Messenger | 2014 |
EETs alleviate ox-LDL-induced inflammation by inhibiting LOX-1 receptor expression in rat pulmonary arterial endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Inflammation; Inflammation Mediators; Lipoproteins, LDL; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Pulmonary Artery; Rats, Sprague-Dawley; RNA, Messenger; Scavenger Receptors, Class E; Signal Transduction | 2014 |
Inhibitory effect of 14,15-EET on endothelial senescence through activation of mTOR complex 2/Akt signaling pathways.
Topics: 8,11,14-Eicosatrienoic Acid; Age Factors; Animals; Cellular Senescence; Endothelial Cells; Endothelium, Vascular; Male; Mechanistic Target of Rapamycin Complex 2; Mesenteric Arteries; Multiprotein Complexes; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Risk Factors; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Vasodilatory effect of 14,15-epoxyeicosatrienoic acid on mesenteric arteries in hypertensive and aged rats.
Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Hypertension; Male; Mesenteric Arteries; Potassium Channels, Calcium-Activated; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Prostaglandin E, EP2 Subtype; Vasodilator Agents | 2014 |
14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Glucose; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Neuroprotective Agents; Oxygen | 2014 |
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Chemistry Techniques, Synthetic; Coronary Vessels; Enzyme Inhibitors; Epoxide Hydrolases; Humans; In Vitro Techniques; Molecular Mimicry; Oxadiazoles; Oxamic Acid; Tetrazoles; Vasodilation; Vasodilator Agents | 2014 |
Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates MPTP-Induced Parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Behavior, Animal; Cell Survival; Cells, Cultured; Dopaminergic Neurons; Epoxide Hydrolases; Lauric Acids; Male; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Paraquat; Parkinsonian Disorders; Rotarod Performance Test; Solubility; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation | 2015 |
Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Endothelial Cells; Gene Expression Regulation; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; Nitric Oxide; Signal Transduction; TRPV Cation Channels; Vasodilator Agents | 2014 |
Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage.
Topics: 8,11,14-Eicosatrienoic Acid; Aged; Animals; Brain Ischemia; Disease Models, Animal; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Mice; Middle Aged; Neuroprotective Agents; Subarachnoid Hemorrhage | 2015 |
Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Biocatalysis; Blood Platelets; Chromatography, High Pressure Liquid; Eicosanoids; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Linolenic Acids; Lipid Peroxides; Lipoxygenase; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Recombinant Proteins; Soybean Proteins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism | 2014 |
The protective effect of epoxyeicosatrienoic acids on cerebral ischemia/reperfusion injury is associated with PI3K/Akt pathway and ATP-sensitive potassium channels.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brain Injuries; Cell Survival; Cells, Cultured; Hypoxia, Brain; KATP Channels; Male; Neuroprotective Agents; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Vasodilator Agents | 2015 |
Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.
Topics: 8,11,14-Eicosatrienoic Acid; Adipose Tissue; Animals; Cardiovascular Diseases; Fatty Acid-Binding Proteins; Female; Humans; Male; Myocardial Contraction; Myocytes, Cardiac; Obesity; Rats | 2015 |
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.
Topics: 8,11,14-Eicosatrienoic Acid; Alanine Transaminase; Animals; Aspartate Aminotransferases; Catalase; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytokines; Diet, High-Fat; Disease Models, Animal; Glutathione Peroxidase; Hep G2 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Palmitic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Superoxide Dismutase; Triglycerides | 2015 |
Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Aged; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Disease Progression; Epoxide Hydrolases; Female; Humans; Immunohistochemistry; Intracellular Space; Lymphatic Metastasis; Middle Aged; Neoplasm Grading; Tumor Burden | 2014 |
Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents; Bronchi; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Epithelial Cells; Gene Expression Regulation; Humans; Interleukin-8; MAP Kinase Signaling System; Smoking; Vasodilator Agents | 2015 |
Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Blood; Culex; Eicosanoic Acids; Eicosanoids; Epoxide Hydrolases; Epoxy Compounds; Fatty Acids; Feeding Behavior; Female; Insect Proteins; Larva; Lipid Metabolism; Male | 2015 |
14,15-epoxyeicosatrienoic Acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress.
Topics: 8,11,14-Eicosatrienoic Acid; Antioxidants; Apoptosis; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Epithelial Cells; Humans; Lung; Nicotiana; Reactive Oxygen Species; Smoke; Smoking | 2015 |
EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonate 5-Lipoxygenase; Blotting, Western; Cells, Cultured; Inflammation; Leukotriene B4; Lipoproteins, LDL; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Leukotriene B4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilator Agents | 2015 |
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Cell Movement; Core Binding Factor Alpha 2 Subunit; Female; Gene Expression Regulation; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Human Umbilical Vein Endothelial Cells; Humans; Kidney; Male; Mice; Phosphatidylinositol 3-Kinases; Transcription Factor AP-1; Transcription, Genetic; Zebrafish | 2015 |
Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Diabetes Mellitus, Type 2; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Leukemia, Myeloid; Liver; Male; Myocardium; Organ Specificity; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Topics: 8,11,14-Eicosatrienoic Acid; Administration, Oral; Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hydroxyeicosatetraenoic Acids; Hypertension, Renovascular; Kidney; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Renin-Angiotensin System; Signal Transduction; Telemetry; Time Factors | 2015 |
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Male; Mice, Inbred C57BL; Pulmonary Artery; Time Factors; Ventricular Function, Right; Ventricular Pressure | 2016 |
EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Epoxide Hydrolases; Female; Hypertension, Pulmonary; Male; Mice; Mice, Knockout; Pulmonary Artery; Sex Characteristics; Vasoconstriction | 2015 |
14,15-epoxyeicosatrienoic acid promotes production of brain derived neurotrophic factor from astrocytes and exerts neuroprotective effects during ischaemic injury.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Survival; Epoxide Hydrolases; Humans; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Signal Transduction | 2016 |
Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Apoptosis; Epoxide Hydrolases; Infarction, Middle Cerebral Artery; Lauric Acids; Male; Neovascularization, Physiologic; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Hypertension, Renovascular; Kidney; Male; Rats; Rats, Sprague-Dawley; Renal Artery; Vasodilation; Vasodilator Agents | 2016 |
Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; Hydrogen-Ion Concentration; Kinetics; Phosphorus Radioisotopes; Solutions; Stereoisomerism | 2016 |
14,15-EET induces the infiltration and tumor-promoting function of neutrophils to trigger the growth of minimal dormant metastases.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Chemokines, CXC; Down-Regulation; Granulocyte Colony-Stimulating Factor; Hep G2 Cells; Humans; Interleukin-6; Interleukin-8; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Neoplasm Micrometastasis; Neoplasm Recurrence, Local; Neovascularization, Pathologic; Neutrophil Infiltration; Neutrophils; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Up-Regulation; Xenograft Model Antitumor Assays | 2016 |
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.
Topics: 8,11,14-Eicosatrienoic Acid; Aconitate Hydratase; Cell Line; Cyclic AMP Response Element-Binding Protein; GTP Phosphohydrolases; Humans; Mitochondria, Heart; NF-E2-Related Factor 2; Nuclear Respiratory Factor 1; Oleic Acids; Sirtuin 1 | 2016 |
14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy.
Topics: 8,11,14-Eicosatrienoic Acid; Anti-Inflammatory Agents; Autophagy; Cell Line; Cell Nucleus; Epithelial Cells; Gene Knockdown Techniques; Heme Oxygenase-1; Humans; Inflammation; Inflammation Mediators; Lung; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Protein Transport; RNA-Binding Proteins; Signal Transduction; Smoking; TOR Serine-Threonine Kinases; Up-Regulation | 2016 |
Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; beta-Arrestins; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Intracellular Space; Mesenteric Arteries; Mice; Oocytes; Phosphorylation; Protein Transport; Receptors, G-Protein-Coupled; Receptors, Prostaglandin; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Vasoconstriction; Xenopus | 2017 |
Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Epoxide Hydrolases; Interleukin-1beta; Lipopolysaccharides; Mice; NF-kappa B; Pneumonia; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2017 |
Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimenta
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Disease Progression; Dose-Response Relationship, Drug; Heart Failure; Hypertension; Kidney; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renal Circulation; Renin; Vasodilation | 2017 |
Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
Topics: 8,11,14-Eicosatrienoic Acid; Bacterial Proteins; Bronchoalveolar Lavage Fluid; Cell Line; Crystallography, X-Ray; Cystic Fibrosis; Humans; Inflammation; Lipoxins; Lung Diseases; Neutrophil Activation; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; Retrospective Studies; Virulence Factors | 2017 |
Epoxyeicosanoids prevent intervertebral disc degeneration in vitro and in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Hydrogen Peroxide; Intervertebral Disc Degeneration; Male; NF-kappa B; Nucleus Pulposus; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Angiotensin II Receptor Blockers Inhibit the Generation of Epoxyeicosatrienoic Acid from Arachidonic Acid in Recombinant CYP2C9, CYP2J2 and Human Liver Microsomes.
Topics: 8,11,14-Eicosatrienoic Acid; Angiotensin II Type 1 Receptor Blockers; Arachidonic Acid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kinetics; Liver; Microsomes, Liver; Recombinant Proteins | 2017 |
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
Topics: 8,11,14-Eicosatrienoic Acid; Angiogenesis Inducing Agents; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Humans | 2017 |
14,15-EET Suppresses Neuronal Apoptosis in Ischemia-Reperfusion Through the Mitochondrial Pathway.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Apoptosis; Cytochromes c; Male; Mice, Inbred C57BL; Mitochondria; Phosphatidylinositol 3-Kinases; Reperfusion Injury; Signal Transduction | 2017 |
11,12 -Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anticonvulsants; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Glutamic Acid; Hippocampus; Immunohistochemistry; Male; Mice, Inbred C57BL; Neurotransmitter Agents; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Synaptic Transmission; Tissue Culture Techniques | 2017 |
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Arachidonic Acid; Benzene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythrocyte Membrane; Female; Humans; Liposomes; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Peroxides; Stereoisomerism; Tandem Mass Spectrometry | 2017 |
The role of soluble epoxide hydrolase in preeclampsia.
Topics: 8,11,14-Eicosatrienoic Acid; Adult; Antihypertensive Agents; Blood Pressure; Epoprostenol; Epoxide Hydrolases; Female; Glucuronidase; Humans; Hypertension; Maternal Age; Nitric Oxide; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Vasoconstriction; Vasodilator Agents; Young Adult | 2017 |
Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Docosahexaenoic Acids; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Kidney Tubules; Lipocalin-2; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Reperfusion Injury; Signal Transduction; Survival Analysis | 2017 |
Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP; Epoxide Hydrolases; Hippocampus; Long-Term Potentiation; Mice, Inbred C57BL; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Line; Cell Survival; Dronedarone; Humans; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac | 2018 |
14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Humans; Immunohistochemistry; Integrin alphaVbeta3; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Bone Marrow Cells; Cells, Cultured; Fatty Acids, Unsaturated; Hematoma; Interleukin-6; Lipids; Lipopolysaccharides; Macrophages; Male; Metabolome; Mice; Mice, Inbred C57BL; Mice, Nude; RAW 264.7 Cells; Skin; Thromboxane B2; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo.
Topics: 3T3-L1 Cells; 8,11,14-Eicosatrienoic Acid; Adipocytes; Adiponectin; Adipose Tissue, Beige; Adipose Tissue, White; Animals; Cells, Cultured; Epoxide Hydrolases; Gene Expression; Heme Oxygenase-1; Humans; Mesenchymal Stem Cells; Mice; Mice, Knockout; Mitochondria; RNA Interference; Solubility; Vasodilator Agents | 2018 |
A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma.
Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Humans; Molecular Structure; Solid Phase Extraction; Stereoisomerism; Tandem Mass Spectrometry | 2018 |
14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Calcium; Capsaicin; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Hippocampus; Neurites; Neuronal Outgrowth; PC12 Cells; Primary Cell Culture; Rats; Rats, Wistar; TRPV Cation Channels | 2018 |
Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann-Pick-type C disease.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Autophagy; Cells, Cultured; Cholesterol; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Homeostasis; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Niemann-Pick Disease, Type C; Purkinje Cells | 2018 |
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors.
Topics: 8,11,14-Eicosatrienoic Acid; Analgesics; Animals; Cerebral Hemorrhage; Disease Models, Animal; Gabapentin; Hyperalgesia; Male; Pregnanolone; Proof of Concept Study; Random Allocation; Rats, Sprague-Dawley; Receptors, GABA-A; Stroke; Thalamus | 2019 |
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Kidney Injury; Animals; Cardiac Surgical Procedures; Fatty Acids; Humans; Hydroxyeicosatetraenoic Acids; Ischemia; Kidney; Male; Postoperative Complications; Rats; Rats, Inbred Lew; Reperfusion Injury; Signal Transduction | 2019 |
Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Astrocytes; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Epoxide Hydrolases; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Homeostasis; Kainic Acid; Lauric Acids; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Models, Biological; N-Methylaspartate; Neuroglia; Neuronal Plasticity; Neurons; Neurotoxins; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Solubility | 2019 |
Inhibition of soluble epoxide hydrolase attenuates airway remodeling in a chronic asthma model.
Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Female; Humans; Lauric Acids; Lung; MAP Kinase Signaling System; Mice; Ovalbumin; Signal Transduction; STAT3 Transcription Factor | 2020 |
Soluble epoxide hydrolase inhibitor protects against blood-brain barrier dysfunction in a mouse model of type 2 diabetes via the AMPK/HO-1 pathway.
Topics: 8,11,14-Eicosatrienoic Acid; AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Signal Transduction | 2020 |
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Forecasting; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Natriuresis; Potassium; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Vasodilation; Water-Electrolyte Balance; Water-Electrolyte Imbalance | 2020 |
Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-κB-mediated transcription of SGLT2 in renal tubular epithelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cell Line; Diabetes Mellitus, Experimental; Epithelial Cells; Glucose; Homeostasis; Humans; Insulin; Kidney Tubules, Proximal; Mice, Inbred C57BL; NF-kappa B; Phenylurea Compounds; Piperidines; Sodium-Glucose Transporter 2; Transcription, Genetic | 2021 |
Pharmacological regulation of cytochrome P450 metabolites of arachidonic acid attenuates cardiac injury in diabetic rats.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiomyopathies; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Hydroxyeicosatetraenoic Acids; Male; NADPH Oxidase 4; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Streptozocin | 2021 |
Mapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors.
Topics: 8,11,14-Eicosatrienoic Acid; Binding Sites; Humans; Ligands; Lipids; Protein Binding; Receptors, G-Protein-Coupled | 2021 |
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Endoplasmic Reticulum Stress; Epoxide Hydrolases; Male; Neuralgia; Neuroinflammatory Diseases; Nociception; Phenylurea Compounds; Piperidines; Rats; Rats, Sprague-Dawley; Stroke; Vasodilator Agents | 2021 |
14,15-EET Reduced Brain Injury from Cerebral Ischemia and Reperfusion via Suppressing Neuronal Parthanatos.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brain Injuries; Brain Ischemia; Disease Models, Animal; Glucose; Male; Mice; Models, Biological; Neurons; Neuroprotective Agents; Oxidative Stress; Parthanatos; Reactive Oxygen Species; Reperfusion Injury | 2021 |
Antinociception role of 14,15-epoxyeicosatrienoic acid in a central post-stroke pain model in rats mediated by anti-inflammation and anti-apoptosis effect.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents; Neuralgia; Rats; Rats, Sprague-Dawley | 2022 |
14,15-EET involved in the development of diabetic cardiac hypertrophy mediated by PPARs.
Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cardiomegaly; Diabetes Mellitus; Diabetic Cardiomyopathies; Glucose; Mice; Myocytes, Cardiac; PPAR gamma | 2022 |