Compounds > 14,15-epoxy-5,8,11-eicosatrienoic acid

14,15-epoxy-5,8,11-eicosatrienoic acid and 5,6-epoxy-8,11,14-eicosatrienoic acid

14,15-epoxy-5,8,11-eicosatrienoic acid has been researched along with 5,6-epoxy-8,11,14-eicosatrienoic acid in 52 studies

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19905 (9.62)18.7374
1990's19 (36.54)18.2507
2000's17 (32.69)29.6817
2010's10 (19.23)24.3611
2020's1 (1.92)2.80

Authors

AuthorsStudies
Hasunuma, K; Tamura, Y; Terano, T; Yoshida, S1
Amruthesh, SC; Ellis, EF; Falck, JR1
Carroll, MA; Falck, JR; Garcia, MP; McGiff, JC1
Amruthesh, SC; Ellis, EF; Police, RJ; Yancey, LM1
Campbell, WB; Falck, JR; Rosolowsky, M1
Campbell, WB; Falck, JR; Pfister, SL1
Amruthesh, SC; Ellis, EF; McKinney, JS; Police, RJ; Yancey, L1
Teien, G; Ulsaker, GA1
Falck, JR; Snyder, GD; Yadagiri, P1
Blair, IA; Capdevila, JH; Falck, JR; Hammonds, TD1
Jacoby, M; Levine, SD; Oates, JA; Petty, E; Schlondorff, D1
Capdevila, J; Falck, JR; Proctor, KG1
Capdevila, J; Carroll, MA; Falck, JR; McGiff, JC; Schwartzman, M1
Balazy, M; McGiff, JC; Schieber, EB1
Abraham, N; Escalante, BA; Schwartzman, M; Staudinger, R1
Evans, RW; Kochanek, PM; Nemoto, EM; Schiding, JK; VanRollins, M1
Campbell, WB; Rosolowsky, M1
Boyle, JE; Foley, J; Ma, J; Moomaw, CR; Pascual, JM; Steenbergen, C; Tomer, KB; Wu, S; Zeldin, DC1
Gimeno, MA; Gonzalez, E; Jawerbaum, A; Novaro, V1
Fedinec, AL; Leffler, CW1
Ellis, EF; Falck, JR; Hoffman, SW; Rzigalinski, BA; Willoughby, KA1
Lee, HC; Lu, T; Shibata, EF; Spector, AA; VanRollins, M; Weintraub, NL1
Huo, Y; Ley, K; Liao, JK; Node, K; Ruan, X; Spiecker, M; Yang, B; Zeldin, DC1
Fang, X; Spector, AA; Stoll, LL; Weintraub, NL1
Bousamra, M; Falck, JR; Harder, DR; Jacobs, ER; Roman, RJ; Townsley, M; Zeldin, DC; Zhu, D1
Campbell, WB; Nithipatikom, K; Pratt, PF1
Dai, J; Graham, L; Liao, JK; Node, K; Ruan, XL; Yang, SX; Zeldin, DC1
Benoit, C; Renaudon, B; Rousseau, E; Salvail, D1
Harder, D; Medhora, M; Narayanan, J1
Balazy, M; Falck, JR; Krishna, UM; Reddy, MM; Xia, J1
Cloutier, M; Rousseau, E; Salvail, D1
Bondlela, M; Campbell, WB; Deeter, C; Falck, JR; Gauthier, KM; Krishna, UM; Reddy, YK1
Harder, DR; Zhang, C1
Callewaert, DM; Campbell, WB; Falck, JR; Gikas, K; Nithipatikom, K; Reddy, M; Sasaki, DM; Yuan, Y1
Campbell, WB; Falck, JR; Gauthier, KM; Jagadeesh, SG1
Alvarez, DF; Gjerde, EA; Townsley, MI1
Buerkle, MA; Campbell, WB; Gloe, T; Krötz, F; Nithipatikom, K; Pohl, U; Riexinger, T; Sohn, HY1
Lee, HC; Ye, D; Zhou, W1
Liao, JK; Spiecker, M1
Anjaiah, S; Brittin, JJ; Campbell, WB; Capdevila, JH; Cui, L; Falck, JR; Nithipatikom, K; Wei, S1
Abraham, NG; Bolognesi, M; Di Pascoli, M; Gatta, A; McGiff, JC; Sacerdoti, D; Schwartzman, ML1
Brewer, J; Dechend, R; Ekholm, E; Gauster, M; Herse, F; Hoyer, J; Hubel, CA; Huppertz, B; Kaartokallio, T; Kacik, M; Laivuori, H; Lamarca, B; Lokki, AI; Luft, FC; Muller, DN; Novotny, S; Park, JK; Rothe, M; Ryan, MJ; Schunck, WH; Staff, AC; Sugulle, M; Verlohren, S; Wallukat, G1
Cracowski, C; Cracowski, JL; Gaillard-Bigot, F; Millet, C; Roustit, M; Sors, C1
Diani-Moore, S; Gross, SS; Ma, Y; Rifkind, AB1
Bornstein, SR; Lamounier-Zepter, V; Look, C; Morano, I; Schlottmann, I; Schunck, WH; Woischwill, C; Xu, A1
Feng, YQ; Hao, YH; Liu, MZ; Ni, J; Yuan, BF; Yue, J; Zhu, QF1
Froogh, G; Huang, A; Kandhi, S; Luo, M; Qin, J; Sun, D; Wolin, MS1
Funk, DJ; Kopka, K; Schmeiser, HH; Sorg, BL1
Barnych, B; Cajka, T; Hammock, BD; Lee, KSS; Morisseau, C; Panigrahy, D; Rand, AA1
Aliwarga, T; Gharib, SA; Lemaitre, RN; Raccor, BS; Sotoodehnia, N; Totah, RA; Xu, L1
Chan, ECY; Hagen, T; Karkhanis, A; Leow, JWH1
Imig, JD; Jankiewicz, WK; Khan, AH1

Reviews

2 review(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 5,6-epoxy-8,11,14-eicosatrienoic acid

ArticleYear
Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.
    Trends in cardiovascular medicine, 2001, Volume: 11, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain Chemistry; Cerebrovascular Circulation; Endothelium, Vascular; Humans; Microcirculation; Muscle, Smooth, Vascular; Vasodilation

2001
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids.
    Archives of biochemistry and biophysics, 2005, Jan-15, Volume: 433, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cell Movement; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Eicosanoids; Fibrinolysis; Humans; Inflammation; Isoenzymes; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Cardiac; NF-kappa B; Oxygenases; Protective Agents; Stereoisomerism; Vasodilation

2005

Trials

1 trial(s) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 5,6-epoxy-8,11,14-eicosatrienoic acid

ArticleYear
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 2013, Jan-15, Volume: 114, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Adult; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Female; Fluconazole; Humans; Hyperemia; Lidocaine; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Regional Blood Flow; Sensory Receptor Cells; Skin; Skin Diseases

2013

Other Studies

49 other study(ies) available for 14,15-epoxy-5,8,11-eicosatrienoic acid and 5,6-epoxy-8,11,14-eicosatrienoic acid

ArticleYear
Formation of epoxyeicosatrienoic acids from arachidonic acid by cultured rat aortic smooth muscle cell microsomes.
    Prostaglandins, leukotrienes, and essential fatty acids, 1991, Volume: 42, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Male; Metyrapone; Microsomes; Mixed Function Oxygenases; Muscle, Smooth, Vascular; NADP; NADPH-Ferrihemoprotein Reductase; Pyridines; Rats; Rats, Inbred WKY

1991
Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid.
    Journal of neurochemistry, 1992, Volume: 58, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Brain; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Male; Mice; Mice, Inbred ICR; Oxygenases

1992
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Eicosanoids; Free Radicals; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Renal Circulation; Vascular Resistance

1992
Brain synthesis and cerebrovascular action of cytochrome P-450/monooxygenase metabolites of arachidonic acid.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Brain Chemistry; Cerebrovascular Circulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Free Radicals; Indomethacin; Mice; Oxygen; Oxygenases; Prostaglandins; Vasodilation

1991
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Cells, Cultured; Coronary Vessels; Dogs; Endothelium, Vascular; Epoprostenol; Hydroxyeicosatetraenoic Acids; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Vasodilation

1991
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 2

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Arachidonic Acids; Carbon Radioisotopes; Cholesterol, Dietary; Clotrimazole; Diet, Atherogenic; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Indomethacin; Kinetics; Masoprocol; Metyrapone; Muscle, Smooth, Vascular; Rabbits; Reference Values; Stereoisomerism

1991
Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid.
    The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Arterioles; Brain; Cats; Cerebrovascular Circulation; Cytochrome P-450 Enzyme System; Rabbits; Vasodilation

1990
Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma.
    The Analyst, 1990, Volume: 115, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Aluminum; Aluminum Compounds; Deuterium; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Lithium; Lithium Compounds; Molecular Structure; Oxidation-Reduction

1990
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs.
    The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cells, Cultured; Fatty Acids, Unsaturated; Growth Hormone; Growth Hormone-Releasing Hormone; Indomethacin; Kinetics; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Somatostatin

1989
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
    Analytical biochemistry, 1989, Nov-01, Volume: 182, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Chromatography, High Pressure Liquid; Fatty Acids, Unsaturated; Stereoisomerism

1989
Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder.
    The American journal of physiology, 1987, Volume: 253, Issue:3 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Bufo marinus; Colforsin; Cyclic AMP; Epithelium; Fatty Acids, Unsaturated; Female; In Vitro Techniques; Urinary Bladder; Vasopressins; Water-Electrolyte Balance

1987
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase.
    Circulation research, 1987, Volume: 60, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Intestinal Mucosa; Intestines; Male; Rats; Regional Blood Flow; Structure-Activity Relationship; Vasodilation

1987
Vasoactivity of arachidonic acid epoxides.
    European journal of pharmacology, 1987, Jun-19, Volume: 138, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Rats; Vasodilator Agents

1987
Identification of arachidonate epoxides in human platelets.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: 8,11,14-Eicosatrienoic Acid; Blood Platelets; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Phospholipids

1995
Amiloride-sensitive ion transport inhibition by epoxyeicosatrienoic acids in renal epithelial cells.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: 8,11,14-Eicosatrienoic Acid; Amiloride; Animals; Biological Transport; Cell Line; Epithelium; Kidney; Rubidium; Rubidium Radioisotopes; Structure-Activity Relationship

1995
Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo.
    Biochimica et biophysica acta, 1995, Jun-06, Volume: 1256, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Infusions, Intravenous; Male; Rats; Rats, Wistar

1995
Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid.
    The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Arteries; Cattle; Coronary Vessels; Epoprostenol; Vasodilation

1993
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance.
    Molecular pharmacology, 1996, Volume: 50, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gas Chromatography-Mass Spectrometry; Humans; Immunoblotting; Immunohistochemistry; Isoenzymes; Lung; Macrophages, Alveolar; Muscle, Smooth, Vascular; Rats

1996
Influence of epoxyeicosatrienoic acids on uterine function.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Clotrimazole; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Ovariectomy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Uterine Contraction

1997
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arterioles; Carbon Dioxide; Cyclic AMP; Dose-Response Relationship, Drug; Iloprost; Indomethacin; Muscle, Smooth, Vascular; Nitroprusside; Pia Mater; Structure-Activity Relationship; Swine; Vasodilation; Vasodilator Agents

1997
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.
    The Journal of biological chemistry, 1999, Jan-01, Volume: 274, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Astrocytes; Calcium; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Ion Transport; Phospholipases A; Phospholipases A2; Rats; Signal Transduction; Thapsigargin

1999
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes.
    The Journal of physiology, 1999, Aug-15, Volume: 519 Pt 1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Animals, Newborn; Arachidonic Acid; Cells, Cultured; Heart; Heart Ventricles; Membrane Potentials; Myocardium; Rats; Rats, Sprague-Dawley; Sodium Channels; Structure-Activity Relationship

1999
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
    Science (New York, N.Y.), 1999, Aug-20, Volume: 285, Issue:5431

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Cattle; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Coronary Vessels; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA-Binding Proteins; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; I-kappa B Kinase; I-kappa B Proteins; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Oxygenases; Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

1999
Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Intracellular Fluid; Muscle Contraction; Muscle, Smooth, Vascular; Structure-Activity Relationship; Swine; Vasoconstrictor Agents; Vasodilator Agents

1999
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 278, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Amides; Animals; Arachidonic Acid; Cytochrome P-450 Enzyme System; Dogs; In Vitro Techniques; Male; Pressure; Pulmonary Artery; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasomotor System

2000
Determination of EETs using microbore liquid chromatography with fluorescence detection.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bradykinin; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Coronary Vessels; Endothelium, Vascular; Methacholine Chloride; Microchemistry; Spectrometry, Fluorescence

2000
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids.
    The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Aorta; Atropine Derivatives; Cattle; Cells, Cultured; Cyclic AMP; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Humans; Oxygenases; Polymerase Chain Reaction; Proadifen; Promoter Regions, Genetic; Saphenous Vein; Tissue Plasminogen Activator; Transcription, Genetic; Transfection

2001
EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Biological Factors; Bronchoconstriction; Cattle; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Muscarinic Agonists; Muscle, Smooth; Nitric Oxide Synthase; Peptides; Potassium Channels; Potassium Channels, Calcium-Activated; Rabbits; Trachea

2001
Stereospecific synthesis of trans-arachidonic acids.
    Bioorganic & medicinal chemistry letters, 2001, Sep-17, Volume: 11, Issue:18

    Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acid; Biochemistry; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Stereoisomerism

2001
Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle.
    American journal of physiology. Cell physiology, 2002, Volume: 282, Issue:3

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Cattle; Cell Fractionation; Chloride Channels; Electric Conductivity; Electrophysiology; Immunoblotting; Lipid Bilayers; Liposomes; Muscle, Smooth; Sarcolemma; Trachea; Vasodilator Agents

2002
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
    Circulation research, 2002, May-17, Volume: 90, Issue:9

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Benzimidazoles; Benzopyrans; Bradykinin; Cattle; Coronary Vessels; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium, Vascular; Iloprost; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Muscle, Smooth, Vascular; Nitroprusside; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2002
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid.
    Stroke, 2002, Volume: 33, Issue:12

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Astrocytes; Brain; Capillaries; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Lymphokines; Mitosis; Neovascularization, Physiologic; Rats; Thymidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Development of enzyme immunoassays for 5,6-, 8,9-, 11,12-, and 14,15- EETs and the corresponding DHETs.
    Advances in experimental medicine and biology, 2002, Volume: 507

    Topics: 8,11,14-Eicosatrienoic Acid; Antibodies; Arachidonic Acids; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Hydroxylation; Isomerism; Sensitivity and Specificity

2002
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cattle; Coronary Vessels; Culture Techniques; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Rats; Sulfonamides; Vasodilator Agents

2003
Role of EETs in regulation of endothelial permeability in rat lung.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Calcium; Capillary Permeability; Endothelium, Vascular; Lung; Male; Pulmonary Circulation; Rats; Rats, Inbred Strains; Vasodilator Agents

2004
Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Apamin; Aryl Hydrocarbon Hydroxylases; Biological Factors; Blood Platelets; Cells, Cultured; Charybdotoxin; Cytochrome P-450 CYP2C9; Endothelial Cells; Endothelium, Vascular; Humans; Hydroxyeicosatetraenoic Acids; Ion Channels; Membrane Potentials; Peptides; Platelet Adhesiveness; Platelet Aggregation; Potassium Channels; Recombinant Fusion Proteins; Transfection; Umbilical Veins

2004
Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Cyclic AMP-Dependent Protein Kinases; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Potassium Channels; Rats; Vasodilation; Vasodilator Agents

2005
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
    Analytical biochemistry, 2006, May-01, Volume: 352, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Liver; Male; Microsomes, Liver; Oxygenases; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents

2006
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:4

    Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Carbon Monoxide; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Male; Mesenteric Arteries; Mesoporphyrins; Organometallic Compounds; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2006
Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia.
    Circulation, 2012, Dec-18, Volume: 126, Issue:25

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Female; Humans; Hydrazines; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Oligonucleotide Array Sequence Analysis; Placenta; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley

2012
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolas
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:2

    Topics: 8,11,14-Eicosatrienoic Acid; Adamantane; Animals; Chick Embryo; Enzyme Inhibitors; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Heart; Hydroxyeicosatetraenoic Acids; Lauric Acids; Liver; Polychlorinated Dibenzodioxins; RNA, Messenger

2014
Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.
    International journal of obesity (2005), 2015, Volume: 39, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Adipose Tissue; Animals; Cardiovascular Diseases; Fatty Acid-Binding Proteins; Female; Humans; Male; Myocardial Contraction; Myocytes, Cardiac; Obesity; Rats

2015
Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
    Journal of chromatography. A, 2015, Sep-04, Volume: 1410

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Deuterium; Diabetes Mellitus, Type 2; Eicosanoids; Humans; Hydroxyeicosatetraenoic Acids; Isotope Labeling; Leukemia, Myeloid; Liver; Male; Myocardium; Organ Specificity; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2015
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice.
    American journal of hypertension, 2016, Volume: 29, Issue:5

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arterial Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Hypoxia; Infusions, Intravenous; Male; Mice, Inbred C57BL; Pulmonary Artery; Time Factors; Ventricular Function, Right; Ventricular Pressure

2016
Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro.
    Prostaglandins & other lipid mediators, 2016, Volume: 123

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Cattle; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; Hydrogen-Ion Concentration; Kinetics; Phosphorus Radioisotopes; Solutions; Stereoisomerism

2016
Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 04-25, Volume: 114, Issue:17

    Topics: 8,11,14-Eicosatrienoic Acid; Angiogenesis Inducing Agents; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; Humans

2017
Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
    Free radical biology & medicine, 2017, Volume: 112

    Topics: 8,11,14-Eicosatrienoic Acid; Aging; Animals; Arachidonic Acid; Benzene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Erythrocyte Membrane; Female; Humans; Liposomes; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidation-Reduction; Peroxides; Stereoisomerism; Tandem Mass Spectrometry

2017
Dronedarone-Induced Cardiac Mitochondrial Dysfunction and Its Mitigation by Epoxyeicosatrienoic Acids.
    Toxicological sciences : an official journal of the Society of Toxicology, 2018, 05-01, Volume: 163, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Anti-Arrhythmia Agents; Cardiotonic Agents; Cell Line; Cell Survival; Dronedarone; Humans; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac

2018
Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 76, Issue:1

    Topics: 8,11,14-Eicosatrienoic Acid; Animals; Arachidonic Acid; Cardiovascular Diseases; Cytochrome P-450 Enzyme System; Disease Models, Animal; Epoxide Hydrolases; Forecasting; Humans; Hypertension; Kidney; Kidney Diseases; Mice; Natriuresis; Potassium; Rats; Rats, Inbred Dahl; Sodium Chloride; Sodium Chloride, Dietary; Vasodilation; Water-Electrolyte Balance; Water-Electrolyte Imbalance

2020